Jurnal Farmasi Udayana最新文献

Manfaat Terapi Tambahan Vitamin pada Pasien Nyeri Neuropati Diabetika 补充维生素治疗的好处:糖尿病神经性疼痛患者

Jurnal Farmasi Udayana Pub Date : 2023-08-28 DOI: 10.24843/jfu.2023.v12.i01.p12

Edenia Asisaratu, Rizaldy T. Pinzon, Esdras Ardi Pramudita

{"title":"Manfaat Terapi Tambahan Vitamin pada Pasien Nyeri Neuropati Diabetika","authors":"Edenia Asisaratu, Rizaldy T. Pinzon, Esdras Ardi Pramudita","doi":"10.24843/jfu.2023.v12.i01.p12","DOIUrl":"https://doi.org/10.24843/jfu.2023.v12.i01.p12","url":null,"abstract":"Latar Belakang: Nyeri neuropati diabetika menjadi komplikasi penyakit Diabetes Mellitus yang paling sering terjadi dan dapat menjadi beban sehingga dibutuhkan pengobatan optimal. Pengobatan saat ini yaitu terapi simtomatik dengan kontrol indeks glikemik namun belum dapat mencapai target optimal. Penelitian terdahulu menunjukkan suplementasi vitamin B dan vitamin D dapat memberikan pengurangan nyeri yang signifikan. Cara Kerja: Penelitian ini dilakukan menggunakan metode kohort retrospektif. Pengambilan sampel dilakukan menggunakan metode consecutive sampling dengan total sampel 107 subjek yang mendapatkan terapi simtomatik atau terapi simtomatik ditambah vitamin. Terapi diberikan selama tiga bulan. Pengukuran skala nyeri dilakukan dengan menggunakan Neuropathic Pain Scale. Hasil: Penelitian ini membandingkan subjek dalam tiga kelompok perbandingan. Pada kelompok perbandingan pertama, pengurangan nyeri paling besar pada kelompok terapi simtomatik ditambah vitamin (39,50±14,222) (p=0,000). Pada kelompok perbandingan kedua, pengurangan nyeri paling besar terdapat pada kelompok terapi simtomatik ditambah kombinasi vitamin B dan vitamin D 1000 IU (53,00±6,749) (p=0,000). Pada kelompok perbandingan ketiga, pengurangan nyeri paling besar terdapat pada kelompok terapi simtomatik ditambah vitamin D 1000 IU (44,00±8,944) (p=0,088). Kesimpulan: Terapi tambahan vitamin mengakibatkan pengurangan nyeri yang lebih besar secara bermakna dibandingkan terapi simtomatik saja. Tidak terdapat perbedaan penurunan nyeri yang bermakna antara penambahan vitamin D 400 IU dengan vitamin D 1000 IU. \u0000Kata kunci: intensitas nyeri; nyeri neuropati diabetika; vitamin B; vitamin D","PeriodicalId":17752,"journal":{"name":"Jurnal Farmasi Udayana","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79873331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Studi Potensi Ekstrak Etanol Biji Pepaya (Carica papaya L.) sebagai Pedikulisidal Semprot terhadap Kutu Pediculus humanus var. capitis 木瓜籽乙醇(Carica papaya L)的潜在提取物研究，该提取物是向人类var capitis喷洒的儿科种子

Jurnal Farmasi Udayana Pub Date : 2023-08-28 DOI: 10.24843/jfu.2023.v12.i01.p03

Siti Jubaedah

{"title":"Studi Potensi Ekstrak Etanol Biji Pepaya (Carica papaya L.) sebagai Pedikulisidal Semprot terhadap Kutu Pediculus humanus var. capitis","authors":"Siti Jubaedah","doi":"10.24843/jfu.2023.v12.i01.p03","DOIUrl":"https://doi.org/10.24843/jfu.2023.v12.i01.p03","url":null,"abstract":"— Pediculosis capitis is an infection of the scalp and skin caused by Pediculus humanus var. capitis, which is still common today. Pediculicidal from plants has been widely recommended as an alternative pediculicide because it has a low toxicity effect on humans. This study aims to determine the potential of papaya seed ethanol extract on the death of Pediculus humanus var. capitis. The study used five head lice in each treatment group. The test was carried out with five concentration treatments, namely concentrations of 5%, 10%, 15%, 20%, and 40%. The control used was a positive control, namely 1% permethrin, and negative control, namely aquabides. This research was conducted with three times repetition. The results showed concentrations of 15%, 20%, 40%, and positive control had a high percentage of mortality, namely 100%, 10% concentration was 80% mortality, the lowest lice mortality was 5% concentration of 60%, and negative control was 0%. This research obtained the results of LC50 is 9,685%, while LC90 is 12,038%. The results of the phytochemical test showed that the ethanol extract of papaya seeds contained alkaloids","PeriodicalId":17752,"journal":{"name":"Jurnal Farmasi Udayana","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88610963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aktivitas Anti-Wrinkle Gel Ekstrak Binahong (Anredera cordifolia) secara In Vivo 消凝凝胶萃取物(Anredera cordifolia)的活组织

Jurnal Farmasi Udayana Pub Date : 2023-08-28 DOI: 10.24843/jfu.2023.v12.i01.p01

Kintoko Kintoko, Hardi Astuti Witasari, Yuda Fajar Pratama

引用次数: 0

Formulasi dan Evaluasi Lip cream Halal Menggunakan Ekstrak Tomat (Lycopersicon esculentum Mill) Sebagai Pewarna Alami 配方和清真唇膏评价使用番茄提取物作为天然染料

Jurnal Farmasi Udayana Pub Date : 2023-08-28 DOI: 10.24843/jfu.2023.v12.i01.p06

Abdullah Qosim

{"title":"Formulasi dan Evaluasi Lip cream Halal Menggunakan Ekstrak Tomat (Lycopersicon esculentum Mill) Sebagai Pewarna Alami","authors":"Abdullah Qosim","doi":"10.24843/jfu.2023.v12.i01.p06","DOIUrl":"https://doi.org/10.24843/jfu.2023.v12.i01.p06","url":null,"abstract":"Abstract— Lip cream is a semi-solid to liquid textured preparation that functions as a lip dye. Tomato plants can be used as natural dyes because they contain lycopene compounds which can give a yellow to red color. This study aims to determine whether tomato fruit extract can be formulated as a dye, determine the effect of adding tomato extract concentration and determine the halal critical point in the preparation of tomato fruit extract lip cream as a natural dye. The tomato fruit extraction method was carried out using UAE with methanol solvent. The resulting extract was then added to each formula with concentrations of F0 (0%), F1 (5%), F2 (10%) and F3 (15%). The organoleptic test results showed that all formulas had a semi-solid texture, smelled of roses and F0 was white, F1 was light orange, F2 was orange and F3 was brick red. All formulas comply with the homogeneity and pH test standards as indicated by the pH value range of 6.47 - 5.17. All formulas had good smearing power, adhesion of ?60 seconds and spreadability test values ??ranging from 5.90 to 5.63. The results of the ANOVA analysis on the pH and spreadability tests showed that the preparations had significant differences between the formulas. Evaluation of halal critical points on preparations does not have halal critical points in terms of materials and processing.","PeriodicalId":17752,"journal":{"name":"Jurnal Farmasi Udayana","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85045299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Potensi Senyawa Aktif Tanaman Herbal untuk Pengobatan Kanker Payudara dengan Metode Penambatan Molekuler: Review Artikel 用分子治疗方法治疗乳腺癌的潜在活性化合物:文章复习

Jurnal Farmasi Udayana Pub Date : 2023-08-28 DOI: 10.24843/jfu.2023.v12.i01.p04

Alma Yunita Sari, Ellin Febrina

引用次数: 0

Narrative Review: Analisis Fitokimia Dan Manfaat Ekstrak Ketepeng Cina (Cassia alata L.) Sebagai Antijamur 叙述性综述：中国土贝母提取物的植物化学分析及其抗真菌功效

Jurnal Farmasi Udayana Pub Date : 2023-08-28 DOI: 10.24843/jfu.2023.v12.i01.p08

Baha Udin, Renditya Ismiyati, Renditya Ismiyati, Eva Kholifah, Endah Endah, Endah Endah

引用次数: 0

PENGARUH EKSTRAK ETANOL DAUN KARANDA (Carissa carandas L.) TERHADAP HISTOPATOLOGI GINJAL TIKUS PUTIH (rattus norvegicus) YANG DIINDUKSI ALOKSAN 乙醇提取物的影响KARANDA (Carissa carandas L)。用于白老鼠的肾脏组织性病理(rattus norvegicus)，引起了一种硬度

Jurnal Farmasi Udayana Pub Date : 2023-08-28 DOI: 10.24843/jfu.2023.v12.i01.p05

Ilhammudin Sirait, Husnarika Febriani, Syukriah

{"title":"PENGARUH EKSTRAK ETANOL DAUN KARANDA (Carissa carandas L.) TERHADAP HISTOPATOLOGI GINJAL TIKUS PUTIH (rattus norvegicus) YANG DIINDUKSI ALOKSAN","authors":"Ilhammudin Sirait, Husnarika Febriani, Syukriah","doi":"10.24843/jfu.2023.v12.i01.p05","DOIUrl":"https://doi.org/10.24843/jfu.2023.v12.i01.p05","url":null,"abstract":"Suatu kondisi metabolik yang disebut diabetes melitus (DM) diakibatkan oleh ketidakmampuan untuk mengeluarkan insulin. Tujuan penelitian ini adalah untuk mengetahui pengaruh pemberian ekstrak etanol daun karanda (Carissa carandas L.) terhadap morfologi dan histologi ginjal tikus diabetes. Penelitian ini menggunakan Rancangan Acak Lengkap (RAL) dengan enam kelompok variasi yaitu kelompok glibenklamid, kontrol normal, kontrol negatif. P1: dosis ekstrak daun karanda 500 mg/kg BB, P2: dosis ekstrak daun karanda 750 mg/kg BB, dan P3: Dosis ekstrak daun karanda 1000 mg/kg BB. Pewarnaan hematoksilin-eosin (HE) dan metode parafin untuk preparasi histopatologi ginjal tikus. Tes tindak lanjut Anova dan Duncan digunakan dalam analisis data dalam satu metode. Temuan menunjukkan perbedaan substansial antara kelompok kontrol dan perlakuan dalam morfologi dan histologi ginjal tikus diabetes. Histologi ginjal tikus diabetes menunjukkan edema glomerulus, destruksi sel berupa degenerasi hidropik dan nekrosis tubulus proksimal, serta modifikasi lebar glomerulus. Pemberian ekstrak etanol daun karanda dapat membantu mengatasi edema glomerulus, bentuk, dan penyembuhan sel tubulus proksimal. Mungkin relevan bahwa morfologi ginjal, histologi, dan diameter glomerulus tikus (Rattus norvegicus) dengan diabetes mellitus ditingkatkan oleh ekstrak etanol daun karanda, dengan dosis ekstrak yang paling efektif adalah 1000 mg/kgbb. \u0000Kata Kunci : Diabetes Melitus, Daun Karanda (Carissa carandas L.) dan Ginjal","PeriodicalId":17752,"journal":{"name":"Jurnal Farmasi Udayana","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74307945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Review potensi Emblica officinalis (Amla) dalam mengatasi gangguan metabolisme dislipidemia dan antioksidan Emblica officinalis (Amla)对代谢紊乱、偏移和抗氧化剂的影响的评估

Jurnal Farmasi Udayana Pub Date : 2023-08-28 DOI: 10.24843/jfu.2023.v12.i01.p10

N. K. Warditiani, Pande Made, Nova Armita Sari, Ni Made, Widi Astuti

引用次数: 0

Finding Antitubercular Leads from Marine-Derived and Entomopathogenic Fung 从海洋来源和昆虫病原真菌中发现抗结核铅

Jurnal Farmasi Udayana Pub Date : 2023-08-28 DOI: 10.24843/jfu.2023.v12.i01.p09

Ni Luh, Putu Indah Suryani, Putu Yogi, Astara Putra, I. Nonye, T. Ujam, dan Ni, Putu Ariantari

{"title":"Finding Antitubercular Leads from Marine-Derived and Entomopathogenic Fung","authors":"Ni Luh, Putu Indah Suryani, Putu Yogi, Astara Putra, I. Nonye, T. Ujam, dan Ni, Putu Ariantari","doi":"10.24843/jfu.2023.v12.i01.p09","DOIUrl":"https://doi.org/10.24843/jfu.2023.v12.i01.p09","url":null,"abstract":"The occurrence of Mycobacterium tuberculosis resistance encourages the discovery of new antitubercular candidates. Microbes including fungi and bacteria are well known reservoir for isolating antibiotic compounds, among natural product resources. In this review, we report promising antitubercular compounds from marine-derived and entomopathogenic fungi, reported from 2000 to 2022. A comprehensive literature search was conducted through scientific websites, including Google Scholar, Springer, and Pubmed. Eighty-three antitubercular compounds were reported, where 57 of them derived from fungi associated with marine ecosystem. Those fungi belong to 10 fungal genera. The remaining active compounds were isolated from 7 genera of entomopathogenic fungi. Gliotoxin, 12,13-dihydroxy-fumitremorgin, and helvolic acid as well as hirsutellones A-D are among bioactive compounds reported for their remarkable antitubercular activity, which promising to be investigated further in the search of antitubercular leads. Deeper investigation on these compounds might be promising for the the discovery of antitubercular candidates in the future. \u0000Keywords: Antitubercular; entomopathogenic fungi; marine-derived fungi; Mycobaterium tuberculosis; secondary metabolites","PeriodicalId":17752,"journal":{"name":"Jurnal Farmasi Udayana","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81773519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analisis ABC Dalam Perencanaan Pengadaan Perbekalan Farmasi di Puskesmas Gamping 1 Yogyakarta ABC分析了日惹Puskesmas Gamping 1的制药用品采购计划

Jurnal Farmasi Udayana Pub Date : 2023-08-28 DOI: 10.24843/jfu.2023.v12.i01.p07

Fiqri Zulpadly, S. Rahayu

{"title":"Analisis ABC Dalam Perencanaan Pengadaan Perbekalan Farmasi di Puskesmas Gamping 1 Yogyakarta","authors":"Fiqri Zulpadly, S. Rahayu","doi":"10.24843/jfu.2023.v12.i01.p07","DOIUrl":"https://doi.org/10.24843/jfu.2023.v12.i01.p07","url":null,"abstract":"Dalam pelaksanaan tugas pengelolaan sediaan farmasi dan bahan medis habis pakai (BMHP), Puskesmas perlu melakukan manajemen Puskesmas secara efektif dan efisien. Salah satu kegiatannya adalah manajemen inventaris farmasi. Pada penelitian ini dilakukan analisis ABC dalam perencanaan pengadaan sediaan farmasi dan BMHP di Puskesmas Gamping I Yogyakarta Periode Januari-Desember 2021. Tujuannya adalah untuk mengetahui pengelompokkan item secara ABC berdasarkan nilai investasi serta proporsi persentase setiap kelompok sediaan farmasi dan BMHP di Puskesmas. \u0000Jenis penelitian ini adalah penelitian non eksperimental dengan analisis secara deskriptif menggunakan data kuantitatif yang dilakukan secara retrospektif. Data primer diperoleh melalui wawancara dengan apoteker unit farmasi Puskesmas, sedangkan data sekunder bersumber dari riwayat pengadaan sediaan farmasi dan BMHP berdasarkan LPLPO Puskesmas tersebut selama periode Januari-Desember 2021. \u0000Hasil menunjukkan bahwa untuk kategori sediaan farmasi, sebesar 0,73% item dari jumlah keseluruhan termasuk dalam kelompok A. Kelompok B terdiri dari 9 item dan kelompok C 127 item. Untuk BMHP, persentase kelompok A adalah sebesar 16,67% dari total persediaan yang berjumlah 54 item. Kelompok B dengan persentase 22,22% dan kelompok C 61,11%. \u0000Kata kunci: Analisis ABC, perencanaan pengadaan","PeriodicalId":17752,"journal":{"name":"Jurnal Farmasi Udayana","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89664965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0