Finding Antitubercular Leads from Marine-Derived and Entomopathogenic Fung

Jurnal Farmasi Udayana Pub Date : 2023-08-28 DOI:10.24843/jfu.2023.v12.i01.p09

Ni Luh, Putu Indah Suryani, Putu Yogi, Astara Putra, I. Nonye, T. Ujam, dan Ni, Putu Ariantari

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Abstract

The occurrence of Mycobacterium tuberculosis resistance encourages the discovery of new antitubercular candidates. Microbes including fungi and bacteria are well known reservoir for isolating antibiotic compounds, among natural product resources. In this review, we report promising antitubercular compounds from marine-derived and entomopathogenic fungi, reported from 2000 to 2022. A comprehensive literature search was conducted through scientific websites, including Google Scholar, Springer, and Pubmed. Eighty-three antitubercular compounds were reported, where 57 of them derived from fungi associated with marine ecosystem. Those fungi belong to 10 fungal genera. The remaining active compounds were isolated from 7 genera of entomopathogenic fungi. Gliotoxin, 12,13-dihydroxy-fumitremorgin, and helvolic acid as well as hirsutellones A-D are among bioactive compounds reported for their remarkable antitubercular activity, which promising to be investigated further in the search of antitubercular leads. Deeper investigation on these compounds might be promising for the the discovery of antitubercular candidates in the future. Keywords: Antitubercular; entomopathogenic fungi; marine-derived fungi; Mycobaterium tuberculosis; secondary metabolites

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从海洋来源和昆虫病原真菌中发现抗结核铅

结核分枝杆菌耐药的发生鼓励发现新的抗结核候选药物。在天然产物资源中，包括真菌和细菌在内的微生物是分离抗生素化合物的宿主。在这篇综述中，我们报道了从2000年到2022年报道的来自海洋和昆虫病原真菌的有前途的抗结核化合物。通过谷歌Scholar、施普林格、Pubmed等科学网站进行全面的文献检索。共发现83种抗结核化合物，其中57种来源于与海洋生态系统有关的真菌。这些真菌属于10个真菌属。其余活性化合物从7属昆虫病原真菌中分离得到。胶质毒素、12,13-二羟基呋喃霉素、helvolic acid和hirsutellones A-D是被报道的具有显著抗结核活性的生物活性化合物，在寻找抗结核线索方面有进一步的研究前景。对这些化合物的深入研究可能有助于在未来发现抗结核候选药物。关键词:抗结核的;昆虫病原真菌;marine-derived真菌;Mycobaterium结核病;次生代谢产物

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Jurnal Farmasi Udayana

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