Kidney Research and Clinical Practice最新文献_第7页

The current state of life expectancy of hemodialysis patients in Korea. 韩国血液透析患者的预期寿命现状。

IF 2.9 3区医学

Kidney Research and Clinical Practice Pub Date : 2024-09-01 Epub Date: 2024-05-29 DOI: 10.23876/j.krcp.24.099

Seyoung Ryou, Hye Eun Yoon

引用次数: 0

Cardiac and kidney outcomes after sacubitril-valsartan therapy: recovery of cardiac function relative to kidney function decline. 萨库比特利-缬沙坦治疗后的心脏和肾脏预后：心功能的恢复与肾功能的下降相对应。

IF 2.9 3区医学

Kidney Research and Clinical Practice Pub Date : 2024-09-01 Epub Date: 2024-09-30 DOI: 10.23876/j.krcp.24.021

Hyo Jeong Kim, Eunji Yang, Hee Byung Koh, Jong Hyun Jhee, Hyeong Cheon Park, Hoon Young Choi

{"title":"Cardiac and kidney outcomes after sacubitril-valsartan therapy: recovery of cardiac function relative to kidney function decline.","authors":"Hyo Jeong Kim, Eunji Yang, Hee Byung Koh, Jong Hyun Jhee, Hyeong Cheon Park, Hoon Young Choi","doi":"10.23876/j.krcp.24.021","DOIUrl":"10.23876/j.krcp.24.021","url":null,"abstract":"Background: Sacubitril-valsartan reduces the risk of cardiovascular mortality among patients with heart failure with reduced ejection fraction (HFrEF). However, its long-term protective effects on cardiac function with concurrent acute kidney injury (AKI) remain unclear. This study investigated the recovery of cardiac function relative to kidney function decline.Methods: A total of 512 patients with HFrEF who started sacubitril-valsartan or valsartan treatment were enrolled in cohort 1. Additionally, patients who experienced AKI and underwent follow-up transthoracic echocardiography were enrolled in cohort 2. In cohort 1, short- and long-term kidney outcomes were analyzed. For cohort 2, changes in cardiac function in relation to changes in kidney function after drug initiation were analyzed.Results: The mean age of the patients was 68.3 ± 15.1 years, and 57.4% of the patients were male. AKI occurred in 15.9% of the sacubitril-valsartan group and 12.5% of the valsartan group. After AKI, 78.4% of patients in the sacubitril-valsartan group and 71.4% of those in the valsartan group underwent recovery. Furthermore, cardiovascular outcomes in patients who developed AKI after drug initiation were analyzed in cohort 2. The sacubitril-valsartan group showed a greater improvement in cardiac function compared with the valsartan group (12.4% ± 15.4% vs. 1.4% ± 5.7%, p = 0.046). The ratio of deltas of cardiac and kidney function in the sacubitril-valsartan and valsartan groups were -1.76 ± 2.58 and -0.20 ± 0.58, respectively (p = 0.03).Conclusion: Patients with HFrEF treated with sacubitril-valsartan exhibited significant improvements in cardiovascular outcomes despite AKI.","PeriodicalId":17716,"journal":{"name":"Kidney Research and Clinical Practice","volume":"43 5","pages":"614-625"},"PeriodicalIF":2.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11467369/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142400648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long non-coding RNA MEG3 silencing weakens high glucose-induced mesangial cell injury by decreasing LIN28B expression by sponging and sequestering miR-23c. 长非编码 RNA MEG3 沉默通过海绵化和封存 miR-23c 来减少 LIN28B 的表达，从而减轻高血糖诱导的间质细胞损伤。

IF 2.9 3区医学

Kidney Research and Clinical Practice Pub Date : 2024-09-01 Epub Date: 2023-12-11 DOI: 10.23876/j.krcp.23.090

Lu Rong, Huanzhou Xue, Jianwei Hao, Jianjun Liu, Hao Xu

{"title":"Long non-coding RNA MEG3 silencing weakens high glucose-induced mesangial cell injury by decreasing LIN28B expression by sponging and sequestering miR-23c.","authors":"Lu Rong, Huanzhou Xue, Jianwei Hao, Jianjun Liu, Hao Xu","doi":"10.23876/j.krcp.23.090","DOIUrl":"10.23876/j.krcp.23.090","url":null,"abstract":"Background: Diabetic nephropathy (DN) is a common kidney disease in diabetic patients. Long non-coding RNA maternally expressed gene 3 (MEG3) and microRNA (miR)-23c are reported to be implicated in DN development. Nevertheless, it is unclear that the molecular mechanism between MEG3 and miR-23c in DN remains unclear.Methods: Human mesangial cells (HMCs) were treated with high glucose (HG) to simulate the DN status in vitro. Expression of MEG3 and miR-23c was measured. Effects of MEG3 silencing on HG-stimulated HMC injury were determined. The relationship between MEG3 and miR-23c was verified by the dual-luciferase reporter and RNA immunoprecipitation assays.Results: MEG3 was overexpressed in serums from DN patients and HG-stimulated HMCs. MEG3 knockdown weakened HG-stimulated HMC proliferation, extracellular matrix (ECM) accumulation, and inflammation. MEG3 regulated lin-28 homolog B (LIN28B) expression through adsorbing miR-23c. MiR-23c inhibitor reversed MEG3 knockdown-mediated effects on HG-stimulated HMC proliferation, ECM accumulation, and inflammation. LIN28B overexpression overturned miR-23c mimic-mediated effects on HG-stimulated HMC proliferation, ECM accumulation, and inflammation.Conclusion: MEG3 regulated HMC injury via regulation of the miR-23c/LIN28B axis in DN, which can help us better understand the mechanism of DN mediated by MEG3.","PeriodicalId":17716,"journal":{"name":"Kidney Research and Clinical Practice","volume":" ","pages":"600-613"},"PeriodicalIF":2.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11467368/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139040208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Air pollution can affect kidney disease? Scientific evidence from epidemiology to experimental studies. 空气污染会影响肾病？从流行病学到实验研究的科学证据。

IF 2.9 3区医学

Kidney Research and Clinical Practice Pub Date : 2024-09-01 Epub Date: 2024-08-12 DOI: 10.23876/j.krcp.24.103

Jiwoo Park, Whanhee Lee

引用次数: 0

Effect of immunosuppressive agents on clinical outcomes in idiopathic membranous nephropathy. 免疫抑制剂对特发性膜性肾病临床疗效的影响。

IF 2.9 3区医学

Kidney Research and Clinical Practice Pub Date : 2024-09-01 Epub Date: 2023-09-08 DOI: 10.23876/j.krcp.22.255

Ji-Young Choi, Ho Jun Chin, Hajeong Lee, Yena Jeon, Jeong-Hoon Lim, Hee-Yeon Jung, Jang-Hee Cho, Chan-Duck Kim, Yong-Lim Kim, Sun-Hee Park

{"title":"Effect of immunosuppressive agents on clinical outcomes in idiopathic membranous nephropathy.","authors":"Ji-Young Choi, Ho Jun Chin, Hajeong Lee, Yena Jeon, Jeong-Hoon Lim, Hee-Yeon Jung, Jang-Hee Cho, Chan-Duck Kim, Yong-Lim Kim, Sun-Hee Park","doi":"10.23876/j.krcp.22.255","DOIUrl":"10.23876/j.krcp.22.255","url":null,"abstract":"Background: Few comparative studies on the effects of immunosuppressants in patients with idiopathic membranous nephropathy have been conducted.Methods: Data from 489 patients who received conservative treatment or immunosuppressants were retrospectively analyzed by propensity score matching. Primary outcomes were complete or partial remission (CR or PR) of proteinuria, and secondary outcomes were renal survival and infection.Results: Of the 489 patients, 357 (73.0%) received immunosuppressants. Propensity score matching identified 82 patients from the conservative group and 82 patients in the immunosuppressant group. CR or PR at 12 months was significantly higher in the immunosuppressant group compared with the conservative group for the total population (p = 0.002) and the propensity score-matched population (p = 0.02). The use of immunosuppressants was significantly more effective with respect to achieving a CR or PR at 12 months in patients who were aged <65 years or female, or who had a proteinuria level of ≥4.0 g/g or an estimated glomerular filtration rate of ≥60 mL/min/1.73 m2 (p < 0.05). Renal survival was similar between patients receiving immunosuppressants and conservative treatment in both the total and matched populations. The immunosuppressant group (21.8%) had a significantly higher incidence of infections compared with the conservative group (13.6%) for the total population (p = 0.03), but statistical significance disappeared in the matched population (p > 0.99).Conclusion: The remission rate was significantly higher in the immunosuppressant group than in the conservative group, particularly in the subgroup of patients who were young or female, or those with heavy proteinuria loads or good renal function.","PeriodicalId":17716,"journal":{"name":"Kidney Research and Clinical Practice","volume":" ","pages":"635-647"},"PeriodicalIF":2.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11467357/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41132358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Personalized nutritional management in the transition from non-dialysis dependent chronic kidney disease to dialysis. 从非透析依赖型慢性肾病向透析过渡期间的个性化营养管理。

IF 2.9 3区医学

Kidney Research and Clinical Practice Pub Date : 2024-09-01 Epub Date: 2024-05-10 DOI: 10.23876/j.krcp.23.142

Yoko Narasaki, Man Kit Siu, Matthew Nguyen, Kamyar Kalantar-Zadeh, Connie M Rhee

{"title":"Personalized nutritional management in the transition from non-dialysis dependent chronic kidney disease to dialysis.","authors":"Yoko Narasaki, Man Kit Siu, Matthew Nguyen, Kamyar Kalantar-Zadeh, Connie M Rhee","doi":"10.23876/j.krcp.23.142","DOIUrl":"10.23876/j.krcp.23.142","url":null,"abstract":"Dialysis has been the dominant treatment regimen in end-stage kidney disease as a means to remove uremic waste products and to maintain electrolyte, acid base, and fluid balance. However, given that dialysis may not always provide a survival benefit nor improved quality of life in certain subpopulations, there is growing recognition of the need for conservative and preservative management as an alternative treatment strategy for advanced chronic kidney disease (CKD). Personalized nutritional management tailored to patient's sociodemographics, social needs, psychological status, health literacy level, and preferences is a key component of conservative and preservative care, as well as in the management of patients transitioning from non-dialysis dependent CKD to dialysis. In this review, we discuss the nutritional and metabolic alterations that ensue in CKD; the rationale for low-protein diets in the conservative and preservative management of advanced CKD; the role of plant-based diets in kidney health; emerging data on dietary potassium and sodium intake on CKD outcomes; and the practical implementation of dietary interventions in advanced kidney disease.","PeriodicalId":17716,"journal":{"name":"Kidney Research and Clinical Practice","volume":" ","pages":"575-585"},"PeriodicalIF":2.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11467355/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140912452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of current clinical practices and perceptions of patients and caregivers regarding Alport syndrome in South Korea. 调查韩国目前的临床实践以及患者和护理人员对 Alport 综合征的看法。

IF 2.9 3区医学

Kidney Research and Clinical Practice Pub Date : 2024-08-24 DOI: 10.23876/j.krcp.23.260

Dabin Kim, Yo Han Ahn, Eunjeong Kang, Hajeong Lee, Min Hyun Cho, Hee Gyung Kang, Ji Hyun Kim

{"title":"Investigation of current clinical practices and perceptions of patients and caregivers regarding Alport syndrome in South Korea.","authors":"Dabin Kim, Yo Han Ahn, Eunjeong Kang, Hajeong Lee, Min Hyun Cho, Hee Gyung Kang, Ji Hyun Kim","doi":"10.23876/j.krcp.23.260","DOIUrl":"https://doi.org/10.23876/j.krcp.23.260","url":null,"abstract":"Background: Alport syndrome (AS) is a highly prevalent inherited kidney disease. Early diagnosis and intervention are crucial for improved kidney outcomes. This study evaluated awareness among Korean clinicians about AS and assessed the understanding of AS patients and caregivers.Methods: An online survey targeting registered members of the Korean Society of Nephrology, the Korean Society of Pediatric Nephrology, AS patients, and their caregivers was conducted from January to April 2023.Results: Out of 103 respondents, most had treated fewer than 10 AS patients. For certain kidney diseases, such as chronic kidney disease of unknown origin and focal segmental glomerulosclerosis, half or fewer considered AS as a potential diagnosis. Only half preferred immediate confirmation tests for suspected AS. Genetic testing was available at half of the medical centers, and fewer than half of the adult nephrologists considered genetic testing to be essential. While all the surveyed nephrologists would prescribe renin-angiotensin system blockade, the majority hesitated to initiate treatment. Vigilant genetic testing for donor candidates was not a common practice. While 80% of patients and 50% of caregivers understood the nature and prognosis of AS, they regretted the delayed diagnoses, insufficient explanations, and the absence of support groups.Conclusion: Not rarely, AS patients may have been unrecognized as AS. Despite the noteworthy advancement of AS, the recent guidelines have not been widely adopted in clinical practice in Korea. Considering the challenges in Korea, there is an urgent need for locally tailored clinical practice recommendations and a dedicated registry to optimize patient outcomes.","PeriodicalId":17716,"journal":{"name":"Kidney Research and Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142391566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pathological diagnosis of Alport syndrome. 阿尔波特综合征的病理诊断。

IF 2.9 3区医学

Kidney Research and Clinical Practice Pub Date : 2024-08-23 DOI: 10.23876/j.krcp.24.063

Kyoung Bun Lee, Minsun Jung, Beom Jin Lim

引用次数: 0

GAIT-CKD (Gait Analysis using Artificial Intelligence for digital Therapeutics of patients with Chronic Kidney Disease): design and methods. GAIT-CKD（利用人工智能进行步态分析，为慢性肾病患者提供数字化治疗）：设计与方法。

IF 2.9 3区医学

Kidney Research and Clinical Practice Pub Date : 2024-08-22 DOI: 10.23876/j.krcp.23.273

Youngjin Song, In Cheol Jeong, Semin Ryu, Sunghan Lee, Jeonghwan Koh, Seokjue Jeong, Seongmin Park, Munsang Kim, Wonjun Lee, Okhyeon Rye, Yeojin Kim, Sanggyu Lee, Mooeob Ahn, Hyunsuk Kim

{"title":"GAIT-CKD (Gait Analysis using Artificial Intelligence for digital Therapeutics of patients with Chronic Kidney Disease): design and methods.","authors":"Youngjin Song, In Cheol Jeong, Semin Ryu, Sunghan Lee, Jeonghwan Koh, Seokjue Jeong, Seongmin Park, Munsang Kim, Wonjun Lee, Okhyeon Rye, Yeojin Kim, Sanggyu Lee, Mooeob Ahn, Hyunsuk Kim","doi":"10.23876/j.krcp.23.273","DOIUrl":"https://doi.org/10.23876/j.krcp.23.273","url":null,"abstract":"Background: Digital therapeutics are emerging as treatments for diseases and disabilities. In chronic kidney disease (CKD), gait is a potential biomarker for health status and intervention effectiveness. This study aims to analyze gait characteristics in CKD patients, providing baseline data for digital therapeutics development.Methods: At baseline and after an 8-week intervention, we performed bioimpedance analysis measurements, the Timed Up and Go, Tinetti, and grip strength tests, and gait analysis in 217 healthy individuals and 276 patients with CKD. Demographic and clinical information was collected, including underlying diseases and medications, laboratory tests, and quality of life satisfaction surveys. Gait analysis was performed using skeleton data, which involved acquiring three-dimensional skeleton data of a walker using a single Kinect sensor. The performance of an artificial intelligence-based classification model in distinguishing between healthy individuals and those with CKD was then investigated. Simultaneously, inertia measurement unit analysis was conducted using measurements taken from the wrist and waist.Results: Most subjects received a health intervention via an app, and their gait was assessed for improvements after an 8-week period. Incidents such as falls, fractures, hospitalizations, and deaths will be investigated in years 1 and 3.Conclusion: This study confirmed that the gaits of healthy individuals and CKD patients were different, and the effect of the 8-week app-based health intervention will be analyzed. The study will yield important baseline data for creating digital therapeutics for CKD patients' diet/exercise in the future.","PeriodicalId":17716,"journal":{"name":"Kidney Research and Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142391563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparisons of clinical outcomes between hypertensive and normotensive living kidney donors: a prospective, multicenter nationwide cohort study. 高血压和正常血压活体肾脏捐献者临床结果的比较：一项前瞻性、多中心全国性队列研究。

IF 2.9 3区医学

Kidney Research and Clinical Practice Pub Date : 2024-08-21 DOI: 10.23876/j.krcp.23.283

Jong Ho Kim, Yu Ho Lee, Dae Kyu Kim, Jin Sug Kim, Kyung Hwan Jeong, Ku Yong Chung, Jong Cheol Jeong, Soo Jin Na Choi, Jaeseok Yang, Myoung Soo Kim, Hyeon Seok Hwang

{"title":"Comparisons of clinical outcomes between hypertensive and normotensive living kidney donors: a prospective, multicenter nationwide cohort study.","authors":"Jong Ho Kim, Yu Ho Lee, Dae Kyu Kim, Jin Sug Kim, Kyung Hwan Jeong, Ku Yong Chung, Jong Cheol Jeong, Soo Jin Na Choi, Jaeseok Yang, Myoung Soo Kim, Hyeon Seok Hwang","doi":"10.23876/j.krcp.23.283","DOIUrl":"https://doi.org/10.23876/j.krcp.23.283","url":null,"abstract":"Background: Living kidney donors with hypertension are potential candidates for solving the donor shortages in renal transplantation. However, the safety of donors with hypertension after nephrectomy has not been sufficiently confirmed.Methods: A total of 642 hypertensive and 4,848 normotensive living kidney donors who were enrolled in the Korean Organ Transplantation Registry between May 2014 and December 2020 were included in this study. The study endpoints were a decreased estimated glomerular filtration rate (eGFR) and proteinuria.Results: In the entire cohort, donors with hypertension had a lower eGFR before nephrectomy in comparison to normotensive donors which remained lower after kidney transplantation. The incidence of proteinuria in hypertensive donors increased during follow-up. In propensity score-matched analysis, the risk of eGFR being <60 mL/min/1.73 m2 (hazard ratio [HR], 0.77; 95% confidence interval [CI], 0.50-1.19) or <45 mL/min/1.73 m2 (HR, 0.50; 95% CI, 0.06-4.03) was not significantly increased in donors with hypertension. However, hypertensive donors were found to have a significantly higher risk of proteinuria than normotensive donors (HR, 2.28; 95% CI, 1.05-4.94). Similar findings were also observed in the analysis of the entire cohort, indicating that hypertensive donors had a significantly higher risk of proteinuria (adjusted HR, 1.77; 95% CI, 1.10-2.85), without a substantial increase in the risk of decreased renal function.Conclusion: The risk of proteinuria after donation was substantially increased in donors with hypertension. These findings underscore the need for careful monitoring of proteinuria in hypertensive donors following donation.","PeriodicalId":17716,"journal":{"name":"Kidney Research and Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142009023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0