Kidney Research and Clinical Practice最新文献_第10页

To treat or not to treat: CUBN-associated persistent proteinuria. 治疗还是不治疗？CUBN 相关性持续蛋白尿。

IF 2.9 3区医学

Kidney Research and Clinical Practice Pub Date : 2024-09-01 Epub Date: 2024-08-24 DOI: 10.23876/j.krcp.23.258

Yun Young Choi, Yo Han Ahn, Eujin Park, Ji Hyun Kim, Hee Gyung Kang, Hyun Kyung Lee

{"title":"To treat or not to treat: CUBN-associated persistent proteinuria.","authors":"Yun Young Choi, Yo Han Ahn, Eujin Park, Ji Hyun Kim, Hee Gyung Kang, Hyun Kyung Lee","doi":"10.23876/j.krcp.23.258","DOIUrl":"10.23876/j.krcp.23.258","url":null,"abstract":"Background: Persistent proteinuria is an important indicator of kidney damage and requires active evaluation and intervention. However, tubular proteinuria of genetic origin typically does not improve with immunosuppression or antiproteinuric treatment. Recently, defects in CUBN were found to cause isolated proteinuria (mainly albuminuria) due to defective tubular albumin reuptake. Unlike most other genetically caused persistent albuminuria, CUBN C-terminal variants have a benign course without progression to chronic kidney disease according to the literature. Here, we present Korean cases with persistent proteinuria associated with C-terminal variants of CUBN.Methods: We identified Korean patients with CUBN variants among those with an identified genetic cause of proteinuria and evaluated their clinical features and clinical course. We also reviewed the literature on CUBN-associated isolated proteinuria published to date and compared it with Korean patients.Results: All patients presented with incidentally found, asymptomatic isolated proteinuria at a median age of 5 years. The proteinuria was in the subnephrotic range and did not significantly change over time, regardless of renin- angiotensin system inhibition. Initial physical examination, laboratory findings, and kidney biopsy results, when available, were unremarkable other than significant proteinuria. All patients maintained kidney function throughout the follow-up duration. All patients had at least one splicing mutation, and most of the variants were located C-terminal side of the gene.Conclusion: We report Korean experience of CUBN-related benign proteinuria, that aligns with previous reports, indicating that this condition should be considered in cases with incidentally found asymptomatic isolated proteinuria, especially in young children.","PeriodicalId":17716,"journal":{"name":"Kidney Research and Clinical Practice","volume":"43 5","pages":"663-670"},"PeriodicalIF":2.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11467360/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142400651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pathogenesis and management of renal fibrosis induced by unilateral ureteral obstruction. 单侧输尿管梗阻诱发肾脏纤维化的发病机制和治疗方法。

IF 2.9 3区医学

Kidney Research and Clinical Practice Pub Date : 2024-09-01 Epub Date: 2024-02-06 DOI: 10.23876/j.krcp.23.156

Qi Yan Nan, Shang Guo Piao, Ji Zhe Jin, Byung Ha Chung, Chul Woo Yang, Can Li

{"title":"Pathogenesis and management of renal fibrosis induced by unilateral ureteral obstruction.","authors":"Qi Yan Nan, Shang Guo Piao, Ji Zhe Jin, Byung Ha Chung, Chul Woo Yang, Can Li","doi":"10.23876/j.krcp.23.156","DOIUrl":"10.23876/j.krcp.23.156","url":null,"abstract":"Regardless of the underlying etiology, renal fibrosis is the final histological outcome of progressive kidney disease. Unilateral ureteral obstruction (UUO) is an ideal and reproducible experimental rodent model of renal fibrosis, which is characterized by tubulointerstitial inflammatory responses, accumulation of extracellular matrix, tubular dilatation and atrophy, and fibrosis. The magnitude of UUO-induced renal fibrosis is experimentally manipulated by the species chosen, animal age, and the severity and duration of the obstruction, while relief of the obstruction allows the animal to recover from fibrosis. The pathogenesis of renal fibrosis is complex and multifactorial and is orchestrated by activation of renin-angiotensin system (RAS), oxidative stress, inflammatory response, transforming growth factor beta 1-Smad pathway, activated myofibroblasts, cell death (apoptosis, autophagy, ferroptosis, and necroptosis), destruction of intracellular organelles, and signaling pathway. The current therapeutic approaches have limited efficacy. Inhibition of RAS and use of antioxidants and antidiabetic drugs, such as inhibitors of sodium-glucose cotransporter 2 and dipeptidyl peptidase-4, have recently gained attention as therapeutic strategies to prevent renal scarring. This literature review highlights the state of the art regarding the molecular mechanisms relevant to the management of renal fibrosis caused by UUO.","PeriodicalId":17716,"journal":{"name":"Kidney Research and Clinical Practice","volume":" ","pages":"586-599"},"PeriodicalIF":2.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11467363/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139702861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gelsolin amyloidosis associated with the p.D214N gelsolin gene mutation in a Chinese family. 一个中国家庭中与 p.D214N gelsolin 基因突变相关的 Gelsolin 淀粉样变性病。

IF 2.9 3区医学

Kidney Research and Clinical Practice Pub Date : 2024-09-01 Epub Date: 2024-09-24 DOI: 10.23876/j.krcp.24.130

Shuang Wang, Dan-Yang Li, Jin Xu, Wen-Jing Song, Su-Xia Wang

引用次数: 0

Clinical and pathological significance of Orai1 channel expression in human diabetic nephropathy. 人类糖尿病肾病中 Orai1 通道表达的临床和病理意义。

IF 2.9 3区医学

Kidney Research and Clinical Practice Pub Date : 2024-09-01 Epub Date: 2024-08-07 DOI: 10.23876/j.krcp.23.342

Yooujin Kwak, Jun Young Lee, Jae Seok Kim, Jae Won Yang, Kyu-Hee Hwang, Seung-Kuy Cha, Minseob Eom

{"title":"Clinical and pathological significance of Orai1 channel expression in human diabetic nephropathy.","authors":"Yooujin Kwak, Jun Young Lee, Jae Seok Kim, Jae Won Yang, Kyu-Hee Hwang, Seung-Kuy Cha, Minseob Eom","doi":"10.23876/j.krcp.23.342","DOIUrl":"10.23876/j.krcp.23.342","url":null,"abstract":"Background: Targeted therapies for diabetic nephropathy (DN) are lacking, partly due to their irreversible nature. The role of Orai1, a store-operated Ca2+ channel, in DN remains debated, with conflicting evidence on its effect on proteinuria in animal models. We aimed to elucidate the functional relevance of Orai1 expression for clinicopathological parameters in patients with DN.Methods: In this study, we included 93 patients diagnosed with DN between 2009 and 2019. Immunohistochemical staining for Orai1 was performed on paraffin-embedded kidney sections. The significance of Orai1 expression in human DN was assessed by examining its correlation with DN's pathological and clinical parameters using Pearson's correlation coefficient and univariate logistic regression.Results: Orai1 was significantly overexpressed in DN patients compared to control. A strong correlation was observed between increased Orai1 expression and higher Renal Pathology Society DN classification, enhanced interstitial fibrosis and tubular atrophy scores. Positive correlations with serum creatinine levels and prognosis of chronic kidney disease (CKD) by glomerular filtration rate (GFR) and albuminuria category were noted but the estimated GFR was inversely related to Orai1 expression. Orai1's association with advanced CKD stages persisted even after adjusting for confounding variables in multivariate logistic regression analysis.Conclusion: Orai1 expression is closely associated with histological and clinical severities of DN, suggesting its potential as a predictive biomarker for disease progression and prognosis. These findings provide new perspectives on therapeutic interventions targeting Orai1 in DN.","PeriodicalId":17716,"journal":{"name":"Kidney Research and Clinical Practice","volume":" ","pages":"626-634"},"PeriodicalIF":2.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11467362/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141897744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chronic cholesterol crystal embolism: the value of kidney biopsy. 慢性胆固醇结晶栓塞：肾活检的价值。

IF 2.9 3区医学

Kidney Research and Clinical Practice Pub Date : 2024-09-01 Epub Date: 2024-09-30 DOI: 10.23876/j.krcp.24.058

Izabela Silva E Silva, Marcos Adriano Garcia Campos, Ricardo Ferreira Santos, Gyl Eanes Barros Silva

引用次数: 0

Remaining life expectancy of Korean hemodialysis patients: how much longer can they live? 韩国血液透析患者的剩余预期寿命：他们还能活多久？

IF 2.9 3区医学

Kidney Research and Clinical Practice Pub Date : 2024-09-01 Epub Date: 2024-02-19 DOI: 10.23876/j.krcp.23.241

Hayne Cho Park, Do Hyoung Kim, AJin Cho, Bo Yeon Kim, Miri Lee, Gui Ok Kim, Jinseog Kim, Young-Ki Lee

{"title":"Remaining life expectancy of Korean hemodialysis patients: how much longer can they live?","authors":"Hayne Cho Park, Do Hyoung Kim, AJin Cho, Bo Yeon Kim, Miri Lee, Gui Ok Kim, Jinseog Kim, Young-Ki Lee","doi":"10.23876/j.krcp.23.241","DOIUrl":"10.23876/j.krcp.23.241","url":null,"abstract":"Background: Hemodialysis (HD) patients have a higher mortality rate compared to the general population. However, no study has investigated life expectancy in Korean HD patients so far. Therefore, this study aimed to calculate the remaining life expectancy among Korean maintenance HD patients and compare it to those of the general population as well as HD patients from other countries.Methods: Baseline data were retrieved from HD quality assessment data from 2015. Among the patients over 30 years old who were alive at the beginning of 2016 (20,304 males and 14,264 females), a total of 22,078 (12,621 males and 9,457 females) were still alive at the end of 2021 while 12,490 (7,683 males and 4,807 females) were deceased during 6 years of follow-up. We used the life table method to calculate the expected remaining years of life in 2-year increments.Results: The remaining life expectancies for 60-year-old patients were 11.64 years for males and 14.64 years for females. The average remaining life expectancies of the HD population were only about half of the general population. Diabetic patients demonstrated shorter life expectancy compared to patients with hypertension or glomerulonephritis. The remaining life expectancy of Korean HD patients was similar to that of Japanese and was almost double that of HD patients in Western countries such as Europe and the United States.Conclusion: The HD population shows a shorter life expectancy compared to the general population. Longitudinal analysis should be warranted to analyze the effect of advanced dialysis technology on improved survival rates among the HD population.","PeriodicalId":17716,"journal":{"name":"Kidney Research and Clinical Practice","volume":" ","pages":"671-679"},"PeriodicalIF":2.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11467359/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139931735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Asymptomatic hematuria in children: Korean Society of Pediatric Nephrology recommendations for diagnosis and management. 儿童无症状血尿：韩国儿科肾脏病学会关于诊断和处理的建议。

IF 2.9 3区医学

Kidney Research and Clinical Practice Pub Date : 2024-09-01 Epub Date: 2024-03-07 DOI: 10.23876/j.krcp.23.231

Eujin Park, Sang Woon Kim, Su Jin Kim, Minki Baek, Yo Han Ahn, Eun Mi Yang, Myung Hyun Cho, Hyun Kyung Lee, Kyoung Hee Han, Yae Lim Kim, Miyoung Choi, Hee Gyung Kang, Jin-Soon Suh

引用次数: 0

The current state of life expectancy of hemodialysis patients in Korea. 韩国血液透析患者的预期寿命现状。

IF 2.9 3区医学

Kidney Research and Clinical Practice Pub Date : 2024-09-01 Epub Date: 2024-05-29 DOI: 10.23876/j.krcp.24.099

Seyoung Ryou, Hye Eun Yoon

引用次数: 0

Cardiac and kidney outcomes after sacubitril-valsartan therapy: recovery of cardiac function relative to kidney function decline. 萨库比特利-缬沙坦治疗后的心脏和肾脏预后：心功能的恢复与肾功能的下降相对应。

IF 2.9 3区医学

Kidney Research and Clinical Practice Pub Date : 2024-09-01 Epub Date: 2024-09-30 DOI: 10.23876/j.krcp.24.021

Hyo Jeong Kim, Eunji Yang, Hee Byung Koh, Jong Hyun Jhee, Hyeong Cheon Park, Hoon Young Choi

{"title":"Cardiac and kidney outcomes after sacubitril-valsartan therapy: recovery of cardiac function relative to kidney function decline.","authors":"Hyo Jeong Kim, Eunji Yang, Hee Byung Koh, Jong Hyun Jhee, Hyeong Cheon Park, Hoon Young Choi","doi":"10.23876/j.krcp.24.021","DOIUrl":"10.23876/j.krcp.24.021","url":null,"abstract":"Background: Sacubitril-valsartan reduces the risk of cardiovascular mortality among patients with heart failure with reduced ejection fraction (HFrEF). However, its long-term protective effects on cardiac function with concurrent acute kidney injury (AKI) remain unclear. This study investigated the recovery of cardiac function relative to kidney function decline.Methods: A total of 512 patients with HFrEF who started sacubitril-valsartan or valsartan treatment were enrolled in cohort 1. Additionally, patients who experienced AKI and underwent follow-up transthoracic echocardiography were enrolled in cohort 2. In cohort 1, short- and long-term kidney outcomes were analyzed. For cohort 2, changes in cardiac function in relation to changes in kidney function after drug initiation were analyzed.Results: The mean age of the patients was 68.3 ± 15.1 years, and 57.4% of the patients were male. AKI occurred in 15.9% of the sacubitril-valsartan group and 12.5% of the valsartan group. After AKI, 78.4% of patients in the sacubitril-valsartan group and 71.4% of those in the valsartan group underwent recovery. Furthermore, cardiovascular outcomes in patients who developed AKI after drug initiation were analyzed in cohort 2. The sacubitril-valsartan group showed a greater improvement in cardiac function compared with the valsartan group (12.4% ± 15.4% vs. 1.4% ± 5.7%, p = 0.046). The ratio of deltas of cardiac and kidney function in the sacubitril-valsartan and valsartan groups were -1.76 ± 2.58 and -0.20 ± 0.58, respectively (p = 0.03).Conclusion: Patients with HFrEF treated with sacubitril-valsartan exhibited significant improvements in cardiovascular outcomes despite AKI.","PeriodicalId":17716,"journal":{"name":"Kidney Research and Clinical Practice","volume":"43 5","pages":"614-625"},"PeriodicalIF":2.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11467369/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142400648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long non-coding RNA MEG3 silencing weakens high glucose-induced mesangial cell injury by decreasing LIN28B expression by sponging and sequestering miR-23c. 长非编码 RNA MEG3 沉默通过海绵化和封存 miR-23c 来减少 LIN28B 的表达，从而减轻高血糖诱导的间质细胞损伤。

IF 2.9 3区医学

Kidney Research and Clinical Practice Pub Date : 2024-09-01 Epub Date: 2023-12-11 DOI: 10.23876/j.krcp.23.090

Lu Rong, Huanzhou Xue, Jianwei Hao, Jianjun Liu, Hao Xu

{"title":"Long non-coding RNA MEG3 silencing weakens high glucose-induced mesangial cell injury by decreasing LIN28B expression by sponging and sequestering miR-23c.","authors":"Lu Rong, Huanzhou Xue, Jianwei Hao, Jianjun Liu, Hao Xu","doi":"10.23876/j.krcp.23.090","DOIUrl":"10.23876/j.krcp.23.090","url":null,"abstract":"Background: Diabetic nephropathy (DN) is a common kidney disease in diabetic patients. Long non-coding RNA maternally expressed gene 3 (MEG3) and microRNA (miR)-23c are reported to be implicated in DN development. Nevertheless, it is unclear that the molecular mechanism between MEG3 and miR-23c in DN remains unclear.Methods: Human mesangial cells (HMCs) were treated with high glucose (HG) to simulate the DN status in vitro. Expression of MEG3 and miR-23c was measured. Effects of MEG3 silencing on HG-stimulated HMC injury were determined. The relationship between MEG3 and miR-23c was verified by the dual-luciferase reporter and RNA immunoprecipitation assays.Results: MEG3 was overexpressed in serums from DN patients and HG-stimulated HMCs. MEG3 knockdown weakened HG-stimulated HMC proliferation, extracellular matrix (ECM) accumulation, and inflammation. MEG3 regulated lin-28 homolog B (LIN28B) expression through adsorbing miR-23c. MiR-23c inhibitor reversed MEG3 knockdown-mediated effects on HG-stimulated HMC proliferation, ECM accumulation, and inflammation. LIN28B overexpression overturned miR-23c mimic-mediated effects on HG-stimulated HMC proliferation, ECM accumulation, and inflammation.Conclusion: MEG3 regulated HMC injury via regulation of the miR-23c/LIN28B axis in DN, which can help us better understand the mechanism of DN mediated by MEG3.","PeriodicalId":17716,"journal":{"name":"Kidney Research and Clinical Practice","volume":" ","pages":"600-613"},"PeriodicalIF":2.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11467368/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139040208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0