Kidney Research and Clinical Practice最新文献

{"title":"Circulating osteoprotegerin and progression of coronary artery calcification in patients with chronic kidney disease: the KoreaN Cohort Study for Outcome in Patients With Chronic Kidney Disease (KNOW-CKD).","authors":"Sang Heon Suh, Tae Ryom Oh, Hong Sang Choi, Chang Seong Kim, Eun Hui Bae, Seong Kwon Ma, Kook-Hwan Oh, Tae-Hyun Yoo, Soo Wan Kim","doi":"10.23876/j.krcp.24.039","DOIUrl":"10.23876/j.krcp.24.039","url":null,"abstract":"<p><strong>Background: </strong>Coronary artery calcification (CAC) is a surrogate of cardiovascular events in patients with chronic kidney disease (CKD). To establish the role of circulating osteoprotegerin (OPG) as a cardiovascular biomarker in patients with CKD, we investigated whether an increase in serum OPG levels is associated with the risk of CAC progression.</p><p><strong>Methods: </strong>A total of 1,130 patients with CKD stage 1 to predialysis 5 were divided into quartiles according to serum OPG levels (Q1 to Q4). The coronary artery calcium score (CACS) was assessed at baseline and at the 4-year follow-up visit. CAC progression was defined as an increase in the CACS of more than 200 Agatston units over 4 years.</p><p><strong>Results: </strong>Serum OPG levels were positively correlated with the CACS at baseline (R = 0.240, p < 0.001) and at the 4-year follow-up visit (R = 0.280, p < 0.001) as well as with changes in the CACS for 4 years (R = 0.270, p < 0.001) based on scatter plot analysis. Binary logistic regression analysis demonstrated that the risk of CAC progression was significantly increased in Q4 compared with Q1 (adjusted odds ratio, 3.706; 95% confidence interval, 1.154-11.902). Penalized spline curve analysis revealed a linear association between serum OPG levels and the risk of CAC progression.</p><p><strong>Conclusion: </strong>An increase in circulating OPG levels was associated with the risk of CAC progression in patients with predialysis CKD.</p>","PeriodicalId":17716,"journal":{"name":"Kidney Research and Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142668437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The crosstalk of Wnt/β-catenin signaling and p53 in acute kidney injury and chronic kidney disease.","authors":"Wen-Hua Ming, Lin Wen, Wen-Juan Hu, Rong-Fang Qiao, Yang Zhou, Bo-Wei Su, Ya-Nan Bao, Ping Gao, Zhi-Lin Luan","doi":"10.23876/j.krcp.23.344","DOIUrl":"10.23876/j.krcp.23.344","url":null,"abstract":"<p><p>Wnt/β-catenin is a signaling pathway associated with embryonic development, organ formation, cancer, and fibrosis. Its activation can repair kidney damage during acute kidney injury (AKI) and accelerate the occurrence of renal fibrosis after chronic kidney disease (CKD). Interestingly, p53 has also been found as a key modulator in AKI and CKD in recent years. Meantime, some studies have found crosstalk between Wnt/β-catenin signaling pathways and p53, but more evidence is required on whether they have synergistic effects in renal disease progression. This article reviews the role and therapeutic targets of Wnt/β-catenin and p53 in AKI and CKD and proposes for the first time that Wnt/β-catenin and p53 have a synergistic effect in the treatment of renal injury.</p>","PeriodicalId":17716,"journal":{"name":"Kidney Research and Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142668442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hearing loss phenotypes in Alport syndrome: experience in a tertiary referral center.","authors":"Sang-Yoon Han, Myung-Whan Suh, Moo Kyun Park, Jun Ho Lee, Hee Gyung Kang, Sang-Yeon Lee","doi":"10.23876/j.krcp.24.091","DOIUrl":"10.23876/j.krcp.24.091","url":null,"abstract":"<p><strong>Background: </strong>Despite previous reports of auditory phenotypes in Alport syndrome (AS), there have been no studies specifically addressing audiological phenotypes in South Korea. Herein, we elaborated on the audiological characteristics associated with AS based on their genotypes.</p><p><strong>Methods: </strong>We reviewed data from in-house AS patients between March 2014 and February 2023, excluding those without audiological documentation or genetic diagnoses. We retrieved medical history, hearing level, estimated glomerular filtration rate (eGFR), and genotypes from their medical records. The natural course of hearing loss and correlations between audiogram and eGFR were evaluated according to audio-gene profiles.</p><p><strong>Results: </strong>Our study included 49 AS patients from 47 families, identifying 60 disease-causing variants, 45 of which were novel. All variants were classified as pathogenic or likely pathogenic based on ACMG-AMP guidelines. The auditory phenotypes of autosomal recessive AS (ARAS) and male X-linked AS (XLAS) patients demonstrated a progressive nature, with a down-sloping configuration. The ARAS with truncated variants exhibited an earlier onset of hearing loss than those with non-truncated variants. In male XLAS patients, the presence of truncated allele linked to more rapid hearing deterioration across all frequencies. In both ARAS and male XLAS patients, the presence of truncated allele was significantly associated with hearing severity and eGFR. Conversely, the majority of female XLAS and autosomal dominant AS maintained normal hearing levels without any correlation of eGFR, regardless of genotypes.</p><p><strong>Conclusion: </strong>This study detailed the auditory phenotypes and the auditory-renal association of AS at a tertiary center in South Korea, providing valuable references that guide auditory testing and rehabilitation strategies.</p>","PeriodicalId":17716,"journal":{"name":"Kidney Research and Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142668439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of dietary fatty acid on all-cause mortality according to the kidney function based on the nationwide population study.","authors":"Yaerim Kim, Kyungho Ha, Jeonghwan Lee, Eunjin Bae, Jin Hyuk Paek, Woo Yeong Park, Kyubok Jin, Seungyeup Han, Dong Ki Kim, Chun Soo Lim, Jung Pyo Lee","doi":"10.23876/j.krcp.24.121","DOIUrl":"10.23876/j.krcp.24.121","url":null,"abstract":"<p><strong>Background: </strong>Although the relationship between fatty acids (FAs) and the risk of all-cause mortality has been long discussed, there is little evidence about the impact of each FA component on all-cause mortality by kidney function status.</p><p><strong>Methods: </strong>We used data from the U.S. National Health and Nutrition Examination Survey 1999-2016. The intake of FAs was estimated as a percentage of total energy using a 1-day 24-hour dietary recall and divided by quartiles; the first quartile was regarded as a reference. We used a multivariate Cox proportional hazard model to identify the impact of FAs on all-cause mortality.</p><p><strong>Results: </strong>Among 44,332 participants, during 129.0 ± 62.4 months of follow-up, there were 1,623 (6.2%), 3,109 (22.3%), and 2,202 deaths (53.1%) in the estimated glomerular filtration rate (eGFR) ≥90, 60-90, and <60 mL/min/1.73 m2 groups, respectively. Higher intake of SFAs significantly increased the risk of all-cause mortality in participants with eGFR 60-90 mL/min/1.73 m2 (adjusted hazard ratio, 1.20 in the 4th quartile). Likewise, higher intake of most PUFAs (octadecadienoic acid, octadecatrienoic acid, omega-6, and omega-3) significantly decreased the risk of all-cause mortality in participants with eGFR 60-90 mL/min/1.73 m2 . These effects of both SFAs and PUFAs were attenuated in participants with eGFR ≥90 and <60 mL/min/1.73 m2 .</p><p><strong>Conclusion: </strong>The impact of dietary FAs on all-cause mortality was prominent in participants with eGFR 60-90 mL/min/1.73 m2 . More specified and targeted counseling for restricting SFAs and encouraging PUFAs needs to be considered, especially for participants with marginally decreased kidney function.</p>","PeriodicalId":17716,"journal":{"name":"Kidney Research and Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142668438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk of cardiovascular events following hemodialysis initiation: a self-controlled case series study.","authors":"Minyoul Baik, Jimin Jeon, Joonsang Yoo, Hyo Suk Nam, Ji Hoe Heo, Jinkwon Kim, Young Dae Kim","doi":"10.23876/j.krcp.24.097","DOIUrl":"10.23876/j.krcp.24.097","url":null,"abstract":"<p><strong>Background: </strong>Patients with chronic kidney disease (CKD) are at high risk for cardiovascular disease (CVD). We aimed to evaluate whether hemodialysis (HD) initiation is associated with CVD risk in patients with CKD.</p><p><strong>Methods: </strong>This self-controlled case series, using data from a nationwide Korean health claims database, included patients with CKD who initiated HD between 2007 and 2019 and experienced CVD, including acute stroke or myocardial infarction (MI), between 2008 and 2020. The risk periods were categorized relative to HD initiation (-60 to -31, -30 to -11, -10 to -1, +1 to +10, +11 to +30, +31 to +60, and +61 to +150 days); the remaining period was set as baseline. The age-adjusted incidence rate ratio (IRR) of CVD in each risk period relative to the baseline was calculated.</p><p><strong>Results: </strong>Of the 74,584 patients with CKD on incident HD, 12,875 patients with CVD (6,367 with ischemic stroke, 2,396 with hemorrhagic stroke, and 4,112 with MI) were included. Compared with the baseline period, the risk of CVD increased in the post-dialysis periods, decreasing with time since HD initiation; the adjusted IRR during the first 10 days after HD initiation was 2.95 (95% confidence interval, 2.44-3.56). Although the risks of ischemic stroke and MI decreased at 1 to 2 months after HD initiation, the hemorrhagic stroke risk was higher for 5 months.</p><p><strong>Conclusion: </strong>After HD initiation, the CVD risk increases in patients with CKD. For CVD prevention, the CVD risk should be carefully evaluated in patients with CKD who require HD.</p>","PeriodicalId":17716,"journal":{"name":"Kidney Research and Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142668441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Renal transplantation in Alport syndrome.","authors":"Soyeon Kim, Soon Hyo Kwon","doi":"10.23876/j.krcp.24.143","DOIUrl":"10.23876/j.krcp.24.143","url":null,"abstract":"<p><p>Kidney transplantation is recognized as an effective treatment for end-stage renal disease in Alport syndrome, demonstrating outcomes comparable to or even superior to those in other causes of renal failure. When considering living related donor kidney transplantation for Alport syndrome patients, it is crucial to consider genetic factors during the donor selection process. In addition to a comprehensive health check, genetic testing is strongly recommended for potential donors at risk of carrying mutations in COL4A3-COL4A5 before undergoing kidney transplantation. Individuals carrying these mutations face an inherent risk of kidney disease and due to the possibility of further deterioration in renal function after nephrectomy for transplantation, they are not suitable as priority donors. Posttransplant anti-glomerular basement membrane nephritis is rare but can lead to graft loss, especially in males with X-linked Alport syndrome.</p>","PeriodicalId":17716,"journal":{"name":"Kidney Research and Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142668440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study protocol for a consortium linking health medical records, biospecimens, and biosignals in Korean patients with acute kidney injury (LINKA cohort).","authors":"Donghwan Yun, Seung Seok Han, Jeonghwan Lee, Yaerim Kim, Kwangsoo Kim, Kyubok Jin, Ji Eun Kim, Shin Young Ahn, Gang-Jee Ko, Seokwoo Park, Sejoong Kim, Hee-Yeon Jung, Jang-Hee Cho, Sun-Hee Park, Eun Sil Koh, Sungjin Chung, Jung Pyo Lee, Dong Ki Kim, Sung Gyun Kim, Jung Nam An","doi":"10.23876/j.krcp.24.061","DOIUrl":"https://doi.org/10.23876/j.krcp.24.061","url":null,"abstract":"<p><strong>Background: </strong>Acute kidney injury (AKI) may transition into acute kidney disease (AKD) or chronic kidney disease (CKD), leading to subacute and chronic deterioration, respectively. Despite extensive research on AKI, a significant gap exists in understanding the specific biomarkers and development of individualized treatments prior to progression to AKD and CKD.</p><p><strong>Methods: </strong>As a consortium linking health medical records, biospecimens, and biosignals, eight Korean tertiary hospitals participated in the establishment of a retrospective and prospective cohort, each comprising approximately 1,500 patients with AKI receiving continuous kidney replacement therapy (CKRT). Other information included AKI-related information, CKRT prescriptions, and patient outcomes. Follow-up timeframes were set at baseline, 1 week, 3 months, and 1 year after the initiation of CKRT. Human biospecimens will be collected from the prospective cohort. An artificial intelligence model was developed using the retrospective cohort to predict the prognosis of AKD and its subsequent sequelae and to formulate patient-individualized treatments, with validation planned in a prospective cohort. Follow-up studies are scheduled to identify biomarkers related to outcomes using biospecimens. Finally, based on the results and literature review, decision-making on the prevention and management of diseases, as well as the development of treatment guidelines, are being planned.</p><p><strong>Conclusion: </strong>This study will provide scientific evidence on clinical insights and appropriate management targets for AKI and AKD, which will form the basis for relevant treatment guidelines. Additionally, these findings may facilitate a more personalized approach to patient care, enabling clinicians to tailor treatments based on individual biomarker profiles and predictive models.</p>","PeriodicalId":17716,"journal":{"name":"Kidney Research and Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142622916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of clinical outcomes based on dialysis modality and icodextrin usage in patients on peritoneal dialysis.","authors":"Seok Hui Kang, Jun Young Do","doi":"10.23876/j.krcp.24.017","DOIUrl":"https://doi.org/10.23876/j.krcp.24.017","url":null,"abstract":"<p><strong>Background: </strong>There is no conclusive evidence regarding the survival benefits of automated peritoneal dialysis (APD) or the use of icodextrin. This study aimed to evaluate patient and technique survival among four groups divided based on peritoneal dialysis modality and icodextrin use over 1 year.</p><p><strong>Methods: </strong>We specifically included patients who underwent a single peritoneal dialysis modality for at least 1 year during that period (n = 148). The participants were categorized into four groups for comparison: continuous ambulatory peritoneal dialysis (CAPD) without icodextrin (CAPD-ET, n = 39); CAPD with icodextrin (CAPD+ET, n = 35); APD without icodextrin (APD-ET, n = 40); and APD with icodextrin (APD+ET, n = 34).</p><p><strong>Results: </strong>The CAPD+ET group had a higher patient survival rate than that of the APD-ET group and also had a higher technique survival trend than that of the APD-ET group, despite no statistical significance. In patients without diabetes mellitus (DM), the APD-ET group had a poorer patient survival trend than those of the APD+ET or CAPD+ET groups. In patients without DM, the APD+ET group had a higher technique survival than the APD-ET group. In addition, the APD+ET group showed a higher technique survival trend than did the CAPD-ET group, despite non-statistical significance. The edema index after 1 year of follow-up was higher in the APD-ET group than in the other groups.</p><p><strong>Conclusion: </strong>The present study demonstrated that patients undergoing APD without icodextrin had poor patient and technique survival trends, which may be caused by poor volume control.</p>","PeriodicalId":17716,"journal":{"name":"Kidney Research and Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142622912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient-reported mental health problems and clinical outcomes in adults with non-dialysis chronic kidney disease.","authors":"Jihyun Yang, Young Youl Hyun, Kyu-Beck Lee, Hyo Jin Kim, Sang Heon Suh, Hayne Cho Park, Yun Kyu Oh, Sue Kyung Park, Kook-Hwan Oh","doi":"10.23876/j.krcp.24.034","DOIUrl":"https://doi.org/10.23876/j.krcp.24.034","url":null,"abstract":"<p><strong>Background: </strong>Mental health affects well-being and physical health. Among adults with chronic kidney disease (CKD), mental health (MH) problems are common and can induce adverse clinical outcomes. We examined the association between patient-reported MH problems and clinical outcomes in adults with non-dialysis CKD.</p><p><strong>Methods: </strong>This prospective observational study included 1,879 participants from the KNOW-CKD (KoreaN Cohort Study for Outcomes in Patients With CKD). Patients-reported MH problems were determined using four indicators of the Korea National Health and Nutrition Examination Survey questionnaire. We described the cross-sectional differences in health-related quality of life according to MH problems. We prospectively evaluated the hazard ratio (HR) of all-cause death and end-stage kidney disease (ESKD) according to the MH problems for a median follow-up of 6.4 years.</p><p><strong>Results: </strong>The participants (mean age 53 years; 61.6% male) had patient-reported MH problems of inadequate sleep duration (17.4%), subjective distress (27.3%), depressive symptoms (13.2%), and suicidal ideation (16.8%). In the fully adjusted Cox proportional model, poor MH (≥2 problems) was associated with a high risk of ESKD (HR, 1.46; 95% confidence interval [CI], 1.18-1.08) and death (HR, 1.55; 95% CI, 1.04-2.32) compared with good MH. Furthermore, the single indicator of suicidal ideation was associated with a high risk of ESKD (HR, 1.37; 95% CI, 1.11-1.69) and death (HR, 1.98; 95% CI, 1.34-2.92).</p><p><strong>Conclusion: </strong>Patient-reported MH problems are common in adults with CKD. Poor MH and only suicidal ideation are associated with a high risk of ESKD and early death. Age and sex modify the association between poor MH and adverse clinical outcomes in non-dialysis CKD.</p>","PeriodicalId":17716,"journal":{"name":"Kidney Research and Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142622914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blood osteoprotegerin is associated with arteriovenous access thrombosis in hemodialysis patients.","authors":"Tung-Ling Chung, Yi-Hsueh Liu, Pei-Yu Wu, Jiun-Chi Huang, Yi-Chun Tsai, Ya-Ling Hsu, Mei-Chuan Kuo, Yi-Wen Chiu, Ping-Hsun Wu, Szu-Chia Chen","doi":"10.23876/j.krcp.24.153","DOIUrl":"https://doi.org/10.23876/j.krcp.24.153","url":null,"abstract":"<p><strong>Background: </strong>A functioning arteriovenous (AV) access is essential for hemodialysis efficiency and the quality of life in hemodialysis patients. Blood osteoprotegerin (OPG) and soluble receptor activator of nuclear factor kappa B ligand (RANKL) have been linked to cardiovascular diseases and vascular calcification. This study investigated the relationship between blood OPG, RANKL, and the occurrence of AV access thrombosis.</p><p><strong>Methods: </strong>This prospective cohort study was conducted from August 2016 to August 2021 and included patients undergoing prevalent hemodialysis in two hospital-based hemodialysis units. Cox proportional hazards models and Kaplan-Meier analysis were used to evaluate the association between blood OPG, RANKL, and AV access (AV fistula [AVF] and AV graft [AVG]) outcomes.</p><p><strong>Results: </strong>A total of 333 hemodialysis patients were enrolled, with an AV access thrombosis rate of 22.2%. Cox regression identified several factors associated with AV access thrombosis: AV access type (AVF vs. AVG; hazard ratio [HR], 0.24; p < 0.001), C-reactive protein (HR, 1.07; p = 0.002), and log-transformed OPG (HR, 5.52; p = 0.005). Subgroup analysis revealed high log-transformed OPG and RANKL were associated with AVF thrombosis (HR, 10.77; p = 0.002 and HR, 3.26; p = 0.009, respectively), while high C-reactive protein increased the risk of AVG thrombosis (HR, 1.31; p < 0.001). Kaplan-Meier analysis showed that patients with AVF in the highest tertile of log OPG (>402 pg/mL) had the highest AVF thrombosis incidence (p = 0.03).</p><p><strong>Conclusion: </strong>High blood OPG was associated with AV access thrombosis, particularly in the AVF.</p>","PeriodicalId":17716,"journal":{"name":"Kidney Research and Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142622909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}