Global burden and risk factors of chronic kidney disease in adolescents and young adults: a study from 1990 to 2019.

IF 2.9 3区医学 Q1 UROLOGY & NEPHROLOGY

Kidney Research and Clinical Practice Pub Date : 2024-07-22 DOI:10.23876/j.krcp.23.331

Hua Deng, Qin Zou, Zhe Chen, Bo Hu, Xiangping Liao

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Abstract

Background: Few studies have evaluated the global burden of chronic kidney disease (CKD) in adolescents and young adults (AYAs).

Methods: Age-standardized rates of incidence (ASIR), mortality (ASMR), and disability-adjusted life-years (ASDR) were used to describe the CKD burden in AYAs. The estimated annual percentage changes (EAPCs) were calculated to evaluate the temporal trends from 1990 to 2019. Risk factors were calculated by population attributable fractions.

Results: In 2019, the ASIR, ASMR, and ASDR of CKD in AYAs were 32.21 (95% uncertainty interval [UI], 23.73-40.81) per 100,000, 2.86 (2.61-3.11) per 100,000 and 236.85 (209.03-268.91) per 100,000, respectively. The ASIR was higher among females than males, whereas the ASMR was higher among males than females in 2019. From 1990 to 2019, significant increases in ASIR were found for CKD (EAPC, 0.98%; 95% confidence interval [CI], 0.95%-1.01%), although the ASMR had decreased (EAPC, -0.40%; 95% CI, -0.56% to -0.24%). The largest increase in ASIR was observed in countries with a middle sociodemographic index (SDI) (EAPC, 1.30%; 95% CI, 1.28%-1.33%), while the largest increase in ASMR was observed in high SDI. Globally, the proportional contribution of risk factors for CKD mortality varied across regions, with the highest proportions of high fasting plasma glucose being 14.04% in low SDI, compared with 24.01% in high SDI.

Conclusion: CKD is a growing global health problem in AYAs, especially in countries with a middle SDI. Targeted measures are needed to address the rising burden of CKD in AYAs, focusing on prevention, early diagnosis, and reducing disparities.

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青少年和年轻成人慢性肾病的全球负担和风险因素：1990 年至 2019 年的一项研究。

背景：很少有研究对青少年和年轻成人慢性肾病（CKD）的全球负担进行评估：很少有研究对青少年慢性肾脏病（CKD）的全球负担进行评估：方法：采用年龄标准化的发病率（ASIR）、死亡率（ASMR）和残疾调整生命年（ASDR）来描述青少年和年轻成人的慢性肾脏病负担。通过计算估计年度百分比变化（EAPC）来评估 1990 年至 2019 年的时间趋势。风险因素按人口可归因分数计算：2019年，亚健康人群的CKD ASIR、ASMR和ASDR分别为32.21（95%不确定区间[UI]，23.73-40.81）/100,000、2.86（2.61-3.11）/100,000和236.85（209.03-268.91）/100,000。2019年，女性的ASIR高于男性，而男性的ASMR高于女性。从 1990 年到 2019 年，发现慢性肾脏病的 ASIR 显著增加（EAPC，0.98%；95% 置信区间 [CI]，0.95%-1.01%），尽管 ASMR 有所下降（EAPC，-0.40%；95% CI，-0.56% 至 -0.24%）。在社会人口指数（SDI）处于中等水平的国家，ASIR 的增幅最大（EAPC，1.30%；95% CI，1.28%-1.33%），而 ASMR 的增幅在社会人口指数处于较高水平的国家最大。在全球范围内，不同地区的危险因素对 CKD 死亡率的影响比例各不相同，空腹血浆葡萄糖高的比例在低 SDI 地区最高，为 14.04%，而在高 SDI 地区为 24.01%：结论：慢性肾功能衰竭是全球亚健康人群中日益严重的健康问题，尤其是在 SDI 处于中等水平的国家。需要采取有针对性的措施来应对亚健康人群中不断增加的慢性肾脏病负担，重点是预防、早期诊断和缩小差距。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Kidney Research and Clinical Practice UROLOGY & NEPHROLOGY-

CiteScore

4.60

自引率

10.00%

发文量

审稿时长

10 weeks

期刊介绍： Kidney Research and Clinical Practice (formerly The Korean Journal of Nephrology; ISSN 1975-9460, launched in 1982), the official journal of the Korean Society of Nephrology, is an international, peer-reviewed journal published in English. Its ISO abbreviation is Kidney Res Clin Pract. To provide an efficient venue for dissemination of knowledge and discussion of topics related to basic renal science and clinical practice, the journal offers open access (free submission and free access) and considers articles on all aspects of clinical nephrology and hypertension as well as related molecular genetics, anatomy, pathology, physiology, pharmacology, and immunology. In particular, the journal focuses on translational renal research that helps bridging laboratory discovery with the diagnosis and treatment of human kidney disease. Topics covered include basic science with possible clinical applicability and papers on the pathophysiological basis of disease processes of the kidney. Original researches from areas of intervention nephrology or dialysis access are also welcomed. Major article types considered for publication include original research and reviews on current topics of interest. Accepted manuscripts are granted free online open-access immediately after publication, which permits its users to read, download, copy, distribute, print, search, or link to the full texts of its articles to facilitate access to a broad readership. Circulation number of print copies is 1,600.