Kidney Research and Clinical Practice最新文献

{"title":"Diet-microbiota-kidney axis reprogramming: mechanistic insights into microbial metabolite-driven precision nutrition for chronic kidney disease.","authors":"Xiunan Liu, Zhuoxing Li, Hao Liu, Mao Xiao, Xue Zhang, Yanyi Deng, Buyuan Tian, Yun Sun, Xiang Xiao","doi":"10.23876/j.krcp.25.312","DOIUrl":"https://doi.org/10.23876/j.krcp.25.312","url":null,"abstract":"<p><p>Medical nutrition therapy serves as the cornerstone in the management of chronic kidney disease (CKD). While conventional approaches emphasize macronutrient restriction and meal timing adjustments, research highlights the critical mediating role of gut microbiota in translating dietary patterns into physiological effects through metabolite production. Meanwhile, CKD progression is closely associated with dynamic interactions between gut microbiota and their metabolic derivatives. This review introduces the \"diet-microbiota- metabolite-kidney axis\" framework to elucidate how nutritional components modulate CKD progression via microbial compositional changes and subsequent metabolite alterations. Based on synthesized evidence, this review identifies promising directions for precision nutrition strategies targeting microbial metabolites, including artificial intelligence-assisted dietary planning, engineered bacterial therapies, and metabolite analog development. However, significant interindividual variability in host genetics and baseline microbiota composition necessitates overcoming heterogeneity challenges in nutritional interventions. Consequently, the precise modulation of individualized diet-microbiota-metabolite interactions represents a critical research direction to be prioritized in CKD management.</p>","PeriodicalId":17716,"journal":{"name":"Kidney Research and Clinical Practice","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147513225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Xerosis elevates the risk of catheter-related infections in peritoneal dialysis patients.","authors":"Jeong Geon Lee, Jihee Lim, Nam-Jun Cho, Samel Park, Hyo-Wook Gil, Hoonhee Seo, Ho-Yeon Song, Sun-Hee Park, Kook-Hwan Oh, Yong-Lim Kim, Brian A Bieber, Ronald L Pisoni, Eun Young Lee","doi":"10.23876/j.krcp.24.275","DOIUrl":"https://doi.org/10.23876/j.krcp.24.275","url":null,"abstract":"<p><strong>Background: </strong>Catheter-related infections, such as exit-site infection and tunnel infection, are major complications in peritoneal dialysis (PD) patients, affecting their prognosis. This study investigates the association between skin conditions and catheter-related infections.</p><p><strong>Methods: </strong>Data from two distinct sources were analyzed: (1) 626 PD patients in the Korean arm of the Peritoneal Dialysis Outcomes and Practice Patterns Study (PDOPPS) and (2) skin microbiome data from 76 dialysis patients at Soonchunhyang University Cheonan Hospital. The relationship between catheter-related infection and self-reported xerosis and pruritus severity was assessed by Cox regression. Risk factors for xerosis and pruritus were evaluated by logistic regression. Furthermore, we discovered the relationship between the severity of pruritus and the relative abundance of Staphylococcus aureus on the skin.</p><p><strong>Results: </strong>The risk of catheter-related infections in PD patients increased with xerosis (hazard ratio [HR], 2.71; 95% confidence interval [CI], 1.19-6.18) and pruritus (HR, 2.57; 95% CI, 1.27-5.22), particularly increasing the risk of S. aureus-associated catheter-related infections (xerosis: HR, 5.66; 95% CI, 1.97-16.30; pruritus: HR, 5.93; 95% CI, 2.18-16.15). The relative abundance of S. aureus was notably higher in patients with severe pruritus. Moreover, patients were more likely to exhibit severe xerosis if they owned pets, had higher serum creatinine levels, and elevated calcium-phosphorus product levels.</p><p><strong>Conclusion: </strong>Xerosis and pruritus significantly increase the risk of catheter-related infections, especially those caused by S. aureus. Instead of relying solely on prophylactic antibiotics for infection prevention, this study highlights the need for new preventive strategies in PD patients, focusing specifically on effective skin management.</p>","PeriodicalId":17716,"journal":{"name":"Kidney Research and Clinical Practice","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147513261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular health by Life's Essential 8 and chronic kidney disease: Korea National Health and Nutrition Examination Survey 2019-2021.","authors":"Eunji Kim, Yeeun Seo, Dasom Son, Kyoung Hwa Ha, Hyeon Chang Kim, Jong Hyun Jhee, Hokyou Lee","doi":"10.23876/j.krcp.25.231","DOIUrl":"https://doi.org/10.23876/j.krcp.25.231","url":null,"abstract":"<p><strong>Background: </strong>Evidence remains limited regarding the association between cardiovascular health (CVH), as defined by Life's Essential 8 (LE8), and chronic kidney disease (CKD), particularly across its indicators and stages.</p><p><strong>Methods: </strong>We analyzed data from 12,264 adults in the Korea National Health and Nutrition Examination Survey (2019-2021). LE8 scores (range, 0-100), calculated from eight components-diet, physical activity, nicotine exposure, sleep, body mass index, blood lipids, blood glucose, and blood pressure, were analyzed as both continuous and categorical variables: low (0 to <50), moderate (50 to <80), and high CVH (80 to 100). CKD was defined as an estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m2 or albuminuria (urine albumin-to-creatinine ratio ≥30 mg/g). Multivariable logistic regression and restricted cubic spline models were used to examine associations between LE8 scores and CKD, with stratification by CKD indicators and by G and A stages.</p><p><strong>Results: </strong>Overall, 13.3% of participants were classified as having low CVH, 75.4% as moderate CVH, and 11.3% as high CVH. Compared to low CVH, the odds of CKD were lower in moderate CVH (odds ratio [OR], 0.39; 95% confidence interval [CI], 0.33-0.46) and high CVH (OR, 0.22; 95% CI, 0.15-0.33). Each 10-point higher CVH score was associated with 33% lower odds of CKD (OR, 0.67; 95% CI, 0.63-0.71). After stratifying decreased eGFR and albuminuria by G and A stages, higher CVH was consistently associated with lower odds of CKD, even for early stages.</p><p><strong>Conclusion: </strong>Higher LE8 scores were inversely associated with CKD and its indicators, including early-stage CKD.</p>","PeriodicalId":17716,"journal":{"name":"Kidney Research and Clinical Practice","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147513189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic kidney disease in Asia: a meta-analysis.","authors":"Guozhen Chen, Shirui Sun, Yingcong Guo, Qi He, Zepeng Li, Zhenting Zhao, Bingxuan Zheng, Haiping Liu, Wujun Xue, Chenguang Ding","doi":"10.23876/j.krcp.25.254","DOIUrl":"https://doi.org/10.23876/j.krcp.25.254","url":null,"abstract":"<p><p>The prevalence of chronic kidney disease (CKD) in Asia was determined by comparing differences in age, sex, area, and analytical methods. This meta-analysis comprised 42 studies with 2,271,169 participants from five databases that were searched until February 30, 2025. The total prevalence of CKD 1-5 was 17.0%, whereas that of stages 3-5 was 7.7% in Asia. Individuals aged >60 years had a higher prevalence rate of CKD 1-5 compared to those aged <60 years. Compared with Asia (as the comparator), the age-standardized prevalence of CKD (aCKD) 1-5 was the highest in Nepal and South Asia, whereas it was the lowest in Vietnam. Compared with the comparator, Vietnam and Malaysia had the highest aCKD 3-5; while, South Korea and India had lower aCKD 3-5. The sex-standardized prevalence of CKD (sCKD) 1-5 was lower in Nepal, Taiwan, Korea, and South Asia and was higher in Bangladesh than in the comparator. The sCKD 3-5 was lowest in Korea and Taiwan and was highest in Iran and Sri Lanka compared with the comparator. Iranian women and men had the highest prevalence of CKD 3-5. South Asia has a higher prevalence of CKD among men and women than East Asia. The prevalence of CKD was greater in the Chronic Kidney Disease Epidemiology Collaboration-based studies than in the Modification of Diet in Renal Disease (MDRD)-based research. The findings indicate that evaluating populations without considering sex and age is difficult, especially when the sex and age of the groups differ greatly.</p>","PeriodicalId":17716,"journal":{"name":"Kidney Research and Clinical Practice","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147378122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional impairment as predictors of renal outcomes and mortality in elderly patients: a retrospective cohort study.","authors":"Bokeung Peun, Seunghyun Won, Kwang-Il Kim, Jung-Yeon Choi, Ho Jun Chin","doi":"10.23876/j.krcp.25.098","DOIUrl":"https://doi.org/10.23876/j.krcp.25.098","url":null,"abstract":"<p><strong>Background: </strong>Functional impairments in elderly patients with chronic kidney disease may affect prognosis. This study evaluated the associations between activities of daily living (ADL), instrumental activities of daily living (IADL), renal replacement therapy (RRT), and mortality.</p><p><strong>Methods: </strong>We retrospectively analyzed 6,087 adults aged ≥65 years (2,737 men and 3,350 women) who underwent geriatric assessment at Seoul National University Bundang Hospital from 2016 to 2020. All had an estimated glomerular filtration rate (eGFR) >15 mL/min/1.73 m2 and were followed for more than 3 months. ADL and IADL were measured using the Barthel and Lawton-Brody Index, and analyses were stratified by sex due to differences in IADL scoring criteria.</p><p><strong>Results: </strong>Participants (mean age, 78.7 ± 6.0 years; eGFR, 75.8 ± 19.4 mL/min/1.73 m2) were followed for a median of 42 months; 2,108 (34.6%) died and 103 (1.7%) initiated RRT. Impaired ADL and IADL were significantly associated with increased mortality in both sexes. In men, IADL impairment (<5) predicted RRT, whereas ADL (<100) showed a weaker association (p = 0.05). In women, neither ADL (<100) nor IADL (<8) significantly predicted RRT.</p><p><strong>Conclusion: </strong>Functional impairments independently predicted mortality in both sexes and were associated with a higher risk of RRT in men, particularly among younger individuals or those with preserved renal function. ADL and IADL assessments may provide practical indicators for identifying high-risk elderly patients with early-stage kidney disease.</p>","PeriodicalId":17716,"journal":{"name":"Kidney Research and Clinical Practice","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147377284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal triglyceride-glucose index trajectories and kidney outcomes in patients with metabolic dysfunctionassociated fatty liver disease.","authors":"Jong Hyun Jhee, Wooram Bae, Hyo Jeong Kim, Hye Sun Lee, Shinae Kang, Jung Il Lee, Hyeong Cheon Park, Hoon Young Choi","doi":"10.23876/j.krcp.25.246","DOIUrl":"https://doi.org/10.23876/j.krcp.25.246","url":null,"abstract":"<p><strong>Background: </strong>Triglyceride-glucose index (TyGi), a surrogate marker of metabolic dysfunction, has not been evaluated for kidney outcomes in patients with metabolic dysfunction-associated fatty liver disease (MAFLD). We aimed to evaluate this association in individuals with MAFLD.</p><p><strong>Methods: </strong>Totally 868 patients with MAFLD from the Gangnam Severance Medical Cohort (2006-2021) were included. TyGi trajectories were defined using latent class mixture modeling based on their longitudinal changes: decreasing (n = 426) vs. increasing (n = 442). MAFLD was diagnosed based on hepatic steatosis and at least one of the following: overweight or obese, type 2 diabetes, or two or more metabolic abnormalities. Kidney outcomes included: sustained reduction in eGFR to <60 mL/min/1.73 m2 for those with baseline eGFR of ≥60 mL/min/1.73 m2, ≥30% decline from baseline for those with eGFR <60 mL/min/1.73 m2, or initiation of dialysis or kidney transplantation. Cause-specific Cox proportional hazard models assessed the association between TyGi trajectories and kidney outcomes.</p><p><strong>Results: </strong>The participants' mean age was 52.3 ± 10.4 years and 504 (58.1%) were male. Over a median follow-up of 6.9 years (4.0- 10.0 years), 36 kidney outcome events occurred. The incidence rates were 4.02 and 9.06 per 1,000 person-years in the decreasing and increasing TyGi trajectory groups, respectively (p = 0.02). In a multivariable cause-specific Cox model, the increasing trajectory group had a significantly greater risk of kidney outcomes than the decreasing group (hazard ratio, 3.68; 95% confidence interval, 1.68- 8.05; p = 0.001). Subgroup analyses showed consistent findings.</p><p><strong>Conclusion: </strong>Increasing longitudinal TyGi levels are associated with a higher risk of adverse kidney outcomes in patients with MAFLD.</p>","PeriodicalId":17716,"journal":{"name":"Kidney Research and Clinical Practice","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147377342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early hemoglobin levels after kidney transplantation predict clinical outcomes.","authors":"Min-Gyu Kim, You Hyun Jeon, Jae Berm Park, Jung Hwan Park, Su Hyung Lee, Jaeseok Yang, Myoung Soo Kim, Yu Jin Seo, Youn-Sik Oh, Ji-Eun Yoo, Hee-Yeon Jung, Sun-Hee Park, Chan-Duck Kim, Yong-Lim Kim, Jeong-Hoon Lim, Jang-Hee Cho","doi":"10.23876/j.krcp.25.215","DOIUrl":"https://doi.org/10.23876/j.krcp.25.215","url":null,"abstract":"<p><strong>Background: </strong>The impact of early hemoglobin levels following kidney transplantation (KT) on long-term outcomes remains unclear. This study evaluates the association between early posttransplant hemoglobin levels and clinical outcomes.</p><p><strong>Methods: </strong>A total of 7,501 kidney transplant recipients (KTRs) from a nationwide cohort were included. Hemoglobin levels at 6 months post-KT were analyzed. KTRs were categorized into five hemoglobin groups: <10, 10 to <11, 11 to <12, 12 to <13 (reference group), and ≥13 g/dL. The primary outcome was a composite of cardiovascular events, graft loss, and all-cause mortality. Multivariable Cox regression was employed to assess the relationship between hemoglobin levels and the composite outcome.</p><p><strong>Results: </strong>The cohort had a mean age of 49.6 ± 11.6 years, and 60.4% were male. The incidence of the composite outcome and its individual components was highest among KTRs with hemoglobin levels <10 g/dL. Hemoglobin levels <10 g/dL were associated with a significantly increased risk of the composite outcome (hazard ratio [HR], 3.16; 95% confidence interval [CI], 2.05-4.87; p < 0.001) and were identified as an independent risk factor for each component. Conversely, hemoglobin levels ≥13 g/dL were associated with improved survival (HR, 0.44; 95% CI, 0.22-0.90; p = 0.02). Subgroup analyses confirmed that hemoglobin levels <10 g/ dL consistently increased the risk of the composite outcome.</p><p><strong>Conclusion: </strong>Posttransplant anemia with hemoglobin levels <10 g/dL showed a significant association with an increased risk of the composite outcome. Conversely, hemoglobin levels ≥13 g/dL were linked to better patient survival.</p>","PeriodicalId":17716,"journal":{"name":"Kidney Research and Clinical Practice","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147378103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sarcopenia, sarcopenic obesity, and frailty in individuals with chronic kidney disease: a comprehensive review.","authors":"Chia-Ter Chao, Csaba P Kovesdy, Reshma Aziz Merchant","doi":"10.23876/j.krcp.24.207","DOIUrl":"10.23876/j.krcp.24.207","url":null,"abstract":"<p><p>Population aging is a global challenge that increases the burden of chronic kidney disease (CKD) and geriatric syndromes such as sarcopenia, sarcopenic obesity, and frailty. These conditions affect almost half of older CKD individuals and are associated with poor outcomes, including CKD progression, cardiometabolic complications, increased health and social care costs, and mortality. They can be both the cause and consequent of CKD and lead to a vicious downward spiral if not addressed early. Frailty is a multidimensional syndrome characterized by reduced physiological reserve and increased vulnerability to stressors. Sarcopenia refers to the progressive and generalized loss of skeletal muscle mass, strength, and/or physical performance with aging. Sarcopenic obesity denotes the combination of sarcopenia and obesity that synergistically leads to poor outcomes. They share common pathogenic mechanisms, such as multimorbidity, inflammation, oxidative stress, uremic milieu, insulin resistance, endocrine disturbances, CKD complications, and psychosocial factors that may limit access to proper nutrition and resources. Management requires a multidisciplinary and patient-centered approach, taking into consideration their baseline physical function and endurance, CKD stage, nutrition status, comorbidities, symptoms, treatment goals, cost, and accessibility. Interventions include exercise, nutrition, comorbidity optimization, geriatric assessment, sensory training, and kidney-oriented care. This review summarizes the current knowledge on the diagnosis and treatment of sarcopenia, sarcopenic obesity, and frailty in individuals with CKD, followed by up-to-date summaries of how best to manage affected individuals.</p>","PeriodicalId":17716,"journal":{"name":"Kidney Research and Clinical Practice","volume":" ","pages":"174-188"},"PeriodicalIF":3.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12990192/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143458565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient-reported mental health problems and clinical outcomes in adults with non-dialysis chronic kidney disease.","authors":"Jihyun Yang, Young Youl Hyun, Kyu-Beck Lee, Hyo Jin Kim, Sang Heon Suh, Hayne Cho Park, Yun Kyu Oh, Sue Kyung Park, Kook-Hwan Oh","doi":"10.23876/j.krcp.24.034","DOIUrl":"10.23876/j.krcp.24.034","url":null,"abstract":"<p><strong>Background: </strong>Mental health affects well-being and physical health. Among adults with chronic kidney disease (CKD), mental health (MH) problems are common and can induce adverse clinical outcomes. We examined the association between patient-reported MH problems and clinical outcomes in adults with non-dialysis CKD.</p><p><strong>Methods: </strong>This prospective observational study included 1,879 participants from the KNOW-CKD (KoreaN Cohort Study for Outcomes in Patients With CKD). Patients-reported MH problems were determined using four indicators of the Korea National Health and Nutrition Examination Survey questionnaire. We described the cross-sectional differences in health-related quality of life according to MH problems. We prospectively evaluated the hazard ratio (HR) of all-cause death and end-stage kidney disease (ESKD) according to the MH problems for a median follow-up of 6.4 years.</p><p><strong>Results: </strong>The participants (mean age 53 years; 61.6% male) had patient-reported MH problems of inadequate sleep duration (17.4%), subjective distress (27.3%), depressive symptoms (13.2%), and suicidal ideation (16.8%). In the fully adjusted Cox proportional model, poor MH (≥2 problems) was associated with a high risk of ESKD (HR, 1.46; 95% confidence interval [CI], 1.18-1.80) and death (HR, 1.55; 95% CI, 1.04-2.32) compared with good MH. Furthermore, the single indicator of suicidal ideation was associated with a high risk of ESKD (HR, 1.37; 95% CI, 1.11-1.69) and death (HR, 1.98; 95% CI, 1.34-2.92).</p><p><strong>Conclusions: </strong>Patient-reported MH problems are common in adults with CKD. Poor MH and only suicidal ideation are associated with a high risk of ESKD and early death. Age and sex modify the association between poor MH and adverse clinical outcomes in non-dialysis CKD.</p>","PeriodicalId":17716,"journal":{"name":"Kidney Research and Clinical Practice","volume":" ","pages":"232-243"},"PeriodicalIF":3.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13003171/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142622914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Korean Society of Nephrology 2025 evidence-based clinical practice guideline for continuous kidney replacement therapy.","authors":"Jeonghwan Lee, Donghyuk Kang, Jin Hyuk Paek, Jangwook Lee, Jung Nam An, Junseok Jeon, Kyungho Lee, Hye Ryoun Jang, Jong Hyun Jhee, Hyo Jin Kim, Harin Rhee, Sung Yoon Lim, Jihyun Yang, Seong Geun Kim, Seung Seok Han, Shin Young Ahn, Sunghoon Park, Hyun Kyung Lee, Heeyeon Cho, Yeonhee Lee, Hyung Woo Kim, Keonhwa Kim, Miyoung Choi, Sejoong Kim","doi":"10.23876/j.krcp.25.353","DOIUrl":"10.23876/j.krcp.25.353","url":null,"abstract":"<p><p>The Korean Society of Critical Care Nephrology, in collaboration with the Korean Society of Nephrology, has published a Clinical Practice Guideline (CPG) for Continuous Kidney Replacement Therapy (CKRT). This guideline was developed with the goal of improving patient outcomes and reducing complications, based on the latest research related to the application and prescription of CKRT. The development of this guideline involved multidisciplinary participation from leading experts in nephrology and critical care medicine, with methodological support for the guideline development process. This CPG consists of recommendations addressing 17 key questions related to the initiation of CKRT, dose, modality, dialysate, ultrafiltration, anticoagulation, application in special situations, and multidisciplinary care. Each recommendation begins with a statement graded by the strength of the recommendation and the quality of the supporting evidence, followed by a rationale that supports the recommendation. We hope that this CPG will offer practical guidance in clinical settings and contribute to the improvement of patient outcomes.</p>","PeriodicalId":17716,"journal":{"name":"Kidney Research and Clinical Practice","volume":"45 Suppl 1","pages":"S1-S54"},"PeriodicalIF":3.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13064971/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147628238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}