Kidney Research and Clinical Practice最新文献_第3页

Association between the number of pregnancies and chronic kidney disease in Korean women: a population-based cross-sectional study from the Korean Genome and Epidemiology Study-Health Examinee (KoGES-HEXA) cohort. 韩国女性怀孕次数与慢性肾脏疾病之间的关系：来自韩国基因组和流行病学研究-健康体检者（KoGES-HEXA）队列的基于人群的横断面研究

IF 3.5 3区医学

Kidney Research and Clinical Practice Pub Date : 2026-09-18 DOI: 10.23876/j.krcp.25.411

Seung Hee Jeong, Ji Hyun Kim, Ju Hwan Oh, A Young Cho, In O Sun, Ha-Eun Lee

{"title":"Association between the number of pregnancies and chronic kidney disease in Korean women: a population-based cross-sectional study from the Korean Genome and Epidemiology Study-Health Examinee (KoGES-HEXA) cohort.","authors":"Seung Hee Jeong, Ji Hyun Kim, Ju Hwan Oh, A Young Cho, In O Sun, Ha-Eun Lee","doi":"10.23876/j.krcp.25.411","DOIUrl":"https://doi.org/10.23876/j.krcp.25.411","url":null,"abstract":"Background: Chronic kidney disease (CKD) is a growing public health burden. Repeated pregnancies exert anatomical and physiological stress on the kidneys; however, the association between number of pregnancies and CKD is unclear.Methods: This cross-sectional study used data from the Korean Genome and Epidemiology Study-Health Examinee (KoGES-HEXA; 2004-2013). The number of pregnancies was categorized as 0, 1, 2, 3, 4, or ≥5. The primary outcome was CKD, defined as an estimated glomerular filtration rate <60 mL/min/1.73 m2, using the CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration) formula, or dipstick proteinuria ≥1+. We evaluated the association between number of pregnancies and CKD and whether it varied by adverse pregnancy outcomes (APOs).Results: We included 100,433 women (age, 52.7 ± 8.0 years [mean ± standard deviation]). Of the parous women (n = 99,654), 3.8% (n = 3,795) had CKD. In the fully adjusted model, women with ≥5 pregnancies had modestly higher CKD odds than women with one pregnancy (odds ratio, 1.20; 95% confidence interval, 1.01-1.43). The association differed by age (p for interaction <0.001), with a significant trend among women aged ≥60 years (p for trend = 0.009). In subgroup analyses, ≥5 pregnancies remained associated with CKD among women without preeclampsia or gestational diabetes mellitus, with no clear evidence of interactions.Conclusion: A higher number of pregnancies was modestly associated with a higher prevalence of CKD in Korean women, including those without APO history. Although residual confounding by age and birth cohort cannot be excluded, the number of pregnancies may be relevant to women's long-term kidney health.","PeriodicalId":17716,"journal":{"name":"Kidney Research and Clinical Practice","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149012746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of isolated systolic and diastolic hypertension with moderately increased albuminuria: the Korea National Health and Nutrition Examination Survey. 孤立性收缩期和舒张期高血压与蛋白尿中度增高的关系：韩国国民健康和营养检查调查。

IF 3.5 3区医学

Kidney Research and Clinical Practice Pub Date : 2026-09-18 DOI: 10.23876/j.krcp.26.188

Hansol Choi, Jenny Moon, Minsung Cho, Jong Hyun Jhee, Chan Joo Lee, Hyeon Chang Kim, Hokyou Lee

{"title":"Association of isolated systolic and diastolic hypertension with moderately increased albuminuria: the Korea National Health and Nutrition Examination Survey.","authors":"Hansol Choi, Jenny Moon, Minsung Cho, Jong Hyun Jhee, Chan Joo Lee, Hyeon Chang Kim, Hokyou Lee","doi":"10.23876/j.krcp.26.188","DOIUrl":"https://doi.org/10.23876/j.krcp.26.188","url":null,"abstract":"Background: Studies show variable results on health outcomes of isolated diastolic hypertension (IDH); however, data are scarce on its association with early kidney injury.Methods: We analyzed the Korea National Health and Nutrition Examination Survey data (2011-2014 and 2019-2024) in adults ≥19 years. After excluding those taking antihypertensive medication or with established kidney disease, participants were categorized into normal blood pressure (BP [mmHg]; systolic BP [SBP] <120 and diastolic BP [DBP] <80), elevated BP (SBP 120 to <130 and DBP <80), stage 1 hypertension (SBP 130 to <140 or DBP 80 to <90 but not stage 2 hypertension), and stage 2 hypertension (SBP ≥140 or DBP ≥90) according to the 2025 American Heart Association/American College of Cardiology guidelines. Stage 1 and 2 hypertension was further classified as IDH, isolated systolic hypertension (ISH), or systolic-diastolic hypertension (SDH). Moderately increased albuminuria was defined as urine albumin-to-creatinine ratio of 30-<300 mg/g.Results: Among 33,638 participants (mean age, 43.2 years; 47.9% female), multivariable-adjusted ORs (95% CIs) for moderately increased albuminuria were 1.45 (1.18-1.78) for stage 1 IDH, 1.66 (1.21-2.28) for stage 1 ISH, 2.09 (1.60-2.74) for stage 1 SDH, and 3.38 (2.85-4.01) for stage 2 hypertension. In age-stratified analysis, stage 1 IDH showed 1.37- and 1.58-fold higher odds of moderately increased albuminuria in participants aged <50 and ≥50 years, respectively.Conclusion: IDH, even at stage 1, was associated with moderately increased albuminuria, suggesting it may not be benign. Longitudinal studies are needed to determine whether IDH predicts subsequent kidney injury and whether early attention to elevated DBP modifies kidney and cardiovascular outcomes.","PeriodicalId":17716,"journal":{"name":"Kidney Research and Clinical Practice","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149012716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beyond procedure counts: reconsidering physician involvement in maintenance hemodialysis. 超越程序计数：重新考虑医生参与维持性血液透析。

IF 3.5 3区医学

Kidney Research and Clinical Practice Pub Date : 2026-09-17 DOI: 10.23876/j.krcp.26.416

Sungjin Chung, Jeonghwan Lee, Yu Ah Hong, Gang-Jee Ko, Sehoon Park, Jungho Shin, Young-Ki Lee, Won Min Hwang, Donghyung Lee, Jae Won Yang, Jae-Won Lee, Jae Young Kim, Hyeanji Kim, Ji Young You, Jung Pyo Lee

引用次数: 0

Histamine H1 receptor as a potential prophylactic target for COVID-19-induced acute kidney injury during pregnancy. 组胺H1受体作为covid -19诱导的妊娠期急性肾损伤的潜在预防靶点

IF 3.5 3区医学

Kidney Research and Clinical Practice Pub Date : 2026-09-15 DOI: 10.23876/j.krcp.26.273

Itsuro Kazama, Kurumi Sugawara, Hikaru Honda, Kinari Kawamura, Kanata Segawa

引用次数: 0

Advances in the study of sodium-glucose cotransporter 2 inhibitors for peritoneal dialysis. 腹膜透析钠-葡萄糖共转运蛋白2抑制剂的研究进展。

IF 3.5 3区医学

Kidney Research and Clinical Practice Pub Date : 2026-09-15 DOI: 10.23876/j.krcp.25.406

Juan Chen, Jie Yang, Bengang Huo, Mingyu Cai, Wenjiang Gong, Qingli Cai, Yani He, Jia Chen, Kehong Chen

引用次数: 0

Sodium-glucose cotransporter-2 inhibitors, severe sepsis, and infection-related outcomes in patients with chronic kidney disease and type 2 diabetes. 钠-葡萄糖共转运蛋白2抑制剂、慢性肾病和2型糖尿病患者的严重败血症和感染相关结局

IF 3.5 3区医学

Kidney Research and Clinical Practice Pub Date : 2026-09-09 DOI: 10.23876/j.krcp.26.134

Chung-An Wang, Wei-Jie Wang, Jui-Yi Chen, Yen-Heng Tseng, Chung-Yi Cheng, Vin-Cent Wu

{"title":"Sodium-glucose cotransporter-2 inhibitors, severe sepsis, and infection-related outcomes in patients with chronic kidney disease and type 2 diabetes.","authors":"Chung-An Wang, Wei-Jie Wang, Jui-Yi Chen, Yen-Heng Tseng, Chung-Yi Cheng, Vin-Cent Wu","doi":"10.23876/j.krcp.26.134","DOIUrl":"https://doi.org/10.23876/j.krcp.26.134","url":null,"abstract":"Background: Patients with chronic kidney disease (CKD) and type 2 diabetes (T2D) are vulnerable to infections. While sodium-glucose cotransporter-2 (SGLT-2) inhibitors provide established cardiorenal benefits, their effects on infection remain unclear. This study aimed to evaluate the association between SGLT-2 inhibitors and the risks of severe sepsis, infection-related complications, and mortality in this population.Methods: We conducted a real-world, active-comparator, new-user cohort study using the U.S. Collaborative Network of TriNetX. Adults with CKD and T2D who initiated SGLT-2 inhibitors or DPP-4 inhibitors between 2018 and 2024 were included. Propensity score matching was applied to balance baseline characteristics. The primary outcome was severe sepsis; secondary outcomes included septic shock, mortality, hospitalization, pneumonia, urinary tract infection (UTI), and genital infection.Results: After matching, 25,049 patients were included in each group. During 1 year of follow-up, SGLT-2 inhibitor use was associated with a lower risk of severe sepsis than DPP-4 inhibitor use (2.7% vs. 3.3%; HR, 0.81; 95% CI, 0.73-0.90). Risks of septic shock (HR, 0.83), mortality (HR, 0.72), hospitalization (HR, 0.90), pneumonia (HR, 0.77), and UTI (HR, 0.72) were reduced, whereas the risk of genital infection (HR, 1.93) was higher. No significant differences were observed in diabetic ketoacidosis or acidosis.Conclusion: Among patients with CKD and T2D, SGLT-2 inhibitor initiation was associated with lower risks of severe sepsis, infection-related outcomes, hospitalization, and mortality compared with DPP-4 inhibitor initiation, despite a higher risk of genital infection. These findings support SGLT-2 inhibitors as a core therapy with potential benefits extending beyond cardiorenal protection in this high-risk population.","PeriodicalId":17716,"journal":{"name":"Kidney Research and Clinical Practice","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148912542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genome-wide association study of estimated glomerular filtration rate using repeated measurements in the Taiwan Biobank. 在台湾生物库使用重复测量估计肾小球滤过率的全基因组关联研究。

IF 3.5 3区医学

Kidney Research and Clinical Practice Pub Date : 2026-09-09 DOI: 10.23876/j.krcp.25.430

Yi-Chih Lin, Hsiao-Mei Tsao, Jacob Shujui Hsu, Yi-Cheng Chang, Yu-Hsuan Joni Shao, Yu-Hsiang Chou, Vin-Cent Wu, Shuei-Liong Lin, Tai-Shuan Lai

{"title":"Genome-wide association study of estimated glomerular filtration rate using repeated measurements in the Taiwan Biobank.","authors":"Yi-Chih Lin, Hsiao-Mei Tsao, Jacob Shujui Hsu, Yi-Cheng Chang, Yu-Hsuan Joni Shao, Yu-Hsiang Chou, Vin-Cent Wu, Shuei-Liong Lin, Tai-Shuan Lai","doi":"10.23876/j.krcp.25.430","DOIUrl":"https://doi.org/10.23876/j.krcp.25.430","url":null,"abstract":"Background: Chronic kidney disease (CKD) is a major global public health issue, with genetic factors playing a significant role in kidney function. Although genome-wide association studies (GWAS) have identified numerous loci associated with estimated glomerular filtration rate (eGFR), most studies relied on a single time-point measurement, which limits the capacity to account for within-individual measurement variability.Methods: We performed a repeated-measurement GWAS in the prospective Taiwan Biobank (Taiwanese ancestry; n = 25,004) using two repeated creatinine-based eGFR measurements. Repeated eGFR values were analyzed using a linear mixed-effects model with a subject-specific random intercept and time-varying covariates, providing a more precise estimate of eGFR level. Identified loci underwent functional annotation (expression quantitative trait locus, deleteriousness prediction, and epigenetic markers) and were compared with results from a single-measurement GWAS.Results: Six loci associated with eGFR were identified, including four previously reported regions (1q22, 4q21.1, 11p14.1, and 17q21.2) and two additional loci (6p21.32 and 15q24.2). Functional annotation implicated several candidate genes-such as MUC1/EFNA1, SHROOM3, HLA-DQB1, MPPED2, NRG4, and PGAP3/FBXL20-in the regulation of kidney function.Conclusion: Incorporating repeated eGFR measurements into GWAS may improve phenotypic precision for identifying genetic associations with kidney function. This study identified eGFR-associated loci and biologically plausible candidate genes in a Taiwanese population, which require further replication and functional validation.","PeriodicalId":17716,"journal":{"name":"Kidney Research and Clinical Practice","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148912511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rationale and design of a nationwide prospective cohort study in type 2 diabetic kidney disease: the Korean Diabetic Kidney Disease (K-DKD) Cohort. 2型糖尿病肾病的全国前瞻性队列研究的基本原理和设计：韩国糖尿病肾病（K-DKD）队列

IF 3.5 3区医学

Kidney Research and Clinical Practice Pub Date : 2026-09-08 DOI: 10.23876/j.krcp.26.091

Jin Joo Cha, Dae Ryong Cha, Yaeni Kim, Cheol Whee Park, Hyung Duk Kim, Ju-Young Moon, Kyubok Jin, Sang Heon Song, Jung-Hwan Lee, Samel Park, Eun Young Lee, Tae Hyun Yoo, Won Kim, So Young Lee, Jwa-Kyung Kim, Seung Seok Han, Mi-Yeon Yu, Sang Youb Han

{"title":"Rationale and design of a nationwide prospective cohort study in type 2 diabetic kidney disease: the Korean Diabetic Kidney Disease (K-DKD) Cohort.","authors":"Jin Joo Cha, Dae Ryong Cha, Yaeni Kim, Cheol Whee Park, Hyung Duk Kim, Ju-Young Moon, Kyubok Jin, Sang Heon Song, Jung-Hwan Lee, Samel Park, Eun Young Lee, Tae Hyun Yoo, Won Kim, So Young Lee, Jwa-Kyung Kim, Seung Seok Han, Mi-Yeon Yu, Sang Youb Han","doi":"10.23876/j.krcp.26.091","DOIUrl":"https://doi.org/10.23876/j.krcp.26.091","url":null,"abstract":"Background: Diabetic kidney disease (DKD) is the leading cause of end-stage kidney disease (ESKD) worldwide. In South Korea, DKD accounts for nearly half of all ESKD cases, yet prospective data reflecting the clinical characteristics of Korean patients remain limited. This study aims to investigate the clinical and biological features of DKD in Koreans and identify long-term prognostic indicators.Methods: The Korean Diabetic Kidney Disease (K-DKD) Cohort is a nationwide prospective multicenter study investigating the clinical, biochemical, and molecular determinants of DKD progression in Korean adults with type 2 diabetes mellitus. Approximately 1,300 participants will be enrolled from 15 university-affiliated hospitals in South Korea. Demographic, clinical, laboratory data and outcome data are collected using a standardized electronic case report form at baseline and annually for up to 10 years. Blood and urine biospecimens are obtained at baseline and every 2 years thereafter for centralized storage and biospecimen analyses. Clustering analyses will identify the distinct clinical phenotypes of DKD, and long-term prognostic models will be developed on the basis of renal and cardiovascular outcomes using traditional and artificial intelligence-based approaches. Additionally, treatment patterns and management behaviors will be evaluated to understand the real-world clinical practices in Korean DKD.Discussion: The K-DKD Cohort will expand Korea's national big data and biobank platform into a DKD-focused prospective study that integrates standardized clinical and biospecimen data. It aims to facilitate biomarker discovery, data-driven risk prediction, and precision research in Korean patients with DKD.","PeriodicalId":17716,"journal":{"name":"Kidney Research and Clinical Practice","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148912565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Smart medical technologies in peritoneal dialysis: current applications and future perspectives. 腹膜透析中的智能医疗技术：当前应用和未来展望。

IF 3.5 3区医学

Kidney Research and Clinical Practice Pub Date : 2026-09-04 DOI: 10.23876/j.krcp.25.417

Dan Li, Ibtasam Wajid, Hao Liu, Siqi Li, Qin Wang

{"title":"Smart medical technologies in peritoneal dialysis: current applications and future perspectives.","authors":"Dan Li, Ibtasam Wajid, Hao Liu, Siqi Li, Qin Wang","doi":"10.23876/j.krcp.25.417","DOIUrl":"https://doi.org/10.23876/j.krcp.25.417","url":null,"abstract":"With the global rise in end-stage kidney disease cases, peritoneal dialysis (PD) has become a critical treatment modality for maintaining patients' quality of life. This narrative review aims to summarize and analyze the current applications and effectiveness of smart medical technologies in PD treatment, focusing on patient monitoring, treatment optimization, and healthcare delivery. This review examines the integration of smart medical technologies, including the Internet of Things (IoT), artificial intelligence, and cloud computing, in the management of PD. Key advancements discussed include: 1) IoT-enabled sensors for real-time monitoring of ultrafiltration volume and dialysate turbidity, enabling early detection of infection risks; 2) machine learning algorithms for personalized dialysis prescription adjustments to preserve residual kidney function; and 3) telemedicine platforms that enhance physician-patient collaboration and reduce the need for hospital visits. These innovations represent a significant step toward precision and intelligent management of PD, improving operational efficiency and selected outcomes. Future research should focus on addressing challenges related to data security, algorithm transparency, and real-world clinical adoption.","PeriodicalId":17716,"journal":{"name":"Kidney Research and Clinical Practice","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148900969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combined nutcracker syndrome and glomerulonephritis in pediatric patients: a single-center retrospective case series. 合并胡桃夹综合征和肾小球肾炎的儿科患者：单中心回顾性病例系列。

IF 3.5 3区医学

Kidney Research and Clinical Practice Pub Date : 2026-09-01 Epub Date: 2024-11-29 DOI: 10.23876/j.krcp.24.178

So Hyun Ki, Min Hwa Son, Hyung Eun Yim

{"title":"Combined nutcracker syndrome and glomerulonephritis in pediatric patients: a single-center retrospective case series.","authors":"So Hyun Ki, Min Hwa Son, Hyung Eun Yim","doi":"10.23876/j.krcp.24.178","DOIUrl":"10.23876/j.krcp.24.178","url":null,"abstract":"Background: Nutcracker syndrome (NCS) has been reported to coexist with various glomerulonephritis (GN). This study investigated clinical features of NCS combined with GN in a pediatric case series and the possible relationship between these two conditions.Methods: Clinical and pathologic findings of 15 children with NCS and biopsy-proven GN were analyzed. NCS was diagnosed with renal Doppler ultrasonography, abdominal computed tomography, and/or magnetic resonance imaging. Glomerular lesions were divided into two pathological categories: minor glomerular abnormalities (MGAs) and definite GN.Results: Mean age of all patients was 11 ± 3.36 years and mean follow-up duration was 53.8 ± 29.3 months. Chief complaint was proteinuria with or without hematuria. During follow-up, five patients developed left kidney enlargement. Abnormal levels in immunological tests were revealed in 10 patients. Extrarenal symptoms including gonadal varicocele, splenic cyst, syncope, and anemia were found in seven patients. On kidney biopsy, seven patients had MGAs and eight children showed definite GN (one case of focal GN, one case of mesangial proliferative GN, one case of focal segmental glomerulosclerosis, two cases of immunoglobulin A [IgA] vasculitis nephritis, and three cases of IgA nephropathy). While the MGA group showed a higher proportion of isolated proteinuria and a lower estimated glomerular filtration rate (eGFR) at the last visit, there were no differences in age, clinical features of NCS, extrarenal symptoms, immunological tests, and eGFR decline rate between the two groups.Conclusion: NCS may be associated with the presence of various GN. The causal relationship between NCS and GN should be further investigated.","PeriodicalId":17716,"journal":{"name":"Kidney Research and Clinical Practice","volume":" ","pages":"829-841"},"PeriodicalIF":3.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13575261/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142786072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0