Kidney Research and Clinical Practice最新文献_第3页

Unveiling the podocyte-protective effect of sodium-glucose cotransporter-2 inhibitors. 揭示钠-葡萄糖共转运蛋白-2抑制剂对足细胞的保护作用。

IF 2.9 3区医学

Kidney Research and Clinical Practice Pub Date : 2025-01-01 Epub Date: 2024-12-05 DOI: 10.23876/j.krcp.24.144

Buchun Jiang, Zhiwen Cheng, Dongjie Wang, Fei Liu, Jingjing Wang, Haidong Fu, Jianhua Mao

引用次数: 0

Management of high-flow arteriovenous access.

IF 2.9 3区医学

Kidney Research and Clinical Practice Pub Date : 2025-01-01 Epub Date: 2025-01-31 DOI: 10.23876/j.krcp.23.196

Hoon Suk Park, Seok Joon Shin

{"title":"Management of high-flow arteriovenous access.","authors":"Hoon Suk Park, Seok Joon Shin","doi":"10.23876/j.krcp.23.196","DOIUrl":"10.23876/j.krcp.23.196","url":null,"abstract":"An arteriovenous fistula or graft is essential for hemodialysis (HD). It involves connecting a high-resistance artery to a low-resistance vein, which increases cardiac output (CO). In the early days of HD, patients with end-stage kidney disease (ESKD) were typically younger, and their HD access was located in the distal forearm. However, in the modern era, ESKD patients are often the elderly, with many being the very elderly (over 80 years old). These elderly patients often have poor vessel quality, making distal forearm access unsuitable. As a result, upper arm access, which is more prone to high-flow access, is commonly used. The cardiac status of these modern elderly ESKD patients is vulnerable to high-flow access. High-flow HD access can lead to high-output cardiac failure in ESKD patients. Initial evaluation for high-flow access involves measuring the flow volume using Doppler ultrasound. If the HD access flow volume exceeds 2,000 mL/min, further assessments, including CO and cardiopulmonary recirculation ratio caused by the HD access, should be strongly considered. Treatment for high-flow access involves reducing the flow. There are several surgical and endovascular methods for flow reduction, such as aneurysmorrhaphy, short segment small-diameter graft interposition at the inflow area of the HD access, and banding. Patients with high-flow access are generally asymptomatic. Therefore, nephrologists as primary care physicians for HD patients should provide detailed explanations to patients with high-flow access and high-output cardiac failure and ensure that they understand the prognosis of these conditions. Nephrologists need increased attention to high-flow HD access.","PeriodicalId":17716,"journal":{"name":"Kidney Research and Clinical Practice","volume":"44 1","pages":"58-68"},"PeriodicalIF":2.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11838845/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bowman capsule rupture in children with myeloperoxidase-antineutrophil cytoplasmic antibody-associated glomerulonephritis predicts poor renal survival. 患有髓过氧化物酶-抗中性粒细胞胞浆抗体相关肾小球肾炎的儿童Bowman囊破裂预示着肾存活率低。

IF 2.9 3区医学

Kidney Research and Clinical Practice Pub Date : 2025-01-01 Epub Date: 2023-11-01 DOI: 10.23876/j.krcp.23.051

Pei Zhang, Li-Li Jia, Meng-Zhen Fu, Kai-Li Shi, Chun-Lin Gao, Zheng-Kun Xia

{"title":"Bowman capsule rupture in children with myeloperoxidase-antineutrophil cytoplasmic antibody-associated glomerulonephritis predicts poor renal survival.","authors":"Pei Zhang, Li-Li Jia, Meng-Zhen Fu, Kai-Li Shi, Chun-Lin Gao, Zheng-Kun Xia","doi":"10.23876/j.krcp.23.051","DOIUrl":"10.23876/j.krcp.23.051","url":null,"abstract":"Background: Recent developments indicated that Bowman capsule rupture (BCR) is observed in antineutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis (AAGN). We aimed to explore the relationship between BCR and clinical manifestations, pathological changes, and prognosis in children with myeloperoxidase (MPO)-AAGN.Methods: A total of 56 children with MPO-AAGN were divided into BCR (+) and BCR (-) groups according to the status of Bowman's capsule.Results: After retrospective analysis of the data, 24 children (42.9%) were found to have BCR. The results showed that BCR positively correlated with intrarenal immune cell infiltrates, obsolescence and crescents in glomeruli, tubulointerstitial inflammation, tubulitis, and tubular atrophy negatively correlated with normal glomeruli and immunoglobulin G deposition in the kidney. The clinical features and kidney pathological changes were more severe in the BCR (+) group than BCR (-) group, and the renal survival rate was significantly poorer in the BCR (+) group than BCR (-) group (χ2 = 5.45, p = 0.02). Moreover, estimated glomerular filtration rate (≤15 mL/ min/1.73 m2), BCR and ANCA renal risk score (ARRS) were independent risk factors for the development of end-stage kidney disease (ESKD) in children with MPO-AAGN. After combining BCR with the Berden classification and ARRS, our data suggested that the Berden classification + BCR and ARRS + BCR showed better predictive values for ESKD than those of the Berden classification and ARRS, respectively.Conclusion: BCR is an important pathological lesion that correlates with severe clinical manifestations, pathological changes, and poor prognosis in children with MPO-AAGN.","PeriodicalId":17716,"journal":{"name":"Kidney Research and Clinical Practice","volume":" ","pages":"111-122"},"PeriodicalIF":2.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11838847/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71424669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Loss of Cutibacterium is responsible for chronic kidney disease-associated pruritus in patients on dialysis. Cutibacterium的缺失是透析患者慢性肾脏疾病相关瘙痒的原因。

IF 2.9 3区医学

Kidney Research and Clinical Practice Pub Date : 2025-01-01 Epub Date: 2023-09-06 DOI: 10.23876/j.krcp.23.057

Jeong Geon Lee, Hoonhee Seo, Seung Seob Son, Hee Seul Jeong, Kyung Mi Lee, Nam-Jun Cho, Samel Park, Hyo-Wook Gil, Hyun-A Park, Sukyung Kim, Eun Young Lee

{"title":"Loss of Cutibacterium is responsible for chronic kidney disease-associated pruritus in patients on dialysis.","authors":"Jeong Geon Lee, Hoonhee Seo, Seung Seob Son, Hee Seul Jeong, Kyung Mi Lee, Nam-Jun Cho, Samel Park, Hyo-Wook Gil, Hyun-A Park, Sukyung Kim, Eun Young Lee","doi":"10.23876/j.krcp.23.057","DOIUrl":"10.23876/j.krcp.23.057","url":null,"abstract":"Background: Chronic kidney disease (CKD)-associated pruritus is a severe distressing condition that frequently occurs in patients undergoing dialysis. In this study, the profile of the skin microbiome was analyzed to understand the underlying etiology and potential treatments.Methods: Seventy-six end-stage kidney disease (ESKD) patients (hemodialysis, 40; peritoneal dialysis, 36) and 15 healthy controls were enrolled and swabbed at three sites: back, antecubital fossa, and shin. The pruritus severity of the enrolled subjects was validated by the Worst Itch Numeric Rating Scale (WI-NRS), 5-D itch scale, and Uremic Pruritus in Dialysis Patients (UP-Dial). The 16S genebased metagenomics method was applied to skin microbiome analysis.Results: In the comparison of bacterial communities of ESKD patients and the control group, there was a significant difference on back. Specifically, the average composition ratio of the Cutibacterium in the back samples was significantly lower in ESKD patients than in healthy controls (p < 0.01). In further analysis of ESKD patients, Cutibacterium was significantly lower in the high pruritus group than in the low pruritus group (p < 0.05), even though other clinical parameters such as age, calcium-phosphorus product, and intact parathyroid hormone showed no significance difference between the groups.Conclusion: In ESKD patients, the skin microbiome of the back was significantly altered, and the severity of itching was related to the reduction of Cutibacterium. This research reveals the relationship between skin microbiota and CKD-associated pruritus in multiple skin sites for the first time. The results of this study suggest a potential data basis for the diagnosis and treatment of CKD-associated pruritus.","PeriodicalId":17716,"journal":{"name":"Kidney Research and Clinical Practice","volume":" ","pages":"176-188"},"PeriodicalIF":2.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11838852/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41125732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Zebra bodies in lupus nephritis without Fabry disease or hydroxychloroquine therapy.

IF 2.9 3区医学

Kidney Research and Clinical Practice Pub Date : 2025-01-01 Epub Date: 2025-01-17 DOI: 10.23876/j.krcp.24.283

Yaning Wang, Rongdan Cai, Yunqi Liu, Ning Yu, Mingfeng Zhao

引用次数: 0

Clinical consequence of hypophosphatemia during antiviral therapy for chronic hepatitis B.

IF 2.9 3区医学

Kidney Research and Clinical Practice Pub Date : 2025-01-01 Epub Date: 2025-01-17 DOI: 10.23876/j.krcp.22.197

Mee Yeon Park, Hojin Jeon, Kyungho Park, Junseok Jeon, Minsu Park, Sang Ah Chi, Kyunga Kim, Dong Hyun Sinn, Jung Eun Lee, Geum-Youn Gwak, Wooseong Huh, Yoon-Goo Kim, Hye Ryoun Jang

{"title":"Clinical consequence of hypophosphatemia during antiviral therapy for chronic hepatitis B.","authors":"Mee Yeon Park, Hojin Jeon, Kyungho Park, Junseok Jeon, Minsu Park, Sang Ah Chi, Kyunga Kim, Dong Hyun Sinn, Jung Eun Lee, Geum-Youn Gwak, Wooseong Huh, Yoon-Goo Kim, Hye Ryoun Jang","doi":"10.23876/j.krcp.22.197","DOIUrl":"10.23876/j.krcp.22.197","url":null,"abstract":"Background: Antiviral therapy is an essential treatment for chronic hepatitis B (CHB) infection. Although hypophosphatemia is an important adverse effect of antiviral agents, its clinical significance remains unclear. We investigated the incidence and clinical consequences of hypophosphatemia in a large cohort of CHB patients.Methods: This retrospective cohort study included CHB patients who started antiviral therapy between 2005 and 2015 and continued it for at least 1 year. Patients with decompensated liver cirrhosis, diabetes mellitus, hypertension, concomitant diuretic administration, and end-stage renal disease were excluded. The primary outcome was a change in renal function. Secondary outcomes included the incidence of infection and changes in serum potassium, uric acid, and total carbon dioxide (tCO2).Results: Among the 4,335 patients, hypophosphatemia developed in 75 (1.7%). During the median 2-year follow-up period, patients with hypophosphatemia showed a lower estimated glomerular filtration rate than those in the control group. The incidence of infection and changes in serum potassium, uric acid, and tCO2 were similar between groups.Conclusion: Hypophosphatemia was associated with a renal function decline in patients with CHB receiving antiviral therapy.","PeriodicalId":17716,"journal":{"name":"Kidney Research and Clinical Practice","volume":" ","pages":"123-131"},"PeriodicalIF":2.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11877809/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143029036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical guidelines for the diagnosis, evaluation, and management of hypertension for Korean children and adolescents: the Korean Working Group of Pediatric Hypertension.

IF 2.9 3区医学

Kidney Research and Clinical Practice Pub Date : 2025-01-01 Epub Date: 2025-01-31 DOI: 10.23876/j.krcp.24.096

Se Jin Park, Hyo Soon An, Sung Hye Kim, Seong Heon Kim, Hee Yeon Cho, Jae Hyun Kim, Anna Cho, Ji Hee Kwak, Jae Il Shin, Keum Hwa Lee, Jin-Hee Oh, Jung Won Lee, Hae Soon Kim, Hye-Jung Shin, Mi Young Han, Myung Chul Hyun, Tae Sun Ha, Young Hwan Song

{"title":"Clinical guidelines for the diagnosis, evaluation, and management of hypertension for Korean children and adolescents: the Korean Working Group of Pediatric Hypertension.","authors":"Se Jin Park, Hyo Soon An, Sung Hye Kim, Seong Heon Kim, Hee Yeon Cho, Jae Hyun Kim, Anna Cho, Ji Hee Kwak, Jae Il Shin, Keum Hwa Lee, Jin-Hee Oh, Jung Won Lee, Hae Soon Kim, Hye-Jung Shin, Mi Young Han, Myung Chul Hyun, Tae Sun Ha, Young Hwan Song","doi":"10.23876/j.krcp.24.096","DOIUrl":"10.23876/j.krcp.24.096","url":null,"abstract":"Pediatric hypertension (HTN) is a significant, growing health concern worldwide and also in Korea. Diagnosis, evaluation, and treatment of HTN in Korean children and adolescents are uncertain due to limitations in using the current international guidelines, since the recommendations by the American Academy of Pediatrics (AAP) and European Society of Hypertension (ESH) guidelines differ. Furthermore, these are guidelines for Western youth, who are racially and ethnically different from Koreans. In addition, reference blood pressure values for all pediatric age groups, which are essential for the diagnosis of HTN according to these two guidelines, are absent in Korea. Therefore, HTN guidelines for Korean children and adolescents should be established. The Korean Working Group of Pediatric Hypertension established clinical guidelines for the diagnosis, evaluation, and management of HTN in Korean children and adolescents. These guidelines were based on reported clinical evidence, expert recommendations, and AAP and ESH guidelines. The characteristics of Korean youth and the Korean medical and insurance system were considered during the establishment of the guidelines. By providing recommendations suitable for Korean youth, these guidelines will help in the prevention and management of childhood HTN, thus relieving the burden of cardiovascular disease in adulthood in Korea.","PeriodicalId":17716,"journal":{"name":"Kidney Research and Clinical Practice","volume":"44 1","pages":"20-48"},"PeriodicalIF":2.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11864819/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Safety of the reduced fixed dose of mycophenolate mofetil confirmed via therapeutic drug monitoring in de novo kidney transplant recipients. 通过治疗药物监测，确认在新肾移植受者中减少固定剂量的霉酚酸酯的安全性。

IF 2.9 3区医学

Kidney Research and Clinical Practice Pub Date : 2025-01-01 Epub Date: 2024-10-24 DOI: 10.23876/j.krcp.23.274

Hee-Yeon Jung, Yu Jin Seo, Deokbi Hwang, Woo-Sung Yun, Hyung-Kee Kim, Seung Huh, Eun Sang Yoo, Jeong-Hoon Lim, Ji-Young Choi, Sun-Hee Park, Yong-Lim Kim, Dong Il Won, Jang-Hee Cho, Chan-Duck Kim

{"title":"Safety of the reduced fixed dose of mycophenolate mofetil confirmed via therapeutic drug monitoring in de novo kidney transplant recipients.","authors":"Hee-Yeon Jung, Yu Jin Seo, Deokbi Hwang, Woo-Sung Yun, Hyung-Kee Kim, Seung Huh, Eun Sang Yoo, Jeong-Hoon Lim, Ji-Young Choi, Sun-Hee Park, Yong-Lim Kim, Dong Il Won, Jang-Hee Cho, Chan-Duck Kim","doi":"10.23876/j.krcp.23.274","DOIUrl":"10.23876/j.krcp.23.274","url":null,"abstract":"Background: Mycophenolate mofetil (MMF) is usually prescribed with a reduced fixed dose in Asian kidney transplant recipients (KTRs). However, the clinical efficacy and safety of the fixed dose have not yet been investigated via therapeutic drug monitoring. We evaluated whether reduced fixed-dose MMF is an optimal dosing strategy to achieve the therapeutic target of mycophenolic acid (MPA) exposure in Korean KTRs.Methods: This open-label, prospective study enrolled 50 de novo KTRs prescribed with tacrolimus, corticosteroid, and fixed-dose MMF (1.0-1.5 g/day). The trough level (C0) and area under the curve (AUC0-12 hr) of MPA were measured at 1 and 24 weeks after kidney transplantation (KT). The relationship of body weight (BW)-adjusted MMF dose with MPA C0 and MPA AUC0-12 hr was assessed using linear regression analysis.Results: The initial fixed dose of MMF of 1.44 ± 0.16 g/day was adjusted in 24 patients (48.0%) and then reduced to a mean dose of 1.19 ± 0.31 g/day at 24 weeks after KT. Most patients (≥84.0%) attained the minimum required MPA C0 of 1.0 μg/mL and MPA AUC0-12 hr of 30 μg × hr/mL at 1 and 24 weeks. The BW-adjusted MMF dose demonstrated significant positive correlations with MPA C0 and MPA AUC0- 12 hr at 1 and 24 weeks after KT. Moreover, 14 patients (28.0%) reported MPA-related adverse events that were predictable based on MPA AUC0-12 hr (cutoff level, 46.4 μg × hr/mL).Conclusion: The current reduced fixed-dose MMF strategy can help achieve the therapeutic target of MPA exposure in tacrolimus- treated Korean KTRs during the early posttransplant period.","PeriodicalId":17716,"journal":{"name":"Kidney Research and Clinical Practice","volume":" ","pages":"200-209"},"PeriodicalIF":2.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11838851/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142503036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nephrology consultation improves the clinical outcomes of patients with acute kidney injury. 肾病咨询可改善急性肾损伤患者的临床结果。

IF 2.9 3区医学

Kidney Research and Clinical Practice Pub Date : 2025-01-01 Epub Date: 2023-09-08 DOI: 10.23876/j.krcp.23.039

Harin Rhee, Meeyoung Park, Il Young Kim

{"title":"Nephrology consultation improves the clinical outcomes of patients with acute kidney injury.","authors":"Harin Rhee, Meeyoung Park, Il Young Kim","doi":"10.23876/j.krcp.23.039","DOIUrl":"10.23876/j.krcp.23.039","url":null,"abstract":"Background: Acute kidney injury (AKI) is prevalent in critically ill patients and is associated with an increased risk of in-hospital mortality. Nephrology consultation may be protective, but this has rarely been evaluated in South Korea.Methods: This multicenter retrospective study was based on the electronic medical records (EMRs) of two third-affiliated hospitals. We extracted the records of patients admitted to intensive care units (ICUs) between 2011 and 2020, and retrospectively detected AKI using the modified serum creatinine criteria of the Kidney Disease: Improving Global Outcomes (KDIGO) guidelines. The AKI diagnosis date was defined as the first day of a significant change in serum creatinine level (≥0.3 mg/dL) within 48 hours. Nephrology consultation status was retrieved from the EMRs.Results: In total, 2,461 AKI patients were included; the median age was 65 years (interquartile range [IQR], 56-75 years), 1,459 (59.3%) were male, and 1,065 (43.3%) were of AKI stage 3. During a median of 5 days (IQR, 3-11 days) of ICU admission, nephrology consultations were provided to 512 patients (20.8%). Patients who received such consultations were older, had more comorbidities, and more commonly required dialysis. In a multivariable model, nephrology consultation reduced the risk of in-hospital mortality by 30% (hazard ratio, 0.71; 95% confidence interval, 0.57-0.88). Other factors significant for in-hospital mortality were older age, a higher sequential organ failure assessment (SOFA) score, sepsis, diabetes, hypertension, heart disease, and cancer.Conclusion: For AKI patients in ICUs, nephrology consultation reduced the risk of in-hospital mortality, particularly among those with multiple comorbidities. Therefore, nephrology consultation should not be omitted during ICU care.","PeriodicalId":17716,"journal":{"name":"Kidney Research and Clinical Practice","volume":" ","pages":"102-110"},"PeriodicalIF":2.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11838846/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41099956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical significance of the living kidney donor profile index for predicting long-term posttransplant outcomes: results from the Korean Organ Transplantation Registry. 活体肾脏捐献者档案指数预测移植后长期结果的临床意义：来自韩国器官移植登记处的结果。

IF 2.9 3区医学

Kidney Research and Clinical Practice Pub Date : 2025-01-01 Epub Date: 2023-10-19 DOI: 10.23876/j.krcp.22.266

Jong Ho Kim, Sang Ho Lee, Jin Sug Kim, Hyeon Seok Hwang, Hyunmin Ko, Cheol-Woong Jung, Deok Gie Kim, Yeong Hoon Kim, Jaeseok Yang, Curie Ahn, Kyung Hwan Jeong

{"title":"Clinical significance of the living kidney donor profile index for predicting long-term posttransplant outcomes: results from the Korean Organ Transplantation Registry.","authors":"Jong Ho Kim, Sang Ho Lee, Jin Sug Kim, Hyeon Seok Hwang, Hyunmin Ko, Cheol-Woong Jung, Deok Gie Kim, Yeong Hoon Kim, Jaeseok Yang, Curie Ahn, Kyung Hwan Jeong","doi":"10.23876/j.krcp.22.266","DOIUrl":"10.23876/j.krcp.22.266","url":null,"abstract":"Background: The usefulness of the living kidney donor profile index (LKDPI) has not been widely demonstrated; therefore, it requires verification before clinical application. We analyzed the LKDPI using data from the Korean Organ Transplantation Registry (KOTRY) to confirm whether the LKDPI can be used to predict the survival of allografts in living donor kidney transplantation (LDKT) patients in Korea.Methods: The study population was obtained from the KOTRY database. A total of 2,598 kidney recipients registered in the KOTRY database were enrolled between May 2014 and December 2020. Donor and recipient information was observed, and the LKDPI was measured.Results: Median LKDPI score was 15.5 with a follow-up duration of 33.7 ± 16.1 months. According to LKDPI scores (group 1, <0; group 2, 0-20; group 3, 20-40; and group 4, >40), LKDPI group 4 had significantly higher death-censored graft loss than LKDPI group 1 (hazard ratio [HR], 1.89; 95% confidence interval [CI], 1.06- 3.40; p = 0.03). When divided based on the cutoff value (LKDPI, 36.6), the high LKDPI group had higher graft loss than the low LKDPI group (HR, 2.14; 95% CI, 1.37-3.34; p < 0.001). When follow-up was repeated after transplantation, it was confirmed that the higher the LKDPI value was, the lower the average estimated glomerular filtration rate (p < 0.001).Conclusion: This study confirmed that LKDPI can serve as an independent predictor for assessing the risk of allograft failure and transplant outcomes in Korean LDKT patients.","PeriodicalId":17716,"journal":{"name":"Kidney Research and Clinical Practice","volume":" ","pages":"189-199"},"PeriodicalIF":2.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11838853/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54229817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0