Kidney Research and Clinical Practice最新文献_第3页

Intrinsic prefrontal functional connectivity according to cognitive impairment in patients with end-stage renal disease. 终末期肾病患者认知障碍的内在前额叶功能连通性

IF 2.9 3区医学

Kidney Research and Clinical Practice Pub Date : 2024-11-01 Epub Date: 2023-08-10 DOI: 10.23876/j.krcp.22.291

Kang Min Park, Chang Min Heo, Dong Ah Lee, Hyuk Huh, Sihyung Park, Yang Wook Kim, Yoo Jin Lee, Hyeok Jin Yoon, Bong Soo Park

{"title":"Intrinsic prefrontal functional connectivity according to cognitive impairment in patients with end-stage renal disease.","authors":"Kang Min Park, Chang Min Heo, Dong Ah Lee, Hyuk Huh, Sihyung Park, Yang Wook Kim, Yoo Jin Lee, Hyeok Jin Yoon, Bong Soo Park","doi":"10.23876/j.krcp.22.291","DOIUrl":"10.23876/j.krcp.22.291","url":null,"abstract":"Background: This study aimed to investigate differences in intrinsic prefrontal functional connectivity according to the presence of cognitive impairment in patients with end-stage renal disease (ESRD) using functional near-infrared spectroscopy (fNIRS).Methods: We prospectively enrolled 37 patients with ESRD who had been undergoing hemodialysis for more than 6 months and had no history of neurological or psychiatric disorders. All patients with ESRD underwent the Korean version of the Montreal Cognitive Assessment (MoCA-K) to assess cognitive function. The NIRSIT Lite device (OBELAB Inc.) was used to acquire fNIRS data, and the NIRSIT Lite Analysis Tool program was used to process the data and generate a functional connectivity matrix. We obtained functional connectivity measures by applying graph theory to the connectivity matrix using the BRAPH (brain analysis using graph theory) program.Results: Of the 37 patients with ESRD, 23 had cognitive impairment, whereas 14 patients showed no cognitive impairment. Intrinsic prefrontal functional connectivity was significantly different between groups. Network measures of strength, global efficiency, and mean clustering coefficient were lower in ESRD patients with cognitive impairment than in those without cognitive impairment (4.458 vs. 5.129, p = 0.02; 0.397 vs. 0.437, p = 0.03; and 0.316 vs. 0.421, p = 0.003; respectively). There were no significant correlations between MoCA-K scores and clinical characteristics.Conclusion: We demonstrated a significant association between cognitive function and intrinsic prefrontal functional connectivity in patients with ESRD. ESRD patients with cognitive impairment have reduced connectivity and segregation in the prefrontal brain network compared to those without cognitive impairment.","PeriodicalId":17716,"journal":{"name":"Kidney Research and Clinical Practice","volume":" ","pages":"807-817"},"PeriodicalIF":2.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11615448/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10338668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of severe depression on the survival of older patients with end-stage kidney disease. 重度抑郁对老年终末期肾病患者生存的影响

IF 2.9 3区医学

Kidney Research and Clinical Practice Pub Date : 2024-11-01 Epub Date: 2023-08-30 DOI: 10.23876/j.krcp.22.268

You Hyun Jeon, Jeong-Hoon Lim, Yena Jeon, Yu-Kyung Chung, Yon Su Kim, Shin-Wook Kang, Chul Woo Yang, Nam-Ho Kim, Hee-Yeon Jung, Ji-Young Choi, Sun-Hee Park, Chan-Duck Kim, Yong-Lim Kim, Jang-Hee Cho

{"title":"The impact of severe depression on the survival of older patients with end-stage kidney disease.","authors":"You Hyun Jeon, Jeong-Hoon Lim, Yena Jeon, Yu-Kyung Chung, Yon Su Kim, Shin-Wook Kang, Chul Woo Yang, Nam-Ho Kim, Hee-Yeon Jung, Ji-Young Choi, Sun-Hee Park, Chan-Duck Kim, Yong-Lim Kim, Jang-Hee Cho","doi":"10.23876/j.krcp.22.268","DOIUrl":"10.23876/j.krcp.22.268","url":null,"abstract":"Background: Incidence of depression increases in patients with end-stage kidney disease (ESKD). We evaluated the association between depression and mortality among older patients with ESKD, which has not been studied previously.Methods: This nationwide prospective cohort study included 487 patients with ESKD aged >65 years, who were categorized into minimal, mild-to-moderate, and severe depression groups based on their Beck Depression Inventory-II (BDI-II) scores. Predisposing factors for high BDI-II scores and the association between the scores and survival were analyzed.Results: The severe depression group showed a higher modified Charlson comorbidity index value and lower serum albumin, phosphate, and uric acid levels than the other depression groups. The Kaplan-Meier curve revealed a significantly lower survival in the severe depression group than in the minimal and mild-to-moderate depression groups (p = 0.011). Multivariate Cox regression analysis confirmed that severe depression was an independent risk factor for mortality in the study cohort (hazard ratio, 1.39; 95% confidence interval, 1.01-1.91; p = 0.041). Additionally, BDI-II scores were associated with modified Charlson comorbidity index (p = 0.009) and serum albumin level (p = 0.004) in multivariate linear regression. Among the three depressive symptoms, higher somatic symptom scores were associated with increased mortality.Conclusion: Severe depression among older patients with ESKD increases mortality compared with minimal or mild-to-moderate depression, and patients with concomitant somatic symptoms require careful management of their comorbidities and nutritional status.","PeriodicalId":17716,"journal":{"name":"Kidney Research and Clinical Practice","volume":" ","pages":"818-828"},"PeriodicalIF":2.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11615450/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10110471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

What is the final destination of hemodialysis membrane? 血液透析膜的最终去向是什么？

IF 2.9 3区医学

Kidney Research and Clinical Practice Pub Date : 2024-11-01 Epub Date: 2024-08-12 DOI: 10.23876/j.krcp.24.118

Jae Won Yang

引用次数: 0

Precision medicine for focal segmental glomerulosclerosis. 局灶节段性肾小球硬化症的精准医疗。

IF 2.9 3区医学

Kidney Research and Clinical Practice Pub Date : 2024-11-01 Epub Date: 2024-02-06 DOI: 10.23876/j.krcp.23.227

Yi Xie, Fei Liu

引用次数: 0

The association between transferrin saturation and all-cause mortality in chronic kidney disease: findings from Korean Cohort Study for Outcome in Patients with Chronic Kidney Disease. 慢性肾脏病患者转铁蛋白饱和度与全因死亡率之间的关系：韩国慢性肾脏病患者结局队列研究的发现。

IF 2.9 3区医学

Kidney Research and Clinical Practice Pub Date : 2024-11-01 Epub Date: 2024-05-29 DOI: 10.23876/j.krcp.23.278

Eunmi Jo, Hyo Jin Kim, Jayoun Kim, Tae-Hyun Yoo, Yaeni Kim, Soo Wan Kim, Kook-Hwan Oh, Eun Young Seong, Sang Heon Song

{"title":"The association between transferrin saturation and all-cause mortality in chronic kidney disease: findings from Korean Cohort Study for Outcome in Patients with Chronic Kidney Disease.","authors":"Eunmi Jo, Hyo Jin Kim, Jayoun Kim, Tae-Hyun Yoo, Yaeni Kim, Soo Wan Kim, Kook-Hwan Oh, Eun Young Seong, Sang Heon Song","doi":"10.23876/j.krcp.23.278","DOIUrl":"10.23876/j.krcp.23.278","url":null,"abstract":"Background: Transferrin saturation (TSAT) has been used as an indicator of iron deficiency. However, there is no consensus regarding its optimal range for patient with chronic kidney disease (CKD). We aimed to analyze the effect of TSAT on the prognosis of patients with non-dialysis CKD (NDCKD).Methods: From 2011 to 2016, 2157 NDCKD patients with baseline TSAT measurements were followed for 10 years. Patients were divided into three groups based on baseline TSAT values: <25%, ≥25% and <45%, and ≥45%. All-cause mortality and 4-point major adverse cardiovascular events (MACE) were analyzed using multivariable Cox regression analysis. Other iron biomarkers and mortality were also analyzed.Results: During a mean follow-up of 7.1 ± 2.9 years, 182 of a total of 2,157 patients (8.4%) died. Compared with the TSAT ≥25% and <45% group, the TSAT <25% group showed significantly increased all-cause mortality (hazard ratio [HR], 1.44; 95% confidence interval (CI), 1.02-2.03; p = 0.04). The occurrence of 4-point MACE was significantly increased in univariable analysis in the TSAT <25% group (HR, 1.48; 95% CI, 1.02-2.15; p = 0.04), but it was not significant in the multivariable analysis (HR, 1.38; 95% CI, 0.89-2.15; p = 0.15). Tertile comparisons of the iron-to-log-ferritin ratio showed increased mortality in the first tertile group.Conclusion: TSAT <25% is an independent risk factor for all-cause mortality in patients with NDCKD and care should be taken to prevent TSAT values of <25%. Other indicators, such as serum iron and iron-to-log-ferritin ratio, may also be used to assess iron deficiency.","PeriodicalId":17716,"journal":{"name":"Kidney Research and Clinical Practice","volume":" ","pages":"785-796"},"PeriodicalIF":2.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11615453/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141457739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The crosstalk of Wnt/β-catenin signaling and p53 in acute kidney injury and chronic kidney disease. 急性肾损伤和慢性肾病中 Wnt/β-catenin 信号与 p53 的相互影响。

IF 2.9 3区医学

Kidney Research and Clinical Practice Pub Date : 2024-11-01 Epub Date: 2024-11-18 DOI: 10.23876/j.krcp.23.344

Wen-Hua Ming, Lin Wen, Wen-Juan Hu, Rong-Fang Qiao, Yang Zhou, Bo-Wei Su, Ya-Nan Bao, Ping Gao, Zhi-Lin Luan

引用次数: 0

Indoxyl sulfate induces apoptotic cell death by inhibiting glycolysis in human astrocytes. 硫酸吲哚酚通过抑制星形胶质细胞糖酵解诱导细胞凋亡

IF 2.9 3区医学

Kidney Research and Clinical Practice Pub Date : 2024-11-01 Epub Date: 2023-08-10 DOI: 10.23876/j.krcp.23.005

Seung-Hyun Jeong, Samel Park, Jae-Sung Choi, Nam-Jun Cho, Jong-Seok Moon, Hyo-Wook Gil

{"title":"Indoxyl sulfate induces apoptotic cell death by inhibiting glycolysis in human astrocytes.","authors":"Seung-Hyun Jeong, Samel Park, Jae-Sung Choi, Nam-Jun Cho, Jong-Seok Moon, Hyo-Wook Gil","doi":"10.23876/j.krcp.23.005","DOIUrl":"10.23876/j.krcp.23.005","url":null,"abstract":"Background: Neurologic complications, such as cognitive and emotional dysfunction, have frequently been observed in chronic kidney disease (CKD) patients. Previous research shows that uremic toxins play a role in the pathogenesis of CKD-associated cognitive impairment. Since astrocytes contribute to the protection and survival of neurons, astrocyte function and brain metabolism may contribute to the pathogenesis of neurodegeneration. Indoxyl sulfate (IS) is the most popular uremic toxin. However, how IS-induced astrocyte injury brings about neurologic complications in CKD patients has not been elucidated.Methods: The rate of extracellular acidification was measured in astrocytes when IS (0.5-3 mM, 4 or 7 days) treatment was applied. The hexokinase 1 (HK1), pyruvate kinase isozyme M2 (PKM2), pyruvate dehydrogenase (PDH), and phosphofructokinase (PFKP) protein levels were also measured. The activation of the apoptotic pathway was investigated using a confocal microscope, fluorescence- activated cell sorting, and cell three-dimensional imaging was used.Results: In astrocytes, IS affected glycolysis in not only dose-dependently but also time-dependently. Additionally, HK1, PKM2, PDH, and PFKP levels were decreased in IS-treated group when compared to the control. The results were prominent in cases with higher doses and longer exposure duration. The apoptotic features after IS treatment were also observed.Conclusion: Our results showed that the inhibition of glycolysis by IS in astrocytes leads to cell death via apoptosis. Specifically, longterm and higher-dose exposures had more serious effects on astrocytes. Our results suggest that the glycolysis pathway and related targets could provide a novel approach to cognitive dysfunction in CKD patients.","PeriodicalId":17716,"journal":{"name":"Kidney Research and Clinical Practice","volume":"1 1","pages":"774-784"},"PeriodicalIF":2.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11615446/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48123626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Circulating microRNAs as markers for scrub typhus-associated acute kidney injury.

IF 2.9 3区医学

Kidney Research and Clinical Practice Pub Date : 2024-11-01 Epub Date: 2024-11-28 DOI: 10.23876/j.krcp.23.250

Haeun Lee, Jung Min Kim, A Young Cho, Ju Hwan Oh, Kwang Young Lee, Chang-Seop Lee, In O Sun

{"title":"Circulating microRNAs as markers for scrub typhus-associated acute kidney injury.","authors":"Haeun Lee, Jung Min Kim, A Young Cho, Ju Hwan Oh, Kwang Young Lee, Chang-Seop Lee, In O Sun","doi":"10.23876/j.krcp.23.250","DOIUrl":"10.23876/j.krcp.23.250","url":null,"abstract":"Background: Circulating microRNAs (miRNAs) are potential biomarkers for various kidney diseases. In this study, we aimed to identify a circulating miRNA signature for detecting acute kidney injury (AKI) in scrub typhus.Methods: We prospectively enrolled 40 patients with scrub typhus (20 with AKI, AKI group; 20 without AKI, non-AKI group) and 20 healthy volunteers (the HV group). Thereafter, we performed microarray analysis to assess the serum miRNA profiles of all the participants. Then, to identify miRNAs predictive of scrub typhus-associated AKI, we compared miRNA profiles among these three groups.Results: The proportions of miRNAs, small nucleolar RNAs, and small Cajal body-specific ribonucleoproteins were higher in patients with scrub typhus than in the HVs. Further, relative to the HVs, we identified 120 upregulated and 449 downregulated miRNAs in the non-AKI group and 101 upregulated and 468 downregulated miRNAs in the AKI group. We also identified 11 and 110 upregulated and downregulated miRNAs, respectively, in the AKI group relative to the non-AKI group, and among these miRNAs, we noted 14 miRNAs whose levels were significantly upregulated or downregulated in the AKI group relative to their levels in the HV and non-AKI groups. Biological pathway analysis of these 14 miRNAs indicated their potential involvement in various pathways associated with tumor necrosis factor alpha.Conclusion: We identified miRNAs associated with AKI in patients with scrub typhus that have predictive potential for AKI. Thus, they can be used as surrogate markers for the detection of scrub typhus-associated AKI.","PeriodicalId":17716,"journal":{"name":"Kidney Research and Clinical Practice","volume":"43 6","pages":"797-806"},"PeriodicalIF":2.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11615441/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142770140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fostering international coordination in renal disaster preparedness: a collaboration between the Renal Disaster Preparedness Working Group of the International Society of Nephrology and the Disaster Preparedness and Response Committee of the Korean Society of Nephrology.

IF 2.9 3区医学

Kidney Research and Clinical Practice Pub Date : 2024-11-01 Epub Date: 2024-11-28 DOI: 10.23876/j.krcp.24.222

Kyung Don Yoo, Sunhwa Lee, Hayne Cho Park, Won Min Hwang, Jung Pyo Lee, Adrian Liew, Ali Abu-Alfa, Hyeong Cheon Park, Young-Ki Lee

引用次数: 0

Brief review for "Machine learning-based 2-year risk prediction tool in immunoglobulin A nephropathy". 简评：基于机器学习的免疫球蛋白 A 肾病进展 2 年风险预测模型。

IF 2.9 3区医学

Kidney Research and Clinical Practice Pub Date : 2024-11-01 Epub Date: 2024-07-05 DOI: 10.23876/j.krcp.24.998

Hae-Ryong Yun, Tae-Hyun Yoo

引用次数: 0