Kidney Research and Clinical Practice最新文献_第6页

Comparison of clinical outcomes based on dialysis modality and icodextrin usage in patients on peritoneal dialysis. 根据腹膜透析患者的透析方式和冰可糊精用量比较临床效果。

IF 2.9 3区医学

Kidney Research and Clinical Practice Pub Date : 2024-11-05 DOI: 10.23876/j.krcp.24.017

Seok Hui Kang, Jun Young Do

{"title":"Comparison of clinical outcomes based on dialysis modality and icodextrin usage in patients on peritoneal dialysis.","authors":"Seok Hui Kang, Jun Young Do","doi":"10.23876/j.krcp.24.017","DOIUrl":"https://doi.org/10.23876/j.krcp.24.017","url":null,"abstract":"Background: There is no conclusive evidence regarding the survival benefits of automated peritoneal dialysis (APD) or the use of icodextrin. This study aimed to evaluate patient and technique survival among four groups divided based on peritoneal dialysis modality and icodextrin use over 1 year.Methods: We specifically included patients who underwent a single peritoneal dialysis modality for at least 1 year during that period (n = 148). The participants were categorized into four groups for comparison: continuous ambulatory peritoneal dialysis (CAPD) without icodextrin (CAPD-ET, n = 39); CAPD with icodextrin (CAPD+ET, n = 35); APD without icodextrin (APD-ET, n = 40); and APD with icodextrin (APD+ET, n = 34).Results: The CAPD+ET group had a higher patient survival rate than that of the APD-ET group and also had a higher technique survival trend than that of the APD-ET group, despite no statistical significance. In patients without diabetes mellitus (DM), the APD-ET group had a poorer patient survival trend than those of the APD+ET or CAPD+ET groups. In patients without DM, the APD+ET group had a higher technique survival than the APD-ET group. In addition, the APD+ET group showed a higher technique survival trend than did the CAPD-ET group, despite non-statistical significance. The edema index after 1 year of follow-up was higher in the APD-ET group than in the other groups.Conclusion: The present study demonstrated that patients undergoing APD without icodextrin had poor patient and technique survival trends, which may be caused by poor volume control.","PeriodicalId":17716,"journal":{"name":"Kidney Research and Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142622912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pan-Nox inhibitor treatment improves renal function in aging murine diabetic kidneys. 泛氮氧化物抑制剂治疗可改善衰老小鼠糖尿病肾脏的肾功能。

IF 2.9 3区医学

Kidney Research and Clinical Practice Pub Date : 2024-11-01 Epub Date: 2023-08-10 DOI: 10.23876/j.krcp.23.004

Jeong Hoon Park, Sung Gi Yoon, Jung Yeon Ghee, Ji Ae Yoo, Jin Joo Cha, Young Sun Kang, Sang Youb Han, Yun Jae Seol, Jee Young Han, Dae Ryong Cha

{"title":"Pan-Nox inhibitor treatment improves renal function in aging murine diabetic kidneys.","authors":"Jeong Hoon Park, Sung Gi Yoon, Jung Yeon Ghee, Ji Ae Yoo, Jin Joo Cha, Young Sun Kang, Sang Youb Han, Yun Jae Seol, Jee Young Han, Dae Ryong Cha","doi":"10.23876/j.krcp.23.004","DOIUrl":"10.23876/j.krcp.23.004","url":null,"abstract":"Background: Aging is a risk factor for development of chronic kidney disease and diabetes mellitus with commonly shared features of chronic inflammation and increased oxidative stress. Here, we investigated the effect of pan-Nox-inhibitor, APX-115, on renal function in aging diabetic mice.Methods: Diabetes was induced by intraperitoneal injection of streptozotocin at 50 mg/kg/day for 5 days in 52-week-old C57BL/6J mice. APX-115 was administered by oral gavage at a dose of 60 mg/kg/day for 12 weeks in nondiabetic and diabetic aging mice.Results: APX-115 significantly improved insulin resistance in diabetic aging mice. Urinary level of 8-isoprostane was significantly increased in diabetic aging mice than nondiabetic aging mice, and APX-115 treatment reduced 8-isoprostane level. Urinary albumin and nephrin excretion were significantly higher in diabetic aging mice than nondiabetic aging mice. Although APX-115 did not significantly decrease albuminuria, APX-115 markedly improved mesangial expansion, macrophage infiltration, and expression of fibrosis molecules such as transforming growth factor beta 1 and plasminogen activator inhibitor 1. Interestingly, the expression of all Nox isoforms including Nox1, Nox2, and Nox4 was significantly increased in diabetic aging kidneys, and APX-115 treatment decreased Nox1, Nox2, and Nox4 protein expression in the kidney. Furthermore, Klotho expression was significantly decreased in diabetic aging kidneys, and APX-115 restored Klotho level.Conclusion: Our results provide evidence that pan-Nox inhibition may improve systemic insulin resistance and decrease oxidative stress, inflammation, and fibrosis in aging diabetic status and may have potential protective effects on aging diabetic kidney.","PeriodicalId":17716,"journal":{"name":"Kidney Research and Clinical Practice","volume":" ","pages":"763-773"},"PeriodicalIF":2.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11615449/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10020584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pathological and functional significance of aging mouse kidneys: clinical implications to reduce the risk of hyper- or hypokalemia in the elderly. 老化小鼠肾脏的病理和功能意义：降低老年人高钾血症或低钾血症风险的临床意义。

IF 2.9 3区医学

Kidney Research and Clinical Practice Pub Date : 2024-11-01 Epub Date: 2024-08-07 DOI: 10.23876/j.krcp.24.012

Itsuro Kazama

{"title":"Pathological and functional significance of aging mouse kidneys: clinical implications to reduce the risk of hyper- or hypokalemia in the elderly.","authors":"Itsuro Kazama","doi":"10.23876/j.krcp.24.012","DOIUrl":"10.23876/j.krcp.24.012","url":null,"abstract":"Elderly patients are prone to develop hyper- or hypokalemia, since they are susceptible to drugs or diets that affect the urinary or fecal potassium (K+) excretion. In aging mouse kidneys, in addition to glomerulosclerosis, proximal tubular atrophy, and atherosclerosis in renal arterioles, there was diffuse tubulointerstitial fibrosis with a number of inflammatory leukocytes infiltrating into the cortical interstitium. Since these pathological features greatly influence renal K+ handling, slowing the progression of kidney aging would fundamentally reduce the risk of developing hyper- or hypokalemia. Immunohistochemistry demonstrated the overexpression of K+ channels (Kv1.3) in leukocytes within the cortical interstitium, which was strongly associated with \"chronic inflammation\" in aging kidneys and the subsequent progression of renal fibrosis. In our basic studies, antihypertensive drugs (benidipine, nifedipine, verapamil, diltiazem) and anticholesterol drugs (lovastatin, simvastatin, pravastatin) strongly suppressed the leukocyte Kv1.3 channels and thus exerted anti-inflammatory effects. Given such pharmacological properties of these drugs, they may also be useful in slowing the progression of tubulointerstitial fibrosis in aging kidneys and reducing the risk of hyper- or hypokalemia in elderly patients.","PeriodicalId":17716,"journal":{"name":"Kidney Research and Clinical Practice","volume":" ","pages":"703-708"},"PeriodicalIF":2.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11615447/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141897747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intrinsic prefrontal functional connectivity according to cognitive impairment in patients with end-stage renal disease. 终末期肾病患者认知障碍的内在前额叶功能连通性

IF 2.9 3区医学

Kidney Research and Clinical Practice Pub Date : 2024-11-01 Epub Date: 2023-08-10 DOI: 10.23876/j.krcp.22.291

Kang Min Park, Chang Min Heo, Dong Ah Lee, Hyuk Huh, Sihyung Park, Yang Wook Kim, Yoo Jin Lee, Hyeok Jin Yoon, Bong Soo Park

{"title":"Intrinsic prefrontal functional connectivity according to cognitive impairment in patients with end-stage renal disease.","authors":"Kang Min Park, Chang Min Heo, Dong Ah Lee, Hyuk Huh, Sihyung Park, Yang Wook Kim, Yoo Jin Lee, Hyeok Jin Yoon, Bong Soo Park","doi":"10.23876/j.krcp.22.291","DOIUrl":"10.23876/j.krcp.22.291","url":null,"abstract":"Background: This study aimed to investigate differences in intrinsic prefrontal functional connectivity according to the presence of cognitive impairment in patients with end-stage renal disease (ESRD) using functional near-infrared spectroscopy (fNIRS).Methods: We prospectively enrolled 37 patients with ESRD who had been undergoing hemodialysis for more than 6 months and had no history of neurological or psychiatric disorders. All patients with ESRD underwent the Korean version of the Montreal Cognitive Assessment (MoCA-K) to assess cognitive function. The NIRSIT Lite device (OBELAB Inc.) was used to acquire fNIRS data, and the NIRSIT Lite Analysis Tool program was used to process the data and generate a functional connectivity matrix. We obtained functional connectivity measures by applying graph theory to the connectivity matrix using the BRAPH (brain analysis using graph theory) program.Results: Of the 37 patients with ESRD, 23 had cognitive impairment, whereas 14 patients showed no cognitive impairment. Intrinsic prefrontal functional connectivity was significantly different between groups. Network measures of strength, global efficiency, and mean clustering coefficient were lower in ESRD patients with cognitive impairment than in those without cognitive impairment (4.458 vs. 5.129, p = 0.02; 0.397 vs. 0.437, p = 0.03; and 0.316 vs. 0.421, p = 0.003; respectively). There were no significant correlations between MoCA-K scores and clinical characteristics.Conclusion: We demonstrated a significant association between cognitive function and intrinsic prefrontal functional connectivity in patients with ESRD. ESRD patients with cognitive impairment have reduced connectivity and segregation in the prefrontal brain network compared to those without cognitive impairment.","PeriodicalId":17716,"journal":{"name":"Kidney Research and Clinical Practice","volume":" ","pages":"807-817"},"PeriodicalIF":2.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11615448/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10338668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of severe depression on the survival of older patients with end-stage kidney disease. 重度抑郁对老年终末期肾病患者生存的影响

IF 2.9 3区医学

Kidney Research and Clinical Practice Pub Date : 2024-11-01 Epub Date: 2023-08-30 DOI: 10.23876/j.krcp.22.268

You Hyun Jeon, Jeong-Hoon Lim, Yena Jeon, Yu-Kyung Chung, Yon Su Kim, Shin-Wook Kang, Chul Woo Yang, Nam-Ho Kim, Hee-Yeon Jung, Ji-Young Choi, Sun-Hee Park, Chan-Duck Kim, Yong-Lim Kim, Jang-Hee Cho

{"title":"The impact of severe depression on the survival of older patients with end-stage kidney disease.","authors":"You Hyun Jeon, Jeong-Hoon Lim, Yena Jeon, Yu-Kyung Chung, Yon Su Kim, Shin-Wook Kang, Chul Woo Yang, Nam-Ho Kim, Hee-Yeon Jung, Ji-Young Choi, Sun-Hee Park, Chan-Duck Kim, Yong-Lim Kim, Jang-Hee Cho","doi":"10.23876/j.krcp.22.268","DOIUrl":"10.23876/j.krcp.22.268","url":null,"abstract":"Background: Incidence of depression increases in patients with end-stage kidney disease (ESKD). We evaluated the association between depression and mortality among older patients with ESKD, which has not been studied previously.Methods: This nationwide prospective cohort study included 487 patients with ESKD aged >65 years, who were categorized into minimal, mild-to-moderate, and severe depression groups based on their Beck Depression Inventory-II (BDI-II) scores. Predisposing factors for high BDI-II scores and the association between the scores and survival were analyzed.Results: The severe depression group showed a higher modified Charlson comorbidity index value and lower serum albumin, phosphate, and uric acid levels than the other depression groups. The Kaplan-Meier curve revealed a significantly lower survival in the severe depression group than in the minimal and mild-to-moderate depression groups (p = 0.011). Multivariate Cox regression analysis confirmed that severe depression was an independent risk factor for mortality in the study cohort (hazard ratio, 1.39; 95% confidence interval, 1.01-1.91; p = 0.041). Additionally, BDI-II scores were associated with modified Charlson comorbidity index (p = 0.009) and serum albumin level (p = 0.004) in multivariate linear regression. Among the three depressive symptoms, higher somatic symptom scores were associated with increased mortality.Conclusion: Severe depression among older patients with ESKD increases mortality compared with minimal or mild-to-moderate depression, and patients with concomitant somatic symptoms require careful management of their comorbidities and nutritional status.","PeriodicalId":17716,"journal":{"name":"Kidney Research and Clinical Practice","volume":" ","pages":"818-828"},"PeriodicalIF":2.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11615450/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10110471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

What is the final destination of hemodialysis membrane? 血液透析膜的最终去向是什么？

IF 2.9 3区医学

Kidney Research and Clinical Practice Pub Date : 2024-11-01 Epub Date: 2024-08-12 DOI: 10.23876/j.krcp.24.118

Jae Won Yang

引用次数: 0

Precision medicine for focal segmental glomerulosclerosis. 局灶节段性肾小球硬化症的精准医疗。

IF 2.9 3区医学

Kidney Research and Clinical Practice Pub Date : 2024-11-01 Epub Date: 2024-02-06 DOI: 10.23876/j.krcp.23.227

Yi Xie, Fei Liu

引用次数: 0

The association between transferrin saturation and all-cause mortality in chronic kidney disease: findings from Korean Cohort Study for Outcome in Patients with Chronic Kidney Disease. 慢性肾脏病患者转铁蛋白饱和度与全因死亡率之间的关系：韩国慢性肾脏病患者结局队列研究的发现。

IF 2.9 3区医学

Kidney Research and Clinical Practice Pub Date : 2024-11-01 Epub Date: 2024-05-29 DOI: 10.23876/j.krcp.23.278

Eunmi Jo, Hyo Jin Kim, Jayoun Kim, Tae-Hyun Yoo, Yaeni Kim, Soo Wan Kim, Kook-Hwan Oh, Eun Young Seong, Sang Heon Song

{"title":"The association between transferrin saturation and all-cause mortality in chronic kidney disease: findings from Korean Cohort Study for Outcome in Patients with Chronic Kidney Disease.","authors":"Eunmi Jo, Hyo Jin Kim, Jayoun Kim, Tae-Hyun Yoo, Yaeni Kim, Soo Wan Kim, Kook-Hwan Oh, Eun Young Seong, Sang Heon Song","doi":"10.23876/j.krcp.23.278","DOIUrl":"10.23876/j.krcp.23.278","url":null,"abstract":"Background: Transferrin saturation (TSAT) has been used as an indicator of iron deficiency. However, there is no consensus regarding its optimal range for patient with chronic kidney disease (CKD). We aimed to analyze the effect of TSAT on the prognosis of patients with non-dialysis CKD (NDCKD).Methods: From 2011 to 2016, 2157 NDCKD patients with baseline TSAT measurements were followed for 10 years. Patients were divided into three groups based on baseline TSAT values: <25%, ≥25% and <45%, and ≥45%. All-cause mortality and 4-point major adverse cardiovascular events (MACE) were analyzed using multivariable Cox regression analysis. Other iron biomarkers and mortality were also analyzed.Results: During a mean follow-up of 7.1 ± 2.9 years, 182 of a total of 2,157 patients (8.4%) died. Compared with the TSAT ≥25% and <45% group, the TSAT <25% group showed significantly increased all-cause mortality (hazard ratio [HR], 1.44; 95% confidence interval (CI), 1.02-2.03; p = 0.04). The occurrence of 4-point MACE was significantly increased in univariable analysis in the TSAT <25% group (HR, 1.48; 95% CI, 1.02-2.15; p = 0.04), but it was not significant in the multivariable analysis (HR, 1.38; 95% CI, 0.89-2.15; p = 0.15). Tertile comparisons of the iron-to-log-ferritin ratio showed increased mortality in the first tertile group.Conclusion: TSAT <25% is an independent risk factor for all-cause mortality in patients with NDCKD and care should be taken to prevent TSAT values of <25%. Other indicators, such as serum iron and iron-to-log-ferritin ratio, may also be used to assess iron deficiency.","PeriodicalId":17716,"journal":{"name":"Kidney Research and Clinical Practice","volume":" ","pages":"785-796"},"PeriodicalIF":2.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11615453/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141457739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The crosstalk of Wnt/β-catenin signaling and p53 in acute kidney injury and chronic kidney disease. 急性肾损伤和慢性肾病中 Wnt/β-catenin 信号与 p53 的相互影响。

IF 2.9 3区医学

Kidney Research and Clinical Practice Pub Date : 2024-11-01 Epub Date: 2024-11-18 DOI: 10.23876/j.krcp.23.344

Wen-Hua Ming, Lin Wen, Wen-Juan Hu, Rong-Fang Qiao, Yang Zhou, Bo-Wei Su, Ya-Nan Bao, Ping Gao, Zhi-Lin Luan

引用次数: 0

Indoxyl sulfate induces apoptotic cell death by inhibiting glycolysis in human astrocytes. 硫酸吲哚酚通过抑制星形胶质细胞糖酵解诱导细胞凋亡

IF 2.9 3区医学

Kidney Research and Clinical Practice Pub Date : 2024-11-01 Epub Date: 2023-08-10 DOI: 10.23876/j.krcp.23.005

Seung-Hyun Jeong, Samel Park, Jae-Sung Choi, Nam-Jun Cho, Jong-Seok Moon, Hyo-Wook Gil

{"title":"Indoxyl sulfate induces apoptotic cell death by inhibiting glycolysis in human astrocytes.","authors":"Seung-Hyun Jeong, Samel Park, Jae-Sung Choi, Nam-Jun Cho, Jong-Seok Moon, Hyo-Wook Gil","doi":"10.23876/j.krcp.23.005","DOIUrl":"10.23876/j.krcp.23.005","url":null,"abstract":"Background: Neurologic complications, such as cognitive and emotional dysfunction, have frequently been observed in chronic kidney disease (CKD) patients. Previous research shows that uremic toxins play a role in the pathogenesis of CKD-associated cognitive impairment. Since astrocytes contribute to the protection and survival of neurons, astrocyte function and brain metabolism may contribute to the pathogenesis of neurodegeneration. Indoxyl sulfate (IS) is the most popular uremic toxin. However, how IS-induced astrocyte injury brings about neurologic complications in CKD patients has not been elucidated.Methods: The rate of extracellular acidification was measured in astrocytes when IS (0.5-3 mM, 4 or 7 days) treatment was applied. The hexokinase 1 (HK1), pyruvate kinase isozyme M2 (PKM2), pyruvate dehydrogenase (PDH), and phosphofructokinase (PFKP) protein levels were also measured. The activation of the apoptotic pathway was investigated using a confocal microscope, fluorescence- activated cell sorting, and cell three-dimensional imaging was used.Results: In astrocytes, IS affected glycolysis in not only dose-dependently but also time-dependently. Additionally, HK1, PKM2, PDH, and PFKP levels were decreased in IS-treated group when compared to the control. The results were prominent in cases with higher doses and longer exposure duration. The apoptotic features after IS treatment were also observed.Conclusion: Our results showed that the inhibition of glycolysis by IS in astrocytes leads to cell death via apoptosis. Specifically, longterm and higher-dose exposures had more serious effects on astrocytes. Our results suggest that the glycolysis pathway and related targets could provide a novel approach to cognitive dysfunction in CKD patients.","PeriodicalId":17716,"journal":{"name":"Kidney Research and Clinical Practice","volume":"1 1","pages":"774-784"},"PeriodicalIF":2.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11615446/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48123626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0