Kidney Research and Clinical Practice最新文献

{"title":"Before new variants in genes associated with hematuria or proteinuria can be classified as causative, their pathogenicity must be demonstrated.","authors":"Sounira Mehri, Josef Finsterer","doi":"10.23876/j.krcp.26.240","DOIUrl":"10.23876/j.krcp.26.240","url":null,"abstract":"","PeriodicalId":17716,"journal":{"name":"Kidney Research and Clinical Practice","volume":" ","pages":"844-845"},"PeriodicalIF":3.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13575267/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148604486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Xerosis elevates the risk of catheter-related infections in peritoneal dialysis patients.","authors":"Jeong Geon Lee, Jihee Lim, Nam-Jun Cho, Samel Park, Hyo-Wook Gil, Hoonhee Seo, Ho-Yeon Song, Sun-Hee Park, Kook-Hwan Oh, Yong-Lim Kim, Brian A Bieber, Ronald L Pisoni, Eun Young Lee","doi":"10.23876/j.krcp.24.275","DOIUrl":"10.23876/j.krcp.24.275","url":null,"abstract":"<p><strong>Background: </strong>Catheter-related infections, such as exit-site infection and tunnel infection, are major complications in peritoneal dialysis (PD) patients, affecting their prognosis. This study investigates the association between skin conditions and catheter-related infections.</p><p><strong>Methods: </strong>Data from two distinct sources were analyzed: (1) 626 PD patients in the Korean arm of the Peritoneal Dialysis Outcomes and Practice Patterns Study (PDOPPS) and (2) skin microbiome data from 76 dialysis patients at Soonchunhyang University Cheonan Hospital. The relationship between catheter-related infection and self-reported xerosis and pruritus severity was assessed by Cox regression. Risk factors for xerosis and pruritus were evaluated by logistic regression. Furthermore, we discovered the relationship between the severity of pruritus and the relative abundance of Staphylococcus aureus on the skin.</p><p><strong>Results: </strong>The risk of catheter-related infections in PD patients increased with xerosis (hazard ratio [HR], 2.71; 95% confidence interval [CI], 1.19-6.18) and pruritus (HR, 2.57; 95% CI, 1.27-5.22), particularly increasing the risk of S. aureus-associated catheter-related infections (xerosis: HR, 5.66; 95% CI, 1.97-16.30; pruritus: HR, 5.93; 95% CI, 2.18-16.15). The relative abundance of S. aureus was notably higher in patients with severe pruritus. Moreover, patients were more likely to exhibit severe xerosis if they owned pets, had higher serum creatinine levels, and elevated calcium-phosphorus product levels.</p><p><strong>Conclusion: </strong>Xerosis and pruritus significantly increase the risk of catheter-related infections, especially those caused by S. aureus. Instead of relying solely on prophylactic antibiotics for infection prevention, this study highlights the need for new preventive strategies in PD patients, focusing specifically on effective skin management.</p>","PeriodicalId":17716,"journal":{"name":"Kidney Research and Clinical Practice","volume":" ","pages":"807-817"},"PeriodicalIF":3.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13575281/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147513261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A position statement and recommendations for sustainable kidney care.","authors":"Jihyun Yang, So Mi Kim, Eunjeong Kang, Harin Rhee, Jwa-Kyung Kim, Jung-Kook Wi, Ju-Young Moon, Yoosun Joo, Yohan Park, Young-Hwan Hwang, Kyungho Choi, Younglim Kho, Katherine Barraclough, Gangjee Ko","doi":"10.23876/j.krcp.25.139","DOIUrl":"10.23876/j.krcp.25.139","url":null,"abstract":"<p><p>The Korean Society of Nephrology has embraced the principle of \"Green Nephrology\" and launched campaigns addressing environmental sustainability in kidney care. These include initiatives to monitor resource usage, reduce waste generation in treatment facilities, and minimize dialysis-related environmental effects. The Society aims to raise awareness about the environmental impact of kidney disease and its treatments while emphasizing the importance of sustainable practices. Collaboration between health authorities and related academic societies is planned for the development of national strategies. The Special Committee on Sustainable Renal Treatment published the \"Sustainable Kidney Care Recommendations,\" which provides guidelines for efficient measures to reduce the environmental footprint of dialysis. This effort aims to inspire systematic, practical, and sustainable healthcare solutions.</p>","PeriodicalId":17716,"journal":{"name":"Kidney Research and Clinical Practice","volume":" ","pages":"653-667"},"PeriodicalIF":3.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13575282/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148258488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to the letter regarding \"Genetic diagnosis of hereditary kidney disease in pediatric patients through whole-exome sequencing and mitochondrial DNA analysis\".","authors":"Jiyoung Oh, Keumwha Lee, Dongju Won, Young-Mock Lee, Jae Il Shin","doi":"10.23876/j.krcp.26.288","DOIUrl":"10.23876/j.krcp.26.288","url":null,"abstract":"","PeriodicalId":17716,"journal":{"name":"Kidney Research and Clinical Practice","volume":" ","pages":"846-847"},"PeriodicalIF":3.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13575266/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148670045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between obstructive sleep apnea and albuminuria in Korean adults: a nationwide populationbased study.","authors":"Yeojin Yu, Kyungdo Han, Kyu-Na Lee, Jung Hun Koh, Young Sun Shin, Jeong Min Cho, Minsang Kim, Min Woo Kang, Seong Geun Kim, Sehyun Jung, Semin Cho, Hyuk Huh, Eunjeong Kang, Sehoon Park, Yaerim Kim, Kwon Wook Joo, Dong Ki Kim, Soojin Lee","doi":"10.23876/j.krcp.24.159","DOIUrl":"10.23876/j.krcp.24.159","url":null,"abstract":"<p><strong>Background: </strong>Obstructive sleep apnea (OSA) is a sleep disorder associated with an increased risk of cardiovascular and metabolic complications. Albuminuria, an early marker of kidney damage, is a proposed risk factor for OSA and its adverse outcomes. The study explored the association between OSA and albuminuria in Korean adults.</p><p><strong>Methods: </strong>We screened participants from the cross-sectional Korean National Health and Nutrition Examination Survey (2019- 2021). The study included participants aged 40 years and older who completed the STOP-BANG questionnaire, a tool used to assess the OSA risk. Albuminuria was defined as a urine albumin-to-creatinine ratio ≥30 mg/g Cr. The participants were categorized based on albuminuria presence and severity. A multivariate logistic regression analysis examined the association between albuminuria and OSA.</p><p><strong>Results: </strong>This study included 10,923 participants. Participants with albuminuria had significantly higher STOP-BANG scores than those without. Moreover, albuminuria remained strongly associated with an increased risk of OSA (odds ratio, 2.01; 95% confidence interval, 1.66-2.43), after multivariate adjustment. This association was more pronounced as albuminuria severity increased. Participants with high STOP-BANG scores were more likely to have albuminuria (odds ratio, 2.51; 95% confidence interval, 1.89-3.31), highlighting the bidirectional relationship between albuminuria and OSA.</p><p><strong>Conclusion: </strong>The present study demonstrated a significant association between albuminuria and an elevated risk of OSA. These findings underscore the importance of early screening for OSA in patients with albuminuria, particularly in those with additional metabolic risk factors, to improve their long-term outcomes.</p>","PeriodicalId":17716,"journal":{"name":"Kidney Research and Clinical Practice","volume":" ","pages":"743-753"},"PeriodicalIF":3.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13575269/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142921977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frailty-related factors and 1-year renal function change after sodium-glucose cotransporter-2 inhibitors in elderly chronic kidney disease patients.","authors":"Hye-Mi Noh, Sei Hong Min, Hyung-Seok Lee, Sung Gyun Kim, Jun Goo Kang, Jwa-Kyung Kim","doi":"10.23876/j.krcp.25.110","DOIUrl":"10.23876/j.krcp.25.110","url":null,"abstract":"<p><strong>Background: </strong>Sodium-glucose cotransporter-2 inhibitors (SGLT2i) are first-line therapy for chronic kidney disease (CKD). However, evidence regarding their safety and efficacy in frail elderly patients remains limited. This study evaluated the impact of frailty-related factors on renal outcomes in elderly CKD patients treated with SGLT2i.</p><p><strong>Methods: </strong>We retrospectively analyzed 302 elderly CKD patients (≥65 years) newly prescribed SGLT2i. Four frailty-related factors included advanced age (≥75 years), anemia, low Geriatric Nutritional Risk Index (GNRI ≤98), and proteinuria. Rapid renal decline was defined as an absolute decrease in estimated glomerular filtration rate (eGFR) >10 mL/min/1.73 m² within 12 months or a ≥40% reduction from baseline.</p><p><strong>Results: </strong>The mean age was 75.7 ± 8.1 years, and baseline eGFR was 48.1 mL/min/1.73 m². Anemia was present in 49.3% and low GNRI in 12.3% of patients. Those with low GNRI were older, had lower BMI and serum albumin levels, higher prevalence of anemia and proteinuria, and greater 12‑month decline in eGFR (-4.0 mL/min/1.73 m2 vs. -2.0 mL/min/1.73 m2/year, p < 0.01). Rapid renal decline occurred in 29 patients (9.6%), and risk increased with accumulation of frailty factors. Advanced age (≥75 years) alone was associated with higher risk (odds ratio [OR], 2.34; 95% confidence interval [CI], 1.03-5.32), which further increased when combined with anemia and proteinuria (OR, 4.85; 95% CI, 2.19-10.77). Patients with all four components had the highest risk (OR, 9.70; 95% CI, 3.82-24.81).</p><p><strong>Conclusion: </strong>While SGLT2i are generally effective in elderly CKD patients, those with frailty-related factors, particularly malnutrition, proteinuria, and anemia, appear to be at higher risk of rapid decline in renal function. These patients may benefit from more individualized risk assessment and management.</p>","PeriodicalId":17716,"journal":{"name":"Kidney Research and Clinical Practice","volume":" ","pages":"713-723"},"PeriodicalIF":3.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13575270/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148258642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New strategy to regulate immunopathogenic processes of glomerulonephritis.","authors":"Ho Jun Chin","doi":"10.23876/j.krcp.26.104","DOIUrl":"10.23876/j.krcp.26.104","url":null,"abstract":"","PeriodicalId":17716,"journal":{"name":"Kidney Research and Clinical Practice","volume":" ","pages":"645-646"},"PeriodicalIF":3.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13575258/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148405112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Remission of hematuria is associated with a better prognosis in immunoglobulin A nephropathy.","authors":"Geo Neul Park, MinSung Lee, Seon Min Kim, Yoonwon Choi, Soo Jeong Choi, Moo Yong Park, Jin Kuk Kim, Byung Chul Yu","doi":"10.23876/j.krcp.25.064","DOIUrl":"10.23876/j.krcp.25.064","url":null,"abstract":"<p><strong>Background: </strong>The clinical significance of hematuria in immunoglobulin A nephropathy (IgAN) remains unclear. We defined remission of hematuria using stricter yet more intuitive criteria than those in previous studies and evaluated its association with prognosis in IgAN.</p><p><strong>Methods: </strong>This retrospective, multicenter, observational study enrolled 403 patients with IgAN. Hematuria remission was defined as hematuria persisting for at least 3 months before and after diagnostic biopsy, followed by the absence of erythrocytes in four consecutive high-power field microscopic examinations at 3-4-month intervals. Clinical outcomes were compared between the hematuria remission (remission) and persistent hematuria (persistent) groups.</p><p><strong>Results: </strong>The mean annual rate of estimated glomerular filtration rate (eGFR) decline was lower in the remission group than in the persistent group (-1.51 ± 2.86 vs. -2.60 ± 3.18 mL/min/1.73 m2 /yr, p = 0.002). In the remission group, the mean annual rate of eGFR decline decreased after hematuria disappearance (from -1.28 ± 7.06 to 0.09 ± 0.29 mL/min/1.73 m2 /yr, p = 0.02). The proportion of ≥50% decline in eGFR from baseline was also lower in the remission group (p = 0.03). Hematuria remission was an independent prognostic factor of ≥50% decline in eGFR from baseline (hazard ratio, 0.55; 95% confidence interval, 0.33-0.99). However, progression to end-stage kidney disease did not differ significantly between two groups (p = 0.08). Similar results were obtained for propensity score matching.</p><p><strong>Conclusion: </strong>Hematuria remission, defined by the newly proposed stricter criteria, could be a potent prognostic factor in IgAN with straightforward applicability in clinical practice.</p>","PeriodicalId":17716,"journal":{"name":"Kidney Research and Clinical Practice","volume":" ","pages":"702-712"},"PeriodicalIF":3.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13575268/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148405118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evolving therapeutic landscape of immunoglobulin A nephropathy: targeted immune pathways and novel therapies.","authors":"Yaerim Kim","doi":"10.23876/j.krcp.26.090","DOIUrl":"10.23876/j.krcp.26.090","url":null,"abstract":"<p><p>Recent advances in the understanding of immunoglobulin A nephropathy (IgAN) pathogenesis have led to a rapidly expanding therapeutic landscape for the condition. Treatments have historically relied on optimized supportive care aimed at controlling blood pressure and reducing proteinuria through blockading of the renin-angiotensin system and inhibition of the sodium glucose cotransporter 2. Growing insights into immune dysregulation, mucosal immunity, complement activation, and maladaptive hemodynamic responses have facilitated the development of multiple disease-targeting therapies for IgAN. These include agents that modulate mucosal immune responses, inhibit APRIL (a proliferation-inducing ligand) and BAFF (B-cell activating factor) signaling, block complement activation, or target endothelin-mediated pathways. Several of these therapies have shown promising antiproteinuric and kidney-protective effects in clinical trials. This review summarizes recent advances in the treatment of IgAN, with a particular focus on therapies targeting disease-specific pathogenic drivers and their implications for future therapeutic strategies.</p>","PeriodicalId":17716,"journal":{"name":"Kidney Research and Clinical Practice","volume":" ","pages":"677-688"},"PeriodicalIF":3.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13575280/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148405097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outpatient visit intervals in chronic kidney disease: adherence to Kidney Disease: Improving Global Outcomes recommendations and determinants of variation.","authors":"Somi Kim, Ga Young Heo, Cheol Ho Park, Jung Tak Park, Seung Hyeok Han, Tae-Hyun Yoo, Shin-Wook Kang, Song-Hee Kim, Hyung Woo Kim","doi":"10.23876/j.krcp.25.219","DOIUrl":"10.23876/j.krcp.25.219","url":null,"abstract":"<p><strong>Background: </strong>Chronic kidney disease (CKD) is a major global health problem owing to its progressive nature, complications, and substantial healthcare burden. The Kidney Disease: Improving Global Outcomes (KDIGO) guidelines recommend outpatient visit intervals based on CKD severity; however, adherence to these recommendations and the factors influencing the visit interval remain unclear.</p><p><strong>Methods: </strong>This retrospective observational study included 13,621 patients with CKD treated at a tertiary hospital in South Korea. Using electronic medical records, we used linear regression and Shapley Additive exPlanations (SHAP), a method for interpreting model prediction, to assess the influence of clinical, demographic, and healthcare utilization factors on outpatient visit intervals. Key variables included the CKD stage, comorbidities, age, distance to the hospital, and physician assignment.</p><p><strong>Results: </strong>Visit intervals shortened as CKD severity increased, although variability was substantial. Adherence to KDIGO-recommended intervals was higher in earlier CKD stages, but declined in intermediate and advanced stages, except for stage G5-A3, where 90.0% of visits met guidelines. Shorter intervals were associated with advanced stage, older age, greater healthcare use, and shorter distance to the hospital. SHAP analysis confirmed these predictors, identifying CKD stage as the dominant factor and revealing notable physician-level variation.</p><p><strong>Conclusion: </strong>CKD stage was the primary determinant of outpatient follow-up intervals, but adherence to KDIGO recommendations varied across stages. Visit schedules were also affected by age, comorbidities, healthcare utilization, accessibility, and physician practice. These findings underscore the need for tailored follow-up strategies that reflect both disease severity and clinical context.</p>","PeriodicalId":17716,"journal":{"name":"Kidney Research and Clinical Practice","volume":" ","pages":"689-701"},"PeriodicalIF":3.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13575279/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148258619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}