Journal Pharmasci (Journal of Pharmacy and Science)最新文献

{"title":"Hubungan Kepatuhan Penggunaan Obat Anti Epilepsi terhadap Kejadian Kejang Pasien Epilepsi menggunakan kuesioner ARMS (Adherence Refill Medication Scale)","authors":"Iin Ernawati, W. R. Islamiyah","doi":"10.53342/pharmasci.v4i1.128","DOIUrl":"https://doi.org/10.53342/pharmasci.v4i1.128","url":null,"abstract":"ABSTRAKEpilepsi termasuk penyakit kronis otak yang dikarakterisasi dengan kejang berulang (2 kali atau lebih), dimana terjadi gerakan involunter yang melibatkan sebagian tubuh (partial) atau seluruh tubuh (generale), dan seringkali disertai dengan hilangnya kesadaran dan kontrol fungsi saluran cerna atau saluran kemih. Pengobatan epeilepsi sering menggunakan OAE (Obat AntiEpilpsi). Diketahui 70% anak-anak dan dewasa dengan epilepsi berhasil diterapi dengan obat antiepilepsi. Salah satu ukuran manajemen terapi obat pada penyakit epilepsi adalah menurun atau hilangnya kejang, sehingga adanya kejadian kejang menjadi salah satu ukuran pencapaian end outcome. Kejadian kejang dipengaruhi oleh beberapa faktor diantaranya ada tidaknya faktor pemicu kejang dan kepatuhan konsumsi obat antiepilepsi. Penelitian ini merupakan penelitian observasional cross sectional yang dilakukan di poli neurologi Instalasi Rawat Jalan RSUD dr. Soetomo dan Instalasi rawat Jalan RS Universitas Airlangga. Selama penelitian diperoleh 52 pasien epilepsi yang menggunakan obat antiepilepsi. Padapenelitian ini diamati hubungan kepatuhan terhadap adanya kejang pasien epilepsi dalam penggunaan obat anti epilepsi. Pada penelitian ini diketahui nilai koefisien korelasi/ nilai rho (r) sebesar -0,348 dengan nilai p= 0,011 (p<0,05) atau signifikan secara statistik. Hasil tersebut menunjukkan adanya hubungan antara kategori kepatuhan (menggunakan kuesioner ARMS) dengan kejadian kejang, dimana semakin tinggi skor ARMS (dianggap semakin tidak patuh) berbanding lurus dengan peningkatan kejang.Kata kunci: Epilepsi, Kepatuhan, OAE, Kejang, ARMS ABSTRACTEpilepsy is a chronic brain disease characterized by recurrent seizures (2 times or more), in which involuntary movements involve part of the body (partial) or whole body (general). Treatment of epilepsy uses antiepileptic drugs. It is known that 70% of children and adults with epilepsy are successfully treated with antiepileptic drugs. One of measurements of drug therapy management in epilepsy is decreasing or losing seizures, so that the event of seizures is one measure of end outcomes. Seizure events are influenced by severalfactors including the presence or absence of seizure trigger factors and adherence with the consumption of antiepileptic drugs. This study was an observational cross sectional study conducted at the neurology department dr. Soetomo and Airlangga University hospital. This study aims to observe the relationship of adherence of antiepileptic drug consumption with seizures of epilepsy patients. This study observed 52outpatients with epilepsy taking antiepileptic drugs. This study showed that the correlation coefficient / rho value (r) is -0,348 with a value of p = 0.011 (p <0.05). These results indicate that an association between adherence categories (using the arms questionnaire) with the events of seizures, whereas the higher of the arms score (considered to be increasingly disobedient) is directly proportional to the incre","PeriodicalId":17631,"journal":{"name":"Journal Pharmasci (Journal of Pharmacy and Science)","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76454160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sintesis Sol-Gel dan Karakterisasi Struktur Padatan FeF3 dengan Difraksi Sinar-X","authors":"Qurrota A’yuni, Trisna Kumala Dhaniswara","doi":"10.53342/pharmasci.v4i1.127","DOIUrl":"https://doi.org/10.53342/pharmasci.v4i1.127","url":null,"abstract":"ABSTRAKMaterial FeF3 dapat diaplikasikan dalam berbagai bidang diantaranya sebagai material katoda untuk baterai ion litium dan katalis heterogen pada beberapa reaksi yang melibatkan sisi asam. Sintesis FeF3 dapat dilakukan melalui beberapa cara, salah satunya dengan metode sol-gel. Di dalam proses sol-gel adanya agen gelasi dapat mengontrol porositas dan sifat keasaman katalis. Pada penelitian ini dipilih agen gelasi dari senyawa alkohol yaitu metanol dan etanol. Masing-masing padatan yang telah disintesis kemudian dikarakterisasi struktur padatannya dengan difraksi sinar-X. Hasil penelitian menunjukkan bahwa padatan FeF3 telah berhasil disintesis melalui metode sol gel dengan agen gelasi yang berbeda yaitu metanol dan etanol yang masing-masing dituliskan sebagai FeF3(me) dan FeF3(et). Karakterisasi struktur padatan FeF3 menggunakan difraksi sinar-X menghasilkan difraktogram yang sesuai dengan PDF No. 85-0481 dan data ICSD kode 016671 yang memilikistruktur rhombohedral dengan space group R-3cR dan panjang kisi kristal sebesar a = b = c = 5,362 Å dengan sudut α = β = γ = 57,99°. Struktur kristal FeF3 disusun oleh ion Fe3+ dengan jari-jari 0,384 Å dan ion F- dengan jari-jari 0,798 Å dengan tipe ikatan ionik. Rasio besarnya kristalinitas FeF3(et) dibandingkan dengan kristalinitasFeF3(me) sebesar 5:4.Kata kunci: FeF3, sintesis sol-gel, difraksi sinar-X, struktur padatan. ABSTRACTFeF3 material can be applied in various fields including as cathode material for lithium ion batteries and heterogeneous catalysts in some reactions involving the acid side. Synthesis of FeF3 can be done in several ways, one of them is the sol-gel method. In the sol-gel process the gelation agent can control the porosity and acidity of the catalyst. In this study, gelation agents were selected from alcohol compounds, namely methanol and ethanol. The solids that has been synthesized was then solid structure characterized by X-ray diffraction. The results showed that FeF3 solids were successfully synthesized through the sol-gel method with different gelation agents, namely methanol and ethanol, each of which was written as FeF3(me) and FeF3(et). Characterization of the solid structure of FeF3 using X-ray diffraction produces a diffractogram according to the PDF No. 85-0481 and ICSD data code 016671 which has a rhombohedral structure with space group R-3cR andcrystal lattice length of a = b = c = 5.362 Å with an angle α = β = γ = 57.99°. The crystal structure of FeF3 is composed by Fe3+ ions with radius 0.384 Å and F- ions with radius 0.798 Å with ionic bond types. The ratio of the crystallinity of FeF3(et) compared to the crystallinity of FeF3(me) is 5:4.Keywords: FeF3, sol-gel synthesis, X-ray diffraction, solid structur.","PeriodicalId":17631,"journal":{"name":"Journal Pharmasci (Journal of Pharmacy and Science)","volume":"92 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80349759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Induksi Kalus Piper retrofractum Vahl. dengan Zat Pengatur Tumbuh Auksin dan Sitokinin","authors":"Junairiah, Dewi Amelia Sofiana, Y. S. W. Manuhara, Surahmaida","doi":"10.53342/pharmasci.v3i2.116","DOIUrl":"https://doi.org/10.53342/pharmasci.v3i2.116","url":null,"abstract":"ABSTRAK Cabai Jawa (Piper retrofractum Vahl.) dikenal sebagai tanaman hias dan tanaman obat. Metabolit sekunder pada tanaman ini adalah piperin, saponin, kavisin dan minyak atsiri. Metabolit sekunder  tersebut dapat diisolasi dari bahan tanaman atau kalus hasil kultur jaringan tanaman. Pada metode kultur jaringan  tanaman untuk menginduksi kalus diperlukan media dengan konsentrasi zat pengatur tumbuh yang tepat untuk mendapatkan hasil yang optimal. Penelitian ini bertujuan untuk mengetahui pengaruh kombinasi konsentrasi zat pengatur tumbuh Naphthalene Acetic Acid (NAA) dan 6-Benzyl Amino Purin (BAP) yang paling baik untuk induksi kalus P. retrofractum. Jenis penelitian ini adalah eksperimental laboratoris. Penelitian menggunakan rancangan acak lengkap (RAL) dengan 17 perlakuan yang terdiri atas 16 perlakuan kombinasi zat pengatur tumbuh dan 1 perlakuan kontrol, Setiap perlakuan terdiri atas  6 ulangan. Eksplan daun P. retrofractum ditumbuhkan pada medium Murashige dan Skoog padat ditambah  dengan zat pengatur tumbuh dengan konsentrasi masing-masing 0; 0,5; 1; 1,5; 2 mg/L. Data yang diperoleh  berupa data kuantitatif dan kualitatif. Data kuantitatif meliputi lama waktu induksi kalus, persentase eksplan membentuk kalus, berat segar kalus dan berat kering kalus, dianalisis secara statistik dengan SPSS. Data kualitatif meliputi warna dan tekstur kalus. Hasil penelitian menunjukkan bahwa zat pengatur tumbuh NAA dan BAP berpengaruh terhadap pertumbuhan eksplan daun P. retrofractum. Penambahan kombinasi konsentrasi NAA 0,5 mg/L dan BAP 0,5 mg/L menunjukkan respon terbentuknya kalus paling cepat yaitu 11,5 hari. Penambahan kombinasi konsentrasi NAA 1 mg/L dan BAP 0,5 mg/L menghasilkan berat segar terbaik  yaitu 70,6 mg, sedangkan pada kombinasi konsentrasi  NAA 1 mg/L dan BAP 2 mg/L menghasilkan berat kering terbaik  yaitu 18 mg. Warna kalus adalah putih dan putih kecokelatan dengan tekstur friabel dan kompak.Kata kunci: BAP, induksi kalus, NAA, Piper retrofractum Vahl.ABSTRACT Chili Java (Piper retrofractum Vahl.) is known as ornamental plants and medicinal plants. Secondary metabolites in this plant are piperin, saponin, kavisin and essential oils. Secondary metabolites can be isolated from plant material or callus from plant tissue culture. In plant tissue culture method to induce callus required media with the growth regulator concentration to get optimal result. The aim of this research is to know the effect of the combination of growth regulator of Naphthalene Acetic Acid (NAA) and 6-Benzyl Amino Purin (BAP) which is best for the induction of P. retrofractum callus. The type of this study was laboratory experimental. The study used a complete randomized design (RAL) with 17 treatments consisting of 16 treatment combinations of growth regulators and 1 control treatment. Each treatment consisted of 6 replications. P. retrofractum leaf eksplan grown on Murashige and Skoog solid medium coupled with growth regulator substances with respective concentrat","PeriodicalId":17631,"journal":{"name":"Journal Pharmasci (Journal of Pharmacy and Science)","volume":"126 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79529936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efektivitas Daya Hambat Ekstrak Etanol 96% Bonggol Nanas (Ananas Comosus L) Terhadap Pertumbuhan Bakteri Staphylococcus Aureus","authors":"Umar udin, Rinda Yunia Sari, S. Anto","doi":"10.53342/pharmasci.v3i2.114","DOIUrl":"https://doi.org/10.53342/pharmasci.v3i2.114","url":null,"abstract":"ABSTRAKBonggol belum dimanfaatkan secara optimal, padahal bagian bonggol mengandung beberapa komponen aktif salah satunya adalah enzim bromelin. Ezim bromelin bersifat sebagai antibakteri. Tujuan penelitian ini  untuk mengetahui efektivitas daya hambat ekstrak etanol 96% bonggol nanas (Ananas comosus L) terhadap perumbuhan bakteri Staphylococcus aureus. Penelitian ini merupakan penelitian eksperimental menggunakan desain post-test only control group design. Ekstrak etanol 96% bonggol nanas (Ananas comosus L) dilaukan ekstra dengan metode maserasi Bakteri Staphycoccus aureus diambil dari media Manitol salt agar. Hasil penelitian ini menunjukkan ekstrak bonggol nanas pada konsentrasi 50%-100% dengan diulang sebanyak 3 replikasi memiliki daya hambat terhadap pertumbuhan bakteri Staphylococcus aureus. Berdasarkan uji One-Way ANOVA dengan taraf kepercayaan 95% menunjukkan terdapat perbedaan yang bermakna (p<0,05) antara berbagai konsentrasi, sehingga dilanjutkan dengan uji LSD untuk mengetahui adanya perbedaan pada masing-masing perlakuan. Hasil uji LSD menunjukkan bahwa kosentrasi 50% berbeda nyata dengan konsentrasi  70%, 80%, 90% dan 100%, sedangkan control positif tidak berbeda nyata dengan konsentrasi 50% dan 60%. Kesimpulan penelitian ini bahwa ekstrak etanol 96% bonggol nanas (Ananas comosus L) berpengaruh positif dalam menghambat dan membunuh bakteri Staphylococcus aureus dan konsentrasi paling optimal pada 70%.Kata kunci: Ekstrak etanol 96% bonggol nanas, bacitrasin, Staphylococcus aureus, zona hambat antibakteriABSTRACTPineaplle cobs have not been utilized optimally, whereas the cob section contains several active components one of which is the enzyme bromelin.  Bromelin is an antibacterial agent.  The purpose of this research was to determine the effectiveness of inhibitory of ethanol extract 96% pineapple cobs (Ananas comosus L) to Staphylococcus aureus bacteria growth.  This research is an experimental using post-test design only control group design.  Pineaplle cobs extract 96% by maceration method, Staphycoccus aureus bacteria taken from Mantol salt agar medium.  The results of this study showed the pineapple cobs extrac concentrations of 50% -100% with replication as any 3 replications have an inhibitory to the growth of Staphylococcus aureus bacteria.  Based on One-Way ANOVA test with 95% confidence level there was a significant difference (p <0,05) between various concentrations, so it was continued with LSD test to know the difference in each treatment.  LSD test results showed that 50% concentration was significantly different with concentrations of 70%, 80%, 90% and 100%, while the positive control did not differ significantly with concentrations of 50%.  The conclusion of this research is that pineapple  cobs(Ananas comosus L) has positive effect in inhibitied and killing Staphylococcus aureus bacteria and optimal concentration 70%.  Keywords: pineapple cobs etanol extract, bacitrasin, Staphylococcus aureus, zone of inhibition, a","PeriodicalId":17631,"journal":{"name":"Journal Pharmasci (Journal of Pharmacy and Science)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88847714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Karakteristik Fisika Masker Gel Peel Off dan Krim Wajah dengan Kandungan Ekstrak Kulit Buah Kakao ( Theobroma cacao, L.) Sebagai Antioksidan Topikal","authors":"Damaranie Dipahayu","doi":"10.53342/pharmasci.v3i2.113","DOIUrl":"https://doi.org/10.53342/pharmasci.v3i2.113","url":null,"abstract":"ABSTRAKKulit buah kakao adalah salah satu sumber antioksidan alami. Ekstrak etanol kulit buah kakao memiliki nilai IC50 sebesar 0.08 mg/ml. Kulit buah kakao mengandung 37 % katekin, 4%antosianin dan 58 % proantosianidin. Antioksian topikal dalam kosmetika contohnya masker gel peel off dan krim. Formula Kosmetika yang baik adalah yang memiliki karakteristik dan stabilitas yang baik.Studi ini bertujuan untuk memperoleh data dari pengaruh kombinasi HPMC dan PVA = FM 1:FM2:FM3:FM4= (2:12); (4:12): (2:16); (4:16) terhadap daya sebar dan waktu mengering dari sediaan masker gel. Selain itu juga untuk mengetahui pengeruh kecepatan pengadukan 750 rpm dan 1500 rpm terhadap penyebaran dan ukuran globul dari krim antioksidan.Hasil dari penelitian ini menunjukkan baik HPMC dan PVA tidak memiliki pengaruh terhadap daya sebar dan konsentrasi HPMC lebih tinggi akan mempengaruhi waktu mengering dari masker gel peel off selama masa simpan 28 hari. Hasil penelitian ini juga menunjukkan terdapat perbedaan daya sebar dan ukuran globul pada metode pengadukan 750 rpm namun tidak pada pengadukan 1500 rpm  pada krim wajah antioksidan selama masa simpan 28 hari.Kata Kunci: Kulit buah cacao, karakteristik fisik, masker gel peel off , krim antioksidan.ABSTRACTCocoa rind (Theobroma cacao L.) is a natural resourches of antioxidant.  Half percent (0.5 %) Ethanolic extract of Cacao rind (Theobroma cacao L.) has 50 IC value as a 0,08 mg/ mL. Cocoa rind containing 37 % cathecin, 4 % anthocyanins and 58 % proanthocyanidins. Antioxidant topical in cosmetics such as peel off gel mask and cream. A good cosmetics formulation gives a good characteristic and stability.  The study aims to provide data on the effect of HPMC - PVA combination = FM 1:FM2:FM3:FM4= (2:12); (4:12): (2:16); (4:16) to the power spread and drying time of the peel off gel mask. In addition, this study gives data of stirring speed at 750 rpm and 1500 rpm = FC1:FC2 that influence spreading and globul size of antioxidant cream. This study finds that during the storage period of 28 days the difference of HPMC and PVA has no affect on the power spread but it affects the drying time, the greater concentration of HPMC can rapidly dry the gel mask when applied to the skin surface. The study also finds that during the storage period of 28 days, there was a significant difference in power spread and particle size at 750 rpm stirring and no significant difference in 1500 rpm.Key Words: Cocoa rind extract, physic characteristic, peel off gel mask, antioxidant cream.","PeriodicalId":17631,"journal":{"name":"Journal Pharmasci (Journal of Pharmacy and Science)","volume":"113 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85354207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validasi Metode Analisis Formaldehid Pada Tisu Basah","authors":"Dwi Wahyuniati, C. Yulianti, Mercyska Suryandari","doi":"10.53342/pharmasci.v3i2.117","DOIUrl":"https://doi.org/10.53342/pharmasci.v3i2.117","url":null,"abstract":"ABSTRAKTisu basah merupakan istilah umum untuk menggambarkan sepotong bahan, umumnya ditambahkan dengan komposisi cairan atau semi cair, dimaksudkan untuk membersihkan dan memberikan rasa lembut. Tisu basah memiliki struktur berserat terdiri dari campuran serat selulosa pulp dan regenerasi, seperti rayon dan atau liosel, dengan atau tanpa serat pengikat. Pada proses produksi, komponen-komponen yang sengaja ditambahkan pada pembuatan tisu basah salah satunya adalah formaldehid sebagai penguat keadaan basah. Akan tetapi penggunaan yang berlebihan dapat menyebabkan ruam pada kulit (dermatitis). Pada penelitian ini dilakukan validasi metode analisis formaldehid pada tisu basah dengan menggunakan metode absorpsi uap SNI ISO 14184-2:2015 dengan pereaksi nash menggunakan spektrofotometri UV-Vis. Sampel yang digunakan adalah tisu basah dari satu merek. Validasi metode dilakukan untuk memastikan metode SNI ISO 14184-2:2015 dapat diterapkan, diperoleh hasil valid, dengan nilai R = 0,9993, yang mendekati nilai 1, menghasilkan persamaan regresi linier y = 0,0294x - 0,0317. Pengujian akurasi diperoleh rata-rata persen recovery sebesar 84,54%, 102,05%, dan 106,13%. Nilai RSD sebesar 1,62%. Hasil nilai LOD sebesar 0,040, sedangkan hasil nilai LOQ sebesar 0,136. Hasil validasi terhadap metode SNI ISO 14184 – 2 : 2015 dapat disimpulkan bahwa metode SNI ISO 14184-2:2015 dapat digunakan untuk menguji formaldehid pada tisu basah. Kata kunci: Validasi, Tisu basah, Formaldehid, Pereaksi Nash, Spektrofotometri UV-Vis.ABSTRACT Wet wipes are the general terms to describe a piece of material, generally impregnated with a liquid or semi liquid composition, intended to both cleaning and providing a smooth feeling. Wet wipes has fibrous structures consist of a mixture of pulp and regenerated cellulose fibers, such as rayon and/or lyocell, with or without binding fibers. In product process, one of components expressly added was formaldehyde as strengthener as wet condition. But, excessive use of formaldehyde can cause skin rash (dermatitis). This study was aimed to Analysis Method Validation of Formaldehyde of Wet Wipes used vapour absorption SNI ISO 14184-2:2015 method with Nash Reagents by UV-Vis Spectrophotometry, and used vapour absorption method. The wet wipes sample used was from one brand. Method validation was conducted to definite SNI ISO 14184-2:2015 method can be applied, the result was valid, r value is 0,9993, the linear regression y = 0,0294x – 0,0317, accuracy percent recovery study showed 84,54%, 102,05%, and 106,13%., Related standar deviation showed 1,62%, limit of detection was 0,040, limit of quantitation was 0,136. The validation result of SNI ISO 14184-2:2015 method can be concluded that SNI ISO 14184-2:2015 method can be applied to examine formaldehid on wet wipes.Keywords: Wet wipes, Formaldehyde, Validation, Nash Reagent, UV-Vis Spectrophotometry.","PeriodicalId":17631,"journal":{"name":"Journal Pharmasci (Journal of Pharmacy and Science)","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91024916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analisis Kandungan Kimia Daun Dan Batang Sembukan (Paederia Foetida) Dengan Menggunakan 2 Pelarut Yang Berbeda","authors":"Surahmaida, P. Handrianto","doi":"10.53342/pharmasci.v3i2.112","DOIUrl":"https://doi.org/10.53342/pharmasci.v3i2.112","url":null,"abstract":"ABSTRAKTanaman sembukan (Paederia foetida) atau yang lebih kita kenal dengan daun kentut merupakan tanaman yang biasanya digunakan oleh masyarakat sebagai obat diare atau obat kembung. Kandungan senyawa metabolit sekunder tanaman sembukan perlu dikaji lebih lanjut untuk penemuan bahan obat baru. Tujuan dari penelitian adalah untuk menganalisis kandungan senyawa metabolit sekunder yang terdapat pada daun dan batang sembukan dengan metode maserasi yang direndam ke dalam pelarut etanol 96% dan metanol selama 5 hari. Ekstrak etanol dan ekstrak metanol pada masing-masing daun dan batang kemudian dianalisis dengan menggunakan reagen kimia untuk mengidentifikasi senyawa alkaloid, saponin, tanin dan flavonoid. Hasil skrining fitokimia menunjukkan bahwa pada ekstrak etanol dan metanol batang sembukan mengandung alkaloid, saponin, tanin dan flavonoid. Sedangkan pada ekstrak etanol dan metanol daun sembukan mengandung alkaloid, tanin dan flavonoid. Selanjutnya senyawa metabolit sekunder tersebut dianalisis aktivitas biologisnya.Kata kunci: Analisis senyawa metabolit sekunder, ekstrak etanol dan metanol daun dan batang sembukan (Paederia foetida), maserasiABSTRACTPaederia foetida or more familiar with fart leaves is a plant that is usually used by the community as a drug or bloated diarrhea. The content of the secondary metabolite compound of the Paederia foetida plant needs to be studied further for the discovery of new drug ingredients. The purpose of this research is to analyze the content of secondary metabolite compounds found on leaves and stems with a maseration method soaked in 96% ethanol solvent and methanol for 5 days. The ethanol extract and methanol extract on each leaf and stem were then analyzed using chemical reagents to identify the alkaloid compounds, saponins, tanins and flavonoids. The results of phytochemical screening showed that in the ethanol extract and methanol the stem of the Paederia foetida contained alkaloids, saponins, tanins and flavonoids. While on ethanol extract and methanol leaves Paederia foetida contains alkaloids, tanins and flavonoids. Furthermore, the secondary metabolite compounds are analyzed biological activity.Keywords: Analysis of secondary metabolite compounds, ethanol extract and methanol leaves and stirring stem (Paederia foetida), maceration","PeriodicalId":17631,"journal":{"name":"Journal Pharmasci (Journal of Pharmacy and Science)","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87843358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aktivitas Antibakteri Daun Pepaya (Carica Papaya) Menggunakan Pelarut Etanol Terhadap Bakteri Bacillus subtilis","authors":"Tri Puji Lestari Sudarwati","doi":"10.53342/pharmasci.v3i2.105","DOIUrl":"https://doi.org/10.53342/pharmasci.v3i2.105","url":null,"abstract":"ABSTRAKDaun pepaya banyak digunakan masyarakat sebagai obat tradisional. Daun pepaya mengandung senyawa antibakteri seperti tannin, alkaloid, flavonoid, terpenoid, saponin dan alkaloid karpain. Bakteri Bacillus subtilis merupakan  bakteri yang mengontaminasi makanan dan dapat menyebabkan infeksi gastroenteritis. Tujuan penelitian untuk mengetahui kemampuan ekstrak daun pepaya (Carica papaya L) dalam menghambat pertumbuhan bakteri Bacillus subtilis. Jenis penelitian ini adalah eksperimen laboratorium. Uji daya hambat menggunakan metode difusi kertas cakram. Variabel penelitian yaitu konsentrasi ekstrak daun pepaya 20 µg/mL, 40 µg/mL, 60 µg/mL, 80 µg/mL, 100 µg/mL dan zona hambat pertumbuhan bakteri Bacillus subtilis. Hasil penelitian ini didapatkan ekstrak daun papaya (Carica papaya L) dapat menghambat pertumbuhan bakteri Bacillus subtilis pada konsentrasi 20% sampai 100% dengan rata – rata diameter zona hambat 8,1 mm sampai dengan 8,6 mm dengan kategori sedang. Hal ini menunjukkan bahwa ekstrak daun pepaya (Carica papaya L) mempunyai pengaruh terhadap pertumbuhan bakteri Bacillus subtilis.Kata kunci: Daun Pepaya,Etanol, Bacillus subtilis.ABSTRACTPapaya leaves are common to use as a traditional medicine for society. Papaya leaves contain of anti-bacteria compound, such as tannins, alkaloids, flavonoids, terpenoids, saponins, and karpain alkaloids. Bacillus subtilis is a bacteria that contaminates food and can cause gastroenteritis infection. The purpose of this observation is to find out the ability of papaya leaves extract towards the obstruction of Bacillus subtilis bacteria. The observer conducts a laboratory experiment. To conduct obstruction power test, the observer uses disc paper diffusion method. The observation variable measures the papaya leaves extract concentration in 20 µg/mL, 40 µg/mL, 60 µg/mL, 80 µg/mL, 100 µg/mL and the obstruction zone growth of Bacillus subtilis bacteria. Hence, the result shows that papaya leaves (Carica papaya L) extract successfully obstruct the growth of Bacillus subtilis bacteria in a concentration range 20 % to 100 % with the diameter zone average 8,1 mm to 8,6 mm in a medium category. Thus, it shows that papaya leaves (Carica papaya L) extract significantly influence the growth of Bacillus subtilis bacteria.Key Words: Papaya leaves, Ethanol, Bacillus subtilis bacteria.","PeriodicalId":17631,"journal":{"name":"Journal Pharmasci (Journal of Pharmacy and Science)","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72722665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hospitalisasi Pasien Skizofrenia di Rumah Sakit Jiwa Menur Surabaya","authors":"F. Yunitasari, Ilil Maidatuz Zulfa","doi":"10.53342/pharmasci.v3i2.118","DOIUrl":"https://doi.org/10.53342/pharmasci.v3i2.118","url":null,"abstract":"ABSTRAKSkizofrenia merupakan gangguan atau kumpulan gangguan mental yang mempengaruhi pemikiran, persepsi, dan perilaku sosial dan penyebabnya sebagian besar masih belum diketahui. Pengobatan farmakologis skizofrenia menggunakan obat-obat golongan antipsikotik terutama dalam jangka waktu lima tahun setelah episode akut pertama muncul. Penggunaan antipsikotik berpotensi menimbulkan kejadian hospitalisasi yang dapat menurunkan kualitas hidup pasien terkait penurunan fungsi sosial pasien skizofrenia. Penelitian ini bertujuan menganalisis potensi jenis kelamin dan jenis pengobatan antipsikotik sebagai faktor prediktor hospitalisasi pasien skizofrenia. Analisis cross sectional jenis kelamin dan penggunaan antipsikotik dilakukan pada rekam medis pasien rawat inap di Rumah Sakit Jiwa Menur Surabaya Bulan Oktober 2017 yang didiagnosis skizofrenia (ICD-10 F20). Faktor prediktor hospitalisasi pasien  dianalisis menggunakan uji Chi-square for goodness of fit yang membandingkan perbedaan jumlah frekuensi antar kategori pada masing-masing faktor prediktor. Faktor jenis terapi antipsikotik digolongkan menjadi tipikal, atipikal, dan kombinasi. Hasil menunjukan terdapat perbedaan jumlah pasien pada tiga jenis terapi yang berbeda (p-value 0,000) dimana sebagian besar pasien yang dirawat dirumah sakit menerima antipsikotik tipikal (47,41%). Perbandingan jenis kelamin tidak menunjukkan perbedaan yang signifikan pada pasien yang dirawat. Dapat disimpulkan jenis antipsikotik tipikal kemungkinan dapat mempengaruhi kejadian hospitalisasi pada pasien skizofrenia. Kata kunci: Skizofrenia, antipsikotik tipikal, antipsikotik atipikal, hospitalisasi.ABSTRACTSchizophrenia is a mental disorder that affect thought, perception, and social behaviours. Most of causes of schizophrenia are unknown. Pharmacological treatments of schizophrenia use antipsychotics especially during  five years after first acute episode observed. The use of antipsychotics potentially lead to hospitalization that can affect to patients’ quality of life. This study was aimed to analyze the potential of gender and types of antipsychotic treatments as predictor factors in hospitalization of schizophrenia patients. Cross sectional analysis in gender and types of antipsycotics was conducted to medical records of inpatients at Rumah Sakit Jiwa Menur Surabaya diagnozed with Schizophrenia (ICD-10 Code F20) in October 2017. Chi-square for goodness of fit test was used to determine the difference amount of patients among different gender and different types of antipsychotics used as predictor factors. Types of antipsychotics used was classified into three categories which were patients who received typical antipsychotic, atypical antipsycotic and combination. The results showed that there was a significant difference in amount of hospitalized patients who received typical antipsychotic, atypical antipsycotic and combination (p-value 0,000) which most of hospitalized patients received atypical antipsychotics (47,41","PeriodicalId":17631,"journal":{"name":"Journal Pharmasci (Journal of Pharmacy and Science)","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75445262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Penentuan Kadar Asam Lemak Bebas Dan Kadar Air Pada Minyak Goreng Yang Digunakan Oleh Pedagang Gorengan Di Jalan Manyar Sabrangan, Mulyorejo, Surabaya","authors":"Ika Fitri Ulfindrayani, Qurrota A’yuni","doi":"10.53342/pharmasci.v3i2.111","DOIUrl":"https://doi.org/10.53342/pharmasci.v3i2.111","url":null,"abstract":"\u0000ABSTRAK \u0000Kebutuhan minyak goreng sawit di Indonesia terus meningkat dari tahun ke tahun. Kebutuhan terbesar didominasi oleh penggunaan minyak goreng sawit sebagai media untuk menggoreng makanan yang salah satunya yaitu jajanan goreng (gorengan). Mayoritas pedagang gorengan tidak memperhatikan kualitas dari minyak goreng yang digunakan. Banyak pedagang gorengan membeli minyak goreng bekas (jelantah) demi mendapatkan keuntungan yang besar. Pada minyak jelantah mengandung asam lemak bebas akibat pemanasan berkala yang berbahaya bagi tubuh. Oleh karena itu, pada penelitian ini dilakukan pengujian kualitas minyak goreng melalui dua parameter yaitu kadar asam lemak bebas dan kadar air. Hal ini bertujuan untuk mengetahui kualitas minyak goreng yang digunakan oleh para pedagang gorengan. Sampel minyak goreng didapatkan dari pedagang gorengan di sepanjang Jalan Manyar Sabrangan, Mulyorejo, Surabaya. Terdapat 7 pedagang gorengan yang menjual gorengannya dengan harga sekitar Rp. 1.000 – Rp 2.000. Metode yang digunakan yaitu metode titrasi alkalimetri dan metode gravimeteri. Hasil analisa kadar asam lemak bebas dan kadar air menunjukkan bahwa dari 7 sampel terdapat 4 sampel minyak goreng yang tidak layak dikonsumsi karena tidak sesuai dengan syarat mutu minyak goreng SNI 01-3741-2002. \u0000Kata kunci: Asam Lemak Bebas, Kadar Air, Minyak Goreng, Pedagang Gorengan. \u0000ABSTRACT \u0000The requirement of palm cooking oil in Indonesia increase from year to year. It was dominated by the use of palm cooking oil as a medium to fry. Fried food on street seller was one of foods that need oil in frying process. Many street fried food seller did not pay attention to the quality of cooking oil that used to fry. Waste cooking oil was the good choice for street fried food seller in order to get big profits. Waste cooking oil contains of free fatty acids due to periodic warming that is harmful to the body. It was important for us to know the quality of cooking oil which we used. Therefore, in this research, we did test the quality of cooking oil which used street fried food seller. Free fatty acid and water content were two parameters that can describe the quality of cooking oil. The samples of cooking oil were obtained from street fried food seller along Jalan Manyar Sabrangan, Mulyorejo, Surabaya. There are 7 street seller that selling fried food with price of about Rp. 1.000 - Rp 2.000. Alkalimetry titration and gravimetery method were used to determine free fatty acid and water content of samples. The result showed there are 4 samples of cooking oil that was not worthy to be consumed because not in accordance with requirement of cooking oil quality of SNI 01-3741-2002. \u0000Key Words: Free Fatty Acid, Water Content, Cooking Oil, Street Fried Food Seller. \u0000 \u0000 ","PeriodicalId":17631,"journal":{"name":"Journal Pharmasci (Journal of Pharmacy and Science)","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81753719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}