European Journal of Life Sciences最新文献_第2页

Screening of new morpholine dithiocarbamate derivatives bearing benzimidazole moiety for anticholinesterase potential 含有苯并咪唑基团的新型二硫代氨基甲酸啉衍生物抗胆碱酯酶潜力的筛选

European Journal of Life Sciences Pub Date : 2023-08-28 DOI: 10.55971/ejls.1328405

H. Temel, Gülşen Akalın Çiftçi, L. Yurttaş

{"title":"Screening of new morpholine dithiocarbamate derivatives bearing benzimidazole moiety for anticholinesterase potential","authors":"H. Temel, Gülşen Akalın Çiftçi, L. Yurttaş","doi":"10.55971/ejls.1328405","DOIUrl":"https://doi.org/10.55971/ejls.1328405","url":null,"abstract":"Alzheimer’s disease (AD) is basically associated with disturbances of cholinesterase metabolism which result in acetylcholine deficiency. Target of acetylcholinesterase (AChE) inhibitors used in symptomatic therapy of disease is to increase of ACh levels. Consequently, cholinesterase inhibitors were developed to increase acetylcholine is to inhibit AChE and butrylcholinesterase (BuChE). Studies demonstrate the clinical importance of dual inhibitors that inhibit not only the acetylcholinesterase enzyme but also the butyrylcholinesterase enzyme.\u0000\u0000In recent years, benzimidazoles have attracted particular interest owing to their anticolinesterase activity. In this manner, we have synthesized benzimidazole and morpholine including compounds (2a-i). Final compounds were achieved with the reaction of (benzimidazol-2-yl) methyl morpholine-4-carbodithioate and α-bromoacetophenone derivatives in acetone at room temperature with stirring. Inhibition effects of novel morpholine dithiocarbamates (2a-i) were tested on AChE and BuChE. Compound 2d demonstrated dual inhibitory activity on AChE and BuChE (78±1,56, 70,71±1,53, respectively), with the lowest cytotoxicity to normal cell line.","PeriodicalId":176179,"journal":{"name":"European Journal of Life Sciences","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126934650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of immunotherapy in lung cancer: Actual scenery 免疫治疗在肺癌中的作用:实景

European Journal of Life Sciences Pub Date : 2023-04-24 DOI: 10.55971/ejls.1267898

Ipek Ertorun, Aydan Huseynli, Sevinc Nursena Ertekın, Gülşen Akalın Çiftçi

引用次数: 0

Determination of potential probiotic properties of lactic acid bacteria isolated from colostrum milk 初乳分离乳酸菌潜在益生菌特性的测定

European Journal of Life Sciences Pub Date : 2023-04-24 DOI: 10.55971/ejls.1263343

P. Soyer, Melek Tekgöz, Y. Tunalı

引用次数: 0

Knowledge and behavior of community pharmacists towards detecting drug-drug interactions 社区药剂师对检测药物-药物相互作用的知识和行为

European Journal of Life Sciences Pub Date : 2023-04-24 DOI: 10.55971/ejls.1266042

F. Oğuz, M. Arslan

{"title":"Knowledge and behavior of community pharmacists towards detecting drug-drug interactions","authors":"F. Oğuz, M. Arslan","doi":"10.55971/ejls.1266042","DOIUrl":"https://doi.org/10.55971/ejls.1266042","url":null,"abstract":"Drug-drug interactions (DDIs) are preventable medication errors that can cause severe adverse effects for patients, which often involve more than one mechanism. Healthcare practitioners, especially community pharmacists, must know and manage potentially significant DDIs to provide patient safety.\u0000This paper mainly aims to determine the knowledge level of community pharmacists about DDIs and to evaluate the behavior of community pharmacists in detecting DDIs. For this aim, a face-to-face questionnaire, including a knowledge assessment test containing 20 drug pairs and ten behavior statements related to detecting DDIs, was applied to community pharmacists.\u0000Seventy-three pharmacists participated in the study. The study’s findings show that the knowledge level of community pharmacists, who are the closest health consultants, about DDIs is relatively low. In addition, responses were found to be moderate in detecting drug interactions.Although statistically significant and positive effects of vocational training on the knowledge level and behaviors of pharmacists were determined, it was revealed that education levels did not have a significant effect.\u0000In this regard, it is essential to improve community pharmacists’ DDI knowledge level through vocational training programs and encourage their interaction-detecting behavior to improve patient outcomes and patient safety.","PeriodicalId":176179,"journal":{"name":"European Journal of Life Sciences","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121521319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis, biological activity evaluation and molecular docking studies of novel thiazole derivatives 新型噻唑衍生物的合成、生物活性评价及分子对接研究

European Journal of Life Sciences Pub Date : 2023-04-24 DOI: 10.55971/ejls.1270394

Derya Osmaniye, Uğur Kayış, Ü. Gül, Y. Özkay, Z. Kaplancıklı

引用次数: 1

An observational study on drug interactions caused by proton pump inhibitors 质子泵抑制剂引起药物相互作用的观察性研究

European Journal of Life Sciences Pub Date : 2023-04-24 DOI: 10.55971/ejls.1209405

Betül Aykut, M. Arslan

{"title":"An observational study on drug interactions caused by proton pump inhibitors","authors":"Betül Aykut, M. Arslan","doi":"10.55971/ejls.1209405","DOIUrl":"https://doi.org/10.55971/ejls.1209405","url":null,"abstract":"Proton pump inhibitors (PPIs) are widely used to treat gastric acid-related diseases worldwide and in our country. The high reliability of PPIs also allows long-term use for appropriate indications in chronic diseases, which increases the possibility of drug-drug interactions. Therefore, it is clear that the usage of PPIs should be monitored in terms of drug-drug interactions to provide drug treatment success and patient safety. The ability of pharmacists, the closest health consultants, to identify these interactions during prescription fulfillment will significantly contribute to treatment success. Although many studies deal with the rational use of PPIs and drug interactions, the number of studies revealing observational drug interactions is minimal. This research aims to determine drug-drug interactions frequently encountered in community pharmacies for PPIs, which interact with many drug groups and are commonly prescribed. For this purpose, approximately 1700 prescriptions supplied by a selected community pharmacy, serving in Van, were examined. One hundred sixty-four of the prescriptions were evaluated by considering the study’s limitations. Drug-drug interactions were checked by three different electronic database. It was determined that 73 of 164 prescriptions had interactions in at least one of the three databases. In 73 prescriptions, 86 drug interactions were observed. 34% of the interactions detected in the study were caused by lansoprazole.","PeriodicalId":176179,"journal":{"name":"European Journal of Life Sciences","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120957309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Focusing on the moderately active compound (MAC) in the design and development of strategies to optimize the apoptotic effect by molecular mechanics techniques 重点研究适度活性化合物(MAC)的设计和开发策略，利用分子力学技术优化细胞凋亡效应

European Journal of Life Sciences Pub Date : 2023-02-28 DOI: 10.55971/ejls.1209591

A. Evren, Demokrat Nuha, L. Yurttaş

引用次数: 1

Latest research about active pharmaceutical ingredient loaded Poly Lactic Acid-co-Glycolic Acid (PLGA) based drug delivery system in Türkiye 活性药物成分负载聚乳酸-羟基乙酸(PLGA)为基础的体外给药系统研究进展

European Journal of Life Sciences Pub Date : 2023-02-24 DOI: 10.55971/ejls.1197082

Berna Kaval, Fatma Şen, Kemal Kaya Batmaz, Meliha Ekinci, A. A. Öztürk

引用次数: 0

Essential oil composition and antimicrobial activity of Glaucosciadium cordifolium (Boiss.) Burtt. & Davis 青花草精油成分及抑菌活性研究伯特。和戴维斯

European Journal of Life Sciences Pub Date : 2023-02-24 DOI: 10.55971/ejls.1215741

N. Saltan, A. Kaya, G. İşcan, B. Demirci

{"title":"Essential oil composition and antimicrobial activity of Glaucosciadium cordifolium (Boiss.) Burtt. & Davis","authors":"N. Saltan, A. Kaya, G. İşcan, B. Demirci","doi":"10.55971/ejls.1215741","DOIUrl":"https://doi.org/10.55971/ejls.1215741","url":null,"abstract":"Glaucosciadium cordifolium (Boiss.) Burtt. & Davis, which is a monotypic species naturally grown in Turkey belonging to the Apiaceae (Umbelliferae) family. In this study, the essential oil obtained from G. cordifolium was analyzed and evaluated for its antimicrobial effects. In chemical studies, the analyzes of essential oil compounds obtained from the aerial parts of plants by hydrodistillation were carried out with GC-FID and GC-MS. In total, 23 compounds were identified making up 98.7% of the total volatile constituents. Sabinene (42.1%), α-pinene (17.1%), and α-phellandrene (10.1%) were found as the main constituents in the oil.\u0000In antimicrobial studies, the anticandidal and antibacterial effects of essential oils were tested against 14 pathogenic microorganisms according to the standard protocols of the Clinical Laboratory Standards Institute (CLSI). It has been determined that essential oils have a very weak inhibitory effect when compared with standard antibacterial agents. MIC values of 1800, 3600 µg/Ml, and higher were determined. In addition, it was determined that it showed inhibitory effects, especially against C. krusei at a concentration of 250 µg/mL, with MIC values ranging from 250 to 2000 µg/mL.","PeriodicalId":176179,"journal":{"name":"European Journal of Life Sciences","volume":"212 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115673496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Arum italicum Miller tuber extracts: evaluation of synergistic activities with ciprofloxacin against some pathogens 意大利魔芋提取物:与环丙沙星对某些病原体协同作用的评价

European Journal of Life Sciences Pub Date : 2023-02-24 DOI: 10.55971/ejls.1148283

H. G. Ağalar, Gözde Öztürk, N. Kirimer

{"title":"Arum italicum Miller tuber extracts: evaluation of synergistic activities with ciprofloxacin against some pathogens","authors":"H. G. Ağalar, Gözde Öztürk, N. Kirimer","doi":"10.55971/ejls.1148283","DOIUrl":"https://doi.org/10.55971/ejls.1148283","url":null,"abstract":"Antibiotic misuse or overuse leads antibiotic resistance. Antibiotic resistant bacteria infections cause significant clinical problem. Recently, antibiotic resistant bacteria numbers have increased, this situation has become a global public health treat. To achieve these problems, development of new antibacterial compounds is still popular among researchers. The focus on natural compounds/plant extracts in combination with antibiotics increase their activities and decrease the doses of antibiotics and their side effects. Despite known as poisonous, Arum italicum Miller is used as food and/or is used for the treatment such ailments as furuncle, eczema, peptic ulcer, wounds, etc. This interesting species was found as anticancer, cytotoxic, apoptotic agent against some human cancers. In the present study, the fractions of A. italicum tuber extract against human pathogens (Pseudomonas aeruginosa ATCC 27853, Bacillus cereus NRRL B-3711, Staphylococcus aureus ATCC 6538) were evaluated for their antibacterial activities by microdilution method. Each fraction was combined with ciprofloxacin and their synergistic activities were tested by checkerboard method. The MIC (minimum inhibitory concentrations) and FICI (fractional inhibitory concentration indexes) values were calculated. Totally, seven synergic interactions, ten additive interactions, and four indifferent interactions of tested fractions with ciprofloxacin were found.","PeriodicalId":176179,"journal":{"name":"European Journal of Life Sciences","volume":"2015 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129103314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0