European Journal of Life Sciences最新文献_第3页

Volatile compositions of Tilia platyphyllos Scop. infusions by headspace-solid-phase microextraction (HS-SPME), antioxidant activity 白檀挥发性成分研究。顶空固相微萃取法(HS-SPME)，抗氧化活性

European Journal of Life Sciences Pub Date : 2023-02-24 DOI: 10.55971/ejls.1207835

D. Kırcı, Gözde Öztürk, B. Demirci

{"title":"Volatile compositions of Tilia platyphyllos Scop. infusions by headspace-solid-phase microextraction (HS-SPME), antioxidant activity","authors":"D. Kırcı, Gözde Öztürk, B. Demirci","doi":"10.55971/ejls.1207835","DOIUrl":"https://doi.org/10.55971/ejls.1207835","url":null,"abstract":"The genus Tilia (Tiliaceae) represents 45 species, of which six species are European. Tilia sp. are simple, cordate or deciduous trees with long, silicate shaped, 5-valve fruits and fragrant flowers. It is used as a medicinal tea in traditional medicine for colds, coughs, and hypertension and as an antioxidant.\u0000Within the scope of this research, Tilia platyphyllos Scop. in the culture form from Eskişehir was obtained, and infusions were prepared at different times (including 5 min., 10 min., 15 min., and 30 min., respectively). Headspace-solid-phase microextraction (HS-SPME) combined with gas chromatography-mass spectrometry (GC-MS) was used to examine the volatile components in the infusion extracts. Major volatile compounds of infusion extracts determined as E)-β-ocimene (15.7-45.9%) and limonene (11.7-33.4%), respectively. Also, terpinolene (26.0%) were identified as the main compounds for 30 min infusion. After then, the infusion extracts were lyophilized, and the antioxidant activity of the infusion extracts were performed by DPPH· radical scavenging effect. It was determined that inhibition percentages were relatively high in the concentration range of 10-0.02 mg/mL (5.60-72.45%). \u0000Our first research was the chemical composition and biological activity of the time-dependent T. platyphyllos infusions.","PeriodicalId":176179,"journal":{"name":"European Journal of Life Sciences","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130312362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Release kinetics of 3D printed oral solid dosage forms: An overview 3D打印口服固体剂型的释放动力学:概述

European Journal of Life Sciences Pub Date : 2022-11-10 DOI: 10.55971/ejls.1181158

Berna Kaval, Engin Kapkın, M. Kaynak

{"title":"Release kinetics of 3D printed oral solid dosage forms: An overview","authors":"Berna Kaval, Engin Kapkın, M. Kaynak","doi":"10.55971/ejls.1181158","DOIUrl":"https://doi.org/10.55971/ejls.1181158","url":null,"abstract":"Three-dimensional printing (3DP) is one of the most extensively researched methods for producing nano/micro scale biomaterials. This method is typically applied layer by layer. The 3DP method has many advantages over traditional manufacturing methods and ensures that personalized drug design is feasible. Individual dose adjustment provides significant benefits, particularly in some disadvantaged patient groups. Individual release characteristics may be required in these patient groups in addition to dose adjustment. 3DP technology also allows for the adjustment of release kinetics. All of these factors were also increasing interest in 3DP technology in the pharmaceutical industry. The goal of this review is to understand the pharmacological significance of 3DP technology as well as the parameters influencing the release profiles in tablets produced by using technique, and to establish a correlation between them. Within the scope of this review, 79 literature research studies were examined, and it was determined that there is limited data to determine whether there is a correlation between release kinetics and 3DP techniques. When the release profiles obtained by considering the polymer type used in these techniques are evaluated, immediate and rapid release was obtained in studies using PVA + PLA polymers and studies using PVP polymer, immediate release in studies using Kollidon® and Kollicoat® derivatives, and controlled, extended and sustained release was observed in studies using PCL polymer.","PeriodicalId":176179,"journal":{"name":"European Journal of Life Sciences","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127813750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Capsaicin inhibits proliferation and induces apoptosis in human lung adenocarcinoma A549 cell line 辣椒素抑制人肺腺癌A549细胞增殖和诱导细胞凋亡

European Journal of Life Sciences Pub Date : 2022-11-10 DOI: 10.55971/ejls.1151479

Merve Tiltay, Aydan Hüseynli, Gülşen Akalın Çiftçi, İ. Ö. Alatas

{"title":"Capsaicin inhibits proliferation and induces apoptosis in human lung adenocarcinoma A549 cell line","authors":"Merve Tiltay, Aydan Hüseynli, Gülşen Akalın Çiftçi, İ. Ö. Alatas","doi":"10.55971/ejls.1151479","DOIUrl":"https://doi.org/10.55971/ejls.1151479","url":null,"abstract":"Capsaicin is the main component of many hot peppers, exerts anticancer effects on various cancer cells by inducing apoptotic pathways. In addition, the ineffectiveness of this apoptotic effect of capsaicin on healthy cells provides a wide-ranging use of capsaicin. In recent years, many studies have been carried out to determine the safety of capsaicin use in lung cancer, which is a common cancer type worldwide with high mortality rates. In the present study anticancer effects of capsaicin were studied on A549 human lung adenocarcinoma cell line. Also, citotoxicity of this compound was studied on L929 mouse embryonic fibroblast cell line. Various concentration of capsaicin (3.90625-500 μM) effectively decreased cell viability in A549 cell line in a dose-dependent manner. Also, this antiproliferative effect of capsaicin was selective compared to L929 cell line. On the other hand, apoptosis inducing effects of capsaicin were studied by Annexin V-FITC and Caspase 3 assays by using IC50 and IC50/2 concentrations on A549 cell by flow cytometric methods. Our results revealed that the anticancer effects induced by capsaicin on A549 cell line involved apoptosis by inducing Caspase 3 pathway.","PeriodicalId":176179,"journal":{"name":"European Journal of Life Sciences","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121643992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Morpho-anatomical and palynological properties of endemic Astragalus tmoleus var. bounacanthus (Fabaceae) 豆科特有黄芪的形态解剖学和孢粉学特征

European Journal of Life Sciences Pub Date : 2022-11-10 DOI: 10.55971/ejls.1147134

A. Kaya

{"title":"Morpho-anatomical and palynological properties of endemic Astragalus tmoleus var. bounacanthus (Fabaceae)","authors":"A. Kaya","doi":"10.55971/ejls.1147134","DOIUrl":"https://doi.org/10.55971/ejls.1147134","url":null,"abstract":"Astragalus tmoleus Boiss. var. bounacanthus (Boiss.) Chamberlain is a member of the Pterophorus Bunge section of the Fabaceae family and consists of the spiny cushion-forming shrub. In this study, morphological, anatomical and pollen properties of the plant, an endemic species for Turkey, have been investigated in detail. Morphological characters such as the shape of paripinnate leaves, stipules and bracts, the flower number in the inflorescence, the stenonychioid type of standard and the reniform type of seed can be helpful to distinguish A. tmoleus var. bounacanthus. The stem, leaf and rachis characteristics of the plant were examined in anatomical studies. There is a secondary growth in stem anatomy. The number of vascular bundles is 15-18 in a circle. The shape of the transversal section of the rachis is polygonal or almost orbicular. The sclerenchyma tissue is located on the vascular bundles in the rachis. A. tmoleus var. bounacanthus has equifasial leaves. The stomata type is anomocytic and occurs on both leaflet epidermises. The pollen grains of A. tmoleus var. bounacanthus have tricolpate aperture and they are subprolate-shaped. While the pollen exine sculpturing is microreticulate, the seed surface sculpturing is a prominent undulate-ridged pattern formed by irregular cells. Scanning electron microscopy (SEM) is used to determine pollen and seed morphology.","PeriodicalId":176179,"journal":{"name":"European Journal of Life Sciences","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131356111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antimicrobial and antioxidant activities of Sideritis lanata L. extracts 黄络菌提取物的抗菌和抗氧化活性

European Journal of Life Sciences Pub Date : 2022-11-10 DOI: 10.55971/ejls.1181461

Zeynep Gülcan, N. Saltan, G. İşcan, M. Kürkçüoǧlu, Y. Köse

{"title":"Antimicrobial and antioxidant activities of Sideritis lanata L. extracts","authors":"Zeynep Gülcan, N. Saltan, G. İşcan, M. Kürkçüoǧlu, Y. Köse","doi":"10.55971/ejls.1181461","DOIUrl":"https://doi.org/10.55971/ejls.1181461","url":null,"abstract":"Sideritis L. (Lamiaceae) is represented by 45 species in Flora of Turkey. Sideritis lanata L. (Hairy ironwort) is located in the north-west, west, south-west and central Anatolia. Mountain tea (Sideritis plants) is used as a traditional remedy against common cold and gastrointestinal disorders. Its beneficial properties are attributed to its rich bioactive constituents. In this study, the antioxidant activities of the extracts of Sideritis lanata prepared using different solvents (n-hexane, ethyl acetate, and 70% ethanol) from the aerial parts were determined by DPPH· scavenging effect assay. Also; determined of the antimicrobial activity of S. lanata extracts against 4 bacteria and 5 Candida species. Dried aerial parts of Sideritis were subjected to hydrodistillation and the oil obtained was analyzed by using GC and GC/MS. S. lanata extracts prepared with 70% ethanol was found to have a higher DPPH· scavenging activity (IC50= 0.241 mg/mL) than extracts prepared with other solvents. All extracts showed generally weak inhibitory effects (500-8000 μg/mL, MIC) against bacterial strains. Inhibitory doses against the tested Candida species were determined between 125-4000 μg/mL. The 70% ethanol extract of S. lanata inhibited Candida tropicalis (ATCC 750) (MIC: 125 μg/mL).","PeriodicalId":176179,"journal":{"name":"European Journal of Life Sciences","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126834072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Geographical impact on essential oil composition of endemic Salvia absconditiflora collected from different parts of Turkey 土耳其不同地区特有丹参精油成分的地理影响

European Journal of Life Sciences Pub Date : 2022-11-10 DOI: 10.55971/ejls.1140861

A. Kaya, S. Doğu, B. Demirci

引用次数: 0

High-density lipoprotein: Quality is more important than quantity! 高密度脂蛋白:质量比数量更重要!

European Journal of Life Sciences Pub Date : 2022-04-29 DOI: 10.55971/ejls.1099595

Ipek Ertorun, G. Çiftçi, Ö. Alataş

引用次数: 0

Synthesis and characterization of new Piperazine-Dithiocarbamate compounds as potent MAO-A inhibitors

European Journal of Life Sciences Pub Date : 2022-04-29 DOI: 10.55971/ejls.1089254

Derya Osmaniye, B. Sağlık, Serkan Levent, Y. Özkay, Z. Kaplancıklı

引用次数: 0

Design, Synthesis and In vitro COX Inhibitory Profiles of A New Series of Tetrazole-based Hydrazones 一类新型四唑基腙的设计、合成及体外COX抑制谱

European Journal of Life Sciences Pub Date : 2022-04-29 DOI: 10.55971/ejls.1095818

M. Altıntop, Belgin Sever, H. Temel, Z. Kaplancıklı, A. Özdemir

引用次数: 1

Chaerophyllum libanoticum Boiss. Et Kotschy: The fruit essential oil, composition, skin-whitening and antioxidant activities 绿叶蕨。Et Kotschy:水果精油成分，有美白和抗氧化活性

European Journal of Life Sciences Pub Date : 2022-04-29 DOI: 10.55971/ejls.1095855

M. Kürkçüoǧlu, H. G. Ağalar, B. Temiz, A. Duran, K. Başer

引用次数: 0