免疫治疗在肺癌中的作用:实景

Ipek Ertorun, Aydan Huseynli, Sevinc Nursena Ertekın, Gülşen Akalın Çiftçi
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引用次数: 0

摘要

每年死于癌症的人中,有一半以上的人也失去了与疾病的斗争,使癌症成为世界范围内死亡的主要原因。在手术,激素治疗,放疗和化疗,这些在癌症治疗中首选之后,免疫治疗已经发生了革命性的变化。在这篇简短的综述中,我们涵盖了当代癌症免疫治疗中使用的各种免疫治疗方法。它们是免疫检查点封锁,一种计划“释放”强大的T细胞反应的尝试,以及与肿瘤免疫细胞注入体内相关的适应性细胞疗法。2014年,Nivolumab成为首个被批准用于治疗肺癌的ICI。迄今为止,不同的ICIs如pembrolizumab, atezolizumab和durvalumab已连续引入临床医学并显示出显着的效果。因此,在这篇综述中,我们提出了癌症免疫治疗的一些新目标和尝试。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The role of immunotherapy in lung cancer: Actual scenery
More than half of those who succumb to cancer each year also lose their battle with the disease, making cancer a leading cause of death worldwide. After surgery, hormonal therapy, radiotherapy and chemotherapy, which are preferred in cancer management, immunotherapy has revolutionized. In this mini-review, we cover the various immunotherapeutic approaches used in contemporary cancer immunotherapies. These are immune checkpoint blockade, an attemp planned to ‘unleash’ robust T cell responses, and adaptive cellular therapies connected on the infusion of tumor-struggling immune cells into the body. One of these attemps, Nivolumab, became the first ICI to be approved to treat lung cancer in 2014. To date, different ICIs, such as pembrolizumab, atezolizumab, and durvalumab, have been in a row introduced into clinical medicine and have shown significant effect. Therefore, in this mini-review, we present some emerging goals and attemps in cancer immunotherapy.
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