Journal of Veterinary Diagnostic Investigation最新文献_第3页

Spontaneous natural killer cell lymphoproliferative disorder in a rhesus macaque.

IF 1.2 3区农林科学

Journal of Veterinary Diagnostic Investigation Pub Date : 2024-12-04 DOI: 10.1177/10406387241297087

Marietta V Barro, Laura M Garzel, Rebekah I Keesler, Kerriann M Casey, Katherine J Olstad

{"title":"Spontaneous natural killer cell lymphoproliferative disorder in a rhesus macaque.","authors":"Marietta V Barro, Laura M Garzel, Rebekah I Keesler, Kerriann M Casey, Katherine J Olstad","doi":"10.1177/10406387241297087","DOIUrl":"10.1177/10406387241297087","url":null,"abstract":"Lymphoproliferative disorders of natural killer (NK)-cell lineage are well documented in humans but have yet to be documented in non-human primates (NHPs). Here we describe a case of NK-cell lymphoproliferative disorder/leukemia in a 20-y-old captive female rhesus macaque (Macaca mulatta). The animal clinically had mild splenomegaly and marked lymphocytosis with small-to-medium lymphocytes in blood smears. By flow cytometry and cluster differentiation, the lymphocytes were CD3-negative, CD8-positive, CD4-negative, and CD20-negative for cell surface markers; immunohistochemistry revealed the presence of intracellular CD3 and granzyme B. This immunoprofile is consistent with a NK-cell phenotype. Histologically, these cells were predominantly intravascular within the splenic red pulp, liver sinusoids, and to a lesser degree bone marrow. Oncogenic viruses, such as Mason-Pfizer monkey viruses (MPMV; formerly, and commonly known as, simian retroviruses or SRV; Retroviridae, Betaretrovirus maspfimon); simian immunodeficiency virus (SIV; Retroviridae, Lentivirus simimdef), and primate T-lymphotropic virus 1 (PTLV1; commonly known as simian T-lymphotropic virus type 1, STLV1; Retroviridae, Deltaretrovirus priTlym1), were not detected in this animal by serology. Immunohistochemistry using EBNA2 antibody to detect rhesus and cynomolgus monkey lymphocryptovirus (McGHV4/RLV and McGHV10 respectively; Orthoherpesviridae, Lymphocryptovirus macacinegamma4 and Lymphocryptovirus macacinegamma13, respectively) was negative. Together these findings are consistent with a diagnosis of naturally occurring NK-cell lymphoproliferative disorder. NK-cell lymphoproliferative disorder has not been reported previously in rhesus macaques, to our knowledge.","PeriodicalId":17579,"journal":{"name":"Journal of Veterinary Diagnostic Investigation","volume":" ","pages":"10406387241297087"},"PeriodicalIF":1.2,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11618834/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142770263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Skrjabingylus chitwoodorum in a rabies-positive striped skunk in Texas. 得克萨斯州一只狂犬病阳性条纹臭鼬体内的 Skrjabingylus chitwoodorum。

IF 1.2 3区农林科学

Journal of Veterinary Diagnostic Investigation Pub Date : 2024-11-07 DOI: 10.1177/10406387241293421

Sarah Myers, Brianne Taylor, Ragan Wilson, Shannon Caseltine, Ruth C Scimeca

{"title":"Skrjabingylus chitwoodorum in a rabies-positive striped skunk in Texas.","authors":"Sarah Myers, Brianne Taylor, Ragan Wilson, Shannon Caseltine, Ruth C Scimeca","doi":"10.1177/10406387241293421","DOIUrl":"10.1177/10406387241293421","url":null,"abstract":"We describe here a case of the sinus roundworm, Skrjabingylus chitwoodorum, found incidentally in a rabies-positive striped skunk (Mephitis mephitis) in Texas, USA. Skunks serve as a natural definitive host for this metastrongylid nematode in North America, in which infections result in observable damage to the host cranium, where adult parasites reside. Additionally, skunks are considered the primary reservoir of rabies in Texas. In November 2022, the animal was discovered in northern Texas displaying neurologic signs before euthanasia and submission to the Oklahoma Animal Disease Diagnostic Laboratory for rabies testing. Direct fluorescent antibody testing indicated that the animal was rabies-positive, and, upon tissue collection, numerous adult nematodes were recovered from the cranium and identified as S. chitwoodorum by morphology and amplification of the mitochondrial cytochrome c oxidase subunit I gene. Histologically, we found lymphohistiocytic meningitis in several loci and chronic sinusitis rostral to the cribriform plate. Due to behavioral abnormalities, we additionally tested for Toxoplasma gondii via PCR, but no parasite DNA was detected. Concurrent infection by S. chitwoodorum and rabies virus may contribute to neurologic signs in skunks.","PeriodicalId":17579,"journal":{"name":"Journal of Veterinary Diagnostic Investigation","volume":" ","pages":"10406387241293421"},"PeriodicalIF":1.2,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11559893/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142605690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Detection of equine parvovirus-hepatitis and efficacy of governmental regulation for equine biologics purity. 马细小病毒肝炎的检测和政府对马生物制品纯度监管的有效性。

IF 1.2 3区农林科学

Journal of Veterinary Diagnostic Investigation Pub Date : 2024-11-06 DOI: 10.1177/10406387241292343

Alexandra J Scupham, Christopher Tong

{"title":"Detection of equine parvovirus-hepatitis and efficacy of governmental regulation for equine biologics purity.","authors":"Alexandra J Scupham, Christopher Tong","doi":"10.1177/10406387241292343","DOIUrl":"10.1177/10406387241292343","url":null,"abstract":"In 2018, a new virus, named equine parvovirus-hepatitis (EqPV-H), was discovered in a biologic product that had been administered to horses that subsequently developed clinical signs of equine serum hepatitis (Theiler disease). Further correlation of the virus with the disease sparked federal requirements that all equine biologics be free of EqPV-H. The initial quantitative real-time PCR (qPCR) test for EqPV-H has proved to be sensitive to co-extracted PCR inhibitors in template nucleic acids, causing false-negative results. We investigated the use of digital PCR (dPCR) as a more robust test. Examination of 227 equine biologic product lots available for purchase both before and after regulatory implementation using both detection methods indicated that dPCR is a more reliable platform. Nevertheless, use of the qPCR method for product screening had reduced the fraction of serials with EqPV-H detected from 39.6% prior to regulation to 6.8% after regulatory implementation. Adoption of dPCR testing is an opportunity to further decrease the prevalence of EqPV-H in equine biologics.","PeriodicalId":17579,"journal":{"name":"Journal of Veterinary Diagnostic Investigation","volume":" ","pages":"10406387241292343"},"PeriodicalIF":1.2,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11559848/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142590846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Real-time pathologist-assisted field postmortem examinations of beef cattle. 实时病理学家辅助现场肉牛尸检。

IF 1.2 3区农林科学

Journal of Veterinary Diagnostic Investigation Pub Date : 2024-11-01 Epub Date: 2024-08-17 DOI: 10.1177/10406387241269043

Jennifer L Davies, Lindsay Rogers, Dayna Goldsmith, Grace P S Kwong, Carolyn Legge, Erin Zachar

{"title":"Real-time pathologist-assisted field postmortem examinations of beef cattle.","authors":"Jennifer L Davies, Lindsay Rogers, Dayna Goldsmith, Grace P S Kwong, Carolyn Legge, Erin Zachar","doi":"10.1177/10406387241269043","DOIUrl":"10.1177/10406387241269043","url":null,"abstract":"Postmortem examination of deceased production animals with appropriate ancillary testing is fundamental to determining causes of morbidity and mortality. Reaching a definitive diagnosis is crucial to evidence-based herd management and treatment decisions that safeguard animal health and welfare, food safety, and human health. However, for a range of reasons, carcasses sometimes cannot be examined in a veterinary diagnostic laboratory. As a result, postmortem examinations of farmed animals, including cattle, are often performed on-farm by the referring veterinarian (rVet) with tissue samples submitted to a veterinary diagnostic laboratory for ancillary testing. For various reasons, field postmortems can be associated with lower diagnostic rates. We investigated real-time pathologist-assisted field postmortem examination (rtPAP) assistance to beef cattle rVets to gauge any improvement in attaining a final diagnosis. We found that rtPAPs improved the success of reaching a final diagnosis compared to unassisted field postmortem examinations. Both the participating bovine rVets and the pathologists saw benefits to the rtPAPs, with bovine rVets indicating that they would utilize this service in the future if available. Our proof-of-concept study demonstrated the positive role of rtPAPs in diagnosing beef cattle disease and speaks to the need for telepathology services supporting food animal rVets and producers.","PeriodicalId":17579,"journal":{"name":"Journal of Veterinary Diagnostic Investigation","volume":" ","pages":"799-803"},"PeriodicalIF":1.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11529060/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141995985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The artifact of cerebellar granule cell layer conglutination in veterinary medicine: a brief historical perspective and review. 兽医学中的小脑颗粒细胞层凝集假象：简短的历史视角和回顾。

IF 1.2 3区农林科学

Journal of Veterinary Diagnostic Investigation Pub Date : 2024-11-01 Epub Date: 2024-08-17 DOI: 10.1177/10406387241270024

Daniel R Rissi, Ricardo E Mendes, Claudio S L Barros

{"title":"The artifact of cerebellar granule cell layer conglutination in veterinary medicine: a brief historical perspective and review.","authors":"Daniel R Rissi, Ricardo E Mendes, Claudio S L Barros","doi":"10.1177/10406387241270024","DOIUrl":"10.1177/10406387241270024","url":null,"abstract":"Cerebellar granule cell layer conglutination is a tissue artifact associated with postmortem autolysis that causes cerebellar granule cell changes once thought to be caused by degeneration and necrosis. Granule cell layer conglutination has been reported mainly in humans and cattle and rarely in other animal species, but its frequency remains vastly unknown in veterinary medicine, mostly because this postmortem change is typically not recorded in autopsy reports. Pathology trainees should be aware of autolytic tissue changes that may mimic pathologic changes in the CNS, particularly when those changes are highly selective for a specific cell population within the cerebellar cortex. Here we provide a brief historical perspective on the evolution of cerebellar granule cell layer conglutination from \"enzootic cerebellar necrosis,\" a presumed necrotic lesion affecting granule neurons in humans and cattle, to a tissue change associated with postmortem autolysis and increased tissue acidity in the cerebellum. We also provide an update on the animal species in which cerebellar granule cell layer conglutination has been observed during our diagnostic pathology routine.","PeriodicalId":17579,"journal":{"name":"Journal of Veterinary Diagnostic Investigation","volume":" ","pages":"933-936"},"PeriodicalIF":1.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11523252/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141995998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of fluorescent antibody test, immunohistochemistry, and PCR testing for diagnostic confirmation of neurolisteriosis in 25 goats. 比较荧光抗体检测、免疫组化和聚合酶链反应检测对 25 只山羊神经李斯特菌病的诊断确认。

IF 1.2 3区农林科学

Journal of Veterinary Diagnostic Investigation Pub Date : 2024-11-01 Epub Date: 2024-08-17 DOI: 10.1177/10406387241273426

Daniel R Rissi, Amy S McKinney, Jillian D Fishburn, Ricardo E Mendes, Binu T Velayudhan

{"title":"Comparison of fluorescent antibody test, immunohistochemistry, and PCR testing for diagnostic confirmation of neurolisteriosis in 25 goats.","authors":"Daniel R Rissi, Amy S McKinney, Jillian D Fishburn, Ricardo E Mendes, Binu T Velayudhan","doi":"10.1177/10406387241273426","DOIUrl":"10.1177/10406387241273426","url":null,"abstract":"Neurolisteriosis, a common disease of small ruminants, is most often caused by Listeria monocytogenes. Here we describe 25 cases of caprine neurolisteriosis diagnosed in our laboratory over a 5-y period and compare our fluorescent antibody test (FAT) results with immunohistochemistry (IHC) and polymerase chain reaction (PCR) testing for diagnostic confirmation. Neurohistologic changes consistent with neurolisteriosis affected the pons in all cases, extending rostrally to the mesencephalon in 6 cases, caudally to the medulla oblongata in 6 cases, and/or dorsally to the cerebellum in 4 cases. Acute inflammatory changes were observed in 17 cases, and included neuroparenchymal microabscesses, neuronal necrosis and neuronophagia, axonal swelling, microgliosis and astrogliosis, and perivascular neutrophils with macrophages, lymphocytes, and plasma cells that occasionally extended to the leptomeninges. Subacute-to-chronic changes (8 cases) consisted of neuroparenchymal and perivascular clusters of macrophages with rare neutrophils, lymphocytes, and plasma cells admixed with glial nodules. Bacterial bacilli were observed within neutrophils or macrophages in H&E-stained tissue sections in 4 cases. Gram stain highlighted gram-positive bacilli in 13 cases. Neurolisteriosis was confirmed by FAT in 2 cases, by IHC in 19 cases, and by PCR in 20 cases.","PeriodicalId":17579,"journal":{"name":"Journal of Veterinary Diagnostic Investigation","volume":" ","pages":"896-901"},"PeriodicalIF":1.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11520000/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141995982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rostral cranial fossa and sinonasal neoplasms with cribriform plate involvement in 32 dogs and 17 cats. 32 只狗和 17 只猫的颅窝和鼻窦肿瘤累及楔形板。

IF 1.2 3区农林科学

Journal of Veterinary Diagnostic Investigation Pub Date : 2024-11-01 Epub Date: 2024-08-17 DOI: 10.1177/10406387241267899

Daniel R Rissi, Andrew D Miller, Heather Daverio, Elena A Demeter, Molly E Church, Taryn A Donovan

{"title":"Rostral cranial fossa and sinonasal neoplasms with cribriform plate involvement in 32 dogs and 17 cats.","authors":"Daniel R Rissi, Andrew D Miller, Heather Daverio, Elena A Demeter, Molly E Church, Taryn A Donovan","doi":"10.1177/10406387241267899","DOIUrl":"10.1177/10406387241267899","url":null,"abstract":"The rostral cranial fossa (RCF) consists of the sphenoid and ethmoid bones, which accommodate the olfactory bulbs and nerves along the recesses of the cribriform plate. Neoplasms located in the vicinities of the RCF can compress and/or invade the cribriform plate. Here we describe the clinical and pathologic findings of neoplasms involving the cribriform plate in 32 dogs and 17 cats autopsied over a 13-y period. The average ages of affected dogs and cats were 9.2 y and 9.7 y, respectively. No sex or breed predisposition was evident in dogs, but 13 of 18 cats were spayed females and 14 of 18 were domestic shorthair cats. The main clinical signs were seizures (10 cases) and epistaxis (5 cases) in dogs, and red-to-brown nasal discharge (5 cases) and seizures (4 cases) in cats. In dogs, the 22 sinonasal neoplasms included adenocarcinoma (14 cases), transitional carcinoma (4), squamous cell carcinoma (2), lymphoma (1), and histiocytic sarcoma (1); the 10 intracranial neoplasms consisted of high-grade gliomas (3 cases), psammomatous meningiomas (2), histiocytic sarcomas (2), olfactory neuroblastomas (2), and a meningeal granular cell tumor (1). In cats, the 14 sinonasal neoplasms included lymphoma (8 cases), adenocarcinoma (4), adenosquamous carcinoma (1), and squamous cell carcinoma (1); the 3 intracranial neoplasms consisted of oligodendroglioma (1), transitional meningioma (1), and olfactory neuroblastoma (1).","PeriodicalId":17579,"journal":{"name":"Journal of Veterinary Diagnostic Investigation","volume":" ","pages":"925-932"},"PeriodicalIF":1.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11523179/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141995986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sarcocystis sp. meningoencephalitis in a captive bobcat. 一只人工饲养的山猫患了沙眼衣原体脑膜脑炎。

IF 1.2 3区农林科学

Journal of Veterinary Diagnostic Investigation Pub Date : 2024-11-01 Epub Date: 2024-08-21 DOI: 10.1177/10406387241271362

Elizabeth S Majette, Eliza Baker, Erica E Evans, Wesley C Sheley

引用次数: 0

Synovial myxoma or myxosarcoma? Lymph node metastasis in 2 dogs. 滑膜肌瘤还是肌肉瘤？两只狗的淋巴结转移

IF 1.2 3区农林科学

Journal of Veterinary Diagnostic Investigation Pub Date : 2024-11-01 Epub Date: 2024-06-03 DOI: 10.1177/10406387241257254

Imaine Glahn, Taryn A Donovan, Christof A Bertram

{"title":"Synovial myxoma or myxosarcoma? Lymph node metastasis in 2 dogs.","authors":"Imaine Glahn, Taryn A Donovan, Christof A Bertram","doi":"10.1177/10406387241257254","DOIUrl":"10.1177/10406387241257254","url":null,"abstract":"Synovial myxoma, a rare joint tumor in dogs, has traditionally been considered benign, acknowledging that local invasion into regional tissues including bone may be present. Given the diagnostic challenges in distinguishing synovial myxoma from other joint lesions through clinical features and diagnostic imaging, definitive diagnosis relies on characteristic gross and histologic features. Within the inner surface of the joint capsule, synovial myxomas form nodules of stellate-to-spindle cells within abundant myxomatous matrix. We present here 2 cases of synovial myxoma with metastasis to regional lymph nodes and compare these 2 cases to 3 cases without evidence of lymph node metastasis. Aside from lymphovascular invasion in one case with metastasis, there were no overt histologic features of the primary tumor to suggest aggressive biologic behavior. The finding of lymph node metastasis warrants reconsideration of the term \"synovial myxoma\" for this neoplasm. We suggest the term \"synovial myxosarcoma,\" considering that histologic features of the primary tumor do not predict biologic behavior. Our case series highlights the importance of lymph node sampling in suspected synovial myxosarcoma cases as well as thorough histologic examination, emphasizing careful evaluation for lymphovascular invasion.","PeriodicalId":17579,"journal":{"name":"Journal of Veterinary Diagnostic Investigation","volume":" ","pages":"874-878"},"PeriodicalIF":1.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11514113/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141199267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Further validation of 2 nonstructural protein-specific antibody tests for diagnosis and surveillance of foot-and-mouth disease in the United States. 进一步验证用于诊断和监测美国口蹄疫的 2 种非结构蛋白特异性抗体测试。

IF 1.2 3区农林科学

Journal of Veterinary Diagnostic Investigation Pub Date : 2024-11-01 Epub Date: 2024-08-17 DOI: 10.1177/10406387241266900

Chungwon J Chung, Ryan Bagg, Kate Schumann, Leslie Blakemore, Madison Beauchamp

{"title":"Further validation of 2 nonstructural protein-specific antibody tests for diagnosis and surveillance of foot-and-mouth disease in the United States.","authors":"Chungwon J Chung, Ryan Bagg, Kate Schumann, Leslie Blakemore, Madison Beauchamp","doi":"10.1177/10406387241266900","DOIUrl":"10.1177/10406387241266900","url":null,"abstract":"Foot-and-mouth disease (FMD) is a highly contagious disease of cloven-hoofed animals. FMD poses an economic threat to the livestock industry in the United States. Due to the potential use of vaccines composed of partially purified structural proteins of the FMD virus (FMDV), it is important to test samples from infected and vaccinated animals with a competitive ELISA that detects antibodies against nonstructural proteins (NSPs) of FMDV. Our study extends the diagnostic validation of the Prionics ELISA (Thermo Fisher) and the VMRD ELISA. We used diverse serum sample sets from bovine, porcine, and other cloven-hoofed animals to evaluate the analytical specificity and sensitivity, diagnostic specificity and sensitivity, and differentiation of infected from vaccinated animals (DIVA) per validation guidelines outlined by the World Organisation for Animal Health (WOAH). The 2 tests were analytically 100% accurate. The VMRD test was diagnostically more sensitive than Prionics, but Prionics was diagnostically more specific than the VMRD test. Both tests could tell if animals were infected or vaccinated. Considering these data, both VMRD and Prionics ELISAs can be used for serodetection of FMDV antibodies at the Foreign Animal Disease Diagnostic Laboratory and within the National Animal Health Laboratory Network laboratories.","PeriodicalId":17579,"journal":{"name":"Journal of Veterinary Diagnostic Investigation","volume":" ","pages":"790-798"},"PeriodicalIF":1.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11520017/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141995983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0