Journal of Virus Eradication最新文献

{"title":"8.1 – 00022 Short-term Combination Immunotherapy with bNAbs and CCR5 Blockade Mediates ART-Free Viral Control in Infant Rhesus Macaques","authors":"N.L. Haigwood, T. Ordonez, S. Pandey, J. Reed, G.M. Webb, A.J. Hessell, K.K.A. Van Rompay, J.K. Watanabe, J.L. Usachenko, J. Sacha","doi":"10.1016/j.jve.2024.100436","DOIUrl":"10.1016/j.jve.2024.100436","url":null,"abstract":"","PeriodicalId":17552,"journal":{"name":"Journal of Virus Eradication","volume":"10 ","pages":"Pages 28-29"},"PeriodicalIF":3.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143130231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"1.3 – 00084 Persistence of HIV genomes in bacteria-specific CD4+ T cells during ART","authors":"A. Espinosa Ortiz, R. Fromentin, S.G. Deeks, J.P. Routy, N. Chomont","doi":"10.1016/j.jve.2024.100396","DOIUrl":"10.1016/j.jve.2024.100396","url":null,"abstract":"","PeriodicalId":17552,"journal":{"name":"Journal of Virus Eradication","volume":"10 ","pages":"Page 2"},"PeriodicalIF":3.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143176159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2.2 – 00058 Role of HIV integration site on clonal expansion of infected cells and maintenance of latency in vivo","authors":"V. Pal, M. Frauke, A. Danesh, M. Canis, T. Dilling, I. Miller, T. Huynh, T. Hatziioannou, R.B. Jones, G.Q. Lee, P.D. Bieniasz","doi":"10.1016/j.jve.2024.100401","DOIUrl":"10.1016/j.jve.2024.100401","url":null,"abstract":"","PeriodicalId":17552,"journal":{"name":"Journal of Virus Eradication","volume":"10 ","pages":"Page 5"},"PeriodicalIF":3.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143128930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PP3.5 – 00089 Investigating novel designed and synthesized PKC modulators for use in “kick and kill” HIV cure strategies","authors":"J. Morán, Z. Gentry, O. Mcateer, J. Hamad, J.T. Kim, P. Wender, J. Zack, M. Marsden","doi":"10.1016/j.jve.2024.100486","DOIUrl":"10.1016/j.jve.2024.100486","url":null,"abstract":"","PeriodicalId":17552,"journal":{"name":"Journal of Virus Eradication","volume":"10 ","pages":"Pages 62-63"},"PeriodicalIF":3.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143135196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PP3.7 – 00002 Towards a functional cure for HIV-1 infection: BRD4 modulator ZL0580 and LEDGINs additively block and lock HIV-1 transcription","authors":"E. Pellaers, A. Denis, W. Hannes, A. Bhat, Z. Debyser","doi":"10.1016/j.jve.2024.100488","DOIUrl":"10.1016/j.jve.2024.100488","url":null,"abstract":"","PeriodicalId":17552,"journal":{"name":"Journal of Virus Eradication","volume":"10 ","pages":"Pages 63-64"},"PeriodicalIF":3.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143135198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PP4.6 – 00115 Disruption of intestinal germinal centers during HIV infection","authors":"F. Cossarini, A. Krek, P. Canales-Herrerias, M. Tankelevich, B. Chen, J. Aberg, F. Petralia, A. Polydorides, S. Mehandru","doi":"10.1016/j.jve.2024.100493","DOIUrl":"10.1016/j.jve.2024.100493","url":null,"abstract":"","PeriodicalId":17552,"journal":{"name":"Journal of Virus Eradication","volume":"10 ","pages":"Page 67"},"PeriodicalIF":3.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143180200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"7.4 – 00119 Anatomic distribution of HIV-infected clones in tissues after longterm antiretroviral therapy","authors":"F. Maldarelli, A. Glassey, T. Nguyen, R. Gorelick, L. Adams, M. Zipparo, A. Rahman, S. Hewitt, K. Lurain, R. Ramiswami, C.Y. Lau","doi":"10.1016/j.jve.2024.100433","DOIUrl":"10.1016/j.jve.2024.100433","url":null,"abstract":"","PeriodicalId":17552,"journal":{"name":"Journal of Virus Eradication","volume":"10 ","pages":"Page 27"},"PeriodicalIF":3.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143181179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PP3.6 – 00064 Novel synthesized protein kinase C modulators show enhanced HIV latency reversal properties and synergize with a BET bromodomain inhibitor","authors":"T.C. Chou, J.A. Moran, J. Zack, P. Wender, M.D. Marsden","doi":"10.1016/j.jve.2024.100487","DOIUrl":"10.1016/j.jve.2024.100487","url":null,"abstract":"","PeriodicalId":17552,"journal":{"name":"Journal of Virus Eradication","volume":"10 ","pages":"Page 63"},"PeriodicalIF":3.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143135197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Virological and serological outcomes in people with HIV-HBV coinfection who had discontinued tenofovir-containing antiretroviral therapy: Results from a prospective cohort study","authors":"Amir M. Mohareb ,&nbsp;Patrick Miailhes ,&nbsp;Julie Bottero ,&nbsp;Caroline Lascoux-Combe ,&nbsp;Julie Chas ,&nbsp;Sarah Maylin ,&nbsp;Audrey Gabassi ,&nbsp;Hayette Rougier ,&nbsp;Emily P. Hyle ,&nbsp;Constance Delaugerre ,&nbsp;Karine Lacombe ,&nbsp;Anders Boyd","doi":"10.1016/j.jve.2024.100574","DOIUrl":"10.1016/j.jve.2024.100574","url":null,"abstract":"<div><h3>Background and Aims</h3><div>Given advances in antiretroviral therapy (ART), some people with HIV are transitioned to non-tenofovir-containing ART; the implications for people with HIV-hepatitis B virus (HBV) are unknown. We characterized HBV-related outcomes in people with HIV-HBV coinfection while not taking tenofovir-containing ART.</div></div><div><h3>Methods</h3><div>We analyzed participants from the French HIV-HBV Cohort Study in three treatment groups: (1) continuous tenofovir; (2) discontinued tenofovir; (3) never initiated tenofovir. We examined virological and clinical characteristics during follow-up. We assessed determinants of HBV DNA &gt;2000 IU/mL and alanine aminotransferase (ALT) &gt;2x upper limit of normal separately while participants were off tenofovir using univariable logistic regression with generalized estimating equations.</div></div><div><h3>Results</h3><div>Among 192 participants, 161 (83.9 %) were on continuous tenofovir, 22 (11.5 %) discontinued tenofovir, and 9 (4.7 %) never initiated tenofovir during a median follow-up of 14.5 years (IQR = 10.5–14.8). The median proportion of within-participant visits with undetectable HBV DNA was 96.0 % (IQR = 75.0–100) in the continuous group, 100 % (IQR = 84.0–100) in the discontinued tenofovir group (while off tenofovir), and 100 % (IQR = 95.2–100) in the never initiated tenofovir group. Determinants of HBV DNA &gt;2000 IU/mL while people were off tenofovir were detectable HIV RNA (<em>p</em> = 0.041), lower CD4⁺ T-cell count (<em>p</em> = 0.027), HBeAg positive serology (<em>p</em> = 0.004) and positive hepatitis D serology (<em>p</em> = 0.001). ALT elevation was associated with positive hepatitis C antibody serology (<em>p</em> = 0.012).</div></div><div><h3>Conclusions</h3><div>This proof-of-concept study shows that selected people with HIV-HBV coinfection may not lose virologic control of HBV when off tenofovir. HBV virologic activity while off tenofovir may be more closely associated with uncontrolled HIV infection and positive HBeAg serology.</div></div>","PeriodicalId":17552,"journal":{"name":"Journal of Virus Eradication","volume":"10 4","pages":"Article 100574"},"PeriodicalIF":3.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143105156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"6.2 – 00049 Multivalent CAR T Cell Therapy Shows Superior Potency in Controlling HIV Escape and Replication in BLT Humanized Mice","authors":"F. Severi,&nbsp;D. Bercow,&nbsp;K. Stallings,&nbsp;A. Criswell,&nbsp;F. Pennino,&nbsp;R. Acosta,&nbsp;T. Yang,&nbsp;D. Claiborne","doi":"10.1016/j.jve.2024.100425","DOIUrl":"10.1016/j.jve.2024.100425","url":null,"abstract":"","PeriodicalId":17552,"journal":{"name":"Journal of Virus Eradication","volume":"10 ","pages":"Page 21"},"PeriodicalIF":3.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143128836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}