Journal of Virus Eradication最新文献_第6页

7.2 – 00123 Peptide-induced apoptosis of latently infected cells and reduction of the HIV reservoir in people living with HIV: preliminary results of a clinical trial

IF 3.5 4区医学

Journal of Virus Eradication Pub Date : 2024-12-01 DOI: 10.1016/j.jve.2024.100431

R. Sobhie Diaz, M. Schechter, D. Elbirt, E. Naftali, J.T. Maricato, M.V. de Almeida Baptista, J. Galinskas, D. Dias, A. Bassini, N. Lisovoder, J.R. Hunter, E. Finkelshtein

引用次数: 0

PP1.17 – 00054 Optimizing Detection of HIV-1 Infected Cells: A Novel Bioinformatics Pipeline Leveraging Kraken for Single-Cell Multiomics Datasets

IF 3.5 4区医学

Journal of Virus Eradication Pub Date : 2024-12-01 DOI: 10.1016/j.jve.2024.100466

L. Garrido-Sanz, L.B. Soriaga, E. Wong, M.C. Puertas, J. Dalmau, P. Coll, B. Mothe, B. Clotet, A. Telenti, J. Martinez-Picado, S. Morón-López

引用次数: 0

4.2 – 00027 Secondary cytotoxicity of memory CD8+ T cells targeting autologous HIV during treated chronic infection is associated with suppression of provirus and of recrudescent viremia

IF 3.5 4区医学

Journal of Virus Eradication Pub Date : 2024-12-01 DOI: 10.1016/j.jve.2024.100413

D.R. Collins, M.J. Olatotse, E. Mazzola, M. Sagar, B.D. Walker, A. Tsibris

引用次数: 0

PP1.14 – 00005 Q4ddPCR - A New High-Throughput Multicolor Droplet Digital PCR Assay for Precise Intact Reservoir Quantification

IF 3.5 4区医学

Journal of Virus Eradication Pub Date : 2024-12-01 DOI: 10.1016/j.jve.2024.100463

R. Scheck, T.T. Huynh, M. Melzer, G. Gladkov, L. Buchauer, R.B. Jones, C. Gaebler

引用次数: 0

PP3.4 – 00100 Retinoids enhance NK effector functions against HIV infected CD4 T cells

IF 3.5 4区医学

Journal of Virus Eradication Pub Date : 2024-12-01 DOI: 10.1016/j.jve.2024.100485

E. Mcmahon, R. Lynch, A. Bosque

引用次数: 0

PP3.5 – 00089 Investigating novel designed and synthesized PKC modulators for use in “kick and kill” HIV cure strategies

IF 3.5 4区医学

Journal of Virus Eradication Pub Date : 2024-12-01 DOI: 10.1016/j.jve.2024.100486

J. Morán, Z. Gentry, O. Mcateer, J. Hamad, J.T. Kim, P. Wender, J. Zack, M. Marsden

引用次数: 0

PP3.7 – 00002 Towards a functional cure for HIV-1 infection: BRD4 modulator ZL0580 and LEDGINs additively block and lock HIV-1 transcription

IF 3.5 4区医学

Journal of Virus Eradication Pub Date : 2024-12-01 DOI: 10.1016/j.jve.2024.100488

E. Pellaers, A. Denis, W. Hannes, A. Bhat, Z. Debyser

引用次数: 0

1.3 – 00084 Persistence of HIV genomes in bacteria-specific CD4+ T cells during ART

IF 3.5 4区医学

Journal of Virus Eradication Pub Date : 2024-12-01 DOI: 10.1016/j.jve.2024.100396

A. Espinosa Ortiz, R. Fromentin, S.G. Deeks, J.P. Routy, N. Chomont

引用次数: 0

Bypassing primary antiretroviral therapy centres in Sub-Saharan Africa: An integrative review of the theoretical and empirical literature

IF 3.5 4区医学

Journal of Virus Eradication Pub Date : 2024-12-01 DOI: 10.1016/j.jve.2024.100580

Maximillian Kolbe Domapielle , Sadat Zakari Abugbila , Marshall Kala

{"title":"Bypassing primary antiretroviral therapy centres in Sub-Saharan Africa: An integrative review of the theoretical and empirical literature","authors":"Maximillian Kolbe Domapielle , Sadat Zakari Abugbila , Marshall Kala","doi":"10.1016/j.jve.2024.100580","DOIUrl":"10.1016/j.jve.2024.100580","url":null,"abstract":"<div><div>The uptake of antiretroviral therapy (ART) is critical to meeting the global HIV treatment goal of 95-95-95 by 2025. Although a few Sub-Saharan African countries have already achieved this target, the prevalence of bypassing primary ART centres in many countries in the subregion has negative implications for ART uptake and use. This study used the access to health services framework to analyse the evidence and factors contributing to bypassing primary ART centres by individuals in the sub-region seeking HIV care and support. We found compelling evidence of the prevalence of ART clients bypassing their primary ART centres in search of specialised care in higher-tiered health facilities. Others use bypassing to conceal their HIV-positive status to avoid social stigma. We argue that introducing specialised and differentiated ART at the primary level of care can address this phenomenon. While we anticipate that this measure will satisfy clients' desire for specialised care, we recommend enhancing public awareness about the effectiveness of ART to reduce stigma towards ART clients. Legislation and strict enforcement of anti-HIV stigma laws, which outlaw and criminalise stigmatising people living with HIV (PLHIV), could potentially be an effective stigma-deterring measure. To complement this effort, PLHIV should be empowered to understand legislative instruments and steps to take when confidentiality and discriminatory issues arise. We recommend further research in Sub-Saharan Africa to investigate the relationship between bypassing primary ART centres and client adherence. The findings will help design appropriate strategies to increase ART uptake at primary ART centres.</div></div>","PeriodicalId":17552,"journal":{"name":"Journal of Virus Eradication","volume":"10 4","pages":"Article 100580"},"PeriodicalIF":3.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11751520/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143022971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

8.6 – 00097 Increased HIV-1 proviral reactivation and reservoir size in people with HIV on anticancer treatment

IF 3.5 4区医学

Journal of Virus Eradication Pub Date : 2024-12-01 DOI: 10.1016/j.jve.2024.100441

L. Perez-Blazquez, E. Valencia, L. Martin-Carbonero, E. Mateos, M. Coiras

引用次数: 0