Journal of Virus Eradication最新文献

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2.5 – 00074 Propagation of HIV reservoir clones reveals functional heterogeneity, suggesting diverse mechanisms of persistence HIV储存库克隆的繁殖显示出功能的异质性,提示了不同的持久性机制
IF 3.5 4区 医学
Journal of Virus Eradication Pub Date : 2024-12-01 DOI: 10.1016/j.jve.2024.100404
I. Ferreira, A. Herrera, T.T. Huynh, E. Stone, N. Linden, C. Bittar Oliva, M. Caskey, M. Nussenzweig, R.B. Jones
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引用次数: 0
2.4 – 00143 Selective export of HIV mRNAs is regulated by compartmentalized interactions with Sam, PTB and mA RNA methylation in reactivated latently infected T-cells 2.4 - 00143在重新激活的潜伏感染的t细胞中,HIV mrna的选择性输出受Sam、PTB和mA RNA甲基化的区隔相互作用的调控
IF 3.5 4区 医学
Journal of Virus Eradication Pub Date : 2024-12-01 DOI: 10.1016/j.jve.2024.100403
F. Kizito, E. Honeycutt, F. Ye, T. Sweet, A. Agaponova, J. Karn
{"title":"2.4 – 00143 Selective export of HIV mRNAs is regulated by compartmentalized interactions with Sam, PTB and mA RNA methylation in reactivated latently infected T-cells","authors":"F. Kizito, E. Honeycutt, F. Ye, T. Sweet, A. Agaponova, J. Karn","doi":"10.1016/j.jve.2024.100403","DOIUrl":"10.1016/j.jve.2024.100403","url":null,"abstract":"","PeriodicalId":17552,"journal":{"name":"Journal of Virus Eradication","volume":"10 ","pages":"Page 6"},"PeriodicalIF":3.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143176101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
2.3 – 00078 Detection of HIV-1 antisense transcripts in donor samples before and during ART 2.3 - 00078在抗逆转录病毒治疗前和治疗期间供体样本中HIV-1反义转录物的检测
IF 3.5 4区 医学
Journal of Virus Eradication Pub Date : 2024-12-01 DOI: 10.1016/j.jve.2024.100402
A. Capoferri, T.O. Famuyiwa, R. Sklutuis, S. Pathak, J.L. Groebner, R. Li, J.W. Rausch, S.G. Deeks, J.W. Mellors, J.M. Coffin, F. Romerio, M.F. Kearney
{"title":"2.3 – 00078 Detection of HIV-1 antisense transcripts in donor samples before and during ART","authors":"A. Capoferri, T.O. Famuyiwa, R. Sklutuis, S. Pathak, J.L. Groebner, R. Li, J.W. Rausch, S.G. Deeks, J.W. Mellors, J.M. Coffin, F. Romerio, M.F. Kearney","doi":"10.1016/j.jve.2024.100402","DOIUrl":"10.1016/j.jve.2024.100402","url":null,"abstract":"","PeriodicalId":17552,"journal":{"name":"Journal of Virus Eradication","volume":"10 ","pages":"Page 5"},"PeriodicalIF":3.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143176155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PP1.1 – 00164 Nuclear retention of unspliced HIV-1 RNA as a novel reversible posttranscriptional block in latency 未剪接HIV-1 RNA的核保留作为一种新的可逆的潜伏期转录后阻断
IF 3.5 4区 医学
Journal of Virus Eradication Pub Date : 2024-12-01 DOI: 10.1016/j.jve.2024.100450
A. Dorman, M. Bendoumou, A. Valaitiene, J. Wadas, H. Ali, A. Dutilleul, P. Maiuri, L. Nestola, M. Bociaga-Jasik, G. Mchantaf, V. Avettand-Fenoël, A. Marcello, K. Pyrc, A.O. Pasternak, C.V. Lint, A. Kula-Pacurar
{"title":"PP1.1 – 00164 Nuclear retention of unspliced HIV-1 RNA as a novel reversible posttranscriptional block in latency","authors":"A. Dorman, M. Bendoumou, A. Valaitiene, J. Wadas, H. Ali, A. Dutilleul, P. Maiuri, L. Nestola, M. Bociaga-Jasik, G. Mchantaf, V. Avettand-Fenoël, A. Marcello, K. Pyrc, A.O. Pasternak, C.V. Lint, A. Kula-Pacurar","doi":"10.1016/j.jve.2024.100450","DOIUrl":"10.1016/j.jve.2024.100450","url":null,"abstract":"","PeriodicalId":17552,"journal":{"name":"Journal of Virus Eradication","volume":"10 ","pages":"Page 39"},"PeriodicalIF":3.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143179383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
6.1 – 00142 Durable Viral Load Remission in SHIV-infected Macaques after Vectored Delivery of Monoclonal Antibodies 载体递送单克隆抗体后shiv感染猕猴病毒载量持续缓解
IF 3.5 4区 医学
Journal of Virus Eradication Pub Date : 2024-12-01 DOI: 10.1016/j.jve.2024.100424
J.M. Martinez-Navio, S.P. Fuchs, P.G. Mondragon, R. Zabizhin, D.E. Mendes, C.P.R. Muniz, K. Weisgrau, J. Furlott, E. Alexander, E.G. Rakasz, G. Gao, J.D. Lifson, R.C. Desrosiers
{"title":"6.1 – 00142 Durable Viral Load Remission in SHIV-infected Macaques after Vectored Delivery of Monoclonal Antibodies","authors":"J.M. Martinez-Navio, S.P. Fuchs, P.G. Mondragon, R. Zabizhin, D.E. Mendes, C.P.R. Muniz, K. Weisgrau, J. Furlott, E. Alexander, E.G. Rakasz, G. Gao, J.D. Lifson, R.C. Desrosiers","doi":"10.1016/j.jve.2024.100424","DOIUrl":"10.1016/j.jve.2024.100424","url":null,"abstract":"","PeriodicalId":17552,"journal":{"name":"Journal of Virus Eradication","volume":"10 ","pages":"Pages 20-21"},"PeriodicalIF":3.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143128835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PP1.11 – 00021 Impact of HIV-1 Tat and TAR Sequence Diversity on Clinical and Reservoir Characteristics HIV-1 Tat和TAR序列多样性对临床和病毒库特征的影响
IF 3.5 4区 医学
Journal of Virus Eradication Pub Date : 2024-12-01 DOI: 10.1016/j.jve.2024.100460
M.R. Arikatla, N. Sonela, P. Khadka, Z. Tang, E. Benko, C. Kovacs, M. Caskey, R.M. Galiwango, T. Kityamuweesi, P. Buule, S. Tomusange, A. Anok, S.J. Reynolds, T.C. Quinn, J.L. Prodger, A.D. Redd, C. Muzoora, J.E. Haberer, J.N. Martin, D.R. Bangsberg, G.Q. Lee
{"title":"PP1.11 – 00021 Impact of HIV-1 Tat and TAR Sequence Diversity on Clinical and Reservoir Characteristics","authors":"M.R. Arikatla, N. Sonela, P. Khadka, Z. Tang, E. Benko, C. Kovacs, M. Caskey, R.M. Galiwango, T. Kityamuweesi, P. Buule, S. Tomusange, A. Anok, S.J. Reynolds, T.C. Quinn, J.L. Prodger, A.D. Redd, C. Muzoora, J.E. Haberer, J.N. Martin, D.R. Bangsberg, G.Q. Lee","doi":"10.1016/j.jve.2024.100460","DOIUrl":"10.1016/j.jve.2024.100460","url":null,"abstract":"","PeriodicalId":17552,"journal":{"name":"Journal of Virus Eradication","volume":"10 ","pages":"Pages 46-48"},"PeriodicalIF":3.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143131926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
4.5 – 00020 Control of HIV infection is associated with enhanced CD8T cell functionality during consecutive analytical treatment interruptions 在连续的分析治疗中断期间,HIV感染的控制与CD8T细胞功能的增强有关
IF 3.5 4区 医学
Journal of Virus Eradication Pub Date : 2024-12-01 DOI: 10.1016/j.jve.2024.100416
G. Duette, J. Marin-Rojas, S. Cronin, S.G. Deeks, A.D. Kelleher, S. Palmer
{"title":"4.5 – 00020 Control of HIV infection is associated with enhanced CD8T cell functionality during consecutive analytical treatment interruptions","authors":"G. Duette, J. Marin-Rojas, S. Cronin, S.G. Deeks, A.D. Kelleher, S. Palmer","doi":"10.1016/j.jve.2024.100416","DOIUrl":"10.1016/j.jve.2024.100416","url":null,"abstract":"","PeriodicalId":17552,"journal":{"name":"Journal of Virus Eradication","volume":"10 ","pages":"Pages 15-16"},"PeriodicalIF":3.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143140280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Real-life study on the effectiveness and safety of sofosbuvir/velpatasvir-based antiviral agents for hepatitis C eradication in Chinese patients 基于索非布韦/维帕他韦的抗病毒药物在中国丙型肝炎患者根除中的有效性和安全性的现实研究。
IF 3.5 4区 医学
Journal of Virus Eradication Pub Date : 2024-12-01 DOI: 10.1016/j.jve.2024.100571
Jiayi Wang , Lingyao Du , Dongmei Zhang , Chen Zhou , Yilan Zeng , Miao Liu , Xing Cheng , Xiaona Song , Han Chen , Ning Han , Enqiang Chen , Hong Tang
{"title":"Real-life study on the effectiveness and safety of sofosbuvir/velpatasvir-based antiviral agents for hepatitis C eradication in Chinese patients","authors":"Jiayi Wang ,&nbsp;Lingyao Du ,&nbsp;Dongmei Zhang ,&nbsp;Chen Zhou ,&nbsp;Yilan Zeng ,&nbsp;Miao Liu ,&nbsp;Xing Cheng ,&nbsp;Xiaona Song ,&nbsp;Han Chen ,&nbsp;Ning Han ,&nbsp;Enqiang Chen ,&nbsp;Hong Tang","doi":"10.1016/j.jve.2024.100571","DOIUrl":"10.1016/j.jve.2024.100571","url":null,"abstract":"<div><h3>Background</h3><div>Hepatitis C virus (HCV) eradication with sofosbuvir/velpatasvir (SOF/VEL) represents a significant advancement, offering hope for eliminating the virus in diverse patient populations. But real-world data on its effectiveness and safety remains scarce for patients with chronic hepatitis C (CHC) in China, especially those with HCV GT3b, cirrhosis, hepato-cellular carcinoma (HCC), or HCV/hepatitis B (HBV), HCV/HIV, or HCV/HBV/HIV coinfection.</div></div><div><h3>Methods</h3><div>In this real-world prospective observational study, we recruited patients from the West China Hospital and Public Health Clinical Center of Chengdu in China. Patients included adults with with CHC and any genotype (GT), with or without cirrhosis, hepatocellular carcinoma (HCC), HCV/HBV, HCV/HIV, or HCV/HBV/HIV coinfection. Patients were administered SOF/VEL (400/100 mg) ± ribavirin (RBV) once daily for 12 weeks. The primary efficacy endpoint was sustained virological response at post-treatment week 12 (SVR12). Adverse events (AEs) were evaluated during treatment.</div></div><div><h3>Results</h3><div>The study included 483 patients with HCV genotypes 1, 2, 3, 6 and uncertain ones. Among them, 35.4 % (171/483, ITT) and 36.7 % (166/452, mITT) received SOF/VEL + RBV. At the end of treatment , 99.2 % (ITT, 479/483) and 99.1 % (mITT, 448/452) of patients had undetectable HCV RNA. SVR12 rates were 92.8 % [intention to treat (ITT), 448/483] and 99.1 % [modified ITT (mITT), 448/452]. In the mITT analysis, SVR12 for patients with HCV GT3b, those with cirrhosis or HCC, and those coinfected with HBV/HIV was 99.2 % (130/131), 99.4 % (168/169), and 97.6 % (40/41), respectively. The albumin-bilirubin (ALBI) (−3.01 <em>vs.</em> −3.18 <em>P</em> &lt; 0.001), Fibrosis-4 (FIB4) Index (2.53 <em>vs.</em> 1.88, <em>P</em> = 0.004) and AST to Platelet Ratio Index (APRI) (0.99 <em>vs.</em> 0.44, <em>P</em> &lt; 0.001) scores showed a significant decrease from baseline to SVR12. No patients experienced grade 3–5 AEs.</div></div><div><h3>Conclusions</h3><div>Although a high proportion of patients included in this study had HCV GT3b, cirrhosis, HCC, or HCV/HBV, HCV/HIV, or HCV/HBV/HIV coinfection, SOF/VEL ± RBV was highly effective and well tolerated in Chinese patients with CHC.</div></div>","PeriodicalId":17552,"journal":{"name":"Journal of Virus Eradication","volume":"10 4","pages":"Article 100571"},"PeriodicalIF":3.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11681871/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142903305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial 10.4 10.4社论。
IF 3.5 4区 医学
Journal of Virus Eradication Pub Date : 2024-12-01 DOI: 10.1016/j.jve.2024.100579
{"title":"Editorial 10.4","authors":"","doi":"10.1016/j.jve.2024.100579","DOIUrl":"10.1016/j.jve.2024.100579","url":null,"abstract":"","PeriodicalId":17552,"journal":{"name":"Journal of Virus Eradication","volume":"10 4","pages":"Article 100579"},"PeriodicalIF":3.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11772947/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143059448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
7.3 – 00050 Profound reduction of HIV-1 reservoir cells over three decades of antiretroviral therapy started in early infancy 7.3 - 00050 从婴儿期开始进行抗逆转录病毒治疗,30 多年来,HIV-1 储库细胞大幅减少
IF 3.5 4区 医学
Journal of Virus Eradication Pub Date : 2024-12-01 DOI: 10.1016/j.jve.2024.100432
K. Luzuriaga, L. Vela, C. Naasz, S. Kalavacherla, L. de Armas, C. Gao, X.G. Yu, S. Pahwa, M. Lichterfeld
{"title":"7.3 – 00050 Profound reduction of HIV-1 reservoir cells over three decades of antiretroviral therapy started in early infancy","authors":"K. Luzuriaga,&nbsp;L. Vela,&nbsp;C. Naasz,&nbsp;S. Kalavacherla,&nbsp;L. de Armas,&nbsp;C. Gao,&nbsp;X.G. Yu,&nbsp;S. Pahwa,&nbsp;M. Lichterfeld","doi":"10.1016/j.jve.2024.100432","DOIUrl":"10.1016/j.jve.2024.100432","url":null,"abstract":"","PeriodicalId":17552,"journal":{"name":"Journal of Virus Eradication","volume":"10 ","pages":"Page 26"},"PeriodicalIF":3.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143180797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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