Journal of Virus Eradication最新文献

{"title":"3.2 – 00080 New PKC Modulator Latency Reversing Agents for depleting persistent HIV reservoirs","authors":"J. Moran, T. Chou, Z.O. Gentry, O.D. Mcateer, J.L. Hamad, J.T. Kim, P.A. Wender, J.A. Zack, M.D. Marsden","doi":"10.1016/j.jve.2024.100407","DOIUrl":"10.1016/j.jve.2024.100407","url":null,"abstract":"","PeriodicalId":17552,"journal":{"name":"Journal of Virus Eradication","volume":"10 ","pages":"Page 9"},"PeriodicalIF":3.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143181918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2.5 – 00074 Propagation of HIV reservoir clones reveals functional heterogeneity, suggesting diverse mechanisms of persistence","authors":"I. Ferreira, A. Herrera, T.T. Huynh, E. Stone, N. Linden, C. Bittar Oliva, M. Caskey, M. Nussenzweig, R.B. Jones","doi":"10.1016/j.jve.2024.100404","DOIUrl":"10.1016/j.jve.2024.100404","url":null,"abstract":"","PeriodicalId":17552,"journal":{"name":"Journal of Virus Eradication","volume":"10 ","pages":"Pages 6-7"},"PeriodicalIF":3.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143176100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2.4 – 00143 Selective export of HIV mRNAs is regulated by compartmentalized interactions with Sam, PTB and mA RNA methylation in reactivated latently infected T-cells","authors":"F. Kizito, E. Honeycutt, F. Ye, T. Sweet, A. Agaponova, J. Karn","doi":"10.1016/j.jve.2024.100403","DOIUrl":"10.1016/j.jve.2024.100403","url":null,"abstract":"","PeriodicalId":17552,"journal":{"name":"Journal of Virus Eradication","volume":"10 ","pages":"Page 6"},"PeriodicalIF":3.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143176101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2.3 – 00078 Detection of HIV-1 antisense transcripts in donor samples before and during ART","authors":"A. Capoferri, T.O. Famuyiwa, R. Sklutuis, S. Pathak, J.L. Groebner, R. Li, J.W. Rausch, S.G. Deeks, J.W. Mellors, J.M. Coffin, F. Romerio, M.F. Kearney","doi":"10.1016/j.jve.2024.100402","DOIUrl":"10.1016/j.jve.2024.100402","url":null,"abstract":"","PeriodicalId":17552,"journal":{"name":"Journal of Virus Eradication","volume":"10 ","pages":"Page 5"},"PeriodicalIF":3.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143176155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PP1.1 – 00164 Nuclear retention of unspliced HIV-1 RNA as a novel reversible posttranscriptional block in latency","authors":"A. Dorman, M. Bendoumou, A. Valaitiene, J. Wadas, H. Ali, A. Dutilleul, P. Maiuri, L. Nestola, M. Bociaga-Jasik, G. Mchantaf, V. Avettand-Fenoël, A. Marcello, K. Pyrc, A.O. Pasternak, C.V. Lint, A. Kula-Pacurar","doi":"10.1016/j.jve.2024.100450","DOIUrl":"10.1016/j.jve.2024.100450","url":null,"abstract":"","PeriodicalId":17552,"journal":{"name":"Journal of Virus Eradication","volume":"10 ","pages":"Page 39"},"PeriodicalIF":3.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143179383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"6.1 – 00142 Durable Viral Load Remission in SHIV-infected Macaques after Vectored Delivery of Monoclonal Antibodies","authors":"J.M. Martinez-Navio, S.P. Fuchs, P.G. Mondragon, R. Zabizhin, D.E. Mendes, C.P.R. Muniz, K. Weisgrau, J. Furlott, E. Alexander, E.G. Rakasz, G. Gao, J.D. Lifson, R.C. Desrosiers","doi":"10.1016/j.jve.2024.100424","DOIUrl":"10.1016/j.jve.2024.100424","url":null,"abstract":"","PeriodicalId":17552,"journal":{"name":"Journal of Virus Eradication","volume":"10 ","pages":"Pages 20-21"},"PeriodicalIF":3.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143128835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PP1.11 – 00021 Impact of HIV-1 Tat and TAR Sequence Diversity on Clinical and Reservoir Characteristics","authors":"M.R. Arikatla, N. Sonela, P. Khadka, Z. Tang, E. Benko, C. Kovacs, M. Caskey, R.M. Galiwango, T. Kityamuweesi, P. Buule, S. Tomusange, A. Anok, S.J. Reynolds, T.C. Quinn, J.L. Prodger, A.D. Redd, C. Muzoora, J.E. Haberer, J.N. Martin, D.R. Bangsberg, G.Q. Lee","doi":"10.1016/j.jve.2024.100460","DOIUrl":"10.1016/j.jve.2024.100460","url":null,"abstract":"","PeriodicalId":17552,"journal":{"name":"Journal of Virus Eradication","volume":"10 ","pages":"Pages 46-48"},"PeriodicalIF":3.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143131926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"4.5 – 00020 Control of HIV infection is associated with enhanced CD8T cell functionality during consecutive analytical treatment interruptions","authors":"G. Duette, J. Marin-Rojas, S. Cronin, S.G. Deeks, A.D. Kelleher, S. Palmer","doi":"10.1016/j.jve.2024.100416","DOIUrl":"10.1016/j.jve.2024.100416","url":null,"abstract":"","PeriodicalId":17552,"journal":{"name":"Journal of Virus Eradication","volume":"10 ","pages":"Pages 15-16"},"PeriodicalIF":3.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143140280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-life study on the effectiveness and safety of sofosbuvir/velpatasvir-based antiviral agents for hepatitis C eradication in Chinese patients","authors":"Jiayi Wang ,&nbsp;Lingyao Du ,&nbsp;Dongmei Zhang ,&nbsp;Chen Zhou ,&nbsp;Yilan Zeng ,&nbsp;Miao Liu ,&nbsp;Xing Cheng ,&nbsp;Xiaona Song ,&nbsp;Han Chen ,&nbsp;Ning Han ,&nbsp;Enqiang Chen ,&nbsp;Hong Tang","doi":"10.1016/j.jve.2024.100571","DOIUrl":"10.1016/j.jve.2024.100571","url":null,"abstract":"<div><h3>Background</h3><div>Hepatitis C virus (HCV) eradication with sofosbuvir/velpatasvir (SOF/VEL) represents a significant advancement, offering hope for eliminating the virus in diverse patient populations. But real-world data on its effectiveness and safety remains scarce for patients with chronic hepatitis C (CHC) in China, especially those with HCV GT3b, cirrhosis, hepato-cellular carcinoma (HCC), or HCV/hepatitis B (HBV), HCV/HIV, or HCV/HBV/HIV coinfection.</div></div><div><h3>Methods</h3><div>In this real-world prospective observational study, we recruited patients from the West China Hospital and Public Health Clinical Center of Chengdu in China. Patients included adults with with CHC and any genotype (GT), with or without cirrhosis, hepatocellular carcinoma (HCC), HCV/HBV, HCV/HIV, or HCV/HBV/HIV coinfection. Patients were administered SOF/VEL (400/100 mg) ± ribavirin (RBV) once daily for 12 weeks. The primary efficacy endpoint was sustained virological response at post-treatment week 12 (SVR12). Adverse events (AEs) were evaluated during treatment.</div></div><div><h3>Results</h3><div>The study included 483 patients with HCV genotypes 1, 2, 3, 6 and uncertain ones. Among them, 35.4 % (171/483, ITT) and 36.7 % (166/452, mITT) received SOF/VEL + RBV. At the end of treatment , 99.2 % (ITT, 479/483) and 99.1 % (mITT, 448/452) of patients had undetectable HCV RNA. SVR12 rates were 92.8 % [intention to treat (ITT), 448/483] and 99.1 % [modified ITT (mITT), 448/452]. In the mITT analysis, SVR12 for patients with HCV GT3b, those with cirrhosis or HCC, and those coinfected with HBV/HIV was 99.2 % (130/131), 99.4 % (168/169), and 97.6 % (40/41), respectively. The albumin-bilirubin (ALBI) (−3.01 <em>vs.</em> −3.18 <em>P</em> &lt; 0.001), Fibrosis-4 (FIB4) Index (2.53 <em>vs.</em> 1.88, <em>P</em> = 0.004) and AST to Platelet Ratio Index (APRI) (0.99 <em>vs.</em> 0.44, <em>P</em> &lt; 0.001) scores showed a significant decrease from baseline to SVR12. No patients experienced grade 3–5 AEs.</div></div><div><h3>Conclusions</h3><div>Although a high proportion of patients included in this study had HCV GT3b, cirrhosis, HCC, or HCV/HBV, HCV/HIV, or HCV/HBV/HIV coinfection, SOF/VEL ± RBV was highly effective and well tolerated in Chinese patients with CHC.</div></div>","PeriodicalId":17552,"journal":{"name":"Journal of Virus Eradication","volume":"10 4","pages":"Article 100571"},"PeriodicalIF":3.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11681871/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142903305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial 10.4","authors":"","doi":"10.1016/j.jve.2024.100579","DOIUrl":"10.1016/j.jve.2024.100579","url":null,"abstract":"","PeriodicalId":17552,"journal":{"name":"Journal of Virus Eradication","volume":"10 4","pages":"Article 100579"},"PeriodicalIF":3.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11772947/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143059448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}