Journal of Vascular Research最新文献_第3页

Accumulation of Carbamylation-Derived Products in Aneurysmal Aorta. 动脉瘤主动脉中氨甲酰化衍生产物的积累

IF 1.7 4区医学

Journal of Vascular Research Pub Date : 2024-01-01 Epub Date: 2024-01-19 DOI: 10.1159/000534613

Manon Doué, Guillaume Marques, Anaïs Okwieka, Laëtitia Gorisse, Christine Piétrement, Philippe Gillery, Stéphane Jaisson

{"title":"Accumulation of Carbamylation-Derived Products in Aneurysmal Aorta.","authors":"Manon Doué, Guillaume Marques, Anaïs Okwieka, Laëtitia Gorisse, Christine Piétrement, Philippe Gillery, Stéphane Jaisson","doi":"10.1159/000534613","DOIUrl":"10.1159/000534613","url":null,"abstract":"Introduction: Carbamylation is a nonenzymatic post-translational modification of proteins characterized by the binding of isocyanic acid to amino groups of proteins, which leads to the alteration of their properties. An increase in serum carbamylation-derived products, including homocitrulline (HCit), has been shown to be associated with the development of cardiovascular diseases.Methods: HCit was quantified by LC-MS/MS within extracts of aneurysmal and control human aortas. A mouse model of aortic aneurysm (ApoE-/- mice perfused with angiotensin II and fed with sodium cyanate) was used to evaluate the role of carbamylation in aneurysm development.Results: HCit quantification showed a greater heterogeneity of values in aneurysmal aortas in comparison with control ones. At the maximum diameter of dilation, HCit values were significantly higher (+94%, p < 0.05) compared with less dilated areas. No differences were observed according to aneurysm size or when comparing ruptured and unruptured aneurysms. No significant effect of carbamylation on aneurysm development was observed using the animal model.Conclusions: These results evidenced the accumulation of HCit within aneurysmal aortas but do not allow concluding about the exact participation of protein carbamylation in the development of human abdominal aortic aneurysms.","PeriodicalId":17530,"journal":{"name":"Journal of Vascular Research","volume":" ","pages":"51-58"},"PeriodicalIF":1.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139513120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expression of Concern. 表达关切。

IF 1.7 4区医学

Journal of Vascular Research Pub Date : 2024-01-01 Epub Date: 2023-12-15 DOI: 10.1159/000535557

引用次数: 0

Plasma Volume Oscillations during Fluid Therapy in Humans. 人体输液治疗过程中的血浆容量振荡。

IF 1.8 4区医学

Journal of Vascular Research Pub Date : 2024-01-01 Epub Date: 2023-12-14 DOI: 10.1159/000535376

Robert G Hahn

{"title":"Plasma Volume Oscillations during Fluid Therapy in Humans.","authors":"Robert G Hahn","doi":"10.1159/000535376","DOIUrl":"10.1159/000535376","url":null,"abstract":"Introduction: Oscillations are frequently observed on plasma dilution curves during intravenous fluid therapy. This study aimed to examine how common these oscillations are and what they represent.Methods: Fourier transforms were used to analyze the residuals obtained during fitting of a volume kinetic model to 269 plasma dilution curves. Oscillating patterns were identified in two-thirds of the fluid infusion experiments.Results: The wave frequency usually had a dominating frequency of 1 h or multiples thereof. The wave amplitudes varied between 1% and 4% of the plasma volume. The \"peak-to-peak\" amplitudes were then twice as large, which corresponded to blood volume changes of 60-240 mL. A population kinetic analysis of the distribution of infused fluid between body fluid compartments was then applied to search for clues that could explain the oscillations. This analysis showed that amplitudes >1.5% were associated with doubled turnover of fluid in a fast-exchange interstitial fluid compartment and, together with data on plasma albumin, suggested that oscillations might represent bursts of efferent lymph.Conclusions: Oscillations with very low frequency were often observed on plasma dilution-time curves obtained during fluid therapy. They were associated with fast turnover of interstitial fluid and can possibly have resulted from accelerated lymphatic flow.","PeriodicalId":17530,"journal":{"name":"Journal of Vascular Research","volume":" ","pages":"16-25"},"PeriodicalIF":1.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10836926/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138805884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Toll-Like Receptor 2 Attenuates the Formation and Progression of Angiotensin II-Induced Abdominal Aortic Aneurysm in ApoE-/- Mice. Toll-Like Receptor 2 可减轻血管紧张素 II 诱导的载脂蛋白E-/-小鼠腹主动脉瘤的形成和发展。

IF 1.8 4区医学

Journal of Vascular Research Pub Date : 2024-01-01 Epub Date: 2024-10-28 DOI: 10.1159/000541651

Yali Zhang, Jessamyn Bagley, Ho-Jin Park, Xuehong Cao, Elena Maganto-Garcia, Andrew Lichtman, Debbie Beasley, Jonas B Galper

{"title":"Toll-Like Receptor 2 Attenuates the Formation and Progression of Angiotensin II-Induced Abdominal Aortic Aneurysm in ApoE-/- Mice.","authors":"Yali Zhang, Jessamyn Bagley, Ho-Jin Park, Xuehong Cao, Elena Maganto-Garcia, Andrew Lichtman, Debbie Beasley, Jonas B Galper","doi":"10.1159/000541651","DOIUrl":"10.1159/000541651","url":null,"abstract":"Introduction: We demonstrated Toll-like receptor (TLR) 4 in the pathogenesis of angiotensin II (AngII)-mediated abdominal aortic aneurysm (AAA) formation. Here, we study TLR2 in the AAA formation.Methods: Male ApoE-/- and ApoE-/-TLR2-/- mice were treated with AngII. Mice were injected with the TLR2 agonist Pam3CSK4. The incidence and severity of AAA were determined. MCP-1, MCP-5, RANTES, CXCL10, CCR5, and CXCR3 were analyzed. M1 and M2 macrophages in the aorta were detected by flow cytometry.Results: These studies demonstrated an increase in AAA formation in TLR2-/- mice and a decrease by Pam3CSK4. Pam3CSK4 decreased the ratio of M1/M2 and the levels of RANTES, CXCL10, CCR5, and CXCR3. Furthermore, Pam3CSK4 treatment 1 week following AngII retarded the progression of AAA.Conclusion: These data demonstrated a protective effect of TLR2 signaling on AAA in association with a decrease in the ratio of M1 to M2 macrophages and the expression of chemokines and their receptors. Furthermore, the treatment of Pam3CSK4 after AngII demonstrated a marked retardation of lesion progression. Given the fact that most AAA patients are detected late in the disease process, these findings suggest that TLR2 stimulation may play a therapeutic role in retarding disease progression.","PeriodicalId":17530,"journal":{"name":"Journal of Vascular Research","volume":" ","pages":"304-317"},"PeriodicalIF":1.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11651225/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142522250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Autophagy Induced by Low Shear Stress Leads to Endothelial Glycocalyx Disruption. 低剪切应力诱导的自噬导致内皮细胞糖萼破坏

IF 1.7 4区医学

Journal of Vascular Research Pub Date : 2024-01-01 Epub Date: 2024-03-19 DOI: 10.1159/000537772

Lina Lin, Wei Gao, Linya Feng, Chundong Wang, Ruiqi Yang, Weijian Wang, Qiaolin Wu

{"title":"Autophagy Induced by Low Shear Stress Leads to Endothelial Glycocalyx Disruption.","authors":"Lina Lin, Wei Gao, Linya Feng, Chundong Wang, Ruiqi Yang, Weijian Wang, Qiaolin Wu","doi":"10.1159/000537772","DOIUrl":"10.1159/000537772","url":null,"abstract":"Introduction: Previous studies have confirmed that low shear stress (LSS) induces glycocalyx disruption, leading to endothelial dysfunction. However, the role of autophagy in LSS-induced glycocalyx disruption and relevant mechanism are not clear. In this study, we hypothesized that LSS may promote autophagy, disrupting the endothelium glycocalyx.Methods: Human umbilical vein endothelial cells were subjected to physiological shear stress and LSS treatments, followed by the application of autophagy inducers and inhibitors. Additionally, cells were treated with specific matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) inhibitor. The expression of autophagic markers, glycocalyx, MMP-2, and MMP-9 was measured.Results: LSS impacted the expression of endothelium autophagy markers, increasing the expression of LC3II.LC3I-1 and Beclin-1, and decreasing the levels of p62, accompanied by glycocalyx disturbance. Moreover, LSS upregulated the expression of MMP-2 and MMP-9 and downregulated the levels of syndecan-1 and heparan sulfate (HS). Additionally, expression of MMP-2 and MMP-9 was increased by an autophagy promoter but was decreased by autophagy inhibitor treatment under LSS. Autophagy and MMP-2 and MMP-9 further caused glycocalyx disruption.Conclusion: LSS promotes autophagy, leading to glycocalyx disruption. Autophagy increases the expression of MMP-2 and MMP-9, which are correlated with the glycocalyx destruction induced by LSS.","PeriodicalId":17530,"journal":{"name":"Journal of Vascular Research","volume":" ","pages":"77-88"},"PeriodicalIF":1.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140175185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Regulation of Skeletal Muscle Resistance Arteriolar Tone: Temporal Variability in Vascular Responses. 骨骼肌阻力动脉张力的调节：血管反应的时空变异性。

IF 1.8 4区医学

Journal of Vascular Research Pub Date : 2024-01-01 Epub Date: 2024-10-03 DOI: 10.1159/000541169

Brayden D Halvorson, Aaron D Ward, Donna Murrell, James C Lacefield, Robert W Wiseman, Daniel Goldman, Jefferson C Frisbee

{"title":"Regulation of Skeletal Muscle Resistance Arteriolar Tone: Temporal Variability in Vascular Responses.","authors":"Brayden D Halvorson, Aaron D Ward, Donna Murrell, James C Lacefield, Robert W Wiseman, Daniel Goldman, Jefferson C Frisbee","doi":"10.1159/000541169","DOIUrl":"10.1159/000541169","url":null,"abstract":"Introduction: A full understanding of the integration of the mechanisms of vascular tone regulation requires an interrogation of the temporal behavior of arterioles across vasoactive challenges. Building on previous work, the purpose of the present study was to start to interrogate the temporal nature of arteriolar tone regulation with physiological stimuli.Methods: We determined the response rate of ex vivo proximal and in situ distal resistance arterioles when challenged by one-, two-, and three-parameter combinations of five major physiological stimuli (norepinephrine, intravascular pressure, oxygen, adenosine [metabolism], and intralumenal flow). Predictive machine learning models determined which factors were most influential in controlling the rate of arteriolar responses.Results: Results indicate that vascular response rate is dependent on the intensity of the stimulus used and can be severely hindered by altered environments, caused by application of secondary or tertiary stimuli. Advanced analytics suggest that adrenergic influences were dominant in predicting proximal arteriolar response rate compared to metabolic influences in distal arterioles.Conclusion: These data suggest that the vascular response rate to physiologic stimuli can be strongly influenced by the local environment. Translating how these effects impact vascular networks is imperative for understanding how the microcirculation appropriately perfuses tissue across conditions.","PeriodicalId":17530,"journal":{"name":"Journal of Vascular Research","volume":" ","pages":"269-297"},"PeriodicalIF":1.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11652243/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142372206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cerebral Cortical Vasodilation via Nicotinic Receptors by Heated Tobacco Product Aerosol Extract in Rats. 加热烟草制品气溶胶提取物通过尼古丁受体对大鼠大脑皮层血管的扩张作用

IF 1.8 4区医学

Journal of Vascular Research Pub Date : 2024-01-01 Epub Date: 2024-11-05 DOI: 10.1159/000541726

Sae Uchida, Jura Moriya, Daichi Morihara, Mayura Shimura, Fusako Kagitani

{"title":"Cerebral Cortical Vasodilation via Nicotinic Receptors by Heated Tobacco Product Aerosol Extract in Rats.","authors":"Sae Uchida, Jura Moriya, Daichi Morihara, Mayura Shimura, Fusako Kagitani","doi":"10.1159/000541726","DOIUrl":"10.1159/000541726","url":null,"abstract":"Introduction: Smoking increases the risk of lung cancer due to a number of components of smoke. The use of novel heated tobacco products (HTPs), alternative to conventional combustion cigarettes, has increased in recent years. However, the in vivo biological effects of HTPs are poorly understood. This study aimed to clarify the acute effects of injecting aerosol extract prepared from an HTP on regional cerebral blood flow (rCBF) in rat cortex by comparing them to the effects of injecting smoke extract prepared from conventional combustible cigarettes.Methods: In urethane anesthetized rats, rCBF was measured using laser speckle contrast imaging simultaneously with arterial pressure.Results: Both cigarette smoke extract and HTP aerosol extract, at a dose equivalent to 30 μg nicotine/kg, injected intravenously, increased cortical rCBF without changing arterial pressure. The magnitude and time course of the increased rCBF response to both extracts were similar throughout the cortical area, and the rCBF increases were all abolished by dihydro-β-erythroidine, an α4β2-preferring nicotinic acetylcholine receptor (nAChR) antagonist.Conclusion: In conclusion, our study demonstrated that the effect of injecting aerosol extract prepared from an HTP, an acute increase in cortical rCBF, is mediated via activation of α4β2-like neuronal nAChRs in the brain.","PeriodicalId":17530,"journal":{"name":"Journal of Vascular Research","volume":" ","pages":"318-326"},"PeriodicalIF":1.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11651226/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142583763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Scoping Review: Integration of the Major Mechanisms Underlying the Regulation of Arteriolar Tone. 范围审查：整合动脉调节的主要机制。

IF 1.8 4区医学

Journal of Vascular Research Pub Date : 2024-01-01 Epub Date: 2023-12-14 DOI: 10.1159/000535404

Brayden D Halvorson, Moeiz Ahmed, Sophie J Huang, Jefferson C Frisbee

{"title":"Scoping Review: Integration of the Major Mechanisms Underlying the Regulation of Arteriolar Tone.","authors":"Brayden D Halvorson, Moeiz Ahmed, Sophie J Huang, Jefferson C Frisbee","doi":"10.1159/000535404","DOIUrl":"10.1159/000535404","url":null,"abstract":"Background: Cardiovascular diseases remain the leading cause of morbidity and mortality worldwide. Arteriolar tone regulation plays a critical role in maintaining appropriate organ blood flow and perfusion distribution, which is vital for both vascular and overall health.Summary: This scoping review aimed to explore the interplay between five major regulators of arteriolar tone: metabolism (adenosine), adrenergic control (norepinephrine), myogenic activation (intravascular pressure), perivascular oxygen tension, and intraluminal flow rates. Specifically, the aim was to address how arteriolar reactivity changes in the presence of other vasoactive stimuli and by what mechanisms. The review focused on animal studies that investigated the impact of combining two or more of these stimuli on arteriolar diameter. Overall, 848 articles were identified through MEDLINE and EMBASE database searches, and 38 studies were included in the final review.Key messages: The results indicate that arteriolar reactivity is influenced by multiple factors, including competitive processes, structural limitations, and indirect interactions among stimuli. Additionally, the review identified a lack of research involving female animal models and limited insight into the interaction of molecular signaling pathways, which represent gaps in the literature.","PeriodicalId":17530,"journal":{"name":"Journal of Vascular Research","volume":" ","pages":"1-15"},"PeriodicalIF":1.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138805885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preserving Endothelial Integrity in Human Saphenous Veins during Preparation for Coronary Bypass Surgery. 在准备冠状动脉搭桥手术期间保持人体无隐静脉内皮的完整性。

IF 1.7 4区医学

Journal of Vascular Research Pub Date : 2024-01-01 Epub Date: 2024-01-12 DOI: 10.1159/000535843

Meghan W Sedovy, Xinyan Leng, Farwah Iqbal, Mark C Renton, Melissa Leaf, Kailynn Roberts, Arya Malek, W Scott Arnold, David A Wyatt, Cynthia W Choate, Joseph F Rowe, Joseph W Baker, Scott R Johnstone, Mark Joseph

{"title":"Preserving Endothelial Integrity in Human Saphenous Veins during Preparation for Coronary Bypass Surgery.","authors":"Meghan W Sedovy, Xinyan Leng, Farwah Iqbal, Mark C Renton, Melissa Leaf, Kailynn Roberts, Arya Malek, W Scott Arnold, David A Wyatt, Cynthia W Choate, Joseph F Rowe, Joseph W Baker, Scott R Johnstone, Mark Joseph","doi":"10.1159/000535843","DOIUrl":"10.1159/000535843","url":null,"abstract":"Introduction: While multiple factors influence coronary artery bypass graft (CABG) success rates, preserving saphenous vein endothelium during surgery may improve patency. Standard preparations include saphenous vein preparation in heparinized saline (saline) which can result in endothelial loss and damage. Here, we investigated the impact of preparing saphenous graft vessels in heparinized patient blood (blood) versus saline.Methods: Saphenous vein tissues from a total of 23 patients undergoing CABG were split into 2 groups (1) saline and (2) heparinized patient blood. Excess tissue was fixed for analysis immediately following surgery. Level of endothelial coverage, oxidative stress marker 4-hydroxynonenal (4HNE), and oxidative stress protective marker nuclear factor erythroid 2-related factor 2 (NRF2) were evaluated.Results: In saline patient veins, histological analysis revealed a limited luminal layer, suggesting a loss of endothelial cells (ECs). Immunofluorescent staining of EC markers vascular endothelial cadherin (VE-cadherin) and endothelial nitric oxide identified a significant improvement in EC coverage in the blood versus saline groups. Although both treatment groups expressed 4HNE to similar levels, EC blood samples expressed higher levels of NRF2.Conclusion: Our data indicate that use of heparinized patient blood helps preserve the endothelium and promotes vein graft health. This has the potential to improve long-term outcomes in patients.","PeriodicalId":17530,"journal":{"name":"Journal of Vascular Research","volume":" ","pages":"68-76"},"PeriodicalIF":1.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139466636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nitric Oxide/Glucose Transporter Type 4 Pathway Mediates Cardioprotection against Ischemia/Reperfusion Injury under Hyperglycemic and Diabetic Conditions in Rats. 一氧化氮/葡萄糖转运体 4 型通路介导大鼠在高血糖和糖尿病条件下对缺血/再灌注损伤的心脏保护作用

IF 1.8 4区医学

Journal of Vascular Research Pub Date : 2024-01-01 Epub Date: 2024-06-28 DOI: 10.1159/000539461

Aisha Al-Kouh, Fawzi Babiker

{"title":"Nitric Oxide/Glucose Transporter Type 4 Pathway Mediates Cardioprotection against Ischemia/Reperfusion Injury under Hyperglycemic and Diabetic Conditions in Rats.","authors":"Aisha Al-Kouh, Fawzi Babiker","doi":"10.1159/000539461","DOIUrl":"10.1159/000539461","url":null,"abstract":"Introduction: The comorbidities of ischemic heart disease (IHD) and diabetes mellitus (DM) compromise the protection of the diabetic heart from ischemia/reperfusion (I/R) injury. We hypothesized that manipulation of reperfusion injury salvage kinase (RISK) and survivor activating factor enhancement (SAFE) pathways might protect the diabetic heart, and intervention of these pathways could be a new avenue for potentially protecting the diabetic heart.Methods: All hearts were subjected to 30-min ischemia and 30-min reperfusion. During reperfusion, hearts were exposed to molecules proven to protect the heart from I/R injury. The hemodynamic data were collected using suitable software. The infarct size, troponin T levels, and protein levels in hearts were evaluated.Results: Both cyclosporine-A and nitric oxide donor (SNAP) infusion at reperfusion protected 4-week diabetic hearts from I/R injury. However, 6-week diabetic hearts were protected only by SNAP, but not cyclosporin-A. These treatments significantly (p < 0.05) improved cardiac hemodynamics and decreased infarct size.Conclusions: The administration of SNAP to diabetic hearts protected both 4- and 6-week diabetic hearts; however, cyclosporine-A protected only the 4-week diabetic hearts. The eNOS/GLUT-4 pathway executed the SNAP-mediated cardioprotection.","PeriodicalId":17530,"journal":{"name":"Journal of Vascular Research","volume":" ","pages":"179-196"},"PeriodicalIF":1.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141476895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0