Senescent CD4+ T-Cell Phenotypes and Inflammatory Milieu in the Coronary and Systemic Circulation in ST-Elevation Myocardial Infarction: An Exploratory Study.

IF 1.8 4区医学 Q3 PERIPHERAL VASCULAR DISEASE

Journal of Vascular Research Pub Date : 2024-09-18 DOI:10.1159/000541069

Fernanda Bocanegra-Zamora,Fernanda Espinosa-Bautista,Gian M Jiménez-Rodríguez,Felipe Masso,Araceli Paez,Hector Gonzalez-Pacheco,Mariana Patlán,Guering Eid-Lidt,Luis M Amezcua-Guerra

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Abstract

INTRODUCTION In ST-elevation myocardial infarction (STEMI), inflammation is pivotal, with early senescent CD4+CD28null cells implicated in its pathogenesis. However, the functional phenotype of these cells within the coronary circulation remains unclear. METHODS We examined CD4+ cell subpopulations in blood samples from the coronary sinus and vena cava of 24 STEMI patients and the cephalic vein of seven healthy controls. RESULTS Our findings revealed reduced CD4+ cell counts in STEMI patients compared to controls (1,998, 1,275-3,268 vs. 4,278, 3,595-4,449), alongside an increased proportion of CD4+ cells lacking CD28 expression (20.1 vs. 6.1%). These CD4+CD28null cells in STEMI predominantly exhibited a Th1 phenotype (47.8% vs. 6.6%). Intriguingly, no significant differences were detected in CD4+CD28null cells between coronary sinus and vena cava, and cytokine levels in these compartments remained similar. CONCLUSION CD4+CD28null cells are increased in STEMI, mainly polarized toward a Th1 phenotype, and distributed equally between the different vascular beds.

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ST段抬高型心肌梗死患者冠状动脉和全身循环中衰老的CD4+ T细胞表型和炎症环境：一项探索性研究

引言在 ST 段抬高型心肌梗死（STEMI）中，炎症是关键因素，早期衰老的 CD4+CD28null 细胞与心肌梗死的发病机制有关。方法我们检测了 24 名 STEMI 患者冠状窦和腔静脉血液样本中的 CD4+ 细胞亚群，以及 7 名健康对照者的头静脉血液样本。结果我们的研究结果显示，与对照组相比，STEMI 患者的 CD4+ 细胞数量减少（1,998，1,275-3,268 对 4,278，3,595-4,449），同时缺乏 CD28 表达的 CD4+ 细胞比例增加（20.1 对 6.1%）。在 STEMI 中，这些 CD4+CD28 空细胞主要表现出 Th1 表型（47.8% 对 6.6%）。耐人寻味的是，冠状窦和腔静脉中的 CD4+CD28null 细胞没有发现明显差异，而且这些区域的细胞因子水平仍然相似。

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来源期刊

Journal of Vascular Research 医学-生理学

CiteScore

3.40

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： The ''Journal of Vascular Research'' publishes original articles and reviews of scientific excellence in vascular and microvascular biology, physiology and pathophysiology. The scope of the journal covers a broad spectrum of vascular and lymphatic research, including vascular structure, vascular function, haemodynamics, mechanics, cell signalling, intercellular communication, growth and differentiation. JVR''s ''Vascular Update'' series regularly presents state-of-the-art reviews on hot topics in vascular biology. Manuscript processing times are, consistent with stringent review, kept as short as possible due to electronic submission. All articles are published online first, ensuring rapid publication. The ''Journal of Vascular Research'' is the official journal of the European Society for Microcirculation. A biennial prize is awarded to the authors of the best paper published in the journal over the previous two years, thus encouraging young scientists working in the exciting field of vascular biology to publish their findings.