Journal of Tropical Medicine最新文献

{"title":"Preliminary Phytoconstituent Analysis and In Vitro Evaluation of Antibacterial and Antioxidant Activities of <i>Verbascum sinaiticum</i> Benth Leaf Extracts.","authors":"Ayalew Temesgen Wodajo, Birhan Amanie Mekonnen, Shewaye Lakew Mekuria, Gizachew Mulugeta Manahelohe","doi":"10.1155/jotm/6626328","DOIUrl":"10.1155/jotm/6626328","url":null,"abstract":"&lt;p&gt;&lt;p&gt;&lt;i&gt;Verbascum sinaiticum&lt;/i&gt; Benth. commonly known as \"Qetetina\" in Ethiopia, the family Scrophulariaceae has considerable importance in traditional medicine worldwide because of its antioxidant and anti-inflammatory activities. &lt;i&gt;V. sinaiticum&lt;/i&gt; is one of the commonly used traditional medicinal plants in Ethiopia for treating wounds, cancer, and animal trypanosomiasis. Hence, the present study was undertaken to screen the phytochemical constituents and evaluate the antibacterial and antioxidant activity of &lt;i&gt;V. sinaiticum&lt;/i&gt; chloroform and methanol leaf extracts against two Gram-positive bacteria (&lt;i&gt;Staphylococcus aureus&lt;/i&gt; and &lt;i&gt;Streptococcus pneumoniae&lt;/i&gt;) and two Gram-negative bacterial strains (&lt;i&gt;Klebsiella pneumoniae&lt;/i&gt; and &lt;i&gt;Escherichia coli&lt;/i&gt;) by the agar disc well diffusion method. The study revealed the presence of phenols, flavonoids, steroids, saponins, terpenoids, alkaloids, and tannins. Thus, the present investigation was undertaken to estimate total phenols and flavonoids in chloroform and methanol extracts of &lt;i&gt;V. sinaiticum&lt;/i&gt; leaves. In vitro antioxidant activity was also evaluated in the methanol and chloroform extracts using DPPH and FRAP assays. The DPPH assay showed that standard IC&lt;sub&gt;50&lt;/sub&gt; for ascorbic acid (AA) was 23.79 μg/mL, whereas for methanol extract the IC&lt;sub&gt;50&lt;/sub&gt; value was 29.88 μg/mL and 86.38 μg/mL for chloroform extract, while the FRAP assay showed standard IC&lt;sub&gt;50&lt;/sub&gt; value for AA as 46.2 μg/mL, 80.3 µg/mL for methanol extract and 201.2 µg/mL for chloroform extract with &lt;i&gt;p&lt;/i&gt; values &lt; 0.05, which indicates that methanol extract exhibits higher antioxidant activity than chloroform crude extract. The methanolic extracts of &lt;i&gt;V. sinaiticum&lt;/i&gt; leaves showed moderate amounts of total phenolic and flavonoid contents, 7.81 ± 0.14 mg GAE/g (milligrams of gallic acid equivalent) and 14.20 ± 0.98 mg QE/g of dried crude, respectively. Using the agar well diffusion method, the two extracts were evaluated against Gram-positive (&lt;i&gt;S. aureus&lt;/i&gt; and &lt;i&gt;S. pneumonia&lt;/i&gt;) and Gram-negative (&lt;i&gt;Salmonella typhi&lt;/i&gt; and &lt;i&gt;E. coli&lt;/i&gt;) bacterial strains. The leaf extract displayed a greater impact on both Gram-positive bacterial strains and Gram-negative bacterial strains. 21.7 ± 0.6 against &lt;i&gt;E. coli&lt;/i&gt; at concentrations of 100 and 50 μg/mL and 19.7 ± 0.6 against &lt;i&gt;S. typhi&lt;/i&gt; compared to positive control ciprofloxacin 23.6 ± 0.4 and 28.6 ± 0.6, respectively. The minimum inhibitory concentration assay was determined using the concentrations of 100 mg/mL, 50 mg/mL, 25 mg/mL, and 12.5 mg/mL by the agar well diffusion method. All extracts had shown a significant antibacterial activity (&lt;i&gt;p&lt;/i&gt; value &lt; 0.05) within the average inhibition zone ranging from 10.2 ± 1.3 to 21.7 ± 0.6. &lt;i&gt;V. sinaiticum&lt;/i&gt; leaves showed strong antibacterial activities against &lt;i&gt;S. aureus&lt;/i&gt;, &lt;i&gt;S. pneumonia&lt;/i&gt;, &lt;i&gt;E. coli&lt;/i&gt;, and &lt;i&gt;S. typhi&lt;/i&gt;. Therefore, it is evident from this study that the highest t","PeriodicalId":17527,"journal":{"name":"Journal of Tropical Medicine","volume":"2026 ","pages":"6626328"},"PeriodicalIF":2.6,"publicationDate":"2026-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13277388/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148295602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Environmental Factors Influencing Cutaneous Leishmaniasis and Importance of a Newly Designed Sand Fly (Diptera: Psychodidae) Sticky Traps.","authors":"Khurshaid Khan, Nazma Habib Khan, Rahaf Ajaj, Samia Al-Shouli, Nasir Ullah Shah","doi":"10.1155/jotm/5517833","DOIUrl":"10.1155/jotm/5517833","url":null,"abstract":"<p><p>Cutaneous leishmaniasis (CL) is endemic in Khyber Pakhtunkhwa (KP) Province of Pakistan, and exploring its epidemiological status is critical for its control. The current study described the spatial occurrence of CL and its associated risk factors in KP. Records of 5123 confirmed CL patients obtained from 17 district hospitals for the year 2020 revealed that Khyber district hospital had the highest influx of CL patients, followed by North Waziristan and Mardan districts. Additionally, a questionnaire to assess CL risk factors was administered to the heads of 576 randomly selected households across the same 17 districts. Multivariate logistic regression analysis of risk factors showed that education, family size greater than five individuals, information about CL, knowledge of the difference between sand flies and mosquitoes and use of insecticide sprays were risk factors for CL. Adult sand flies were sampled using sticky traps that were placed at variable heights at multiple locations within Mardan and Lower Dir districts. Collections showed that the number captured was maximum at the heights of 30-121 cm above the ground. Risk factors for CL and assessment of specific sand fly nocturnal height activities may assist in developing effective control strategies for CL in the province.</p>","PeriodicalId":17527,"journal":{"name":"Journal of Tropical Medicine","volume":"2026 ","pages":"5517833"},"PeriodicalIF":2.6,"publicationDate":"2026-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13273631/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148277998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experimental Evaluation of Fecal-Mediated Transfer of <i>Salmonella</i> Typhi From <i>Blattella germanica</i> to Mice.","authors":"Dong-Fen Geng, Teng Zhao, Xiao-Hui Liu, Rui-Xiang Zhang, Hao-Tian Yu, Xiao-Li Chen, Dan Xing, Jia-Hong Wu, Chun-Xiao Li","doi":"10.1155/jotm/5010895","DOIUrl":"10.1155/jotm/5010895","url":null,"abstract":"<p><p><i>Blattella germanica</i> (German cockroaches) are recognized as potential carriers of intestinal pathogens, yet their role in delivering human pathogens to mammals via fecal contamination has not been experimentally evaluated. In this study, we established an experimental model using 100 <i>B. germanica</i> infected with a fluorescently labeled <i>Salmonella enterica</i> serovar Typhi Ty21a strain and assessed their ability to contaminate food and water. Fluorescent signals were detected in both midgut tissues and fecal matter of cockroaches within 6 h postinfection, peaking at 1 day (midgut: 4.52 × 10¹⁰ relative fluorescence unit [RFU] and feces: 6.12 × 10⁸ RFU) and persisting up to 7 days. Importantly, cockroach-derived fecal suspensions administered to BALB/c mice resulted in rapid and transient intestinal exposure, with detectable bacterial signals in mouse feces within 30 min (1.13 × 10³ to 1.08 × 10⁴ RFU) and in intestinal tissues for up to 12 h; no fluorescent signal was detected thereafter (up to 7 days). Fluorescence quantification showed a positive correlation with viable bacterial counts (CFUs) (<i>R</i> ² = 0.78, <i>p</i> < 0.05), supporting use of RFU as a proxy for Ty21a sfgfp abundance. Collectively, these findings support the potential role of <i>B. germanica</i> as a mechanical vector that can contaminate food and water and facilitate fecal-oral exposure of mammals to <i>Salmonella</i> under enclosed conditions.</p>","PeriodicalId":17527,"journal":{"name":"Journal of Tropical Medicine","volume":"2026 ","pages":"5010895"},"PeriodicalIF":2.6,"publicationDate":"2026-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13239187/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148199580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Family Pathology in Noma: A Scoping Review of Household-Level Risk Factors in Sub-Saharan Africa.","authors":"Mujtaba Bala, Mohammed Adam Sheikh Abdullahi, Ramat Oyebunmi Braimah, Abdurrazaq Olanrewaju Taiwo, Ibrahim Kayode Suleiman, K Hakki Karagozoglu","doi":"10.1155/jotm/4767171","DOIUrl":"10.1155/jotm/4767171","url":null,"abstract":"<p><strong>Background: </strong>Noma is a neglected tropical disease that predominantly affects young children in sub-Saharan Africa, characterized by rapid orofacial tissue destruction and high mortality. While malnutrition and infections are well-recognized risk factors, less attention has been given to family-level and psychosocial determinants.</p><p><strong>Objectives: </strong>To synthesize existing evidence on the role of family pathology in Noma and identify household-level risk factors affecting disease development and outcomes.</p><p><strong>Methods: </strong>A scoping review was conducted in accordance with PRISMA-ScR guidelines. PubMed and MEDLINE were searched through May 2024 for Noma-specific literature and broader child health studies related to family environment. Data extraction focused on predefined family pathology themes. Narrative synthesis was performed due to the heterogeneity of study designs.</p><p><strong>Results: </strong>Thirty-five studies met the eligibility criteria, including Noma-specific case series, epidemiological reports, and child health literature. Eleven family pathology themes were identified: child developmental stage, family structure, living area, family income, family size, parental education, parental viability, marital conflict, family separation, primary caregiver, and caregiving quality. Poverty, large family size, limited caregiving quality, and psychosocial instability were interconnected, increasing the vulnerability to Noma.</p><p><strong>Conclusion: </strong>Family dysfunction and socioeconomic deprivation contribute significantly to Noma risk. Prevention strategies should integrate family-level interventions, including caregiver education, birth spacing, economic support, and community health outreach. Addressing both biomedical and familial determinants is essential for reducing disease burden.</p>","PeriodicalId":17527,"journal":{"name":"Journal of Tropical Medicine","volume":"2026 ","pages":"4767171"},"PeriodicalIF":2.6,"publicationDate":"2026-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13216661/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148138337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human Metapneumovirus Nucleocapsid Inhibitors Discovery for Targeting Viral Replication and Genome Encapsidation: An In Silico Approach.","authors":"Abdullah R Alzahrani, Talha Jawaid, Maha M Bakhuraysah, Amani A Alrehaili, Hayaa M Alhuthali, Abdullah Yahya Abdullah Alzahrani, Zia Ur Rehman, Abida Khan","doi":"10.1155/jotm/3511825","DOIUrl":"10.1155/jotm/3511825","url":null,"abstract":"<p><p>Human metapneumovirus (HMPV) is a major respiratory pathogen, and its infection is more severe in infants, the elderly, and immunocompromised individuals. Despite its significance, no antiviral drugs are approved to combat HMPV infection. Therefore, it is important to develop drugs that target the nucleocapsid protein, which is crucial for viral replication and genome encapsidation. In this study, computational drug discovery was used to identify new potential molecules targeting the HMPV nucleocapsid protein. In the first step, the virtual screening method was applied to a compound library, and the top three compounds were selected for further redocking using AutoDock Vina. Finally, the chosen compounds were subjected to molecular dynamics simulations, and the stability of the complex and its conformational stability were evaluated using root mean square deviation, root mean square fluctuation, principal component analysis, and binding free energy landscape analysis. Among the chosen compounds, 24,330,502, 24,292,974, and 17,515,455 showed high binding affinity, stability, and conformational stability, and their results were better than those of the reference compound, Gamma-Fagarine, and they retained the ligands in the binding pocket with high stability. Therefore, the results of the present study reveal that the selected compounds, namely, 24,330,502, 24,292,974, and 17,515,455, have the potential to inhibit the HMPV nucleocapsid protein and are thus important for the treatment of HMPV infection.</p>","PeriodicalId":17527,"journal":{"name":"Journal of Tropical Medicine","volume":"2026 ","pages":"3511825"},"PeriodicalIF":2.6,"publicationDate":"2026-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13191828/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148015912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Platelet Depletion Alters MCP-1 Measurements in Plasma From Children With Dengue.","authors":"Héctor Felipe Ocampo-Amariles, Sebastián Castro-Trujillo, Carlos F Narváez","doi":"10.1155/jotm/8409965","DOIUrl":"10.1155/jotm/8409965","url":null,"abstract":"<p><strong>Background: </strong>Platelets are increasingly recognized as contributors to the cytokine storm in dengue, yet their residual presence in plasma may bias cytokine measurements. We compared MCP-1 levels between paired regular plasma (RP) and platelet-poor plasma (PPP) in children with dengue and evaluated how depletion influences cytokine quantification.</p><p><strong>Methods: </strong>We first conducted a systematic review of plasma isolation methods in pediatric dengue studies. We then collected paired RP and PPP from 16 hospitalized children with dengue (11 with warning signs and 5 with severe dengue). The PPP was obtained by double centrifugation and verified to contain < 10,000 platelets/μL. Absolute platelet counts were determined by flow cytometry using an antihuman CD41 antibody and bead-based quantification. After one freeze-thaw cycle, MCP-1 and IFN-γ (negative control for platelet secretion) were measured by cytometric bead array.</p><p><strong>Results: </strong>Among 167 reviewed articles, only 40% reported plasma isolation methods and 5% performed platelet depletion, with wide variability in centrifugation protocols. In our cohort, 63% of RP samples exceeded the platelet-poor threshold compared with only 10% of PPP after double-spin depletion. After effective platelet removal, MCP-1 levels increased nearly 5-fold in PPP versus RP (<i>p</i> = 0.008), while IFN-γ showed only a very modest rise, indicating that platelets are highly susceptible to physical and mechanical factors during the depletion process.</p><p><strong>Conclusion: </strong>Standard plasma isolation fails to consistently remove platelets, and subsequent depletion protocols can artifactually elevate the platelet-associated cytokines MCP-1. These findings underscore the need for standardized reporting of platelet depletion methods in dengue immunology research.</p>","PeriodicalId":17527,"journal":{"name":"Journal of Tropical Medicine","volume":"2026 ","pages":"8409965"},"PeriodicalIF":2.6,"publicationDate":"2026-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13189491/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147988035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Species Diversity of Mosquitoes (Diptera: Culicidae) in Various Coastal Bioecological Regions of Southern Iran.","authors":"Ebrahim Abbasi, Hamzeh Alipour, Shahyad Azari-Hamidian, Kourosh Azizi, Amirhossein Darabi, Sanaz Amiri, Hasan Bakhshi, Mohammad Darvishi, Mohammad Djaefar Moemenbellah-Fard","doi":"10.1155/jotm/6289369","DOIUrl":"10.1155/jotm/6289369","url":null,"abstract":"<p><p>Blood-feeding mosquitoes (Diptera: Culicidae) impose a major public-health burden in tropical regions of the world. They transmit many pathogens to humans and domesticated animals. This study investigated the diversity and abundance of mosquito larvae and adults in nine bioecological regions of Bushehr Province, southern Iran, from May to December 2022. Specimens were collected using standard dippers, CDC light traps, pit shelters, and aspirators on human and animal baits alongside key ecological variables such as temperature and habitat type. Diversity was further analyzed using Hill numbers (<i>q</i> = 0, 1, 2) through rarefaction and extrapolation with the iNEXT R package, which standardized sampling effort and confirmed that observed richness approached asymptotic values. Nineteen species representing five genera-<i>Aedes</i> (41%), <i>Anopheles</i> (12%), <i>Culex</i> (44.5%), <i>Culiseta</i> (1.2%), and <i>Uranotaenia</i> (1.2%)-were identified. Diversity analyses yielded mean <i>α</i> = 10.1 ± 3.2 species per habitat, β (Whittaker's index) = 1.8, and <i>γ</i> = 19 species for the entire region; Shannon <i>H</i>' = 2.31 ± 0.41, Simpson <i>D</i> = 0.44 ± 0.17, and evenness <i>J</i> = 0.63 ± 0.18. The dominance index (Cd = <i>ni</i>/<i>N</i> × 100) indicated <i>Ae. caspius</i> s.l. (Cd = 45% of adults, 30% of larvae) as the most preponderant species across habitats. The highest percentage (65.77%) distribution of this species was in the second largest, mainly nonlittoral county of Dashti, with a relatively high (0.451) Simpson Index incorporating both the abundance (biomass) patterns and species richness. The results highlight marked spatial heterogeneity related to temperature, humidity, and habitat type. Routine entomological surveillance and targeted vector-management strategies are suggested to reduce mosquito-borne disease risks in southern Iran. Since several collected species are potential vectors of medically important pathogens, regular surveillance, habitat management, and community awareness programs are recommended to mitigate mosquito-borne disease risks in southern Iran.</p>","PeriodicalId":17527,"journal":{"name":"Journal of Tropical Medicine","volume":"2026 ","pages":"6289369"},"PeriodicalIF":2.6,"publicationDate":"2026-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13184387/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147982154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Contribution Toward Understanding Trematode Diversity in Freshwater Snails of the Southwestern Kathmandu Valley, Nepal.","authors":"Minu Shilpakar, Rajendra Prasad Parajuli, Nishan Limbu, Mahendra Maharjan","doi":"10.1155/jotm/1315939","DOIUrl":"10.1155/jotm/1315939","url":null,"abstract":"<p><strong>Background: </strong>Freshwater snails serve as intermediate hosts for trematode parasites and play a key role in transmitting various parasitic diseases. Snail-borne trematodiases pose important public and veterinary health risks in South Asia, where freshwater snails sustain transmission in agricultural and periurban waters. However, data from the Kathmandu Valley remain limited and fragmented across habitats and seasons.</p><p><strong>Objectives: </strong>This study aimed to determine the diversity and distribution of cercarial larvae in freshwater snail species from the southwestern part of the Kathmandu Valley, Nepal.</p><p><strong>Methods: </strong>From July to October 2023, a total of 1893 snail samples were collected from grazing swamps, ditches, paddy fields, and canals. The samples represented five genera within four families: <i>Lymnaea acuminata</i> and <i>Radix</i> spp. (Lymnaeidae), <i>Gabbia orcula</i> (Bithyniidae), <i>Physa acuta</i> (Physidae), and <i>Indoplanorbis exustus</i> (Planorbidae). Cercarial infections were examined using the light-induced shedding method.</p><p><strong>Results: </strong>Four of the five snail species examined harbored trematode cercariae, with an overall prevalence of 3.01% (57/1893), while <i>Radix</i> spp. showed no infection. Nine cercarial morphotypes were identified: <i>Amphistome, Mutabile, Cercariaeum, Echinostome, Gymnocephalus, Cystophorous, Parapleurolophocerous, Xiphidiocercariae</i>, and <i>Brevifurcate apharyngate distome cercariae</i>. The infection prevalence varied significantly by month (Fisher's exact test, <i>p</i> = 0.001), peaking in July (5.56%), August (4.95%), and by habitat (<i>p</i> = 0.001), with the highest prevalence in grazing swamps (4.91%). A significant positive correlation was observed between snail length and infection rate (<i>r</i> = 0.781, <i>p</i> < 0.001), with medium-sized Lymnaea (18-26 mm) and Gabbia (10-13.9 mm) exhibiting the highest infection rates.</p><p><strong>Conclusions: </strong>Elevated infection occurred in July-August and among larger swamp-dwelling snails. The presence of diverse trematode cercariae, including zoonotically important types, underscores potential public and veterinary health risks and highlights the need for further studies on definitive hosts and control strategies. These patterns provide actionable guidance for risk mapping and prioritizing seasonal, habitat-focused surveillance and control in the Kathmandu Valley.</p>","PeriodicalId":17527,"journal":{"name":"Journal of Tropical Medicine","volume":"2026 ","pages":"1315939"},"PeriodicalIF":2.6,"publicationDate":"2026-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13179510/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147964003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frequency and Distribution of Lymphatic Filariasis in Somalia: A Single-Center Experience.","authors":"Ahmed Mohamed Ali, Ahmet Dogan, Fardowso Ali Mohamud, Tigad Abdisad Ali, Suad Abdikarim Isse, Abdijalil Abdullahi Ali","doi":"10.1155/jotm/7385823","DOIUrl":"10.1155/jotm/7385823","url":null,"abstract":"<p><p>\"Filariasis is a chronic, mosquito-borne parasitic infection. Chronic infection can lead to swelling of extremities, hydroceles, and testicular masses.\"</p><p><strong>Purpose: </strong>The study aimed to evaluate the frequency and distribution of filariasis in Somalia.</p><p><strong>Methods: </strong>Patients were assessed using clinical examination, cytology, peripheral blood smears, and Doppler ultrasonography. Data were analyzed with IBM SPSS V23. Results were presented as tables, graphs, and frequencies (%).</p><p><strong>Result: </strong>A total of 22 cases of lymphatic filariasis were assessed in our hospital's infectious diseases department during follow-up from March 2018 to December 2023. When the regions of residence of the cases were questioned, it was found that a high proportion of the cases were presented from the same region (Mog-86%). To a lesser extent, there were applicants from different regions. When the occupations of the cases were questioned, the majority were retired or housewives. When the presenting complaints and physical examination findings were analyzed, it was observed that the right or left extremity, or both, was usually affected. Swelling was the predominant presenting symptom. Genital involvement was detected in about 41% of cases. More than half of them had a history of mosquito bites.</p><p><strong>Conclusion: </strong>Given LF's effects on public health, it remains an important public health problem in Somalia.</p>","PeriodicalId":17527,"journal":{"name":"Journal of Tropical Medicine","volume":"2026 ","pages":"7385823"},"PeriodicalIF":2.6,"publicationDate":"2026-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13176848/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147964038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RETRACTION: Amelioration of Ovalbumin-Induced Allergic Asthma by <i>Juglans regia</i> via Downregulation of Inflammatory Cytokines and Upregulation of Aquaporin-1 and Aquaporin-5 in Mice.","authors":"Journal Of Tropical Medicine","doi":"10.1155/jotm/9801423","DOIUrl":"10.1155/jotm/9801423","url":null,"abstract":"<p><p>[This retracts the article DOI: 10.1155/2022/6530095.].</p>","PeriodicalId":17527,"journal":{"name":"Journal of Tropical Medicine","volume":"2026 ","pages":"9801423"},"PeriodicalIF":2.6,"publicationDate":"2026-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13161461/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147930838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}