Prevalence of Hepatitis B Virus Infection in Tanzania: A Systematic Review and Meta-Analysis.

IF 2.1 4区 医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Journal of Tropical Medicine Pub Date : 2024-06-05 eCollection Date: 2024-01-01 DOI:10.1155/2024/4178240
Semvua B Kilonzo, Igembe Nkandala, Ladius Rudovick, Hyasinta M Jaka, Mariam M Mirambo, Stephen E Mshana, Violet D Kajogoo, Elichilia R Shao
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引用次数: 0

Abstract

Methods: We systematically searched the PubMed, Web of Science, African Journals Online, Embase, Cochrane Library, and Google Scholar databases for studies conducted up to March 1, 2023, that estimated the prevalence of HBV in Tanzania based on HBV surface antigen measurements. The DerSimonian-Laird random effects model was used to estimate the overall prevalence of HBV with 95% confidence intervals (CIs). Potential sources of heterogeneity were also investigated.

Results: Thirty-one studies with a total sample size of 37,988 were included in the meta-analysis. The overall average HBV prevalence estimate in Tanzania was 6.91% (95% CI = 5.18-8.86%). Subgroup analysis revealed the highest prevalence in the northern zone (9.32%, 95% CI; 2.24-20.36%), among the blood donors (18.72%, 95% CI: 17.43-20.05%) and among the community volunteers (8.76%, 95% CI: 4.55-14.15%). The lowest prevalence was observed in the lake zone at 4.66% (95% CI: 3.49-5.99) and in pregnant women at 4.72% (95% CI: 3.42-6.21). The overall between-study variability showed significant heterogeneity (I 2 = 97.41%, P < 0.001).

Conclusions: Our results showed that Tanzania is a country with moderately high HBV endemicity, with large interregional differences and significantly high numbers of HBV infections within the community. This underscores the need for immediate development of targeted prevention strategies and further epidemiological studies to better understand the pattern of the disease.

坦桑尼亚的乙型肝炎病毒感染流行率:系统回顾与元分析》。
研究方法我们在 PubMed、Web of Science、African Journals Online、Embase、Cochrane Library 和 Google Scholar 数据库中系统检索了截至 2023 年 3 月 1 日根据 HBV 表面抗原测量结果估计坦桑尼亚 HBV 感染率的研究。采用 DerSimonian-Laird 随机效应模型估算 HBV 的总体流行率及 95% 置信区间 (CI)。研究还调查了异质性的潜在来源:荟萃分析共纳入 31 项研究,样本量共计 37,988 份。坦桑尼亚的 HBV 感染率总平均估计值为 6.91%(95% CI = 5.18-8.86%)。分组分析显示,北部地区(9.32%,95% CI;2.24-20.36%)、献血者(18.72%,95% CI:17.43-20.05%)和社区志愿者(8.76%,95% CI:4.55-14.15%)的感染率最高。湖区的发病率最低,为 4.66%(95% CI:3.49-5.99),孕妇的发病率最低,为 4.72%(95% CI:3.42-6.21)。研究间的总体差异显示出显著的异质性(I 2 = 97.41%,P < 0.001):我们的研究结果表明,坦桑尼亚是一个 HBV 中度流行的国家,地区间差异较大,社区内 HBV 感染人数明显偏高。这突出表明,有必要立即制定有针对性的预防策略,并开展进一步的流行病学研究,以更好地了解该疾病的模式。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Tropical Medicine
Journal of Tropical Medicine Immunology and Microbiology-Parasitology
CiteScore
3.90
自引率
4.50%
发文量
0
审稿时长
14 weeks
期刊介绍: Journal of Tropical Medicine is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies on all aspects of tropical diseases. Articles on the pathology, diagnosis, and treatment of tropical diseases, parasites and their hosts, epidemiology, and public health issues will be considered. Journal of Tropical Medicine aims to facilitate the communication of advances addressing global health and mortality relating to tropical diseases.
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