Journal of Tropical Medicine最新文献

{"title":"Correction to \"Epidemiologic Study of <i>Enterobius vermicularis</i> Infection among Schoolchildren in the Republic of Marshall Islands\".","authors":"","doi":"10.1155/jotm/9868907","DOIUrl":"https://doi.org/10.1155/jotm/9868907","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1155/2021/6273954.].</p>","PeriodicalId":17527,"journal":{"name":"Journal of Tropical Medicine","volume":"2025 ","pages":"9868907"},"PeriodicalIF":2.1,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12286692/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144698911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Virulence-Encoding Genes Conserved in <i>Salmonella</i> Isolated From Humans, Poultry, and Seafood.","authors":"Yemisi Olukemi Adesiji, Vijaya Kumar Deekshit, Rasheed A Odunola, Indrani Karunasagar, Oluwafemi B Daodu, Al-Mustapha Ahmad","doi":"10.1155/jotm/1139253","DOIUrl":"10.1155/jotm/1139253","url":null,"abstract":"<p><p>Diverse virulence genes encode for the Type III secretion system (T3SS) in bacteria. In <i>Salmonella</i>, these genes are located in the <i>Salmonella</i> pathogenicity Islands 1 and 2 (SPI-1 and SPI-2), and they facilitate bacterial invasion and replication within macrophages, contributing to the burden of nontyphoidal <i>Salmonella</i> infections. In this study, we investigated the prevalence of selected virulence-encoding genes in 30 laboratory stocks of <i>Salmonella enterica serovar Enteritidis</i> from Nigeria (16 isolates) and nonclinical sources comprising poultry and seafood from India (14 isolates). Analysis of PCR amplicons revealed that the genes <i>sseB</i>, <i>sseD, sseF, sse</i>T, and <i>invH</i> were conserved in all the isolates except for two isolates obtained from clams, which did not have the <i>sseD</i> and <i>sseF</i> genes. In addition, the <i>sseC</i> and <i>sseG</i> genes were absent from all the tested isolates. This study provides insights into the distribution of selected T3SS genes among <i>Salmonella</i> spp. isolated from clinical and raw animal food sources in Nigeria and India, respectively.</p>","PeriodicalId":17527,"journal":{"name":"Journal of Tropical Medicine","volume":"2025 ","pages":"1139253"},"PeriodicalIF":2.1,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12253993/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144626660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>In Silico</i> Mining of NPACT Database Toward Identification of EBNA1 Inhibitor: Virtual Screening, Molecular Dynamics Simulations, and DFT Calculations.","authors":"Mahmoud A A Ibrahim, Alaa M A Hassan, Alaa H M Abdelrahman, Gamal A H Mekhemer, Peter A Sidhom, Shaban R M Sayed, Ashraf M M Abdelbacki, Mohamed-Elamir F Hegazy","doi":"10.1155/jotm/1786204","DOIUrl":"10.1155/jotm/1786204","url":null,"abstract":"<p><p>Epstein-Barr nuclear antigen 1 (EBNA1) is an attractive therapeutic target for identifying pharmaceutical drug molecules to fight Epstein-Barr virus (EBV) contagion because of its key function in viral reproduction. To find potent EBNA1 inhibitors, the Naturally Occurring Plant-based Anticancer Compound-Activity-Target (NPACT) database, including > 1500 compounds, was filtered utilizing computational approaches. The efficiency of the docking technique used to anticipate the inhibitor-EBNA1 binding pose was initially evaluated based on obtainable experimental data. Upon the computed docking scores, molecular dynamics simulations (MDSs) were executed for the most superior NPACT compounds bound to EBNA1, accompanied by binding affinity estimations utilizing the MM/GBSA approach. According to binding affinity computations over 200 ns MDS, bitucarpin A demonstrated stronger Δ<i>G</i> _binding than KWG, an EBNA1 reference inhibitor, with values of -39.1 and -32.4 kcal/mol, respectively. Post-MD analyses assured the steadiness of bitucarpin A inside the EBNA1 binding pocket over 200 ns MDS. Besides, pharmacokinetics, physicochemical, and toxicity features were predicted for bitucarpin A and demonstrated its promising oral bioavailability. Density functional theory calculations were executed, and their outcomes substantiated the results given by docking and MDS computations. According to these findings, bitucarpin A showed promising inhibitory activity as a potent EBNA1 inhibitor that may be a prospective anti-EBV drug candidate.</p>","PeriodicalId":17527,"journal":{"name":"Journal of Tropical Medicine","volume":"2025 ","pages":"1786204"},"PeriodicalIF":2.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12237558/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144591538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antimicrobial, Time-Kill Kinetics, and Biofilm Inhibition Properties of <i>Diospyros lycioides</i> Chewing Stick Used in Namibia Against <i>Enterococcus faecalis</i>.","authors":"Albertina Mariina Ndinelao Shatri, Silas Kudakwashe Bere, Denise Bouman, Davis Ropafadzo Mumbengegwi","doi":"10.1155/jotm/7544856","DOIUrl":"10.1155/jotm/7544856","url":null,"abstract":"<p><p><b>Background:</b> Medicinal plants are used in Namibia for oral hygiene and to treat oral diseases. Validating the content and efficacy of medicinal chewsticks used in communities helps to provide proof of concept of medicinal plants used as a complementary/alternative medicine for oral diseases. <b>Aim:</b> This study presents the first report on quantified phytoconstituents, antimicrobial, time-kill kinetics, and biofilm inhibition properties of <i>Diospyros lycioides</i> organic and aqueous extracts against <i>Enterococcus faecalis</i>. <b>Methodology:</b> Dry plant materials were ground into powder and macerated in methanol and distilled water. Different phytoconstituents were quantified by Folin-Ciocalteu colorimetric method, ferric reducing antioxidant power assay, and DPPH free radical scavenging. An antibacterial assay was performed using the agar well diffusion method and a resazurin 96-well-based assay. Kill-time assay was done at various concentrations over 4 h. Biofilm inhibition was done using the crystal violet method. <b>Results:</b> Higher total flavonoid, total phenol contents, and free radical scavenging abilities were reported in methanol twig extracts. Inhibition zones of 28 ± 0.82 mm, with MICs of 15.6 ± 0.00 μg/mL, are reported against <i>E. faecalis</i>. The bactericidal endpoint of <i>D. lycioides</i> organic extracts for <i>E. faecalis</i> was reached after 4 h of incubation at 8 × MIC (124.8 μg/mL). These were comparable to the positive control, gentamicin. The organic extracts showed ≥ 50% biofilm inhibition against root canal-infecting <i>E. faecalis</i> at concentrations between 7.8 and 500 μg/mL, indicating strong biofilm inhibition. <b>Conclusion:</b> The study demonstrated that <i>D. lycioides</i> crude extracts have promising antibacterial properties and can eradicate <i>E. faecalis</i> biofilms in root canal treatments.</p>","PeriodicalId":17527,"journal":{"name":"Journal of Tropical Medicine","volume":"2025 ","pages":"7544856"},"PeriodicalIF":2.1,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12185201/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Characteristics and Outcome of MPOX Patients Admitted to the Bukavu University Clinics in the Democratic Republic of Congo From July to December 2024: Open Cohort Study.","authors":"Roland Lwandiko Cibenda, Paul Tshonda Ngongo, Delphin Murhula Katabana, Philippe Bianga Katchunga","doi":"10.1155/jotm/9981208","DOIUrl":"10.1155/jotm/9981208","url":null,"abstract":"<p><p><b>Background:</b> Several studies have focused on the town of Kamituga, the epicentre of the current MPOX Clade Ib epidemic, in South Kivu Province, in the east of the Democratic Republic of Congo. However, the disease is widespread in several health zones in this province. <b>Objectives:</b> The aim of this study was to describe the clinical characteristics and vital prognosis of admissions for MPOX in the city of Bukavu (21,808 inhabitants/km²), in the province of South Kivu. <b>Methodology:</b> Between 1 July and 31 December 2024, MPOX patients were recruited as and when they were admitted to the treatment centre at the Bukavu university clinics. For each patient, clinical characteristics and outcome were sought. <b>Results:</b> Of the 343 patients hospitalized during this study period, 201 (58.6%) were men and 142 (41.4%) were women (<i>p</i>=0.001). The median age was 21.0 (11.0-27.7) years. Traders (42.3%) and field workers (24.7%) were more numerous. Contact with an MPOX case (61.2%) was the most frequent mode of contamination. The frequency was 70.2% for elevated white blood cells, 73.0% for elevated c-reactive protein, 37.9% for anemia, 43.1% for genital lesions, 7.0% for pregnancy and 2.6% for HIV. Finally, during the 2400 patient-day observation period, 3 patients subsequently died (0.8%). The incidence of death was 1.25/1000 patient days. <b>Conclusion:</b> The results of this study show that, in the city of Bukavu, MPOX is a disease of young people. Contact with a case of MPOX was the most important mode of contamination, and the professions at risk were trade and field work. Thus, the list of professions at risk of MPOX to be vaccinated must be established according to each region.</p>","PeriodicalId":17527,"journal":{"name":"Journal of Tropical Medicine","volume":"2025 ","pages":"9981208"},"PeriodicalIF":2.1,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12185204/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Global Systematic Review on the Potential of Metal-Based Nanoparticles in the Fight Against Mosquito Vectors.","authors":"Awoke Minwuyelet, Delenasaw Yewhalaw, Yibeltal Aschale, Andrea Sciarretta, Getnet Atenafu","doi":"10.1155/jotm/2420073","DOIUrl":"10.1155/jotm/2420073","url":null,"abstract":"&lt;p&gt;&lt;p&gt;&lt;b&gt;Background:&lt;/b&gt; Mosquito-borne diseases, such as malaria, filariasis, dengue, chikungunya, Zika, and other viral infections, pose significant public health challenges worldwide. For many years, chemical insecticides were used in the form of indoor residual spraying (IRS) and insecticide-treated nets (ITNs). However, these methods have encountered several limitations such as the development of resistance, environmental impact, and nontarget effects. In recent years, metal-based nanoparticles (MNPs) have emerged as a promising alternative in the fight against mosquito vectors. This systematic review aimed to explore the potential application of MNPs in combating medically significant vectors. &lt;b&gt;Methods:&lt;/b&gt; Global databases such as PubMed, Scopus, Web of Science, and ProQuest were used to search for relevant articles published from 2011 to 2021. The data search was conducted between July 30 and August 15, 2022. Keywords such as \"Metal-based nanoparticles,\" \"Nanoparticles toxicity,\" \"Mosquito control,\" \"Larvicidal,\" \"Nanomaterials in mosquito control,\" and \"biosynthesized\" were used both individually and in combination to find pertinent studies. Only original articles published in English that offered comprehensive information on the effects of biosynthesized MNPs on mosquitoes were included in the study. These articles were selected based on the presence of key details such as the type and source of nanoparticles (NPs), size range (1-100 nm), and the mosquito larval species tested, exposure duration, and corresponding lethal concentration (LC) levels. Studies lacking sufficient data or with unavailable full texts were excluded from the analysis. The quality of each original article was evaluated using a standardized quality assessment tool adapted from the Joanna Briggs Institute (JBI) Critical Appraisal Checklist. Data were extracted from texts, tables, and figures of the included articles, and their validity was assessed using standardized tools. &lt;b&gt;Result:&lt;/b&gt; A total of 65 articles were included, covering laboratory and field findings on NPs such as silver (Ag), gold (Au), palladium (Pd), cobalt (Co), titanium dioxide (TiO&lt;sub&gt;2&lt;/sub&gt;), nickel (Ni), copper (Cu), cadmium (Cd), selenium (Se), zinc (Zn), magnesium oxide (MgO), iron and iron oxide (Fe and Fe&lt;sub&gt;2&lt;/sub&gt;O&lt;sub&gt;3&lt;/sub&gt;), and aluminum oxide (Al&lt;sub&gt;2&lt;/sub&gt;O&lt;sub&gt;3&lt;/sub&gt;). Among these, AgNPs and CuNPs were the most extensively tested and found effective against various larval instars, pupae, and adults of &lt;i&gt;Aedes aegypti&lt;/i&gt;, &lt;i&gt;Ae&lt;/i&gt;. &lt;i&gt;albopictus&lt;/i&gt;, &lt;i&gt;Anopheles stephensi&lt;/i&gt;, &lt;i&gt;An&lt;/i&gt;. &lt;i&gt;subpictus&lt;/i&gt;, &lt;i&gt;Culex quinquefasciatus&lt;/i&gt;, and &lt;i&gt;Cx&lt;/i&gt;. &lt;i&gt;pipiens&lt;/i&gt;, with satisfactory 50% and 90% LC values. &lt;b&gt;Conclusions:&lt;/b&gt; The study highlighted the promising potential of MNPs as effective agents for controlling mosquito vectors, particularly at various developmental stages of &lt;i&gt;Anopheles&lt;/i&gt;, &lt;i&gt;Culex&lt;/i&gt;, and &lt;i&gt;Aedes&lt;/i&gt; species. Most studies focused on AgNPs and A","PeriodicalId":17527,"journal":{"name":"Journal of Tropical Medicine","volume":"2025 ","pages":"2420073"},"PeriodicalIF":2.1,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170094/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144310110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence, Mortality, Antifungal Resistance, and Risk Factors of Candidemia Among Cancer Patients in a Single Center of Southern China: A 10-Year Retrospective Study.","authors":"Limei Chen, Jieyu Li, Jianzhong Xie, Yansong Chen, Xiaolong Yu, Na Xin, Yanping Xiao, Guangjian Su, Zhenzhou Xiao","doi":"10.1155/jotm/2653325","DOIUrl":"10.1155/jotm/2653325","url":null,"abstract":"<p><p>Cancer patients are at a high risk of <i>Candida</i> infections, and candidemia may aggravate the prognosis among patients with cancers. To investigate the incidence, mortality, risk factors, and antifungal resistance of candidemia among cancer patients, 100 inpatients with malignant solid tumors and candidemia in Fujian Province, southern China, during the period from January 2014 through December 2023 were recruited. Among the study subjects, <i>Candida albicans</i> was the predominant <i>Candida</i> species (50%), and the prevalence of candidemia showed an overall tendency towards a slight decline during the study period. <i>Candida tropicalis</i> showed 10.53% prevalence of resistance to fluconazole, voriconazole and itraconazole, while <i>C. albicans</i>, <i>Candida glabrata</i> and <i>Candida parapsilosis</i> were all totally susceptible to fluconazole, voriconazole, itraconazole and amphotericin B. The overall 30-day crude mortality of candidemia was 67% among cancer patients, and there was no significant difference between the mortality due to <i>Candida</i> catheter-related bloodstream infection (CRBSI) and bloodstream infection (BSI) (<i>p</i> = 0.59). Multivariate Cox regression analysis identified that the presence of cardiovascular diseases and use of two to three catheters (OR = 385.064, <i>p</i> = 0.005) increased the risk of candidemia among cancer patients. Our data demonstrate an overall tendency towards a slight decline in the prevalence of candidemia and a high mortality rate of candidemia among cancer patients in southeastern China from 2014 to 2023, and development of cardiovascular diseases and use of two to three catheters may increase the risk of candidemia among cancer patients.</p>","PeriodicalId":17527,"journal":{"name":"Journal of Tropical Medicine","volume":"2025 ","pages":"2653325"},"PeriodicalIF":2.1,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12163226/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mycetoma Epidemiology and Clinical Findings in Mogadishu, Somalia.","authors":"Ahmet Doğan, Fadumo Nur Adan, Tigad Abdisad Ali, Ali Kutta Çelik, Ahmed Mohamed Ali","doi":"10.1155/jotm/8864108","DOIUrl":"10.1155/jotm/8864108","url":null,"abstract":"<p><p><b>Background:</b> Mycetoma is a public health problem with a high prevalence in Africa. <b>Materials and Methods:</b> The study included 50 cases presenting at a tertiary care research hospital, retrospectively (cases we visited and followed up between November 2022 and March 2023) and prospectively between 1 August and 30 September 2024. Demographic characteristics, clinical features, physical examination findings, and diagnostic methods were reported. <b>Results:</b> Out of 50 patients, 76% were male and 24% were female. The mean age (mean ± SD) of all cases was 35.50 ± 15.14. The most affected occupational group was farmers (44%). All patients presented with complaints of swelling. Symptoms continued for > 1-5 years in about 30 percent of cases. The diagnosis was made by pathological biopsy in 62% of the cases. The lower extremities were most commonly affected (80%), and subcutaneous soft tissue and muscle involvement was also commonly encountered. Bone involvement was higher in eumycetoma cases as compared to actinomycetoma. <b>Conclusion:</b> The frequency of myçetoma cases, which can involve all parts of the lower extremities, was determined, especially in Somali farmers. Difficulties in diagnosis and follow-up were analyzed.</p>","PeriodicalId":17527,"journal":{"name":"Journal of Tropical Medicine","volume":"2025 ","pages":"8864108"},"PeriodicalIF":2.1,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12136858/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144225793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Association Between Statin Therapy and the Subsequent Clinical Course of Patients With Melioidosis.","authors":"Laura Prideaux, Hayley Stratton, Meg Sandeman, Simon Smith, Josh Hanson","doi":"10.1155/jotm/8838580","DOIUrl":"10.1155/jotm/8838580","url":null,"abstract":"<p><p><b>Background:</b> Even in well-resourced settings, the case-fatality rate of melioidosis approaches 10%. This has prompted an interest in identifying adjunctive therapies that might improve survival. A prospective, multicentre study in Thailand suggested that statin therapy may reduce the incidence of pneumonia in patients with melioidosis; however, the impact of statins on the clinical course of patients with the infection is incompletely defined. <b>Materials and Methods:</b> We examined all cases of culture-confirmed melioidosis in Far North Queensland, tropical Australia, since October 2016 to determine if statin therapy influenced the clinical phenotype of melioidosis and the patients' clinical course. <b>Results:</b> Of 321 individuals with culture-confirmed melioidosis, 100 (31%) were prescribed a statin at the time of their diagnosis. There was no difference in the clinical phenotype of patients who were- and were not-taking statin therapy. Pulmonary involvement, specifically, was no less common in patients taking a statin (79/100 [79%] versus 175/221 [79%], <i>p</i> = 0.97). A smaller proportion of patients taking statin therapy died before hospital discharge, but this difference did not reach statistical significance (5/100 [5%] versus 26/221 [12%], <i>p</i> = 0.07). This finding was at least partially explained by the fact that fewer patients with an active malignancy were taking a statin (7/37 [19%] versus 93/284 [33%] patients without a malignancy, <i>p</i> = 0.09) and that, in multivariable analysis, patients with malignancy were more likely to die before hospital discharge (odds ratio [95% confidence interval]: 4.73 [1.62-13.87], <i>p</i> = 0.005). Among 290 individuals surviving to hospital discharge, there was no difference in 12-month mortality between those that were-and were not-prescribed a statin at presentation (11/95 [12%] versus 23/195 [12%], <i>p</i> = 0.96). <b>Conclusion:</b> Statin therapy does not appear to have any significant influence on the clinical phenotype of patients with melioidosis. There is also no appreciable impact of statin therapy on patients with melioidosis' short-term or 12-month survival.</p>","PeriodicalId":17527,"journal":{"name":"Journal of Tropical Medicine","volume":"2025 ","pages":"8838580"},"PeriodicalIF":2.1,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12127124/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144208876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychiatric Sequelae of Dengue: A Review of the Interface.","authors":"Priyanka Renita D'Souza, Debora Sona D'Silva","doi":"10.1155/jotm/7136558","DOIUrl":"10.1155/jotm/7136558","url":null,"abstract":"<p><p>Dengue is one of the major public health concerns in tropical and subtropical countries. In addition to neurological sequelae which are well documented, emerging evidence suggests that dengue may also lead to psychiatric sequelae including mood disorders, psychosis, anxiety, and body dysmorphic disorder. This narrative review aims to synthesize the existing literature to explore the psychiatric manifestations and postulated pathophysiological mechanisms and identify predictors and treatment of psychiatric sequelae in dengue. This review identified 30 studies including observational studies, case reports, and case series. The immune-inflammatory responses due to cytokine dysregulation, blood-brain barrier disruption, direct viral effects, and epigenetic mechanisms with histone deacetylase activation are possible contributors to psychiatric sequelae in dengue. The main predictors include severity of dengue, thrombocytopenia, central nervous system involvement, febrile and critical phase of illness, specific dengue virus serotypes (DENV-2 and DENV-3), and stress due to hospitalization. Psychiatric symptoms often persist beyond the acute phase, highlighting the importance of long-term follow-up to evaluate the impact of dengue on mental health. Additionally, comparisons with other Flaviviridae viruses, such as Zika, West Nile, and Japanese encephalitis viruses, reveal both shared and distinct psychiatric implications, suggesting potential virus-specific mechanisms. The current treatment approaches are largely extrapolated from general psychiatric practice, with limited research on targeted interventions. Future research should focus on standardized diagnostic assessment, longitudinal follow-up, diagnostic biomarkers, and developing targeted treatment strategies to improve clinical outcomes. With rising cases of dengue, integrating psychiatric screening into routine dengue management may enhance early recognition and intervention. Hence, a multidisciplinary research approach involving psychiatrists, neurologists, infectious disease specialists, immunologists, and policymakers is crucial for addressing psychiatric sequelae in dengue fever and mitigating the detrimental implications on public health.</p>","PeriodicalId":17527,"journal":{"name":"Journal of Tropical Medicine","volume":"2025 ","pages":"7136558"},"PeriodicalIF":2.1,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12127122/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144208875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}