Journal of Thoracic Oncology最新文献

{"title":"OA08.03 Datopotamab Deruxtecan Vs Docetaxel in Patients with Non-Small Cell Lung Cancer: Final Overall Survival from TROPION-Lung01","authors":"J. Sands , A. Lisberg , I. Okamoto , L. Paz-Ares , R. Cornelissen , N. Girard , E. Pons-Tostivint , D. Vicente , S. Sugawara , M. Cobo Dols , M. Pérol , C. Mascaux , E. Poddubskaya , S. Kitazono , H. Hayashi , M.H. Hong , E. Felip , R. Hall , O. Juan-Vidal , D. Brungs , M.-J. Ahn","doi":"10.1016/j.jtho.2024.09.048","DOIUrl":"10.1016/j.jtho.2024.09.048","url":null,"abstract":"","PeriodicalId":17515,"journal":{"name":"Journal of Thoracic Oncology","volume":"19 10","pages":"Page S24"},"PeriodicalIF":21.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142442893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Response to the Letter to the Editor: “Comment on Stereotactic Body Radiotherapy for Centrally Located Inoperable Early Stage NSCLC: EORTC 22113-08113 LungTech Phase II Trial Results”","authors":"Antonin Levy MD, PhD, Sonja Adebahr MD, Coen Hurkmans PhD, Catherine Fortpied MSs, Cécile Le Pechoux MD, Corinne Faivre-Finn MD, PhD, Ursula Nestle MD, PhD","doi":"10.1016/j.jtho.2024.08.001","DOIUrl":"10.1016/j.jtho.2024.08.001","url":null,"abstract":"","PeriodicalId":17515,"journal":{"name":"Journal of Thoracic Oncology","volume":"19 10","pages":"Pages e57-e59"},"PeriodicalIF":21.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142381128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MA02.07 AI as Primary Reader in 4-IN-THE-LUNG-RUN Lung Cancer Screening Trial: Impact on Negative Misclassification and Referral Rate","authors":"A. Walstra , H.L. Lancaster , M.A. Heuvelmans , J.W. Gratama , M. Silva , M. Oudkerk","doi":"10.1016/j.jtho.2024.09.103","DOIUrl":"10.1016/j.jtho.2024.09.103","url":null,"abstract":"","PeriodicalId":17515,"journal":{"name":"Journal of Thoracic Oncology","volume":"19 10","pages":"Page S58"},"PeriodicalIF":21.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142442467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"OA16.05 Trastuzumab Deruxtecan Monotherapy in Pretreated HER2-overexpressing Nonsquamous Non-Small Cell Lung Cancer: DESTINY-Lung03 Part 1","authors":"D. Planchard , H.R. Kim , T. Suksombooncharoen , R. Li , J. Samol , Y. Runglodvatana , K.-Y. Lee , G.-C. Chang , D. Kowalski , J.-Y. Han , S. Saw , Y. Huang , A. Sookprasert , E. Nakajima , J. Alfon , Y.-T. Chang , J.C.-H. Yang","doi":"10.1016/j.jtho.2024.09.082","DOIUrl":"10.1016/j.jtho.2024.09.082","url":null,"abstract":"","PeriodicalId":17515,"journal":{"name":"Journal of Thoracic Oncology","volume":"19 10","pages":"Pages S46-S47"},"PeriodicalIF":21.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142442605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"OA12.04 Neoadjuvant Concurrent Chemo-Immuno-Radiation Therapy Followed by Surgery for Stage III-N2 NSCLC: SQUAT Trial (WJOG 12119L)","authors":"S. Toyooka , A. Hamada , J. Soh , A. Hata , K. Nakamatsu , M. Shimokawa , Y. Yatabe , J. Suzuki , M. Tsuboi , H. Horinouchi , Y. Sakairi , M. Tanahashi , H. Yamamoto , M. Okada , N. Matsuura , H. Shigematsu , Y. Nishimura , N. Yamamoto , K. Nakagawa , T. Mitsudomi","doi":"10.1016/j.jtho.2024.09.066","DOIUrl":"10.1016/j.jtho.2024.09.066","url":null,"abstract":"","PeriodicalId":17515,"journal":{"name":"Journal of Thoracic Oncology","volume":"19 10","pages":"Pages S36-S37"},"PeriodicalIF":21.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142442608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"OA07.04 Optimising Care of Older Patients with Lung Cancer - An Innovative Nurse-led Model of Care","authors":"S. Vinod , N. Knox , K. Knight , V. Bray , A. Khoo , E. Tcharkhedian , J. Campisi , P. Dufton , G. McErlean , M. Agar , L. Hickman","doi":"10.1016/j.jtho.2024.09.045","DOIUrl":"10.1016/j.jtho.2024.09.045","url":null,"abstract":"","PeriodicalId":17515,"journal":{"name":"Journal of Thoracic Oncology","volume":"19 10","pages":"Page S22"},"PeriodicalIF":21.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142442670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"OA13.04 ALINA Safety Results: Adjuvant Alectinib vs Chemotherapy in Patients with Resected ALK+ Non-Small Cell Lung Cancer (NSCLC)","authors":"H. Horinouchi , B.J. Solomon , Y.-L. Wu , F. Barlesi , M. Nishio , J.S. Ahn , D.H. Lee , J.-S. Lee , W. Zhong , M. Hochmair , I. Bondarenko , D. Planchard , A. Rittmeyer , B. Ding , T. Ruf , L. Adler , A. Scalori , R. Dziadziuszko","doi":"10.1016/j.jtho.2024.09.070","DOIUrl":"10.1016/j.jtho.2024.09.070","url":null,"abstract":"","PeriodicalId":17515,"journal":{"name":"Journal of Thoracic Oncology","volume":"19 10","pages":"Page S39"},"PeriodicalIF":21.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142442691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of Circulating Tumor DNA Predicts Outcomes of Short-Course Consolidation Immunotherapy in Unresectable Stage III NSCLC","authors":"","doi":"10.1016/j.jtho.2024.06.024","DOIUrl":"10.1016/j.jtho.2024.06.024","url":null,"abstract":"<div><h3>Introduction</h3><div>The current standard of care for patients with inoperable stage III non-small cell lung cancer includes chemoradiotherapy (CRT) followed by 1 year of checkpoint inhibitor (CPI) therapy. Nevertheless, the optimal duration of consolidation CPI remains unknown. Here, we characterized the relationship between circulating tumor DNA (ctDNA) minimal residual disease (MRD) and clinical outcomes of patients with unresectable locally advanced non-small cell lung cancer treated on a phase 2 trial of short-course consolidation immunotherapy after CRT, with the goal of testing whether ctDNA may be able to identify patients who do not require a full year of treatment.</div></div><div><h3>Methods</h3><div>Plasma samples for ctDNA analysis were collected from patients on the Big Ten Cancer Research Consortium LUN 16-081 trial after completion of CRT, before day 1 of cycle 2 (C2D1) of CPI (i.e., 1 mo after treatment start), and at the end of up to 6 months of treatment. Tumor-informed ctDNA MRD analysis was performed using cancer personalized profiling by deep sequencing. Levels of ctDNA at each time point were correlated with clinical outcomes.</div></div><div><h3>Results</h3><div>Detection of ctDNA predicted significantly inferior progression-free survival after completion of CRT (24-mo 29% versus 65%, <em>p</em> = 0.0048), before C2D1 of CPI (24-mo 0% versus 72%, <em>p</em> &lt; 0.0001) and at the end of CPI (24-mo 15% versus 67%, <em>p</em> = 0.0011). In addition, patients with decreasing or undetectable ctDNA levels after 1 cycle of CPI had improved outcomes compared with patients with increasing ctDNA levels (24-mo progression-free survival 72% versus 0%, <em>p</em> &lt; 0.0001). Progression of disease occurred within less than 12 months of starting CPI in all patients with increasing ctDNA levels at C2D1.</div></div><div><h3>Conclusions</h3><div>Detection of ctDNA before, during, or after 6 months of consolidation CPI is strongly associated with inferior outcomes. Our findings suggest that analysis of ctDNA MRD may enable personalizing the duration of consolidation immunotherapy treatment.</div></div>","PeriodicalId":17515,"journal":{"name":"Journal of Thoracic Oncology","volume":"19 10","pages":"Pages 1427-1437"},"PeriodicalIF":21.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141544985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"OA09.03 Randomized, Open-Label, Phase III Study of SAF-189s Versus Crizotinib in First-Line ALK-Positive Advanced Non-Small Cell Lung Cancer (NSCLC)","authors":"A. Xiong ,&nbsp;N. Yang ,&nbsp;X. Dong ,&nbsp;Y. Fan ,&nbsp;L. Xu ,&nbsp;P. Pan ,&nbsp;Y. Yu ,&nbsp;J. Zhou ,&nbsp;Y. Li ,&nbsp;J. Cui ,&nbsp;M. Wang ,&nbsp;Y. Zhang ,&nbsp;R. Chen ,&nbsp;H. Niu ,&nbsp;H. Qin ,&nbsp;S. Guo ,&nbsp;D. Huang ,&nbsp;H. Wu ,&nbsp;W. Yao ,&nbsp;Z. Zhang ,&nbsp;C. Zhou","doi":"10.1016/j.jtho.2024.09.053","DOIUrl":"10.1016/j.jtho.2024.09.053","url":null,"abstract":"","PeriodicalId":17515,"journal":{"name":"Journal of Thoracic Oncology","volume":"19 10","pages":"Pages S27-S28"},"PeriodicalIF":21.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142442789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"OA18.05 Neoadjuvant Versus Adjuvant Therapy for Locally Advanced Esophageal Squamous Cell Carcinoma: A Randomized Clinical Trial","authors":"Y. Zhu ,&nbsp;X. Sun ,&nbsp;L. Wu ,&nbsp;Q. Chen ,&nbsp;Q. Wei ,&nbsp;P. Ye ,&nbsp;S. Han ,&nbsp;X. Yu ,&nbsp;J. Liu ,&nbsp;Q. Zhao ,&nbsp;Y. Jiang ,&nbsp;X. Zhou ,&nbsp;W. Zhang ,&nbsp;W. Mao ,&nbsp;Y. Xu","doi":"10.1016/j.jtho.2024.09.089","DOIUrl":"10.1016/j.jtho.2024.09.089","url":null,"abstract":"","PeriodicalId":17515,"journal":{"name":"Journal of Thoracic Oncology","volume":"19 10","pages":"Page S51"},"PeriodicalIF":21.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142441046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}