A. Knuuttila , L. Nurmi , M. Ekblom , A. Bonin , E.K. Heikkila , M. Silvoniemi
{"title":"60P: The FIN-EGFR study: A retrospective observational study to investigate the treatment landscape and outcomes of early and advanced stage patients with EGFR mutated non-small cell lung cancer (NSCLC)","authors":"A. Knuuttila , L. Nurmi , M. Ekblom , A. Bonin , E.K. Heikkila , M. Silvoniemi","doi":"10.1016/S1556-0864(25)00255-2","DOIUrl":"10.1016/S1556-0864(25)00255-2","url":null,"abstract":"","PeriodicalId":17515,"journal":{"name":"Journal of Thoracic Oncology","volume":"20 3","pages":"Page S48"},"PeriodicalIF":21.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143724812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F. Griesinger , X. Wang , P.S. Karia , M. Cooper , L. Servidio , E. Jedy-Agba , J.J. Nieva , D.B. Doroshow
{"title":"76P: Long-term survival outcomes with first-line (1L) osimertinib monotherapy and subsequent treatment (tx) patterns: Final analysis of a real-world (rw) study in US patients (pts) with epidermal growth factor receptor-mutated (EGFRm) advanced non-small cell lung cancer (NSCLC)","authors":"F. Griesinger , X. Wang , P.S. Karia , M. Cooper , L. Servidio , E. Jedy-Agba , J.J. Nieva , D.B. Doroshow","doi":"10.1016/S1556-0864(25)00271-0","DOIUrl":"10.1016/S1556-0864(25)00271-0","url":null,"abstract":"","PeriodicalId":17515,"journal":{"name":"Journal of Thoracic Oncology","volume":"20 3","pages":"Pages S56-S57"},"PeriodicalIF":21.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143724814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S.R. Punekar , D.S. Hong , J. Luo , S-H.I. Ou , M.L. Johnson , A. Spira , I. Garrido-Laguna , J.W. Goldman , B. Herzberg , A. Saltos , P. Mitra , A. Hegde , R. Vora , M. Hiremath , K.C. Arbour
{"title":"6MO: Safety and clinical activity of daraxonrasib (RMC-6236) in RAS mutant non-small cell lung cancer (NSCLC)","authors":"S.R. Punekar , D.S. Hong , J. Luo , S-H.I. Ou , M.L. Johnson , A. Spira , I. Garrido-Laguna , J.W. Goldman , B. Herzberg , A. Saltos , P. Mitra , A. Hegde , R. Vora , M. Hiremath , K.C. Arbour","doi":"10.1016/S1556-0864(25)00201-1","DOIUrl":"10.1016/S1556-0864(25)00201-1","url":null,"abstract":"","PeriodicalId":17515,"journal":{"name":"Journal of Thoracic Oncology","volume":"20 3","pages":"Pages S10-S11"},"PeriodicalIF":21.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143725646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
P. Tomasini , Y. Wang , S-H. Lee , J. Cui , E. Felip , A. Spira , Y. Li , L. Wu , S. Michels , E. Ichihara , J. Neal , L. Demirdjian , C.S. Meyer , Y. Zhang , H. Kanakamedala , A. Louder , L. Trani , I. Leconte , M. Baig , B.C. Cho
{"title":"59P: Evaluating the effectiveness of amivantamab plus lazertinib in CHRYSALIS-2 vs EGFR TKI monotherapy in a matched real-world cohort of participants with atypical EGFR-mutated advanced NSCLC","authors":"P. Tomasini , Y. Wang , S-H. Lee , J. Cui , E. Felip , A. Spira , Y. Li , L. Wu , S. Michels , E. Ichihara , J. Neal , L. Demirdjian , C.S. Meyer , Y. Zhang , H. Kanakamedala , A. Louder , L. Trani , I. Leconte , M. Baig , B.C. Cho","doi":"10.1016/S1556-0864(25)00254-0","DOIUrl":"10.1016/S1556-0864(25)00254-0","url":null,"abstract":"","PeriodicalId":17515,"journal":{"name":"Journal of Thoracic Oncology","volume":"20 3","pages":"Pages S47-S48"},"PeriodicalIF":21.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143725793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"International Association for the Study of Lung Cancer (IASLC)","authors":"","doi":"10.1016/S1556-0864(25)00188-1","DOIUrl":"10.1016/S1556-0864(25)00188-1","url":null,"abstract":"","PeriodicalId":17515,"journal":{"name":"Journal of Thoracic Oncology","volume":"20 3","pages":"Page x"},"PeriodicalIF":21.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143725873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Chen , P. Wang , Z. Sun , Y. Li , F. Yang , K. Chen , J. Wang , M. Qiu
{"title":"35P: Clinical and safety outcomes of cancer vaccines in patients with advanced non-small cell lung cancer after first-line therapy: A systematic review and meta-analysis","authors":"S. Chen , P. Wang , Z. Sun , Y. Li , F. Yang , K. Chen , J. Wang , M. Qiu","doi":"10.1016/S1556-0864(25)00230-8","DOIUrl":"10.1016/S1556-0864(25)00230-8","url":null,"abstract":"","PeriodicalId":17515,"journal":{"name":"Journal of Thoracic Oncology","volume":"20 3","pages":"Page S33"},"PeriodicalIF":21.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143726069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Ronga , F. Vitiello , F. Ambrosio , B. Miranda , F.J. Romano , G. Viscardi , S. Campione , G. Guggino , A. Vaia , A. Farinaro , P. Maione , C. Gridelli , F. Riccardi
{"title":"Artificial Intelligence Technologies for Managing High-Risk Patients With Immune-Related Adverse Events and Optimizing Timing","authors":"Fangjie Liu MD, Hui Li MD","doi":"10.1016/j.jtho.2024.08.004","DOIUrl":"10.1016/j.jtho.2024.08.004","url":null,"abstract":"","PeriodicalId":17515,"journal":{"name":"Journal of Thoracic Oncology","volume":"20 3","pages":"Pages e47-e48"},"PeriodicalIF":21.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143535101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Tuminello PhD , R. Flores MD , M. Untalan MPH , T. Ivic-Pavlicic MPH , C.I. Henschke MD , R. Yip PhD , D.F. Yankelevitz MD , Emanuela Taioli MD, PhD
{"title":"Predicted Effect of Incidental Pulmonary Nodule Findings on NSCLC Mortality","authors":"S. Tuminello PhD , R. Flores MD , M. Untalan MPH , T. Ivic-Pavlicic MPH , C.I. Henschke MD , R. Yip PhD , D.F. Yankelevitz MD , Emanuela Taioli MD, PhD","doi":"10.1016/j.jtho.2024.11.009","DOIUrl":"10.1016/j.jtho.2024.11.009","url":null,"abstract":"<div><h3>Introduction</h3><div>Despite the reduction in mortality by low-dose computed tomography lung cancer screening, the uptake is still low. Patients undergo chest imaging for several other medical reasons, and this is a unique opportunity to detect lung nodules.</div></div><div><h3>Methods</h3><div>In a cohort of patients with NSCLC from the Surveillance, Epidemiology, and End Results-Medicare–linked data, tumor size at previous imaging was calculated as follows: volume doubling time = [(T<sub>2</sub>-T<sub>1</sub>)·ln2]/ln(V<sub>2</sub>/V<sub>1</sub>), solving for the diameter of V<sub>1</sub>. V<sub>1</sub> and V<sub>2</sub> are tumor volume at times T<sub>1</sub> (previous imaging) and T<sub>2</sub> (diagnostic procedure) according to three different growth models. The 10-year lung cancer-specific mortality was calculated as follows: lung cancer survival rate = (−0.0098 × maximum tumor diameter) + 1.</div></div><div><h3>Results</h3><div>A total of 1007 patients who had a chest imaging performed up to 1 year before lung cancer diagnosis were included in this study. The median size of the tumor at diagnosis was 25 mm, and the predicted median tumor size at previous imaging was 12.16 mm, 17.3 mm, and 20.42 mm under the fast, medium, and slow growth model, respectively. Under the fast growth model, a detection of the nodule at previous imaging would have yield a decrease in mortality of 7.79%; the corresponding value for the medium growth model is 4.5% and for the slow growth model 2.45%.</div></div><div><h3>Conclusions</h3><div>Identifying malignant lung nodules in imaging performed for other clinical reasons can help decrease the burden of NSCLC, especially for patients not eligible for low-dose computed tomography and the medically vulnerable. We reveal here that clinical benefits, especially among patients with aggressive disease, can be considerable.</div></div>","PeriodicalId":17515,"journal":{"name":"Journal of Thoracic Oncology","volume":"20 3","pages":"Pages 273-284"},"PeriodicalIF":21.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142621845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}