Journal of Thoracic Oncology最新文献

{"title":"PP01.57 Understanding the molecular mechanism of Supinoxin on Small cell Lung Cancer Therapy","authors":"Subhadeep Das , Matt Russon , Maria P. Zea Rojas , Bennett D. Elzey , Elizabeth Tran","doi":"10.1016/j.jtho.2024.05.292","DOIUrl":"https://doi.org/10.1016/j.jtho.2024.05.292","url":null,"abstract":"","PeriodicalId":17515,"journal":{"name":"Journal of Thoracic Oncology","volume":null,"pages":null},"PeriodicalIF":21.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141592681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PPD01.86 Phase 1 Study of Fianlimab, a Human Lymphocyte Activation Gene-3 (LAG-3) Monoclonal Antibody, in Combination With Cemiplimab in Advanced NSCLC","authors":"Byoung Chul Cho , Grace K. Dy , Tae Min Kim , Debashis Sarker , Omid Hamid , Stephen K. Williamson , Sang-We Kim , Hatim Husain , Fang Fang , Shuquan Chen , Jayakumar Mani , Vladimir Jankovic , Anne Paccaly , Sheila Masinde , Israel Lowy , Laura Brennan , Mark Salvati , Matthew Fury , Karl Lewis","doi":"10.1016/j.jtho.2024.05.159","DOIUrl":"https://doi.org/10.1016/j.jtho.2024.05.159","url":null,"abstract":"","PeriodicalId":17515,"journal":{"name":"Journal of Thoracic Oncology","volume":null,"pages":null},"PeriodicalIF":21.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141592975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PP01.46 Real-World Rebiopsy and Biomarker Retesting Rates Among Patients With Non-Small Cell Lung Cancer Across Patient Demographics in the United States","authors":"Charu Aggarwal , Qingqing Xu , Sophia Ng , Rajesh Kamalakar , Samuel Crawford , Sue Beruti , Aida Myftiu , Mary Beth Beasley","doi":"10.1016/j.jtho.2024.05.285","DOIUrl":"https://doi.org/10.1016/j.jtho.2024.05.285","url":null,"abstract":"","PeriodicalId":17515,"journal":{"name":"Journal of Thoracic Oncology","volume":null,"pages":null},"PeriodicalIF":21.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141592988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The International Association for the Study of Lung Cancer Lung Cancer Staging Project: Proposals for Revision of the TNM Stage Groups in the Forthcoming (Ninth) Edition of the TNM Classification for Lung Cancer","authors":"Ramón Rami-Porta MD ,&nbsp;Katherine K. Nishimura PhD, MPH ,&nbsp;Dorothy J. Giroux MS ,&nbsp;Frank Detterbeck MD ,&nbsp;Giuseppe Cardillo FRCS, FETCS ,&nbsp;John G. Edwards PhD, FRCS(C/Th) ,&nbsp;Kwun M. Fong MD, M.B.B.S., FRACP ,&nbsp;Meredith Giuliani M.B.B.S. ,&nbsp;James Huang MD ,&nbsp;Kemp H. Kernstine Sr. MD, PhD ,&nbsp;Edith M. Marom MD ,&nbsp;Andrew G. Nicholson DM, FRCPath. ,&nbsp;Paul E. Van Schil MD ,&nbsp;William D. Travis MD ,&nbsp;Ming S. Tsao MD ,&nbsp;Shun-Ichi Watanabe MD ,&nbsp;Valerie W. Rusch MD ,&nbsp;Hisao Asamura MD ,&nbsp;Members of the IASLC Staging and Prognostic Factors Committee and of the Advisory Boards, and Participating Institutions","doi":"10.1016/j.jtho.2024.02.011","DOIUrl":"10.1016/j.jtho.2024.02.011","url":null,"abstract":"<div><h3>Introduction</h3><p>The TNM classification of lung cancer is periodically revised. The International Association for the Study of Lung Cancer collected and analyzed a new database to inform the forthcoming ninth edition of the TNM classification. The results are herewith presented.</p></div><div><h3>Methods</h3><p>After exclusions, 76,518 patients from a total of 124,581 registered patients were available for analyses: 58,193 with clinical stage, 39,192 with pathologic stage, and 62,611 with best stage NSCLC. The proposed new N2 subcategories (N2a, involvement of single ipsilateral mediastinal or subcarinal nodal station, and N2b, involvement of multiple ipsilateral mediastinal nodal stations with or without involvement of the subcarinal nodal station) and the new M1c subcategories (M1c1, multiple extrathoracic metastases in one organ system, and M1c2, multiple extrathoracic metastases in multiple organ systems) were considered in the survival analyses. Several potential stage groupings were evaluated, using multiple analyses, including recursive partitioning, assessment of homogeneity within and discrimination between potential groups, clinical and statistical significance of survival differences, multivariable regression, and broad assessment of generalizability.</p></div><div><h3>Results</h3><p>T1N1, T1N2a, and T3N2a subgroups are assigned to IIA, IIB, and IIIA stage groups, respectively. T2aN2b and T2bN2b subgroups are assigned to IIIB. M1c1 and M1c2 remain in stage group IVB. Analyses reveal consistent ordering, discrimination of prognosis, and broad generalizability of the proposed ninth edition stage classification of lung cancer.</p></div><div><h3>Conclusions</h3><p>The proposed stages for the ninth edition TNM improve the granularity of nomenclature about anatomic extent that has benefits as treatment approaches become increasingly differentiated and complex.</p></div>","PeriodicalId":17515,"journal":{"name":"Journal of Thoracic Oncology","volume":null,"pages":null},"PeriodicalIF":21.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140049791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TOC","authors":"","doi":"10.1016/S1556-0864(24)00594-X","DOIUrl":"https://doi.org/10.1016/S1556-0864(24)00594-X","url":null,"abstract":"","PeriodicalId":17515,"journal":{"name":"Journal of Thoracic Oncology","volume":null,"pages":null},"PeriodicalIF":21.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S155608642400594X/pdfft?md5=71f09c0b888f1eff88e7998580c2415c&pid=1-s2.0-S155608642400594X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141539238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PP01.112 Treatment Patterns and Outcomes in Second-Line Advanced NSCLC Treated After Prior Platinum Chemotherapy and Immunotherapy Combination Therapy: A Real-World Study","authors":"D. Daniel, Ran Gao, S.K. Mhatre, C. Carroll, R. Patel, Joseph Park, D. Haggstrom","doi":"10.1016/j.jtho.2024.05.338","DOIUrl":"https://doi.org/10.1016/j.jtho.2024.05.338","url":null,"abstract":"","PeriodicalId":17515,"journal":{"name":"Journal of Thoracic Oncology","volume":null,"pages":null},"PeriodicalIF":21.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141693101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PP01.101 Estimated Cost of Adverse Events and Surgery for Resectable Non-Small Cell Lung Cancer Patients Receiving Neoadjuvant Nivolumab Plus Platinum-Doublet Chemotherapy","authors":"Sherry Wu ,&nbsp;Paul Lozowicki ,&nbsp;Stefano Lucherini ,&nbsp;Sandra Milev ,&nbsp;Saurabh Ray ,&nbsp;Lien Vo","doi":"10.1016/j.jtho.2024.05.329","DOIUrl":"https://doi.org/10.1016/j.jtho.2024.05.329","url":null,"abstract":"","PeriodicalId":17515,"journal":{"name":"Journal of Thoracic Oncology","volume":null,"pages":null},"PeriodicalIF":21.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141594277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PP01.36 Applying a Lung Cancer Screening Model on a Real-World Population","authors":"Warren R. Coons,&nbsp;Panayiotis Petousis,&nbsp;Ashley E. Prosper,&nbsp;Simon X. Han,&nbsp;Alex A. Bui","doi":"10.1016/j.jtho.2024.05.278","DOIUrl":"https://doi.org/10.1016/j.jtho.2024.05.278","url":null,"abstract":"","PeriodicalId":17515,"journal":{"name":"Journal of Thoracic Oncology","volume":null,"pages":null},"PeriodicalIF":21.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141592800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PP01.15 Healthcare Costs Amongst Patients with Non-Small Cell lung cancer (NSCLC) Before and After Testing with a Host Immune Classifier (HIC)","authors":"Wade Iams MD ,&nbsp;Kimberly Le PharmD, MS, MBA ,&nbsp;Nicole Princic MS","doi":"10.1016/j.jtho.2024.05.261","DOIUrl":"https://doi.org/10.1016/j.jtho.2024.05.261","url":null,"abstract":"","PeriodicalId":17515,"journal":{"name":"Journal of Thoracic Oncology","volume":null,"pages":null},"PeriodicalIF":21.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141593084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PP01.22 Single Institution Experience of MRI-Guided Radiotherapy for Thoracic Tumors and Clinical Characteristics Impacting Treatment Duty Cycle","authors":"Joseph A. Miccio MD,&nbsp;Nicholas J. Potter PhD,&nbsp;Anaum Showkat,&nbsp;Min Yao MD,&nbsp;Sean Mahase MD,&nbsp;Michele Ferenci PhD,&nbsp;Kaitlin Sisley RTT,&nbsp;Amy Dailey RTT,&nbsp;Jamie Knipple CMD,&nbsp;Amy Blakely CMD,&nbsp;Leonard Tuanquin MD,&nbsp;Mitch Machtay MD","doi":"10.1016/j.jtho.2024.05.268","DOIUrl":"https://doi.org/10.1016/j.jtho.2024.05.268","url":null,"abstract":"","PeriodicalId":17515,"journal":{"name":"Journal of Thoracic Oncology","volume":null,"pages":null},"PeriodicalIF":21.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141593989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}