{"title":"Ficonalkib’s Promise and the Path Forward: A Comment on Advanced ALK-Positive NSCLC Treatment","authors":"Meng-Wei Ge MS, Hong-Lin Chen MD","doi":"10.1016/j.jtho.2024.06.019","DOIUrl":"10.1016/j.jtho.2024.06.019","url":null,"abstract":"","PeriodicalId":17515,"journal":{"name":"Journal of Thoracic Oncology","volume":"19 10","pages":"Pages e47-e48"},"PeriodicalIF":21.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142381176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Yang, B. Chen, J. Yu, X. Liu, T. Jiang, F. Wu, A. Li, G. Gao, X. Chen, S. Ren
{"title":"OA05.03 Ablation to Oligo-Residual Sites Plus ICIs Improved Survival of Patients with Advanced NSCLC: Preliminary Results of a Prospective Phase II Trial","authors":"S. Yang, B. Chen, J. Yu, X. Liu, T. Jiang, F. Wu, A. Li, G. Gao, X. Chen, S. Ren","doi":"10.1016/j.jtho.2024.09.037","DOIUrl":"10.1016/j.jtho.2024.09.037","url":null,"abstract":"","PeriodicalId":17515,"journal":{"name":"Journal of Thoracic Oncology","volume":"19 10","pages":"Pages S17-S18"},"PeriodicalIF":21.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142442366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A.M. McWilliams , M. Tammemagi , S. Atkar-Khattra , J. Mayo , R. Meyers , J. Yee , J. English , H. Marshall , L. Passmore , R. Bowman , I. Yang , F. Brims , J. Logan , K.P. Lim , L. Mo , S. Melsom , B. Saffar , Y. Kwok , R. Sheehan , M. Teh , S. Lam
{"title":"PL02.14 Triaging ILST Screening Participants at Program Entry: Comparative Performance of PanCan versus LungRADSv1.1 Protocol","authors":"A.M. McWilliams , M. Tammemagi , S. Atkar-Khattra , J. Mayo , R. Meyers , J. Yee , J. English , H. Marshall , L. Passmore , R. Bowman , I. Yang , F. Brims , J. Logan , K.P. Lim , L. Mo , S. Melsom , B. Saffar , Y. Kwok , R. Sheehan , M. Teh , S. Lam","doi":"10.1016/j.jtho.2024.09.016","DOIUrl":"10.1016/j.jtho.2024.09.016","url":null,"abstract":"","PeriodicalId":17515,"journal":{"name":"Journal of Thoracic Oncology","volume":"19 10","pages":"Pages S3-S4"},"PeriodicalIF":21.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142442381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Smeltzer , C. Connolly , S. Lantuejoul , R. Soo , A. Kerpel-Fronius , A. Mohan , G. Woodard , U. Basu Roy , M. Chau , K. Brunson , R. Santos , M. Wynes , J.C. King , A. Young , Y. Yatabe , K. Kelly
{"title":"OA03.03 The 2024 International Association for the Study of Lung Cancer (IASLC) Global Survey on Biomarker Testing","authors":"M. Smeltzer , C. Connolly , S. Lantuejoul , R. Soo , A. Kerpel-Fronius , A. Mohan , G. Woodard , U. Basu Roy , M. Chau , K. Brunson , R. Santos , M. Wynes , J.C. King , A. Young , Y. Yatabe , K. Kelly","doi":"10.1016/j.jtho.2024.09.029","DOIUrl":"10.1016/j.jtho.2024.09.029","url":null,"abstract":"","PeriodicalId":17515,"journal":{"name":"Journal of Thoracic Oncology","volume":"19 10","pages":"Pages S12-S13"},"PeriodicalIF":21.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142442413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"MA02.13 Deep Learning-Based Multiomic Model for Lung Cancer Diagnosis","authors":"M. Zhao, Y. She","doi":"10.1016/j.jtho.2024.09.108","DOIUrl":"10.1016/j.jtho.2024.09.108","url":null,"abstract":"","PeriodicalId":17515,"journal":{"name":"Journal of Thoracic Oncology","volume":"19 10","pages":"Pages S60-S61"},"PeriodicalIF":21.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142442472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
X. Chen , C. Dai , M. Peng , D. Wang , X. Sui , L. Duan , X. Wang , X. Wang , W. Weng , S. Wang , H. Zhao , Z. Wang , J. Geng , C. Chen , Y. Yan , Q. Hu , C. Jiang , H. Zheng , Y. Bao , C. Sun , F. Yang
{"title":"MA03.03 The Impact of AI-driven 3D Reconstruction on Pulmonary Surgery Planning (AIR-SURGE): A Multi-Center Multi-Reader Multi-Case Study","authors":"X. Chen , C. Dai , M. Peng , D. Wang , X. Sui , L. Duan , X. Wang , X. Wang , W. Weng , S. Wang , H. Zhao , Z. Wang , J. Geng , C. Chen , Y. Yan , Q. Hu , C. Jiang , H. Zheng , Y. Bao , C. Sun , F. Yang","doi":"10.1016/j.jtho.2024.09.109","DOIUrl":"10.1016/j.jtho.2024.09.109","url":null,"abstract":"","PeriodicalId":17515,"journal":{"name":"Journal of Thoracic Oncology","volume":"19 10","pages":"Page S61"},"PeriodicalIF":21.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142442473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Leonetti , L. Boni , L. Gnetti , D.L. Cortinovis , F. Mazzoni , G. Pasello , F. Passiglia , A. Bearz , S. Pilotto , F. Gelsomino , G. Metro , F. Bertolini , L. Toschi , H. Soto Parra , A. Delmonte , F.L. Cecere , S. Ricciardi , E. Bria , M. Tognetto , M. Tiseo
{"title":"MA01.03 Neoadjuvant Alectinib in Potentially Resectable Stage III ALK-Positive NSCLC: Interim Analysis of ALNEO-GOIRC-01-2020 Phase II Trial","authors":"A. Leonetti , L. Boni , L. Gnetti , D.L. Cortinovis , F. Mazzoni , G. Pasello , F. Passiglia , A. Bearz , S. Pilotto , F. Gelsomino , G. Metro , F. Bertolini , L. Toschi , H. Soto Parra , A. Delmonte , F.L. Cecere , S. Ricciardi , E. Bria , M. Tognetto , M. Tiseo","doi":"10.1016/j.jtho.2024.09.091","DOIUrl":"10.1016/j.jtho.2024.09.091","url":null,"abstract":"","PeriodicalId":17515,"journal":{"name":"Journal of Thoracic Oncology","volume":"19 10","pages":"Page S52"},"PeriodicalIF":21.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142442632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
L. Zhang , Y. Zhao , M. Zhang , J. Yao , S. Leng , X. Li , L. Lin , J. Chen , S. Zhang , X. Qin , Z. Qin , T. Yi , R. Wang , X. Li , Y. Yu , Z. Wang , Q. Zheng , J. Mei , Y. Wang , H. Wang
{"title":"OA07.05 Phase 3 Study of HR20013 For Prevention of Cisplatin-based Chemotherapy-induced Nausea and Vomiting (PROFIT Study)","authors":"L. Zhang , Y. Zhao , M. Zhang , J. Yao , S. Leng , X. Li , L. Lin , J. Chen , S. Zhang , X. Qin , Z. Qin , T. Yi , R. Wang , X. Li , Y. Yu , Z. Wang , Q. Zheng , J. Mei , Y. Wang , H. Wang","doi":"10.1016/j.jtho.2024.09.047","DOIUrl":"10.1016/j.jtho.2024.09.047","url":null,"abstract":"","PeriodicalId":17515,"journal":{"name":"Journal of Thoracic Oncology","volume":"19 10","pages":"Pages S23-S24"},"PeriodicalIF":21.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142442672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Provencio , B. Campos , M. Guirado , L. Vilà , M.R. García Campelo , M. Dorta , S. Vázquez Estévez , A. Ferrández , M.A. Sala , A.L. Ortega , A. Blasco , A. Insa , M.C. Areses , I. Sullivan , R. López Castro , V. Calvo , D. Rodríguez - Abreu , J. Bosch-Barrera , A. López-Martín , R. Marsé , A. Cruz-Bermudez
{"title":"OA12.05 APOLO: Phase II Trial of Induction Chemo-Immunotherapy Plus Chemoradiotherapy and Maintenance Immunotherapy in Stage III NSCLC","authors":"M. Provencio , B. Campos , M. Guirado , L. Vilà , M.R. García Campelo , M. Dorta , S. Vázquez Estévez , A. Ferrández , M.A. Sala , A.L. Ortega , A. Blasco , A. Insa , M.C. Areses , I. Sullivan , R. López Castro , V. Calvo , D. Rodríguez - Abreu , J. Bosch-Barrera , A. López-Martín , R. Marsé , A. Cruz-Bermudez","doi":"10.1016/j.jtho.2024.09.067","DOIUrl":"10.1016/j.jtho.2024.09.067","url":null,"abstract":"","PeriodicalId":17515,"journal":{"name":"Journal of Thoracic Oncology","volume":"19 10","pages":"Page S37"},"PeriodicalIF":21.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142442609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Brief Report: Updated Data From IMscin001 Part 2, a Randomized Phase III Study of Subcutaneous Versus Intravenous Atezolizumab in Patients With Locally Advanced or Metastatic NSCLC","authors":"","doi":"10.1016/j.jtho.2024.05.005","DOIUrl":"10.1016/j.jtho.2024.05.005","url":null,"abstract":"<div><h3>Introduction</h3><div>Subcutaneous atezolizumab is approved for the treatment of various solid tumors. Previous results from the IMscin001 study (NCT03735121) revealed that the pharmacokinetics, efficacy, immunogenicity, and safety of subcutaneous and intravenous atezolizumab were consistent (data cutoff: April 26, 2022). We present updated data from this trial (data cutoff: January 16, 2023).</div></div><div><h3>Methods</h3><div>Eligible patients aged above or equal to 18 years with locally advanced or metastatic NSCLC were randomized (2:1) to receive atezolizumab subcutaneously (1875 mg, n = 247) or intravenously (1200 mg, n = 124) every 3 weeks. Here, we present updated efficacy (overall survival [OS]; progression-free survival; objective response rate; duration of response), safety, and immunogenicity end points, alongside patient-reported outcomes and health care practitioner (HCP) perspectives.</div></div><div><h3>Results</h3><div>In this updated analysis, the median survival follow-up was 9.5 months. Median subcutaneous injection time was 7.1 minutes, with an average subcutaneous injection time of 4 to 8 minutes in most patients (75.7%). OS data were mature: median OS was similar between treatment arms, at 10.7 and 10.1 months in the subcutaneous and intravenous arms, respectively (hazard ratio: 0.88; 95% confidence interval: 0.67–1.16). Other efficacy end points, as well as immunogenicity, patient-reported outcomes, and safety, were similar between arms. Most HCPs found subcutaneous administration convenient (79.5%), easy to administer (89.7%), and were satisfied with the treatment (84.6%); 75.0% of HCPs agreed that administering atezolizumab subcutaneously compared with intravenously could save time.</div></div><div><h3>Conclusions</h3><div>In this analysis, mature OS data were similar between treatments. The updated efficacy and safety profile of subcutaneous atezolizumab is consistent with previous findings and equivalent to intravenous atezolizumab.</div></div>","PeriodicalId":17515,"journal":{"name":"Journal of Thoracic Oncology","volume":"19 10","pages":"Pages 1460-1466"},"PeriodicalIF":21.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140904608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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