Journal of Urology最新文献

{"title":"Reply: Diagnosis and Treatment of Non-Muscle Invasive Bladder Cancer: AUA/SUO Guideline: 2024 Amendment.","authors":"Jeffrey M Holzbeierlein","doi":"10.1097/JU.0000000000004452","DOIUrl":"https://doi.org/10.1097/JU.0000000000004452","url":null,"abstract":"","PeriodicalId":17471,"journal":{"name":"Journal of Urology","volume":" ","pages":"101097JU0000000000004452"},"PeriodicalIF":5.9,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply: Clinician-Reported Management Recommendations in Response to Universal Germline Genetic Testing in Patients With Prostate Cancer.","authors":"Neal Shore","doi":"10.1097/JU.0000000000004439","DOIUrl":"https://doi.org/10.1097/JU.0000000000004439","url":null,"abstract":"","PeriodicalId":17471,"journal":{"name":"Journal of Urology","volume":" ","pages":"101097JU0000000000004439"},"PeriodicalIF":5.9,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adjuvant radiation therapy or observation with or without early salvage radiation therapy for men with node positive prostate cancer after surgery and negative pre-operative conventional imaging: a multicenter study.","authors":"Giancarlo Marra, Francesco Barletta, Simone Scuderi, Gabriele Montefusco, Jonathan Olivier, Andres Affentranger, Josias Bastian Grogg, Thomas Hermanns, Luca Afferi, Christian Fankhauser, Agostino Mattei, Bartosz Malkiewicz, Alberto Bianchi, Alessandro Antonelli, Fabio Zattoni, Fabrizio Dal Moro, Lieke Wever, Timo F W Soeterik, Roderick C N Van Den Bergh, Pawel Rajwa, Shahrokh F Shariat, Rafael Sanchez-Salas, Lara Rodriguez-Sanchez, Rossella Nicoletti, Riccardo Campi, Mohamed Ahmed, R Jeffrey Karnes, Isabel Heidegger, Alberto Briganti, Francesco Montorsi, Paolo Gontero, Giorgio Gandaglia","doi":"10.1097/JU.0000000000004468","DOIUrl":"https://doi.org/10.1097/JU.0000000000004468","url":null,"abstract":"<p><strong>Purpose: </strong>To assess the survival outcomes of adjuvant radiation therapy (aRT) versus observation with or without early salvage RT (Obs±esRT) for cN0M0 pN1 PCa and to create a model for clinical decision making.</p><p><strong>Materials and methods: </strong>We retrospectively identified 1,103 patients with cN0M0 PCa with pN1 PCa after surgery ( 2000-2021) at 18 referral centers. Kaplan-Meier curves, Cox proportional hazards were used.</p><p><strong>Results: </strong>Overall, 670 (61%) had ISUP 4-5 and the median number of positive nodes was 1. On multivariable analyses, ≥3 positive nodes (HR 2.03,95% CI 1.22-3.37; p=0.006) and ISUP 5 (HR 1.92,95% CI 1.15-3.18; p=0.01) were associated with an increased all-cause mortality. Based on pT stage, ISUP and positive nodes, a two risk categories model was created. In men undergoing observation, seven years disease-free survival was 27% (95%CI 20.4-36) for low-intermediate and 11% (95%CI 6.7-17) for high risk patients; aRT had higher OS rates in the high-risk group (92%;95%CI 87-96 vs observation 84%, 95%CI 77-90; p=0.006). In interaction term analyses aRT confirmed its protective effect on mortality in high risk patients (HR 0.28, 95% CI 0.09-0.84, p=0.024). Results were comparable when excluding men with PSA persistence.</p><p><strong>Conclusions: </strong>In cN0M0 pN+ PCa, aRT yields a survival benefit compared to Obs±esRT only in men with a high risk disease based on unfavorable prognostic factors. We created a risk model to guide clinical decision making in this setting.</p>","PeriodicalId":17471,"journal":{"name":"Journal of Urology","volume":" ","pages":"101097JU0000000000004468"},"PeriodicalIF":5.9,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143391091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gemcitabine versus Bacillus Calmette-Guerin for Intravesical Therapy in Treatment-Naïve Low-Grade Intermediate-Risk Non-Muscle Invasive Bladder Cancer.","authors":"Zine-Eddine Khene, Raj Bhanvadia, Sarah Attia, Willian Ito, Ivan Trevino, Solomon L Woldu, Vitaly Margulis, Yair Lotan","doi":"10.1097/JU.0000000000004472","DOIUrl":"https://doi.org/10.1097/JU.0000000000004472","url":null,"abstract":"<p><strong>Purpose: </strong>Patients with intermediate-risk (IR) non-muscle-invasive bladder cancer (NMIBC) are recommended to receive induction intravesical chemotherapy or immunotherapy. However, the comparison between gemcitabine and BCG in treatment-naive, low-grade IR-NMIBC patients remains underexplored. This study aims to evaluate the efficacy of gemcitabine compared to BCG in a cohort of treatment-naive IR-NMIBC patients.</p><p><strong>Materials and methods: </strong>A retrospective analysis was conducted on patients with low grade IR-NMIBC, classified according to International Bladder Cancer Group criteria, with no prior history of induction intravesical treatment. Patients received either induction intravesical BCG or gemcitabine. Recurrence was defined as histologically confirmed cancer during follow-up, while progression included stage/grade progression. Kaplan-Meier estimates were used for survival analysis, and multivariable Cox analysis identified factors associated with recurrence and progression.</p><p><strong>Results: </strong>Of the 151 patients with IR-NMIBC, 78 received BCG and 73 received gemcitabine. Both groups completed the 6-week induction treatment at similar rates (100%), and maintenance therapy was administered to 47% of BCG patients and 53% of gemcitabine patients (p = 0.46). The median number of maintenance doses was 6 (IQR: 3-9) in the BCG group and 8 (IQR: 4-10) in the gemcitabine group (p = 0.83). Median follow-up was 54 months for patients receiving BCG and 36 months for patients receiving gemcitabine. After adjusting for age, IBCG subgroups, year of treatment, single postoperative instillation, and maintenance therapy, gemcitabine was associated with a higher risk of recurrence compared to BCG (p=0.02), while the risk of progression remained similar between the two groups (p = 0.87). Adverse events were observed in 62 % of patients treated with BCG and 38 % of patients treated with gemcitabine (p = 0.02).</p><p><strong>Conclusions: </strong>Gemcitabine is associated with a higher risk of recurrence than BCG in treatment-naïve IR-NMIBC patients. However, both treatments show comparable efficacy in preventing disease progression.</p>","PeriodicalId":17471,"journal":{"name":"Journal of Urology","volume":" ","pages":"101097JU0000000000004472"},"PeriodicalIF":5.9,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143391092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Comment.","authors":"Gianpaolo P Carpinito, Matthew E Nielsen, Marc A Bjurlin","doi":"10.1097/JU.0000000000004464","DOIUrl":"https://doi.org/10.1097/JU.0000000000004464","url":null,"abstract":"","PeriodicalId":17471,"journal":{"name":"Journal of Urology","volume":" ","pages":"101097JU0000000000004464"},"PeriodicalIF":5.9,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply by Authors.","authors":"Keith Rourke","doi":"10.1097/JU.0000000000004460","DOIUrl":"https://doi.org/10.1097/JU.0000000000004460","url":null,"abstract":"","PeriodicalId":17471,"journal":{"name":"Journal of Urology","volume":" ","pages":"101097JU0000000000004460"},"PeriodicalIF":5.9,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter: Comparative Analysis of Holmium Laser Enucleation of the Prostate and Robotic-Assisted Simple Prostatectomy in Benign Prostatic Hyperplasia Management: A Systematic Review and Meta-Analysis.","authors":"David E Hinojosa-Gonzalez","doi":"10.1097/JU.0000000000004454","DOIUrl":"https://doi.org/10.1097/JU.0000000000004454","url":null,"abstract":"","PeriodicalId":17471,"journal":{"name":"Journal of Urology","volume":" ","pages":"101097JU0000000000004454"},"PeriodicalIF":5.9,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply: Artificial Intelligence as a Discriminator of Competence in Urological Training: Are We There?","authors":"Naji J Touma, Thomas Skinner, Michael Leveridge","doi":"10.1097/JU.0000000000004453","DOIUrl":"https://doi.org/10.1097/JU.0000000000004453","url":null,"abstract":"","PeriodicalId":17471,"journal":{"name":"Journal of Urology","volume":" ","pages":"101097JU0000000000004453"},"PeriodicalIF":5.9,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143364748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply: Development of a Novel Prediction Tool for Response to First-Line Treatments of Monosymptomatic Nocturnal Enuresis: A Randomized, Controlled, International, Multicenter Study (DRYCHILD).","authors":"Cecilie Siggaard Jørgensen, Søren Rittig","doi":"10.1097/JU.0000000000004438","DOIUrl":"https://doi.org/10.1097/JU.0000000000004438","url":null,"abstract":"","PeriodicalId":17471,"journal":{"name":"Journal of Urology","volume":" ","pages":"101097JU0000000000004438"},"PeriodicalIF":5.9,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143364702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trauma and Genital and Urethral Reconstruction.","authors":"Sean P Elliott","doi":"10.1097/JU.0000000000004447","DOIUrl":"https://doi.org/10.1097/JU.0000000000004447","url":null,"abstract":"","PeriodicalId":17471,"journal":{"name":"Journal of Urology","volume":" ","pages":"101097JU0000000000004447"},"PeriodicalIF":5.9,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143364811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}