Journal of Urology最新文献

{"title":"Reply by Authors.","authors":"Giancarlo Marra, Francesco Barletta, Simone Scuderi, Gabriele Montefusco, Jonathan Olivier, Andres Affentranger, Josias Bastian Grogg, Thomas Hermanns, Luca Afferi, Christian Fankhauser, Agostino Mattei, Bartosz Malkiewicz, Alberto Bianchi, Alessandro Antonelli, Fabio Zattoni, Fabrizio Dal Moro, Lieke Wever, Timo F W Soeterik, Roderick C N Van Den Bergh, Pawel Rajwa, Shahrokh F Shariat, Rafael Sanchez-Salas, Lara Rodriguez-Sanchez, Rossella Nicoletti, Riccardo Campi, Mohamed Ahmed, R Jeffrey Karnes, Isabel Heidegger, Alberto Briganti, Francesco Montorsi, Paolo Gontero, Giorgio Gandaglia","doi":"10.1097/JU.0000000000004534","DOIUrl":"10.1097/JU.0000000000004534","url":null,"abstract":"","PeriodicalId":17471,"journal":{"name":"Journal of Urology","volume":" ","pages":"711-712"},"PeriodicalIF":5.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Comment.","authors":"Luigi Nocera","doi":"10.1097/JU.0000000000004519","DOIUrl":"10.1097/JU.0000000000004519","url":null,"abstract":"","PeriodicalId":17471,"journal":{"name":"Journal of Urology","volume":" ","pages":"692"},"PeriodicalIF":5.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Complication and Readmission Rates Between Robot-Assisted and Open Radical Cystectomy: Results From the Randomized RAZOR Clinical Trial.","authors":"Vivek Venkatramani, Isildinha M Reis, Mark L Gonzalgo, Sanjaya Swain, Robert S Svatek, Dipen J Parekh","doi":"10.1097/JU.0000000000004497","DOIUrl":"10.1097/JU.0000000000004497","url":null,"abstract":"<p><strong>Purpose: </strong>We assessed differences in complications and readmissions between robot-assisted radical cystectomy (RARC) and open radical cystectomy (ORC).</p><p><strong>Materials and methods: </strong>This study uses data from the per-protocol population of the Randomized Robotic-Assisted vs Open Radical Cystectomy (RAZOR) study, a multicenter, open-label, phase 3, noninferiority clinical trial. RAZOR enrolled across 15 academic medical centers in the United States between 2011 and 2014. The median follow-up was 2 years. Complications up to 90 days using the Clavien-Dindo classification, and readmissions at 90 days and 1 year postoperatively were compared. Multivariable logistic regression analyses were performed to determine any predictors of major complications and of postsurgery readmission.</p><p><strong>Results: </strong>Baseline characteristics were similar, and there was no significant difference in overall and major complication rates between RARC (n = 150) and ORC (n = 152) arms. Simplified frailty index ≥ 3 (HR, 4.22, 95% CI, 2.67-6.66, <i>P</i> < .0001) was a significant predictor of major complications within 90 days. Readmission rates at 90 days were 24.1% for RARC and 23.1% for ORC, and readmission rates at 1 year were 29.5% for RARC and 28.5% for ORC (<i>P</i> = .80). Simplified frailty index ≥ 3 was a significant predictor of readmission at both time points (subdistribution HR 4.43, 95% CI, 1.75-11.2, <i>P</i> = .002 at 90 days and subdistribution HR, 5.28, 95% CI, 2.22-12.6, <i>P</i> < .001, at 1 year).</p><p><strong>Conclusions: </strong>No significant differences in major complications and readmission rates between ORC and RARC were noted. Patient frailty was an important predictor of these outcomes, and special attention needs to be taken in ensuring appropriate patient selection and preoperative preparation.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov Identifier: NCT01157676.</p>","PeriodicalId":17471,"journal":{"name":"Journal of Urology","volume":" ","pages":"684-692"},"PeriodicalIF":5.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12064358/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Time to Rethink Gleason Grading.","authors":"Daniel D Joyce, Jeffrey J Tosoian","doi":"10.1097/JU.0000000000004506","DOIUrl":"10.1097/JU.0000000000004506","url":null,"abstract":"","PeriodicalId":17471,"journal":{"name":"Journal of Urology","volume":" ","pages":"681-683"},"PeriodicalIF":5.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12064355/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143649568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Male Infertility.","authors":"Craig Niederberger","doi":"10.1097/JU.0000000000004367","DOIUrl":"10.1097/JU.0000000000004367","url":null,"abstract":"","PeriodicalId":17471,"journal":{"name":"Journal of Urology","volume":" ","pages":"813-814"},"PeriodicalIF":5.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142869518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endourology and Nephrolithiasis.","authors":"Dean G Assimos","doi":"10.1097/JU.0000000000004427","DOIUrl":"https://doi.org/10.1097/JU.0000000000004427","url":null,"abstract":"","PeriodicalId":17471,"journal":{"name":"Journal of Urology","volume":"213 6","pages":"803-805"},"PeriodicalIF":5.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143989352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter: Intraoperative Tranexamic Acid in Radical Cystectomy: Impact on Bleeding, Thromboembolism, and Survival Outcomes.","authors":"Henrique L Lepine, Rodrigo Gilles, William Carlos Nahas, Leopoldo Alves Ribeiro-Filho, Caio Vinícius Suartz","doi":"10.1097/JU.0000000000004495","DOIUrl":"10.1097/JU.0000000000004495","url":null,"abstract":"","PeriodicalId":17471,"journal":{"name":"Journal of Urology","volume":" ","pages":"789-790"},"PeriodicalIF":5.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143604943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uro-Science.","authors":"Anthony Atala","doi":"10.1097/JU.0000000000004417","DOIUrl":"10.1097/JU.0000000000004417","url":null,"abstract":"","PeriodicalId":17471,"journal":{"name":"Journal of Urology","volume":" ","pages":"805-806"},"PeriodicalIF":5.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Comment.","authors":"Sophia C Kamran, Tyler M Seibert","doi":"10.1097/JU.0000000000004481","DOIUrl":"10.1097/JU.0000000000004481","url":null,"abstract":"","PeriodicalId":17471,"journal":{"name":"Journal of Urology","volume":" ","pages":"711"},"PeriodicalIF":5.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143492600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Restriction Spectrum Imaging as a quantitative biomarker for prostate cancer with reliable positive predictive value.","authors":"Mariluz Rojo Domingo, Deondre D Do, Christopher C Conlin, Aditya Bagrodia, Tristan Barrett, Madison T Baxter, Matthew Cooperberg, Felix Feng, Michael E Hahn, Mukesh Harisinghani, Gary Hollenberg, Juan Javier-Desloges, Karoline Kallis, Sophia Kamran, Christopher J Kane, Dimitri Kessler, Joshua Kuperman, Kang-Lung Lee, Jonathan Levine, Michael A Liss, Daniel Ja Margolis, Ian Matthews, Paul M Murphy, Nabih Nakrour, Michael Ohliger, Courtney Ollison, Thomas Osinski, Anthony James Pamatmat, Isabella R Pompa, Rebecca Rakow-Penner, Jacob L Roberts, Ahmed S Shabaik, Yuze Song, David Song, Clare M Tempany, Shaun Trecarten, Natasha Wehrli, Eric P Weinberg, Sean Woolen, George Xu, Allison Y Zhong, Anders M Dale, Tyler M Seibert","doi":"10.1097/JU.0000000000004611","DOIUrl":"https://doi.org/10.1097/JU.0000000000004611","url":null,"abstract":"<p><strong>Purpose: </strong>Positive predictive value of PI-RADS for clinically significant prostate cancer (csPCa, grade group [GG]≥2) varies widely between radiologists. The Restriction Spectrum Imaging restriction score (RSIrs) is a biophysics-based metric derived from diffusion MRI that could be an objectively interpretable biomarker for csPCa. We aimed to evaluate performance of RSIrs for patient-level detection of csPCa in a large and heterogenous dataset, and to combine RSIrs with clinical and imaging parameters for csPCa detection.</p><p><strong>Materials and methods: </strong>At 7 centers, participants underwent prostate MRI between January of 2016 and March of 2024. We calculated patient-level csPCa probability based on maximum RSIrs in the prostate and compared patient-level csPCa detection to apparent diffusion coefficient (ADC) and PI-RADS using area under the ROC curve (AUC). We also evaluated csPCa discrimination by grade group and combining RSIrs with clinical risk factors via multivariable regression.</p><p><strong>Results and conclusions: </strong>Among patients that met the inclusion criteria (n=1892), probability of csPCa increased with higher RSIrs. Among biopsy-naïve patients (n=877), AUCs for GG≥2 vs. non-csPCa were: RSIrs=0.73 (0.69-0.76), ADC=0.54 (0.50-0.57), and PI-RADS=0.75 (0.71-0.78). RSIrs significantly outperformed ADC (<i>p</i><0.01) and was comparable to PI-RADS (<i>p</i>=0.31). RSIrs and PI-RADS combined outperformed either alone. The model with RSIrs, PI-RADS, age, and PSA density achieved the best discrimination of csPCa. RSIrs is an accurate and reliable quantitative biomarker that performs better than conventional ADC and comparably to expert-defined PI-RADS for patient-level detection of csPCa. RSIrs provides objective estimates of probability of csPCa that do not require radiology expertise.</p>","PeriodicalId":17471,"journal":{"name":"Journal of Urology","volume":" ","pages":"101097JU0000000000004611"},"PeriodicalIF":5.9,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}