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Journal of Urology最新文献

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Urological Oncology: Bladder, Penis, and Urethra Cancer, and Basic Principles of Oncology. 泌尿肿瘤学》：膀胱癌、阴茎癌和尿道癌》和《肿瘤学基本原理》。
IF 5.9 2区 医学
Journal of Urology Pub Date : 2024-11-01 Epub Date: 2024-07-25 DOI: 10.1097/JU.0000000000004120
Sam S Chang
{"title":"Urological Oncology: Bladder, Penis, and Urethra Cancer, and Basic Principles of Oncology.","authors":"Sam S Chang","doi":"10.1097/JU.0000000000004120","DOIUrl":"https://doi.org/10.1097/JU.0000000000004120","url":null,"abstract":"","PeriodicalId":17471,"journal":{"name":"Journal of Urology","volume":"212 5","pages":"779-780"},"PeriodicalIF":5.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142605675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endourology and Nephrolithiasis. 内排泄学和肾结石。
IF 5.9 2区 医学
Journal of Urology Pub Date : 2024-11-01 Epub Date: 2024-07-25 DOI: 10.1097/JU.0000000000004152
Dean G Assimos
{"title":"Endourology and Nephrolithiasis.","authors":"Dean G Assimos","doi":"10.1097/JU.0000000000004152","DOIUrl":"10.1097/JU.0000000000004152","url":null,"abstract":"","PeriodicalId":17471,"journal":{"name":"Journal of Urology","volume":" ","pages":"769-771"},"PeriodicalIF":5.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141759534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Letter: Impact of Family History and Germline Genetic Risk Single Nucleotide Polymorphisms on Long-Term Outcomes of Favorable-Risk Prostate Cancer. 信：家族史和种系遗传风险单核苷酸多态性对有利风险前列腺癌长期预后的影响
IF 5.9 2区 医学
Journal of Urology Pub Date : 2024-11-01 Epub Date: 2024-07-31 DOI: 10.1097/JU.0000000000004171
Francesco Montorsi, Riccardo Leni, Alberto Briganti, Giorgio Gandaglia
{"title":"Letter: Impact of Family History and Germline Genetic Risk Single Nucleotide Polymorphisms on Long-Term Outcomes of Favorable-Risk Prostate Cancer.","authors":"Francesco Montorsi, Riccardo Leni, Alberto Briganti, Giorgio Gandaglia","doi":"10.1097/JU.0000000000004171","DOIUrl":"10.1097/JU.0000000000004171","url":null,"abstract":"","PeriodicalId":17471,"journal":{"name":"Journal of Urology","volume":" ","pages":"760-761"},"PeriodicalIF":5.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141855883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Male Infertility. 男性不育
IF 5.9 2区 医学
Journal of Urology Pub Date : 2024-11-01 Epub Date: 2024-06-24 DOI: 10.1097/JU.0000000000004114
Craig Niederberger
{"title":"Male Infertility.","authors":"Craig Niederberger","doi":"10.1097/JU.0000000000004114","DOIUrl":"https://doi.org/10.1097/JU.0000000000004114","url":null,"abstract":"","PeriodicalId":17471,"journal":{"name":"Journal of Urology","volume":"212 5","pages":"774-775"},"PeriodicalIF":5.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142605673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Trauma, and Genital and Urethral Reconstruction. 创伤以及生殖器和尿道重建。
IF 5.9 2区 医学
Journal of Urology Pub Date : 2024-11-01 Epub Date: 2024-06-21 DOI: 10.1097/JU.0000000000004111
Sean P Elliott
{"title":"Trauma, and Genital and Urethral Reconstruction.","authors":"Sean P Elliott","doi":"10.1097/JU.0000000000004111","DOIUrl":"https://doi.org/10.1097/JU.0000000000004111","url":null,"abstract":"","PeriodicalId":17471,"journal":{"name":"Journal of Urology","volume":"212 5","pages":"776-777"},"PeriodicalIF":5.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142605674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Apalutamide for High-Risk Localized Prostate Cancer Following Radical Prostatectomy (Apa-RP). 阿帕鲁胺治疗前列腺癌根治术后的高危局部前列腺癌（Apa-RP）。
IF 5.9 2区 医学
Journal of Urology Pub Date : 2024-11-01 Epub Date: 2024-08-01 DOI: 10.1097/JU.0000000000004163
Neal Shore, Jason Hafron, Daniel Saltzstein, Gordon Brown, Laurence Belkoff, Pankaj Aggarwal, Jennifer Phillips, Amitabha Bhaumik, Tracy McGowan
{"title":"Apalutamide for High-Risk Localized Prostate Cancer Following Radical Prostatectomy (Apa-RP).","authors":"Neal Shore, Jason Hafron, Daniel Saltzstein, Gordon Brown, Laurence Belkoff, Pankaj Aggarwal, Jennifer Phillips, Amitabha Bhaumik, Tracy McGowan","doi":"10.1097/JU.0000000000004163","DOIUrl":"10.1097/JU.0000000000004163","url":null,"abstract":"<p><strong>Purpose: </strong>Approximately 25% to 50% of patients with high-risk localized prostate cancer experience biochemical recurrence (BCR) within 2 years of radical prostatectomy. The Apa-RP study (NCT04523207) investigated whether adjuvant apalutamide plus androgen deprivation therapy (ADT) in high-risk patients who have undergone radical prostatectomy improved BCR-free survival.</p><p><strong>Materials and methods: </strong>Apa-RP was a multicenter, open-label, single-arm, phase 2 study conducted in community urology practices in the US. High-risk patients who had radical prostatectomy received 12 cycles of apalutamide (240 mg daily; 28-day cycles) plus ADT. The primary end point was BCR-free survival. Secondary end points included testosterone recovery (≥150 ng/dL) and safety.</p><p><strong>Results: </strong>One hundred eight patients were enrolled; median age was 66.0 years (range 46.0-77.0 years). Median preoperative PSA and baseline testosterone were 7.6 ng/mL (range 2.2-62.7 ng/mL) and 340.0 ng/dL (range 43.0-939.0 ng/dL), respectively. The BCR-free rate at 24 months (12 months after completion of planned therapy) was 100% (90% CI 93-100). Serum testosterone recovery rate (≥50 and ≥150 ng/dL) 12 months after treatment completion was 96% (95% CI 88-98) and 77% (95% CI 66-85), respectively. Overall, 107 (99%) patients experienced treatment-emergent adverse events, with 24 (22%) experiencing grade 3 to 4 events.</p><p><strong>Conclusions: </strong>In Apa-RP, BCR-free survival was 100% with 77% of patients having testosterone recovery (≥150 ng/dL) within 12 months of actual treatment completion and a manageable safety profile. These results provide proof of concept that treatment intensification with 12 cycles of apalutamide plus ADT could become an option for patients with high-risk localized prostate cancer who have undergone radical prostatectomy.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov Identifier: NCT04523207.</p>","PeriodicalId":17471,"journal":{"name":"Journal of Urology","volume":" ","pages":"682-691"},"PeriodicalIF":5.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141875220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Education and Simulation in Urology. 泌尿外科教育与模拟。
IF 5.9 2区 医学
Journal of Urology Pub Date : 2024-11-01 Epub Date: 2024-07-25 DOI: 10.1097/JU.0000000000004167
Yash B Shah
{"title":"Education and Simulation in Urology.","authors":"Yash B Shah","doi":"10.1097/JU.0000000000004167","DOIUrl":"10.1097/JU.0000000000004167","url":null,"abstract":"","PeriodicalId":17471,"journal":{"name":"Journal of Urology","volume":" ","pages":"768-769"},"PeriodicalIF":5.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141759533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Letter: Efficacy and Safety of Vibegron for Persistent Symptoms of Overactive Bladder in Men Being Pharmacologically Treated for Benign Prostatic Hyperplasia: Results From the Phase 3 Randomized Controlled COURAGE Trial. 信Vibegron治疗因良性前列腺增生而接受药物治疗的男性膀胱过度活动症持续症状的有效性和安全性：3 期随机对照 COURAGE 试验的结果。
IF 5.9 2区 医学
Journal of Urology Pub Date : 2024-11-01 Epub Date: 2024-07-25 DOI: 10.1097/JU.0000000000004156
Ali Furkan Batur, Emre Altıntaş, Murat Gül
{"title":"Letter: Efficacy and Safety of Vibegron for Persistent Symptoms of Overactive Bladder in Men Being Pharmacologically Treated for Benign Prostatic Hyperplasia: Results From the Phase 3 Randomized Controlled COURAGE Trial.","authors":"Ali Furkan Batur, Emre Altıntaş, Murat Gül","doi":"10.1097/JU.0000000000004156","DOIUrl":"10.1097/JU.0000000000004156","url":null,"abstract":"","PeriodicalId":17471,"journal":{"name":"Journal of Urology","volume":" ","pages":"758-759"},"PeriodicalIF":5.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141759539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Trauma, and Genital and Urethral Reconstruction. 创伤以及生殖器和尿道重建。
IF 5.9 2区 医学
Journal of Urology Pub Date : 2024-11-01 Epub Date: 2024-06-21 DOI: 10.1097/JU.0000000000004111
Sean P Elliott
{"title":"Trauma, and Genital and Urethral Reconstruction.","authors":"Sean P Elliott","doi":"10.1097/JU.0000000000004111","DOIUrl":"10.1097/JU.0000000000004111","url":null,"abstract":"","PeriodicalId":17471,"journal":{"name":"Journal of Urology","volume":" ","pages":"776-777"},"PeriodicalIF":5.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141432176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Male Infertility. 男性不育
IF 5.9 2区 医学
Journal of Urology Pub Date : 2024-11-01 Epub Date: 2024-06-24 DOI: 10.1097/JU.0000000000004114
Craig Niederberger
{"title":"Male Infertility.","authors":"Craig Niederberger","doi":"10.1097/JU.0000000000004114","DOIUrl":"10.1097/JU.0000000000004114","url":null,"abstract":"","PeriodicalId":17471,"journal":{"name":"Journal of Urology","volume":" ","pages":"774-775"},"PeriodicalIF":5.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141442961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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