Journal of UrologyPub Date : 2025-06-01Epub Date: 2025-02-25DOI: 10.1097/JU.0000000000004481
Sophia C Kamran, Tyler M Seibert
{"title":"Editorial Comment.","authors":"Sophia C Kamran, Tyler M Seibert","doi":"10.1097/JU.0000000000004481","DOIUrl":"10.1097/JU.0000000000004481","url":null,"abstract":"","PeriodicalId":17471,"journal":{"name":"Journal of Urology","volume":" ","pages":"711"},"PeriodicalIF":5.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143492600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Editorial Comment.","authors":"David T Tzou","doi":"10.1097/JU.0000000000004613","DOIUrl":"https://doi.org/10.1097/JU.0000000000004613","url":null,"abstract":"","PeriodicalId":17471,"journal":{"name":"Journal of Urology","volume":" ","pages":"101097JU0000000000004613"},"PeriodicalIF":5.9,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144181090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"RE: Letter to the Editor \"Re: Perioperative Complications and Omission of Ureteral Stents During Robot-Assisted Radical Cystectomy With Intracorporeal Ileal Conduit\".","authors":"Jacob E Tallman, Alvin C Goh","doi":"10.1097/JU.0000000000004604","DOIUrl":"https://doi.org/10.1097/JU.0000000000004604","url":null,"abstract":"","PeriodicalId":17471,"journal":{"name":"Journal of Urology","volume":" ","pages":"101097JU0000000000004604"},"PeriodicalIF":5.9,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144173897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Endourology and Nephrolithiasis.","authors":"Dean G Assimos","doi":"10.1097/JU.0000000000004603","DOIUrl":"https://doi.org/10.1097/JU.0000000000004603","url":null,"abstract":"","PeriodicalId":17471,"journal":{"name":"Journal of Urology","volume":" ","pages":"101097JU0000000000004603"},"PeriodicalIF":5.9,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144128010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Editorial Comment.","authors":"Mohamed E Ahmed, R Jeffrey Karnes","doi":"10.1097/JU.0000000000004605","DOIUrl":"https://doi.org/10.1097/JU.0000000000004605","url":null,"abstract":"","PeriodicalId":17471,"journal":{"name":"Journal of Urology","volume":" ","pages":"101097JU0000000000004605"},"PeriodicalIF":5.9,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144120126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Education and Simulation in Urology.","authors":"Yash B Shah","doi":"10.1097/JU.0000000000004594","DOIUrl":"https://doi.org/10.1097/JU.0000000000004594","url":null,"abstract":"","PeriodicalId":17471,"journal":{"name":"Journal of Urology","volume":" ","pages":"101097JU0000000000004594"},"PeriodicalIF":5.9,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144120129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mariluz Rojo Domingo, Deondre D Do, Christopher C Conlin, Aditya Bagrodia, Tristan Barrett, Madison T Baxter, Matthew Cooperberg, Felix Feng, Michael E Hahn, Mukesh Harisinghani, Gary Hollenberg, Juan Javier-Desloges, Karoline Kallis, Sophia Kamran, Christopher J Kane, Dimitri Kessler, Joshua Kuperman, Kang-Lung Lee, Jonathan Levine, Michael A Liss, Daniel J A Margolis, Ian Matthews, Paul M Murphy, Nabih Nakrour, Michael Ohliger, Courtney Ollison, Thomas Osinski, Anthony James Pamatmat, Isabella R Pompa, Rebecca Rakow-Penner, Jacob L Roberts, Ahmed S Shabaik, Yuze Song, David Song, Clare M Tempany, Shaun Trecarten, Natasha Wehrli, Eric P Weinberg, Sean Woolen, George Xu, Allison Y Zhong, Anders M Dale, Tyler M Seibert
{"title":"Restriction Spectrum Imaging as a Quantitative Biomarker for Prostate Cancer With Reliable Positive Predictive Value.","authors":"Mariluz Rojo Domingo, Deondre D Do, Christopher C Conlin, Aditya Bagrodia, Tristan Barrett, Madison T Baxter, Matthew Cooperberg, Felix Feng, Michael E Hahn, Mukesh Harisinghani, Gary Hollenberg, Juan Javier-Desloges, Karoline Kallis, Sophia Kamran, Christopher J Kane, Dimitri Kessler, Joshua Kuperman, Kang-Lung Lee, Jonathan Levine, Michael A Liss, Daniel J A Margolis, Ian Matthews, Paul M Murphy, Nabih Nakrour, Michael Ohliger, Courtney Ollison, Thomas Osinski, Anthony James Pamatmat, Isabella R Pompa, Rebecca Rakow-Penner, Jacob L Roberts, Ahmed S Shabaik, Yuze Song, David Song, Clare M Tempany, Shaun Trecarten, Natasha Wehrli, Eric P Weinberg, Sean Woolen, George Xu, Allison Y Zhong, Anders M Dale, Tyler M Seibert","doi":"10.1097/JU.0000000000004611","DOIUrl":"10.1097/JU.0000000000004611","url":null,"abstract":"<p><strong>Purpose: </strong>Positive predictive value of Prostate Imaging Reporting and Data System (PI-RADS) for clinically significant prostate cancer (csPCa, grade group [GG] ≥2) varies widely between radiologists. The Restriction Spectrum Imaging restriction score (RSIrs) is a biophysics-based metric derived from diffusion MRI that could be an objectively interpretable biomarker for csPCa. We aimed to evaluate performance of RSIrs for patient-level detection of csPCa in a large and heterogenous data set, and to combine RSIrs with clinical and imaging parameters for csPCa detection.</p><p><strong>Materials and methods: </strong>At 7 centers, participants underwent prostate MRI between January 2016 and March 2024. We calculated patient-level csPCa probability based on maximum RSIrs in the prostate and compared patient-level csPCa detection to apparent diffusion coefficient (ADC) and PI-RADS using area under the ROC curve (AUC). We also evaluated csPCa discrimination by grade group and combining RSIrs with clinical risk factors through multivariable regression.</p><p><strong>Results and conclusions: </strong>Among patients who met the inclusion criteria (n = 1892), probability of csPCa increased with higher RSIrs. Among biopsy-naïve patients (n = 877), AUCs for GG ≥ 2 vs non-csPCa were RSIrs = 0.73 (0.69-0.76), ADC = 0.54 (0.50-0.57), and PI-RADS = 0.75 (0.71-0.78). RSIrs significantly outperformed ADC (<i>P</i> < .01) and was comparable with PI-RADS (<i>P</i> = .31). RSIrs and PI-RADS combined outperformed either alone. The model with RSIrs, PI-RADS, age, and PSA density achieved the best discrimination of csPCa. RSIrs is an accurate and reliable quantitative biomarker that performs better than conventional ADC and comparably with expert-defined PI-RADS for patient-level detection of csPCa. RSIrs provides objective estimates of probability of csPCa that do not require radiology expertise.</p>","PeriodicalId":17471,"journal":{"name":"Journal of Urology","volume":" ","pages":"101097JU0000000000004611"},"PeriodicalIF":5.9,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}