Journal of Urology最新文献

{"title":"Letter: Clinician-Reported Management Recommendations in Response to Universal Germline Genetic Testing in Patients With Prostate Cancer.","authors":"Giovanni Lughezzani, Vittorio Fasulo, Massimo Lazzeri","doi":"10.1097/JU.0000000000004420","DOIUrl":"10.1097/JU.0000000000004420","url":null,"abstract":"","PeriodicalId":17471,"journal":{"name":"Journal of Urology","volume":" ","pages":"648-649"},"PeriodicalIF":5.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143033406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter: Development of Prediction Models for Severe Pain and Urinary Symptoms After Ureteroscopy With Ureteral Stent Placement: Results From the STENTS Study and Initial Validation of Pain Interference.","authors":"Juntao Guo, Shuai Guo, Lingxiang Lu","doi":"10.1097/JU.0000000000004423","DOIUrl":"10.1097/JU.0000000000004423","url":null,"abstract":"","PeriodicalId":17471,"journal":{"name":"Journal of Urology","volume":" ","pages":"653-654"},"PeriodicalIF":5.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143059278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term Decision Regret and Associated Factors After Urinary Reconstruction in Underserved Patients With Spinal Cord Injury.","authors":"Aidin Abedi, Luis Morales Ojeda, Stefania Montero, Nhi Ha, Priya Kohli, Petr Gaburak, Armita Abedi, David Chapman, Evgeniy Kreydin, David A Ginsberg","doi":"10.1097/JU.0000000000004392","DOIUrl":"10.1097/JU.0000000000004392","url":null,"abstract":"<p><strong>Purpose: </strong>Patients with refractory neurogenic bladder dysfunction may require urinary reconstruction due to severe incontinence, difficulty with catheterization, and to prevent upper urinary tract compromise. We evaluated long-term decisional regret and associated factors after urinary reconstruction in patients with spinal cord injury.</p><p><strong>Materials and methods: </strong>We interviewed patients with spinal cord injuries who underwent bladder reconstruction surgery at least 10 years ago, administering validated surveys on bowel quality of life (QoL) and dysfunction, UTIs, and decisional regret. Daily bladder management and symptoms were assessed using the Neurogenic Bladder Symptom Score, a validated questionnaire consisting of 3 domains that examine incontinence, storage and voiding, and other health and QoL consequences of neurogenic lower urinary tract dysfunction. Demographics, injury characteristics, and surgical modality were collected through chart reviews. Decisional regret was compared among subgroups and correlated with patient-reported outcomes.</p><p><strong>Results: </strong>We evaluated 52 patients (41 men, 78.8%; mean age 54.9 ± 10 years) with average follow-up of 30 ± 8.6 years of postinjury and 21.9 ± 5.3 years of postsurgery. Reconstruction procedures mostly included bladder augmentation (n = 38, 73.1%) and augmentation with continent catheterizable stoma (n = 9, 17.3%). Most of the patients were of Hispanic origin (n = 41, 78.8%) with complete spinal cord injuries (n = 39, 76%). The median decision regret score was 7.5 (IQR: 0-25), indicating low regret among most participants. Bladder irrigation frequency (<i>P</i> = .002) was associated with decision regret, while other patient and surgical factors (eg, demographics, UTI frequency, and surgery type) were not. Surgical regret was moderately correlated with diminished bowel-related QoL (<i>ρ</i> = 0.333, <i>P</i> = .016) and increased Neurogenic Bladder Symptom Score (<i>ρ</i> = 0.328, <i>P</i> = .018). The Incontinence (<i>ρ</i> = 0.286, <i>P</i> = .040) and Consequences (<i>ρ</i> = 0.299, <i>P</i> = .031) domains of this measure showed weak statistically significant correlations with regret, while the Storage and Voiding domain did not reach significance (<i>ρ</i> = 0.245, <i>P</i> = .080).</p><p><strong>Conclusions: </strong>Long-term follow-up suggests that lower urinary tract reconstruction with bowel interposition is a well-accepted and durable approach for managing refractory neurogenic bladder. Factors associated with decision regret, such as need for irrigation, should be incorporated in patient-centered decision-making.</p>","PeriodicalId":17471,"journal":{"name":"Journal of Urology","volume":" ","pages":"617-627"},"PeriodicalIF":5.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply: Diagnosis and Treatment of Non-Muscle Invasive Bladder Cancer: AUA/SUO Guideline: 2024 Amendment.","authors":"Jeffrey M Holzbeierlein","doi":"10.1097/JU.0000000000004452","DOIUrl":"10.1097/JU.0000000000004452","url":null,"abstract":"","PeriodicalId":17471,"journal":{"name":"Journal of Urology","volume":" ","pages":"652-653"},"PeriodicalIF":5.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uro-Science.","authors":"Anthony Atala","doi":"10.1097/JU.0000000000004366","DOIUrl":"10.1097/JU.0000000000004366","url":null,"abstract":"","PeriodicalId":17471,"journal":{"name":"Journal of Urology","volume":" ","pages":"665-666"},"PeriodicalIF":5.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142864756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Artificial Intelligence-Digital Pathology Algorithm Predicts Survival After Radical Prostatectomy From the Prostate, Lung, Colorectal, and Ovarian Cancer Trial.","authors":"Eric V Li, Yi Ren, Jacqueline Griffin, Jialin Han, Rikiya Yamashita, Akinori Mitani, Ruoji Zhou, Huei-Chung Huang, Ximing Yang, Felix Y Feng, Andre Esteva, Hiten D Patel, Edward M Schaeffer, Lee A D Cooper, Ashley E Ross","doi":"10.1097/JU.0000000000004435","DOIUrl":"10.1097/JU.0000000000004435","url":null,"abstract":"<p><strong>Purpose: </strong>Clinical variables alone have limited ability to determine which patients will have recurrence after radical prostatectomy (RP). We evaluated the ability of locked multimodal artificial intelligence (MMAI) algorithms trained on prostate biopsy specimens to predict prostate cancer-specific mortality (PCSM) and overall survival (OS) among patients undergoing RP with digitized RP specimens.</p><p><strong>Materials and methods: </strong>The Prostate, Lung, Colorectal, and Ovarian Cancer Screening Randomized Controlled Trial randomized subjects from 1993 to 2001 to cancer screening or control. A subset of patients who underwent RP with available digitized histopathological images and subsequent survival data were identified. Distant metastasis (DM) and PCSM MMAIs originally trained on biopsy slides for patients undergoing radiation were evaluated for prediction of PCSM and OS. Cox proportional hazards modeling and Kaplan-Meier survival curve analysis were used.</p><p><strong>Results: </strong>In total, 1032 patients who underwent RP with median follow-up of 17 years (IQR, 14.3, 19.3 years) were identified. MMAI algorithms for PCSM and DM both predicted PCSM (HR, 2.31, 95% CI, 1.6-3.35, <i>P</i> < .001 and HR, 1.96, 95% CI, 1.35-2.85, <i>P</i> < .001, respectively). Similarly, DM and PCSM MMAI predicted OS (HR, 1.22, 95% CI, 1.01-1.47, <i>P</i> = .04 and HR, 1.19, 95% CI, 1.02-1.4, <i>P</i> = .03).</p><p><strong>Conclusions: </strong>Locked MMAI algorithms previously developed and validated on biopsy specimens from patients undergoing radiation for prostate cancer successfully predicted clinical outcomes when applied to RP specimens from patients treated with surgery. MMAI models and other biomarkers may help select patients who may benefit from postoperative treatment intensification with androgen deprivation therapy or radiation.</p>","PeriodicalId":17471,"journal":{"name":"Journal of Urology","volume":" ","pages":"600-608"},"PeriodicalIF":5.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143023989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Infection and Inflammation of the Genitourinary Tract.","authors":"J Quentin Clemens","doi":"10.1097/JU.0000000000004424","DOIUrl":"10.1097/JU.0000000000004424","url":null,"abstract":"","PeriodicalId":17471,"journal":{"name":"Journal of Urology","volume":" ","pages":"668-669"},"PeriodicalIF":5.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143059265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Comment.","authors":"Niels V Johnsen","doi":"10.1097/JU.0000000000004449","DOIUrl":"10.1097/JU.0000000000004449","url":null,"abstract":"","PeriodicalId":17471,"journal":{"name":"Journal of Urology","volume":" ","pages":"635-636"},"PeriodicalIF":5.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Comment.","authors":"Benjamin Borgert, Mary E Westerman","doi":"10.1097/JU.0000000000004467","DOIUrl":"10.1097/JU.0000000000004467","url":null,"abstract":"","PeriodicalId":17471,"journal":{"name":"Journal of Urology","volume":" ","pages":"567"},"PeriodicalIF":5.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143399439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urologic Oncology: Bladder, Penis, and Urethral Cancer and Basic Principles of Oncology.","authors":"Sam S Chang","doi":"10.1097/JU.0000000000004349","DOIUrl":"10.1097/JU.0000000000004349","url":null,"abstract":"","PeriodicalId":17471,"journal":{"name":"Journal of Urology","volume":" ","pages":"666-668"},"PeriodicalIF":5.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}