Konuralp Tıp Dergisi最新文献_第4页

Konuralp Tıp Dergisi Pub Date : 2023-01-02 DOI: 10.18521/ktd.1162175

Fatih Kurt, R. Eröz, K. Kocabay

{"title":"Apoptosis-associated speck-like protein containing a CARD (ASC), TNF Like Factor 1a(TL-1a) and B Cell Chemoattractant Chemokine Ligand 13(CXCL-13) expression profiles in familial Mediterranean fever (FMF) patients","authors":"Fatih Kurt, R. Eröz, K. Kocabay","doi":"10.18521/ktd.1162175","DOIUrl":"https://doi.org/10.18521/ktd.1162175","url":null,"abstract":"Objectives: This study was carried out to compare the expression levels of ASC(Apoptosis Associated Speck Like Protein Containing a CARD), TL-1a(TNF Like Factor 1a) and CXCL 13(B Cell Chemoattractant Chemokine Ligand 13) genes in FMF patients According to Tell-Hashomer Criteria and Genetic analysis result in Düzce University Research and Application Hospital with healthy controls and to determine their clinical significance in FMF. \u0000Method: 36 patients (20 girls, 16 boys) and 12 healthy controls (7 girls, 5 boys) were included in the study. RNA was isolated from the peripheral blood of each individual and expression levels of ASC, TL-1a and CXCL 13 genes were determined. Routine biochemical parameters were also determined. \u0000Result: CXCL 13 and TL-1a gene expression levels were significantly increased in patients with FMF, the expression level of the ASC gene was found to be increased in FMF patients, but not significantly. \u0000Conclusion: The expression levels of these genes may be related to the pathogenesis of the disease and these genes could be used as a marker in the early diagnosis of the disease.","PeriodicalId":174708,"journal":{"name":"Konuralp Tıp Dergisi","volume":"368 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127585068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anxiety and Sleep Quality in Healthcare Professionals During the Covid-19 Pandemic Process Covid-19大流行期间医护人员的焦虑和睡眠质量

Konuralp Tıp Dergisi Pub Date : 2022-12-16 DOI: 10.18521/ktd.1190491

Kadir Celik, Senay Kocakoglu

引用次数: 0

A new predictor for prediabetes: Chemerin 一种新的前驱糖尿病预测因子:Chemerin

Konuralp Tıp Dergisi Pub Date : 2022-12-15 DOI: 10.18521/ktd.1148541

E. Ergün, A. Or Koca, E. Beyan, D. Ertuğrul, T. Akkan, K. Dal

{"title":"A new predictor for prediabetes: Chemerin","authors":"E. Ergün, A. Or Koca, E. Beyan, D. Ertuğrul, T. Akkan, K. Dal","doi":"10.18521/ktd.1148541","DOIUrl":"https://doi.org/10.18521/ktd.1148541","url":null,"abstract":"Objective: It was aimed to investigate irisin and chemerin levels in prediabetic individuals and their value in predicting prediabetes. \u0000Method: Thirty-eight prediabetic patients aged 18-65 years (22 impaired fasting glucose (IFG), 10 impaired glucose tolerance (IGT), 6 patients with coexisting IFG and IGT) and thirty-five healthy volunteers were included in which was designed as a cross-sectional study. The basic demographic characteristics of all participants in the case and control groups were compared with the serum chemerin, irisin, creatinine, aspartate aminotransferase (AST), alanine aminotransferase (ALT), high-density lipoprotein (HDL-cholesterol), low-density lipoprotein (LDL-cholesterol), triglyceride (TG), free thyroxine (sT4), and thyroid-stimulating hormone (TSH) levels. \u0000Result: Serum chemerin level was found to be higher in the prediabetic group (p=0.03), while no significant difference was found for the irisin level between the two groups. In the multivariate logistic regression analysis, we showed that chemerin was an independent risk factor in predicting prediabetes. There was a positive correlation (p=0.01, r=0.279) between all participants' body mass index (BMI) and chemerin level and a negative correlation between irisin level and high-density lipoprotein cholesterol (HDL-C) level, and Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) (p=0.04 r=-0.295, p=0.01 r=-0.407, respectively). \u0000Conclusion: Chemerin is a new generation chemokine that predicts prediabetes. Studies aimed at irisin and chemerin may provide important role to prevent the prediabetes to Type 2 diabetes progression.","PeriodicalId":174708,"journal":{"name":"Konuralp Tıp Dergisi","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126797130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation Of The Clinical Results Of Using Microfluidic Channel System For Sperm Selection In IVF Cycles In Patients With Low Sperm Concentration. 微流控通道系统用于低精子浓度患者体外受精周期精子选择的临床效果评价。

Konuralp Tıp Dergisi Pub Date : 2022-12-05 DOI: 10.18521/ktd.1171576

Ö. Budak, M. S. Bostancı, Osman Köse, N. Akdemi̇r, A. Gökçe, S. Cevrioğlu

{"title":"Evaluation Of The Clinical Results Of Using Microfluidic Channel System For Sperm Selection In IVF Cycles In Patients With Low Sperm Concentration.","authors":"Ö. Budak, M. S. Bostancı, Osman Köse, N. Akdemi̇r, A. Gökçe, S. Cevrioğlu","doi":"10.18521/ktd.1171576","DOIUrl":"https://doi.org/10.18521/ktd.1171576","url":null,"abstract":"Objective: Microfluidic channel system (MAC), a new generation method, gives the chance to select better quality spermatozoa with lower DNA fragmentation indices. This study evaluated the treatment results in patients who underwent ICSI-ET due to the MAC technique's male factors. \u0000 \u0000Methods: Sakarya University ART Center carried out this retrospective study. Patients with 35 male factor indications were included in our study. In these patients, swim-up (SU) was used in the first of two consecutive IVF cycles, and the MAC sperm preparation technique was used in the second. Our study compared fertilization, quality embryo counts, implantation after fresh embryo transfer, pregnancy rates, fifth-day embryo, and frozen embryo numbers. \u0000 \u0000Results: Fertilization rate was higher in the MAC group than in the SU group (P=0.009). The number of 3rd and 5th Day Grade 1 embryo in the MAC group was statistically higher than in the SU group (p=0.000 for both parameters). The number of quality embryos frozen on day 5 was higher in the MAC group than in the SU group (P=0.000). \u0000 \u0000Conclusions: It is thought that MAC application does not make a statistically significant contribution on implantation and pregnancy in IVF cycles performed due to the malefactor. However, it may positively affect fertilization rate and embryo quality. In addition, we think that it increases the number of embryos frozen at the end of the cycle, and for this reason, the MAC technique may provide positive benefits to IVF treatments.","PeriodicalId":174708,"journal":{"name":"Konuralp Tıp Dergisi","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122830321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationship between vitamin D level and clinical status in COVID-19 patients COVID-19患者维生素D水平与临床状况的关系

Konuralp Tıp Dergisi Pub Date : 2022-12-02 DOI: 10.18521/ktd.1134319

F. Davran, C. Hacıoğlu, P. Duran, E. Unlu, B. Keski̇n, Eda Kayabasi, Elif Eşcan, Ş. Cangür, C. Öztürk

引用次数: 0

Emergency Surgery due to Giant Diaphragm Hernia Causing Acute Abdominal and Dyspnea: A Case Report 巨膈疝致急性腹部及呼吸困难急诊手术一例报告

Konuralp Tıp Dergisi Pub Date : 2022-12-01 DOI: 10.18521/ktd.1202200

Mehmet Emin Gönüllü, İ̇smet Özaydin, N. Altinsoy, Hasan Can Demirkaya

引用次数: 0

Contribution to Diagnosis of Magnetic Resonance Imaging and Inflammatory Markers in Musculoskeletal Involvement of Brucellosis 对布鲁氏菌病累及肌肉骨骼的磁共振成像和炎症标志物诊断的贡献

Konuralp Tıp Dergisi Pub Date : 2022-11-16 DOI: 10.18521/ktd.1112409

Yasemin Ogul, V. Ayyıldız, M. Güzel, O. Akpınar, H. Orhan

{"title":"Contribution to Diagnosis of Magnetic Resonance Imaging and Inflammatory Markers in Musculoskeletal Involvement of Brucellosis","authors":"Yasemin Ogul, V. Ayyıldız, M. Güzel, O. Akpınar, H. Orhan","doi":"10.18521/ktd.1112409","DOIUrl":"https://doi.org/10.18521/ktd.1112409","url":null,"abstract":"ABSTRACT \u0000Objective: Musculoskeletal involvement in brucellosis is very important. This study aimed to evaluate the magnetic resonance imaging (MRI) findings and hematological parameters as a predictive value for the diagnosis of musculoskeletal brucellosis. \u0000Methods: This prospective case-control study was conducted between June 2011 and November 2019 in a university hospital. Ninety-nine patients with the confirmed diagnosis of brucellosis without musculoskeletal involvement and forty-three brucellosis patients with musculoskeletal involvement were examined. The hematological, biochemical parameters, and radiological imaging findings of both groups were recorded. These parameters were statistically compared between the two groups. \u0000Results: The mean age of the patients (non-involvement group) and musculoskeletal involvement groups was 44.04 ± 23.11 and 37.92 ± 24.80 years, respectively (P = 0.062). C-reactive protein (CRP) and alkaline phosphatase (ALP) levels were significantly higher in the musculoskeletal involvement group (P < 0.05). The lower lymphocyte level was statistically significant in this group. Based on the receiver operating characteristic (ROC) analysis, the sensitivity and specificity were 70% and 65% for ALP, 77% and 58% for CRP, 83% and 45% for lymphopenia, respectively. There was no statistically significant difference between the two groups in terms of the other hematological and biochemical parameters. Spondylodiscitis (34.8%) was the most common MRI finding in patients with musculoskeletal involvement. \u0000Conclusions: Our study results show that CRP, ALP, and lymphopenia can be used as valuable markers in the preliminary diagnosis of musculoskeletal brucellosis.","PeriodicalId":174708,"journal":{"name":"Konuralp Tıp Dergisi","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122740597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Do We Need to Repeat the Initially Normal Head Computerized Tomography for Patients with Mild Head Trauma Using Anticoagulant and/or Antiplatelet Therapy? 对于使用抗凝和/或抗血小板治疗的轻度头部创伤患者，我们是否需要重复最初正常的头部计算机断层扫描?

Konuralp Tıp Dergisi Pub Date : 2022-10-27 DOI: 10.18521/ktd.1167329

Yaşar Çatal, M. Günalp, S. Genç, Ahmet Burak Oğuz, A. Koca, Onur Polat

{"title":"Do We Need to Repeat the Initially Normal Head Computerized Tomography for Patients with Mild Head Trauma Using Anticoagulant and/or Antiplatelet Therapy?","authors":"Yaşar Çatal, M. Günalp, S. Genç, Ahmet Burak Oğuz, A. Koca, Onur Polat","doi":"10.18521/ktd.1167329","DOIUrl":"https://doi.org/10.18521/ktd.1167329","url":null,"abstract":"Objective: Patients using anticoagulant and/or antiplatelet (AC/AP) medications are at an increased risk of intracranial hemorrhage (ICH) subsequent to head trauma and current guidelines recommend a head computed tomography (CT) scan for these patients. There is a lack of consensus about management recommendations for mild head trauma patients on AC/AP treatment who had an initially normal head CT. The aim of this study was to determine the rate of delayed ICH after a 24-hour observation in patients with mild head trauma using AC/AP who had an initially normal head CT. \u0000Method: Patients aged 18 and older, using AC/AP drugs with mild head trauma were included prospectively. Patients underwent head CT for suspected bleeding. A repeat CT scan was performed after a 24-hours observation period for the patients who had an initially normal head CT for detecting delayed intracranial hemorrhage. \u0000Result: A total of 101 patients were included and, 57.4% (n=58) of the patients were female. Delayed ICH was detected in 2.9% (n=3) of the patients after a 24-hour observation. None of the patients with delayed ICH needed surgical treatment or further intervention. Delayed ICH was found in patients who used acetylsalicylic acid (n=1), dabigatran (n=1), and apixaban (n=1). \u0000Conclusion: In patients with mild head trauma using AC/AP, delayed intracranial hemorrhage is rare and may be clinically insignificant. A repeat CT scanning after 24-hour observation may not be necessary for patients with mild head trauma using AC/AP therapy who had initially normal head CT.","PeriodicalId":174708,"journal":{"name":"Konuralp Tıp Dergisi","volume":"219 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128967391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Health Literacy Assessment Tool related to Antenatal Care (HLAT-ANC) for pregnant women: a Methodological Research from Turkey 与孕妇产前保健相关的健康素养评估工具(hla - anc):来自土耳其的方法学研究

Konuralp Tıp Dergisi Pub Date : 2022-10-10 DOI: 10.18521/ktd.1053510

Gülsüm ÖZTÜRK EMİRAL, A. Ünsal, D. Arslantaş

{"title":"Health Literacy Assessment Tool related to Antenatal Care (HLAT-ANC) for pregnant women: a Methodological Research from Turkey","authors":"Gülsüm ÖZTÜRK EMİRAL, A. Ünsal, D. Arslantaş","doi":"10.18521/ktd.1053510","DOIUrl":"https://doi.org/10.18521/ktd.1053510","url":null,"abstract":"Objectives: It is important to provide adequate antenatal care (ANC) for the lowest maternal-fetal complications in pregnancy. The increase in the level of health literacy increases the quality of the ANC, compliance with the follow-up.To develop a tool to evaluate health literacy (HL) levels of pregnant women in antenatal care (ANC). \u0000Method: This study is methodological research conducted between 15.02.2016-01.07.2018. \"Health Literacy Assessment Tool related to Antenatal Care (HLAT-ANC)\" was developed. Its validity-reliability was tested by item analysis, exploratory factor analysis (EFA), concurrent criterion validity, intergroup dissociation, and confirmatory factor analysis (CFA), and determination of the Kuder-Richardson-20 (KR-20) coefficient. \u0000Results: The discrimination coefficients of the items in HLAT-ANC varied between 0.20-0.57 and factor loads between 0.34-0.85. It was determined that HLAT-ANC has KR-20≥0.85 in each subdomain. The scores of fit criteria obtained in the confirmatory factor analysis were within acceptable limits. \u0000Conclusion: HLAT-ANC was found to be a valid and reliable scale.","PeriodicalId":174708,"journal":{"name":"Konuralp Tıp Dergisi","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128244630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effect of Different Doses of Amantadine on Lung Tissue In Hepatıc Ischemia Reperfusion Injury in Rats 不同剂量金刚烷胺对Hepatıc缺血再灌注损伤大鼠肺组织的影响

Konuralp Tıp Dergisi Pub Date : 2022-10-06 DOI: 10.18521/ktd.1161896

F. Şahin, M. Orhan, A. Tas Tuna, Onur Palabıyık, Nevcihan ŞAHUTOĞLU BAL, S. I. Gözükara, Ö. Budak, H. Cakiroglu

{"title":"The Effect of Different Doses of Amantadine on Lung Tissue In Hepatıc Ischemia Reperfusion Injury in Rats","authors":"F. Şahin, M. Orhan, A. Tas Tuna, Onur Palabıyık, Nevcihan ŞAHUTOĞLU BAL, S. I. Gözükara, Ö. Budak, H. Cakiroglu","doi":"10.18521/ktd.1161896","DOIUrl":"https://doi.org/10.18521/ktd.1161896","url":null,"abstract":"Objective: N-Methyl D-Aspartate (NMDA) receptor blockers have been shown to have protective effects against ischemia/reperfusion (I/R) injury in various tissues. The aim of this study was to investigate the effects of 90 ve 135 mg/kg doses of amantadine on lung in hepatic I/R injury. \u0000Method: The rats were randomly divided into six groups: Group Sham, Group I/R, Group Amantadine-90, Group Amantadine-135, Group I/R-90 and Group I/R-135. In I/R, an atraumatic vascular clamp was applied to the structures in the left portal triad for 45 minutes and reperfusion period was 2 hours after ischemia. Malondialdehyde (MDA), superoxide dismutase (SOD) and catalase (CAT) enzyme levels were performed the lung tissue and tissues were examined histopathologically. \u0000Result: A significant difference was found between the groups in terms of MDA, SOD, CAT levels (respectively; p < 0.001, p=0.008, p < 0.001). A significant difference was found between the groups in terms of lung tissue neutrophil/lymphocyte infiltration scores and alveolar wall thickening scores (respectively p=0.009, p=0.002). \u0000Conclusion: The biochemical and histopathological results of the present study suggested that amantadine, like other NMDA antagonist agents, may have a protective effect on lung tissues against the damage caused by hepatic I/R injury. Although we observed significant improvements after the administration of both doses studied, there was no significant difference between these two doses in terms of their success in protecting against distant organ lung injury. Amantadine appears promising as a therapeutic agent in treatment.","PeriodicalId":174708,"journal":{"name":"Konuralp Tıp Dergisi","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130268525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0