Konuralp Tıp Dergisi最新文献

{"title":"THE EFFECT OF IRON REPLACEMENT ON COGNITIVE FUNCTIONS IN REPRODUCTIVE WOMEN WITH IRON DEFICIENCY","authors":"Şükran Berkman, Özlem Suvak","doi":"10.18521/ktd.1148337","DOIUrl":"https://doi.org/10.18521/ktd.1148337","url":null,"abstract":"Objectives: Iron plays key roles in brain development including neurogenesis, myelination, synaptic development, energy and neurotransmitter metabolism as well as normal brain functioning. The aim of this study is to examine the effect of iron replacement on cognitive functions in women with iron deficiency. \u0000Methods: An intervention study was conducted in 165 women aged 15-49 years with low iron levels (ID;hemoglobin >12 gr/dl, ferritin","PeriodicalId":174708,"journal":{"name":"Konuralp Tıp Dergisi","volume":"78 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126248146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of the relationship between vitamin D and peripheral inflammatory parameters in children with attention deficit and hyperactivity disorder","authors":"E. Esnafoglu","doi":"10.18521/ktd.1179272","DOIUrl":"https://doi.org/10.18521/ktd.1179272","url":null,"abstract":"Aim: We aimed to investigate the effects of vitamin D and some nutritional factors such as vitamin B12, folate, homocysteine, and ferritin, which play a role in the pathogenesis of attention deficit and hyperactivity disorder (ADHD), on inflammation, which is also claimed to play a role in the pathogenesis of ADHD. \u0000Materials and methods: 39 ADHD and 39 healthy controls were compared with similar age, gender and BMI. The severity of the disease was evaluated with the Turgay ADHD scale. Inflammatory and nutritional parameters were measured routinely. \u0000Results: In the patient group, Vitamin D was found to be significantly lower (p","PeriodicalId":174708,"journal":{"name":"Konuralp Tıp Dergisi","volume":"67 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121242524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age- and Sex- Dependent Changes in Serum Levels of TAS, TOS, TLR2, TLR4, HSP60, HSP90, and HMGB1","authors":"S. Kaya","doi":"10.18521/ktd.1214575","DOIUrl":"https://doi.org/10.18521/ktd.1214575","url":null,"abstract":"Objective: Cellular and physiological functions may be affected in an age- and sex-specific manner. The aim of this study is to investigate sex- and age-specific differences in the serum levels of Total Antioxidant Status (TAS), Total Oxidant Status (TOS), Oxidative Stress Index (OSI), Toll-like Receptor 2 (TLR2), Toll-Like Receptor 4 (TLR4), Heat Shock Protein 60 (HSP60), Heat Shock Protein 90 (HSP90), and High Mobility Group Box 1 (HMGB1) as well as to examine the correlation between them. \u0000Methods: Four groups of mice, each including seven animals, were used in the present study: young males and females (6 months old); old males and females (24 months old). Blood samples were taken from the heart and serum was used to assay the levels of TLR2, TLR4, HSP60, HSP90, HMGB1, TAS and TOS. \u0000Results: HGMB1, TOS and OSI were higher in old females than in young females (p","PeriodicalId":174708,"journal":{"name":"Konuralp Tıp Dergisi","volume":"53 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124613437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of DMFT index and saliva values in morbidly obese and obese patients","authors":"G. Ayan, B. Dayı, Ş. Şahin, B. Evren","doi":"10.18521/ktd.1206790","DOIUrl":"https://doi.org/10.18521/ktd.1206790","url":null,"abstract":"Objective: Obesity is a global, chronic disease that affects both developed and developing countries. The purpose of this study is to examine the effect of morbid obesity and obesity affect the decayed, missing, and filled teeth (DMFT) index and saliva values. \u0000Methods: The study included 50 morbidly obese, 50 obese, and 50 control group patients ranging in age from 18 to 68. The DMFT index of the patients was determined by clinical examination. The saliva kit was used to determine saliva values [unstimulated saliva flow rate (USFR), stimulated saliva flow rate (SSFR), saliva viscosity (SV), saliva pH (SpH), and saliva buffering capacity (SBC)]. The patients were surveyed to learn about their oral health habits, nutritional habits, and socioeconomic status. \u0000Results: There was no significant difference in the number of decayed teeth, filled teeth, USFR, or SV between the groups (p>0.05). The DMFT index, number of missing teeth, SSFR, SpH, and SBC all showed significant differences between the groups (p","PeriodicalId":174708,"journal":{"name":"Konuralp Tıp Dergisi","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115318232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship of Vitamin B12 and Vitamin D with IL-4, IL-10, TNF Beta in Obese Patients","authors":"Gonca Gülbay, Yasemin Kaya","doi":"10.18521/ktd.1211939","DOIUrl":"https://doi.org/10.18521/ktd.1211939","url":null,"abstract":"Obez Hastalarda Vitamin B12 ve Vitamin D’ nin \u0000IL-4, IL-10, TNF-Beta ile İlişkisi \u0000Öz \u0000Amaç: Obez hastalarda vitamin B12 ve vitamin D nin IL-10, IL-4, TNF-Beta ile ilişkisini incelemeyi amaçladık. \u0000Gereç ve Yöntem: Serum IL-10, IL-4 ve TNF-Beta seviyeleri ELISA (Enzyme Linked Immunosorbent Assay) prensibine dayalı kitler kullanılarak ölçülmüştür. \u0000Bulgular: IL-10 düzeyi, vitamin D düşük olan grupta anlamlı olarak daha düşük bulunmuştur (p= 0.039). Vitamin B12 normal, vitamin B12 düşük ve kontrol grupları karşılaştırıldığında IL-10 açısından gruplar arasında istatistiksel düzeyde fark bulunmuştur (p=0.002). Post hoc analizi sonucunda IL-10 düzeyi, vitamin B12 düşük grubunda vitamin B12 normal grubuna göre anlamlı olarak daha düşük olarak tespit edilmiştir (0.04). Aynı zamanda vitamin B12 normal grupta (obezite pozitif) kontrol grubuna (non-obez vit B12 normal) göre daha yüksek olarak belirlenmiştir (p=0.001). IL-10 ile vitamin B12 ve Vitamin D arasında korelasyon bakıldığında vitamin B12 ile IL-10 arasında pozitif korelasyon bulundu (r=0.203 p= 0.058). \u0000Sonuç: Obez hastalarda vitamin D ve vitamin B12 düşük seviyelerinin IL-10 düzeyinde düşüklüğe neden olduğu gösterilmiştir. Ayrıca obezitenin de IL-10 seviyesinde artışa neden olduğu belirlenmiştir. IL-4 ve TNF-Beta ile vitamin D ve vitamin B12 arasında ilişki bulunamamıştır. Obez hastalarda vitamin B12 ve vitamin D nin IL-4, IL-10, TNF-Beta düzeylerine etkilerini daha iyi görebilmek için daha uzun süreli takip ve daha geniş vaka popülasyonlarında çalışmalara ihtiyaç vardır. \u0000Anahtar Kelimeler: IL-4, IL-10 Obezite, TNF-Beta, Vitamin B12, Vitamin D","PeriodicalId":174708,"journal":{"name":"Konuralp Tıp Dergisi","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125444744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reforms in primary health care in Bulgaria - past, present, future","authors":"Nevena G. IVANOVA","doi":"10.18521/ktd.1230931","DOIUrl":"https://doi.org/10.18521/ktd.1230931","url":null,"abstract":"The health of any nation, and the Bulgarian one in particular, is extremely important for the economy, security and development of the country. Unlike other European countries, due to defects in the structure and functioning, the Bulgarian health system could not achieve satisfactory final results in a number of important aspects of public health. One part of the essential problems includes high rates of morbidity, mortality, wide spread of health risk factors, and on the other - insufficient satisfaction of medical professionals (doctors, nurses, support staff) and patients. This, combined with the changes in the political administration of Bulgaria, led to a decision for a radical reform in the health care system. Conditionally, the changes can be divided, according to their nature, into 6 large groups: 1) Reforms leading to democratization of the system; 2) Reforms related to liberalization; 3) Reforms in the status of primary care practices; 4) Reforms in the organization, construction and structure of the system; 5) Reforms in financing and payment methods; 6) Reforms in the management of the primary care system and practices. The purpose of this review article is to present the theoretical framework, grounds and goals for the reform of the health care system in Bulgaria carried out in the past, with a focus on primary care and the current state.\u0000The health of any nation, and the Bulgarian one in particular, is extremely important for the economy, security and development of the country. Unlike other European countries, due to defects in the structure and functioning, the Bulgarian health system could not achieve satisfactory final results in a number of important aspects of public health. One part of the essential problems includes high rates of morbidity, mortality, wide spread of health risk factors, and on the other - insufficient satisfaction of medical professionals (doctors, nurses, support staff) and patients. This, combined with the changes in the political administration of Bulgaria, led to a decision for a radical reform in the health care system. Conditionally, the changes can be divided, according to their nature, into 6 large groups: 1) Reforms leading to democratization of the system; 2) Reforms related to liberalization; 3) Reforms in the status of primary care practices; 4) Reforms in the organization, construction and structure of the system; 5) Reforms in financing and payment methods; 6) Reforms in the management of the primary care system and practices. The purpose of this review article is to present the theoretical framework, grounds and goals for the reform of the health care system in Bulgaria carried out in the past, with a focus on primary care and the current state.","PeriodicalId":174708,"journal":{"name":"Konuralp Tıp Dergisi","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131554440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-Compassion in Depression and Anxiety Disorders","authors":"A. Akkoyun, Betül Kurtses Gürsoy","doi":"10.18521/ktd.1202613","DOIUrl":"https://doi.org/10.18521/ktd.1202613","url":null,"abstract":"Objective: This study was conducted to determine the levels of self-compassion, psychological well-being and self-esteem in patients with depression and anxiety disorders and the relationship between them. \u0000Methods: 100 depression, 100 anxiety disorder patients who applied to XXXX Psychiatry outpatient clinic and agreed to participate in the study voluntarily and 100 healthy controls were included in the study. Sociodemographic data form, Beck Anxiety Inventory (BAI), Beck Depression Inventory (BDI), Psychological Well-Being Scale (PWBS), Self-Compassion Scale (SCS) and Rosenberg Self-Esteem Scale (RSES) were applied to the participants. \u0000Results: According to the findings of the scales applied to all groups, there was a statistically significant difference between the groups in terms of well-being, self-esteem, and self-understanding (p","PeriodicalId":174708,"journal":{"name":"Konuralp Tıp Dergisi","volume":"150 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116344885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of pathophysiological changes in Type-2 diabetic patients on thyroid dysfunction and nodular goiter development in Turkey","authors":"H. Ergenç, Özlem KARACA OCAK, Erkan Aksoy, Z. Ergenç","doi":"10.18521/ktd.1159387","DOIUrl":"https://doi.org/10.18521/ktd.1159387","url":null,"abstract":"Objective: The prevalence of thyroid dysfunction is higher in patients with diabetes, and its diagnosis could cause better diabetes management. The purpose of the present study is to examine the impact of pathophysiological changes in patients with Type-2 diabetes on the frequency of thyroid dysfunction, thyroid autoimmunity, thyroid nodule, and thyroid cancer in Turkey. \u0000Methods: The study was conducted on a total of 3.276 patients with Type-2 diabetes who underwent thyroid tests and thyroid ultrasonography (US). The demographic characteristics, biochemical and hormonal values, thyroid US reports, and histopathology reports were collected from the patient's electronic records. \u0000Results: Thyroid autoimmunity positive TPOab 15.9% (n = 524) and/or positive TGab 9.9% (n = 327), the rate of positivity of both antibodies (TPOab + TGab) in the same patient, and total thyroid autoimmunity was found to be 32.57% (n=1067) in Type-2 diabetic patients. Thyroid dysfunction was detected in 18.3% (n = 602) of these patients. The distribution of thyroid dysfunction was 9.09% (n = 298) subclinical hypothyroidism, 4.1% (n = 135) clinical hypothyroidism, 3.1% (n = 102) subclinical hyperthyroidism, 2.0% (n = 67) clinical hyperthyroidism. Also, 67.9% (n = 2225) thyroid nodules, and 5% (n = 164) thyroid cancer were detected. \u0000Conclusion: Thyroid dysfunction was found to have increased in patients with Type-2 diabetes at significant levels.","PeriodicalId":174708,"journal":{"name":"Konuralp Tıp Dergisi","volume":"52 3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130512173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Relationship Between Smoking Status, Carbon Monoxide Levels, Quality of Life, and Disease Features in Inflammatory Bowel Diseases","authors":"Yıldız Kıraç, B. Yalcin, Muge Ustaoglu","doi":"10.18521/ktd.1186958","DOIUrl":"https://doi.org/10.18521/ktd.1186958","url":null,"abstract":"Objective: The aim of the study was to analyze the relationship between smoking status and exhaled carbon monoxide (E-CO) levels, quality of life, and disease characteristics in patients with inflammatory bowel disease. \u0000Methods: The demographic and disease characteristics and smoking status of 121 patients with inflammatory bowel disease who presented our hospital between 01.12.2020 and 01.03.2021 were investigated. After the first follow-up, the E-CO levels of these participants were measured every four consecutive weeks. The mean of these E-CO readings was accepted as the main E-CO value. After one month after their first application SF-36 Quality of Life Scale was applied. The relationship between these variables was investigated. \u0000Results: The mean age of the participants was 42.06±14.9 years, and 36.3% were active smokers. While patients with Crohn’s disease (CD) exhibited a higher smoking rate, smokers with ulcerative colitis (UC) registered significantly higher mean CO ppm readings (p","PeriodicalId":174708,"journal":{"name":"Konuralp Tıp Dergisi","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127323230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Metacognition in The Emergence of Anger and Aggression in Patients with Alcohol Use Disorder Alkol Kullanım Bozukluğu Olan Hastalarda Öfke ve Agresyonun Ortaya Çıkışında Üstbilişin Rolü","authors":"N. Kara, Enes Sarigedi̇k, Ahmet Ataoğlu","doi":"10.18521/ktd.1181749","DOIUrl":"https://doi.org/10.18521/ktd.1181749","url":null,"abstract":"ABSTRACT \u0000OBJECTIVE: In this study, weaimed to investigate metacognitive functions, anger and aggression and the relationship in patients with alcohol dependence. It is to have information about which metacognitive beliefs plays a role in the emergence of anger and aggression in people with alcohol dependence. \u0000METHOD: The patient group diagnosed with Alcohol Use Disorder (AUD) according to DSM-5 (n = 72) and the control group without any psychiatric diagnosis (n = 71) were included in the study. Sociodemographic data form, Alcohol Use Disorders Identification Test (AUDIT), Metacognition Questionnaire (MCQ-30), Trait Anger and Anger Expression Scale (STAXI) and Buss-Perry’s Aggression Questionnaire (AQ) were used. \u0000RESULT: In the AUD group, the MCQ-30, STAXI trait anger, anger out and anger in, and AQ scores were found to be significantly higher than the control group (p","PeriodicalId":174708,"journal":{"name":"Konuralp Tıp Dergisi","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114673011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}