Konuralp Tıp Dergisi最新文献

{"title":"Post-COVID-19 Cardiovascular Disorders and the Molecular Mechanism of NET Formation","authors":"Lütfiye Özpak, E. Aksu, İbrahim Seyfettin Çeli̇k, B. M. Kelleci̇, Mustafa Çeli̇k, Celal Kuş","doi":"10.18521/ktd.1323455","DOIUrl":"https://doi.org/10.18521/ktd.1323455","url":null,"abstract":"Objective: The post-COVID-19 process is not completely understood, as it affects COVID-19 survivors at all levels of disease severity, not all of whom are hospitalized. One of the long-lasting COVID-19 symptom categories, cardiovascular disorders (including acute heart failure, palpitations, hypotension, venous thromboembolic diseases, arrhythmias, myocarditis, and increased heart rate), may derive from a systemic inflammatory response to the viral infection. NETs (neutrophil extracellular traps) that fight invading viruses in extracellular cardiac spaces accumulate due to COVID-19, hyperinflammation and cytokine storms. Our study focuses on cardiovascular disorders as COVID-19 sequelae. To determine the role of NETs in these disorders, we aimed to measure levels of PAD4, MPO, MMP-9, and H3Cit. Methods: In this study, forty people with long-term cardiac complications associated with a history of COVID-19 were recruited along with forty healthy people. Results: We found significant differences in PAD4, H3Cit, and MPO plasma levels between the post-COVID-19 and control groups (p values < 0.05). The expression levels of PAD4 mRNA were lower and MMP-9 mRNA levels was higher in the post-COVID-19 group compared with the control subjects. Conclusion: These findings suggest that PAD4, MPO, MMP-9, and H3Cit are potential biomarkers of NET dysregulation and may cause post-COVID-19 symptoms, especially cardiovascular disorders.","PeriodicalId":174708,"journal":{"name":"Konuralp Tıp Dergisi","volume":"108 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115176983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obezite Cerrahisi Hastalarında Obstrüktif Uyku Apne Sıklığı","authors":"A. Annakkaya, Ege GÜLEÇ BALBAY, Mevlut Pehlivan, Öner Balbay","doi":"10.18521/ktd.1291510","DOIUrl":"https://doi.org/10.18521/ktd.1291510","url":null,"abstract":"Objective: Obesity is one of the most important risk factors and also consequences of obstructive sleep apnea (OSA). Weight loss and positive airway pressure therapy are the main approaches in the treatment of OSA. In this study, it was aimed to evaluate the prevalence of OSA in obesity patients scheduled for bariatric surgery. \u0000Methods: In the University Hospital Obesity Center, 141 consecutive patients who were candidates for bariatric surgery in 2015 were clinically evaluated preoperatively for sleep-related respiratory disorders. Preoperative polysomnographic examination was recommended to all cases. \u0000Results: Of 141 bariatric surgery candidates with a mean age of 37±10 years, and 103 (73%) were female. The mean body mass index of the cases was 46.9±6.4 kg/m2. Among the major symptoms of OSA, snoring was present in 119 (84.4%), daytime sleepiness in 63 (44.7%) and witnessed apnea in 49 (34.8%) patients. OSA was detected because AHI>5/hour was found in 75.7% (84/111) of the patients who accepted the polysomnographic evaluation. 24.3% (27/111) of the cases who underwent polysomnography had non OSA, 29.7% (33/111) mild OSA, 17.1% (19/111) moderate OSA, and 28.8% (32 /111), severe OSA was detected. AHI was positively correlated with age (p=0.003), neck and waist diameter (p","PeriodicalId":174708,"journal":{"name":"Konuralp Tıp Dergisi","volume":"128 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126866803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EVALUATION OF ANTIBIOGRAMS OF Escherichia coli STRAINS ISOLATED FROM URINARY CULTURES","authors":"Sedanur Sari, S. Mıstık, P. Sağıroğlu","doi":"10.18521/ktd.1064423","DOIUrl":"https://doi.org/10.18521/ktd.1064423","url":null,"abstract":"Aim: Our aim in this study is to determine the antimicrobial resistance profiles of E. coli strains known to cause urinary tract infections most frequently in the region, to obtain microbiological data about their current status, and to contribute to the development of clinical strategies for the prevention and management of these infections. \u0000Materials and methods: Our study includes patients with Escherichia coli isolated from urine cultures. In the study, urine cultures and antibiograms of patients between January 2019 and January 2020 were scanned retrospectively. 662 patients over the age of 18 were included in the study. The files of the patients included in the study, the information registered in the system and the pre-filled forms were examined by examining age, gender, reproductive status in urine cultures, ESBL status, antibiograms, hospitalization status, admission outpatient clinic, reason for hospitalization, chronic and additional diseases, symptom status, the blood, nitrite, leukocyte parameters in the urinary dipstick test and the antibiotic treatment started were recorded. \u0000Results: The antibiotics most frequently resistant to E. coli strains were cefuroxime (88.5%), tobramycin (75%), ceftazidime (72.9%), cefepime (59.5%) and ampicillin (57.5%). The antibiotics with the highest sensitivity were imipenem (100%), amikacin (99.1%), meropenem (98.2%), nitrofurantoin (96.3%) and fosfomycin (96.3%). It was observed that 25.7% of E. coli strains were ESBL positive. \u0000Conclusion: Our findings showed that E. coli strains, which are the most common causative agents of urinary tract infections, have high resistance to many antibiotics commonly used in treatment. Considering the local resistance rates in empirical treatment and starting the treatment by making a urine culture will guide the treatment. As a result of our research, we think that the use of fosfomycin and nitrofurantoin in uncomplicated infections and the use of carbapenems and aminoglycoside antibiotics in complicated infections and upper urinary tract involvement are appropriate in the empirical treatment of urinary tract infections.","PeriodicalId":174708,"journal":{"name":"Konuralp Tıp Dergisi","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131927316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Turkish Validity and Reliability of the Coronavirus-Related Health Literacy Scale on Health Science Students","authors":"Sibel Peksoy Kaya, P. Demır, S. Kaplan, S. Şahin","doi":"10.18521/ktd.1216651","DOIUrl":"https://doi.org/10.18521/ktd.1216651","url":null,"abstract":"Objective: Health literacy is one’s ability to access, comprehend, appraise, and apply health-related information. Health literacy has become an important topic since the COVID-19 pandemic. This methodological study aimed to adapt the Coronavirus-Related Health Literacy Scale (HLS-COVID-Q22) to Turkish. \u0000Methods: The sample consisted of 539 students of the faculty of health sciences of a university in Turkey. The study was conducted between December 2020 and May 2021. The content validity ratio was calculated for content validity. The construct and concurrent validity, internal consistency reliability, test-retest reliability, and ceiling and floor effects were also determined. A confirmatory factor analysis was performed for construct validity. \u0000Results: The fit indices indicated an adequate fit (2/df: 4.970.70) and Cronbach’s alpha values (>0.90) were above acceptable limits. Most students had “adequate health literacy” (71.8%). A quarter of the students had “problematic health literacy” (24.5%). The remaining students had “inadequate health literacy” (3.7%). Students with lower levels of health literacy were more likely to have confusion about coronavirus-related information (p","PeriodicalId":174708,"journal":{"name":"Konuralp Tıp Dergisi","volume":"64 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127943879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Carbapenem-resistant Enterobacteriaceae infections and the rate of which colonization switch into infection.","authors":"Özlem Aydemir, Gökçen Ormanoğlu, Tuğba Ayhancı, M. Köroğlu, Y. Aydemir, E. Güçlü","doi":"10.18521/ktd.1104037","DOIUrl":"https://doi.org/10.18521/ktd.1104037","url":null,"abstract":"Objectives: Carbapenem-resistant Enterobacterales (CRE) infections have limited treatment options, and these infections are associated with high mortality rates. Asymptomatic carriers colonized with CRE contribute to the spread of CRE in hospitals. It was aimed to determine the frequency of CRE isolates detected in our center, carbapenemase ratios in these strains, carbapenemase genes, antibiotic resistance profiles, rectal CRE colonization rates and to evaluate various clinical features of CRE infections. \u0000Methods: Enterobacterales species isolated from various specimens and Enterobacterales species isolated from rectal swab specimens sent for colonization screening were examined. Patients with CRE colonization in rectal swab samples were examined for the development of CRE infection at a later time. CRE isolates were examined for carbapenemase production and the presence of carbapenemase gene. \u0000Results: 12,721 Enterobacterales (10,161 E. coli and 2395 K. pneumoniae, 165 Citrobacter) isolates were examined. Carbapenem resistance was detected in 10.3% of these strains. CRE was detected in 4.7% of 15695 rectal swab samples evaluated for colonization. In 23.4% of the patients with CRE colonization, CRE growth was detected in other samples besides the rectal swab in the later period. It was observed that CRE infections developed on average 21 days after colonization. \u0000Conclusion: CRE infections have started to emerge as a factor not only in hospitalized patients but also in community-acquired infections. Our study also showed that CRE colonization could be a significant risk factor for the development of infection. Therefore, early screening detection to detect colonization can help prevent or limit CRE infections with appropriate isolation methods.","PeriodicalId":174708,"journal":{"name":"Konuralp Tıp Dergisi","volume":"55 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133695080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Some Biochemical Parameters of COVID-19 Patients as Biomarkers","authors":"Ü. Karadeniz, Serpil Uğraş, Pınar GÖÇ RASGELE","doi":"10.18521/ktd.1268351","DOIUrl":"https://doi.org/10.18521/ktd.1268351","url":null,"abstract":"Objective: SARS-CoV-2 has caused a global pandemic with more than 664 million confirmed cases and more than 6.7 million deaths worldwide. In pandemic, several studies have been done about the relationship of some biochemical and hematological parameters with COVID 19 in order to assist diagnosis and treatment. However, a lot of information is not completely complete and there are contradictions in the data. In the present study, it was focused to compare the biochemical parameters of patients and healthy individuals due to COVID 19 by investigating the relationship between age and gender. \u0000Methods: The 317 individuals who consulted to the Pandemic Outpatient Clinic with the suspicion of COVID 19 between February 2022 and November 2022 were evaluated by laboratory tests. In present study, biochemical parameter values of individuals with positive and negative COVID 19 test outcomes were used as material. These biochemical parameters were compared statistically based on different age ranges and gender groups. \u0000Results: It was ascertained that the values such as UREA, KREA, FER, AST, ALT, HSTI, CK and CRP in male patients with COVID 19 were higher than female patients with COVID 19. Moreover, it was detected that there was a statistically significant increase in parameters such as GLU, FER, AST, LDH, HSTI, CK and CRP in COVID 19 patients aged 18-65 years. \u0000Conclusions: Many biomarkers of prognostic importance are expensive, ordinary and pricey-effective biomarkers such as FER, AST, LDH, HSTI, CK and CRP can be used to monitor disease in patients with COVID 19 infection.","PeriodicalId":174708,"journal":{"name":"Konuralp Tıp Dergisi","volume":"105 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114198725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bir Tıp Fakültesinde Klinik Kayıt Tutma Eğitimindeki İhtiyacı Belirlemeye ve Klinik Kayıtlar Niteliği Üzerine Bir Çalışma","authors":"Emre Emekli, Özlem Coşkun, I. Budakoğlu, Yavuz Selim Kiyak","doi":"10.18521/ktd.1259969","DOIUrl":"https://doi.org/10.18521/ktd.1259969","url":null,"abstract":"Objective: To determine the need for clinical record keeping education in undergraduate programs at our university. \u0000Methods: Qualitative descriptive research method was used. To determine clinical record keeping education needs, interviews were conducted with 10 faculty members working at the Faculty of Medicine in the 2022-2023 academic year, using a semi-structured form. In addition, a 17-question survey was administered to elicit the needs of the students attending the Faculty of Medicine. \u0000Results: A total of 102 students participated in the study. Eighty-two (80.4%) students reported not having received any education on clinical record keeping. For the questions scored on a seven-point Likert scale, related to how competent they considered themselves to be in clinical record keeping and how comfortable they felt while writing patient notes, the mean scores were calculated to be 3.89±1.66 and 3.55±1.74, respectively. Ninety-two (90.2%) students considered it necessary to take a course on how to keep clinical records. Ten faculty members participated in the interviews conducted using a semi-structured form. During these interviews, emerging themes concerning the quality of clinical records were the comprehensiveness and usefulness of these records, and the use of appropriate language. When the reasons for deficiencies in clinical record keeping were questioned, problems in the education system and a lack of education were prominent. \u0000Conclusion: We identified the deficiencies and needs related to clinical record keeping in our faculty. Based on our results, we consider that the implementation of appropriate curricula and activities will increase the quality of clinical records.","PeriodicalId":174708,"journal":{"name":"Konuralp Tıp Dergisi","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125787594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of Subcarinal Angle and Tracheobronchial Morphology in Patients with COVID 19: A Retrospective Computed Tomography Study","authors":"Sibel ATEŞOĞLU KARABAŞ, Rukiye Çiftçi, Hilal Er Ulubaba, A. Yoldaş","doi":"10.18521/ktd.1247746","DOIUrl":"https://doi.org/10.18521/ktd.1247746","url":null,"abstract":"Objective: Morphological features of the trachea are very important in choosing the correct endotracheal tube size for intubation. In this study, it was proposed to reveal the effect of SARS-CoV-2 on tracheobronchial morphology and subcarinal angle. \u0000Method: 56 (26 female, 30 male) COVID-19 and 48 (24 female, 24 male) healthy individuals aged 40 and over were included in the study. The mean age of female patients with COVID-19 was 51.30±12.78 years, while the women in the control group were 45.00±11.89 years. The mean age of male patients with COVID-19 was 48.73±13.99 years, while the mean age of men in the control group was 43.76±8.45 years. The trachea length (TL), proximal, middle and distal levels anteroposterior (AP) and transverse (TR) trachea diameters (TD), subcarinal angle (SA), proximal right main bronchus (RMB) and left main bronchus (LMB) diameters were also measured on computed tomography (CT) images. \u0000Results: The RMB angle was higher in men with COVID-19 than in the control group (p=0.005). TL was lower in women with COVID-19 than in the control group (p=0.030). Proximal AP-TD was higher in men with COVID-19 than in the control group (p=0.006). Proximal TR-TD was lower in men with COVID-19 than in the control group (p=0.029). TL, proximal, middle, and distal levels of AP and TR-TD,SA, RMB, and LMB angles, and proximal RMB and LMB diameters were found to be lower in women with COVID-19 than in men with COVID-19 (p=0.001). \u0000Conclusion: It was deduced that tracheobronchial morphology might change in patients infected with SARS-CoV-2.It is clinically important that this situation should not be overlooked, especially in the indication of endotracheal intubation.","PeriodicalId":174708,"journal":{"name":"Konuralp Tıp Dergisi","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117187662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of the Effect of Psoriasis and Methotrexate Treatment on Liver Stiffness by ARFI Imaging","authors":"Derya Güçlü, Ebru Karagün, E. Unlu, Mehtap Oktay, Özge Pasin","doi":"10.18521/ktd.1280187","DOIUrl":"https://doi.org/10.18521/ktd.1280187","url":null,"abstract":"Objective: To investigate whether psoriasis and methotrexate used in its treatment cause liver fibrosis and eventually to evaluate the safety of methotrexate in treatment. \u0000Method: 44 cases were included in the study. Methotrexate-using (group 1, n=14) and methotrexate-not-using (group 2, n=13) psoriasis patients were compared retrospectively with a healthy control group (group 3, n=17) according to mean shear wave rates obtained from sonoelastographic examinations with ARFI technique. \u0000Results: Mean shear wave velocities were calculated as 2.57 ± 1.13 m/sec in the patients using methotrexate, 2.31 ± 1.16 m/sec in the patients who did not use methotrexate, and 1.56 ± 0.62 m/sec in the healthy control group. While the average shear wave velocity of the 3rd group was found to be significantly lower than that of the 1st and 2nd groups (p=0.032; p=0.012), no significant difference was observed between the 1st and 2nd groups (p=0.755). \u0000Conclusion: We think that the increase in liver tissue stiffness in patients using methotrexate for psoriasis is secondary to the inflammatory process caused by psoriasis itself rather than methotrexate, and methotrexate is safe for the liver in treatment.","PeriodicalId":174708,"journal":{"name":"Konuralp Tıp Dergisi","volume":"87 4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125719705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genç Yetişkinlerde Ruh Sağlığı Okuryazarlığının Geçerlilik ve Güvenilirlik Çalışması (MHLq)","authors":"Nevin Günaydin, Funda Özpulat, Duygu Öztaş, İnci Açikgöz","doi":"10.18521/ktd.1210310","DOIUrl":"https://doi.org/10.18521/ktd.1210310","url":null,"abstract":"Objective: This study was conducted on the Turkish validity and reliability study of the Mental Health Literacy Scale (MHLq) in young adults. \u0000Methods: This methodological investigation was carried out throughout the 2018–2019 academic year at a public university. The MHL, created by Dias et al. in 2018, and a sociodemographic data form were used to gather the data. 350 students between the ages of 18 and 25 participated in the study. \u0000Results: The scale was translated from the original language into Turkish, professional opinion was sought, and to translate it into Turkish, a pilot study was conducted. The content validity index, confirmatory factor analysis, item analyses, reliability, Cronbach's alpha analysis, and test-retest scores were used to test the scale validity as well as its construct validity, internal consistency, and time invariance. The scale is four-dimensional, as was found. Confirmatory factor analysis revealed that the scale's item loads varied between 0.40 and 0.73 while its content validity was 0.98. Its 0.91 Cronbach's alpha value was discovered. The participants' average mental health literacy scores were 84.45±7.80. \u0000Conclusions: The analyses made showed that the MHLq could be safely used as a measurement tool for young adults’ mental health literacy.","PeriodicalId":174708,"journal":{"name":"Konuralp Tıp Dergisi","volume":"60 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125679263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}