Journal of Veterinary Internal Medicine最新文献

{"title":"Prospective evaluation of NT-proBNP assay to detect occult dilated cardiomyopathy and predict survival in Doberman Pinschers.","authors":"G E Singletary,&nbsp;N A Morris,&nbsp;M Lynne O'Sullivan,&nbsp;S G Gordon,&nbsp;M A Oyama","doi":"10.1111/j.1939-1676.2012.1000.x","DOIUrl":"https://doi.org/10.1111/j.1939-1676.2012.1000.x","url":null,"abstract":"<p><strong>Background: </strong>Occult (asymptomatic) dilated cardiomyopathy (ODCM) is highly prevalent in Doberman Pinschers.</p><p><strong>Hypothesis/objectives: </strong>Assess ability of NT-proBNP assay to detect ODCM and predict death.</p><p><strong>Animals: </strong>155 asymptomatic Dobermans presenting for ODCM screening.</p><p><strong>Methods: </strong>Echocardiography, 24-hour Holter, and NT-proBNP assay were performed prospectively. Diagnosis was based on increased left ventricular end-systolic dimension, >50 ventricular premature complexes (VPCs), or both on Holter. Utility was evaluated using receiver-operating characteristic curves. Effect of age, weight, sex, disease status, VPCs, and NT-proBNP on survival was analyzed using Kaplan-Meier and Cox-proportional hazard analysis.</p><p><strong>Results: </strong>Seventy-three (47.1%) Dobermans were diagnosed with ODCM, including 31, 17, and 25 that met Holter, echocardiographic, or both criteria, respectively. Sensitivity of NT-proBNP > 457 pmol/L to detect these groups was 45.2, 76.5, and 96.0%, respectively. Combination of NT-proBNP and Holter to detect ODCM yielded sensitivity of 94.5%, specificity of 87.8%, and accuracy of 91.0%. Follow-up data were available for 78 Dobermans. The median survival time of Dobermans with > 50 VPCs (469 days), NT-proBNP > 900 pmol/L (284 days), or ODCM (474 days) was significantly (P < .0001) shorter than those with < 50 VPCs (1743 days), NT-proBNP < 900 pmol/L (1743 days), or without disease (1743 days). NT-proBNP concentration and disease status were independently predictive of all-cause mortality.</p><p><strong>Conclusions and clinical importance: </strong>The combination of NT-proBNP assay and Holter detected ODCM with high accuracy. NT-proBNP and disease status were independently associated with survival. NT-proBNP assay identified Dobermans with high probability of increased LVIDs consistent with ODCM, and can facilitate pursuit of confirmatory diagnostic testing, such as echocardiography, in suspected Dobermans.</p>","PeriodicalId":17462,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"26 6","pages":"1330-6"},"PeriodicalIF":2.6,"publicationDate":"2012-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1939-1676.2012.1000.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30921229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High prevalence of the c.74A>C SPINK1 variant in miniature and standard Schnauzers.","authors":"E Furrow,&nbsp;P J Armstrong,&nbsp;E E Patterson","doi":"10.1111/j.1939-1676.2012.01013.x","DOIUrl":"https://doi.org/10.1111/j.1939-1676.2012.01013.x","url":null,"abstract":"BACKGROUND Variants in the serine protease inhibitor Kazal type 1 (SPINK1) gene have been associated with pancreatitis in Miniature Schnauzers. Replication of the association in an independent population is necessary to determine if genetic screening for SPINK1 variants should be considered in clinical practice. HYPOTHESIS An association between the SPINK1 exonic variant c.74A > C and pancreatitis exists in Miniature Schnauzers. In addition, the variant is absent or rare in Standard Schnauzers, a related breed that is not reported to have an increased risk for pancreatitis. ANIMALS Case-control study. Seventeen Miniature Schnauzers with pancreatitis (cases), 60 mature Miniature Schnauzers with no substantial history of gastrointestinal signs in their lifetime (controls), and 31 Standard Schnauzers of unknown pancreatitis status. METHODS A PCR-RFLP assay was used to genotype dogs for the c.74A > C SPINK1 variant. Allele and genotype frequencies were reported for Schnauzers and compared between case and control Miniature Schnauzers. RESULTS The c.74A > C variant was the major allele in both Schnauzer breeds with a frequency of 0.77 in Miniatures and 0.55 in Standards. The allele and genotype frequencies were similar between Miniature Schnauzers with and without a history of pancreatitis and did not impart an increased risk for pancreatitis. CONCLUSIONS AND CLINICAL IMPORTANCE Genotyping a larger population of the Miniature Schnauzer breed than a previous study, along with a Standard Schnauzer cohort, demonstrated that the SPINK1 c.74A > C variant is a common polymorphism in the Schnauzer lineage. Furthermore, we were unable to confirm a relationship between the variant and clinically detectable pancreatitis in Miniature Schnauzers.","PeriodicalId":17462,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"26 6","pages":"1295-9"},"PeriodicalIF":2.6,"publicationDate":"2012-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1939-1676.2012.01013.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30973702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interpretation of multisegment bronchoalveolar lavage in cats (1/2001-1/2011).","authors":"W L Ybarra,&nbsp;L R Johnson,&nbsp;T L Drazenovich,&nbsp;E G Johnson,&nbsp;W Vernau","doi":"10.1111/j.1939-1676.2012.01016.x","DOIUrl":"https://doi.org/10.1111/j.1939-1676.2012.01016.x","url":null,"abstract":"<p><strong>Background: </strong>Cytologic results from bronchoscopic BAL in cats with naturally occurring respiratory disease have not been reported, and the clinical utility of multisegment lavage has not been evaluated.</p><p><strong>Hypothesis: </strong>BAL cytology from 2 separate lung segments in cats will have similar cell counts, cytologic interpretation, or both.</p><p><strong>Animals: </strong>Eighty-seven cases in 85 cats (2 examined twice) with naturally occurring lower respiratory disease.</p><p><strong>Methods: </strong>A combined prospective/retrospective evaluation of all cats with multisegment BAL was performed. BAL fluid was evaluated for total nucleated cell counts, differential cell counts, and cytologic characteristics at each lavage site. BAL fluid was categorized as eosinophilic, neutrophilic, lymphocytic, hypercellular, or mixed. Radiographs were assessed for diffuse or focal disease.</p><p><strong>Results: </strong>Clinical diagnoses included inflammatory airway disease (n = 63), pneumonia (n = 15), neoplasia (n = 6), and undetermined (n = 3). Total nucleated cell counts varied between sites regardless of radiographic evidence of focal or diffuse radiographic disease. In 28/87 cases (32%), cell counts differed between lavage sites by 2.2-40 fold. BAL yielded similar cytologic interpretation of inflammation in 45/87 (52%) cases. In 8/14 cases that had BAL performed at the site of a focal radiographic infiltrate, as well as at a site of diffuse infiltrates, the same inflammatory interpretation was made at each site.</p><p><strong>Conclusions and clinical importance: </strong>Total and differential cell counts in BAL fluid often differ between lung segments in cats with lower respiratory disease, and caution is warranted when using a single BAL cytology to define the inflammatory response in cats with spontaneously occurring lower respiratory tract disease.</p>","PeriodicalId":17462,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"26 6","pages":"1281-7"},"PeriodicalIF":2.6,"publicationDate":"2012-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1939-1676.2012.01016.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31009249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of pimobendan in the prevention of congestive heart failure or sudden death in Doberman Pinschers with preclinical dilated cardiomyopathy (the PROTECT Study).","authors":"N J Summerfield,&nbsp;A Boswood,&nbsp;M R O'Grady,&nbsp;S G Gordon,&nbsp;J Dukes-McEwan,&nbsp;M A Oyama,&nbsp;S Smith,&nbsp;M Patteson,&nbsp;A T French,&nbsp;G J Culshaw,&nbsp;L Braz-Ruivo,&nbsp;A Estrada,&nbsp;M L O'Sullivan,&nbsp;J Loureiro,&nbsp;R Willis,&nbsp;P Watson","doi":"10.1111/j.1939-1676.2012.01026.x","DOIUrl":"https://doi.org/10.1111/j.1939-1676.2012.01026.x","url":null,"abstract":"<p><strong>Background: </strong>The benefit of pimobendan in delaying the progression of preclinical dilated cardiomyopathy (DCM) in Dobermans is not reported.</p><p><strong>Hypothesis: </strong>That chronic oral administration of pimobendan to Dobermans with preclinical DCM will delay the onset of CHF or sudden death and improve survival.</p><p><strong>Animals: </strong>Seventy-six client-owned Dobermans recruited at 10 centers in the UK and North America.</p><p><strong>Methods: </strong>The trial was a randomized, blinded, placebo-controlled, parallel group multicenter study. Dogs were allocated in a 1:1 ratio to receive pimobendan (Vetmedin capsules) or visually identical placebo. The composite primary endpoint was prospectively defined as either onset of CHF or sudden death. Time to death from all causes was a secondary endpoint.</p><p><strong>Results: </strong>The proportion of dogs reaching the primary endpoint was not significantly different between groups (P = .1). The median time to the primary endpoint (onset of CHF or sudden death) was significantly longer in the pimobendan (718 days, IQR 441-1152 days) versus the placebo group (441 days, IQR 151-641 days) (log-rank P = 0.0088). The median survival time was significantly longer in the pimobendan (623 days, IQR 491-1531 days) versus the placebo group (466 days, IQR 236-710 days) (log-rank P = .034).</p><p><strong>Conclusion and clinical importance: </strong>The administration of pimobendan to Dobermans with preclinical DCM prolongs the time to the onset of clinical signs and extends survival. Treatment of dogs in the preclinical phase of this common cardiovascular disorder with pimobendan can lead to improved outcome.</p>","PeriodicalId":17462,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"26 6","pages":"1337-49"},"PeriodicalIF":2.6,"publicationDate":"2012-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1939-1676.2012.01026.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30987365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and adverse effects of (R)-9-(2-phosphonylmethoxypropyl)-2,6-diaminopurine in feline immunodeficiency virus-infected cats.","authors":"N Justa,&nbsp;K Weber,&nbsp;D Klein,&nbsp;R S Mueller,&nbsp;C Sauter-Louis,&nbsp;K Hartmann","doi":"10.1111/j.1939-1676.2012.01007.x","DOIUrl":"https://doi.org/10.1111/j.1939-1676.2012.01007.x","url":null,"abstract":"<p><strong>Background: </strong>(R)-9-(2-phosphonylmethoxypropyl)-2,6-diaminopurine (PMPDAP) is active against feline immunodeficiency virus (FIV) in vitro, and is less toxic than other acyclic nucleoside phosphonates. Its efficacy in naturally infected cats has not been evaluated in large controlled studies.</p><p><strong>Hypothesis/objectives: </strong>PMPDAP is effective in naturally FIV-infected cats with minimal adverse effects.</p><p><strong>Animals: </strong>Forty-five privately owned cats naturally infected with FIV.</p><p><strong>Methods: </strong>Prospective, randomized, placebo-controlled, double-blinded clinical study. Cats were randomly assigned to be treated with PMPDAP (25 mg/kg) daily, PMPDAP 3 times a week, or placebo for a period of 6 weeks.</p><p><strong>Results: </strong>Administration of PMPDAP to FIV-infected cats did not lead to detectable improvements in clinical, virological, or immunological variables. Proviral load (FIV copies/10(6) cells) did not change significantly during treatment (placebo group: from 9505 ± 10119 to 8564 ± 8615; PMPDAP 3 times a week: from 4818 ± 4426 to 5041 ± 6197; PMPDAP daily: from 3525 ± 5038 to 3167 ± 5824). There was a significant decrease of red blood cell counts (×10(12) /L) (from 8.91 ± 1.82 to 7.34 ± 1.79 in cats treated 3 times per week (P < .001), and from 8.96 ± 1.13 to 6.01 ± 1.36 in cats treated daily (P < .001)), as well as of packed cell volume, and hemoglobin in both groups receiving PMPDAP.</p><p><strong>Conclusions and clinical importance: </strong>Administration of PMPDAP was not associated with significant improvements in clinical, immunological, or virological parameters, but treatment was associated with adverse effects, mainly anemia. Thus, PMPDAP, as administered in this study, cannot be recommended for treatment of FIV-infected cats.</p>","PeriodicalId":17462,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"26 6","pages":"1267-73"},"PeriodicalIF":2.6,"publicationDate":"2012-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1939-1676.2012.01007.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30956194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparative review of vitamin E and associated equine disorders.","authors":"C J Finno,&nbsp;S J Valberg","doi":"10.1111/j.1939-1676.2012.00994.x","DOIUrl":"https://doi.org/10.1111/j.1939-1676.2012.00994.x","url":null,"abstract":"<p><p>Vitamin E is a primary chain-breaking antioxidant that prevents cyclic propagation of lipid peroxidation. Across species, vitamin E is essential for normal neuromuscular function by acting as a potent antioxidant, as well as by modulating the expression of certain genes, inhibiting platelet aggregation and stabilizing plasma membranes. This review focuses on vitamin E structure, absorption, metabolism, current equine dietary recommendations, the interplay between antioxidants and exercise, a discussion of the necessity of vitamin E supplementation in the horse above the Nutritional Research Council (NRC) 2007 requirements, and a review of equine diseases that are associated with a vitamin E deficiency. Particular emphasis is placed on the proteins involved in vitamin E absorption, transport, and metabolism as potential candidates for vitamin E-associated diseases across species.</p>","PeriodicalId":17462,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"26 6","pages":"1251-66"},"PeriodicalIF":2.6,"publicationDate":"2012-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1939-1676.2012.00994.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30861098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Arterial blood pressure, proteinuria, and renal histopathology in clinically healthy retired racing greyhounds.","authors":"S Surman,&nbsp;C G Couto,&nbsp;S P Dibartola,&nbsp;D J Chew","doi":"10.1111/j.1939-1676.2012.01008.x","DOIUrl":"https://doi.org/10.1111/j.1939-1676.2012.01008.x","url":null,"abstract":"<p><strong>Background: </strong>Physiologic peculiarities of Greyhounds as compared to other dogs make interpretation of laboratory results in this breed challenging for veterinarians. Hypertension in retired racing Greyhounds (RRG) can contribute to microalbuminuria (MA), overt proteinuria, and renal histologic lesions.</p><p><strong>Objectives: </strong>To evaluate clinicopathologic findings, hemodynamic status, and renal histology in a population of healthy RRG.</p><p><strong>Animals: </strong>RRG presented to Ohio State University College of Veterinary Medicine for inclusion in a spay and neuter program.</p><p><strong>Methods: </strong>Cross-sectional study. RRG were classified as normotensive (<160 mmHg) or hypertensive (>160 mmHg) based on blood pressure (BP) determinations using Doppler and oscillometric methods. Of the dogs evaluated, 62% (n = 29) were hypertensive and 38% (n = 18) were normotensive. Health status was evaluated using routine clinicopathologic tests (CBC, serum biochemistry, urinalysis) as well as evaluation of fractional excretion of electrolytes and MA determinations. Adequate renal biopsy specimens (n = 15) were evaluated using light, immunofluoresence, and electron microscopy.</p><p><strong>Results: </strong>All serum biochemistry results were normal in 45/49 dogs, but MA was more common in hypertensive (84% positive for MA) as compared with normotensive (18% positive for MA) RRG. Observed renal lesions were mild and renal biopsy scores were low in this sample of RRG.</p><p><strong>Conclusions: </strong>Hypertension is common in RRG and might be breed-related. It is associated with MA, but observed renal lesions are mild. Whether or not hypertension and MA in RRG leads to progressive renal damage requires longitudinal study.</p>","PeriodicalId":17462,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"26 6","pages":"1320-9"},"PeriodicalIF":2.6,"publicationDate":"2012-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1939-1676.2012.01008.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30989138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Congenital hypothyroidism with goiter in Tenterfield terriers.","authors":"S E Dodgson,&nbsp;R Day,&nbsp;J C Fyfe","doi":"10.1111/j.1939-1676.2012.01015.x","DOIUrl":"https://doi.org/10.1111/j.1939-1676.2012.01015.x","url":null,"abstract":"<p><strong>Background: </strong>A cluster of cases of congenital hypothyroidism with goiter (CHG) in Tenterfield Terriers was identified and hypothesized to be dyshormonogenesis of genetic etiology with autosomal recessive inheritance.</p><p><strong>Objectives: </strong>To describe the phenotype, thyroid histopathology, biochemistry, mode of inheritance, and causal mutation of CHG in Tenterfield Terriers.</p><p><strong>Animals: </strong>Thyroid tissue from 1 CHG-affected Tenterfield Terriers, 2 affected Toy Fox Terriers, and 7 normal control dogs. Genomic DNA from blood or buccal brushings of 114 additional Tenterfield Terriers.</p><p><strong>Methods: </strong>Biochemical and genetic segregation analysis of functional gene candidates in a Tenterfield Terrier kindred. Thyroid peroxidase (TPO) iodide oxidation activity was measured, and TPO protein and SDS-resistant thyroglobulin aggregation were assessed on western blots. TPO cDNA was amplified from thyroid RNA and sequenced. Exons and flanking splice sites were amplified from genomic DNA and sequenced. Variant TPO allele segregation was assessed by restriction enzyme digestion of PCR products.</p><p><strong>Results: </strong>Thyroid from an affected pup had lesions consistent with dyshormonogenesis. TPO activity was absent, but normal sized immunocrossreactive TPO protein was present. Affected dog cDNA and genomic sequences revealed a homozygous TPO missense mutation in exon 9 (R593W) that was heterozygous in all obligate carriers and in 31% of other clinically normal Tenterfield Terriers.</p><p><strong>Conclusions: </strong>The mutation underlying CHG in Tenterfield Terriers was identified, and a convenient carrier test made available for screening Tenterfield Terriers used for breeding.</p>","PeriodicalId":17462,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"26 6","pages":"1350-7"},"PeriodicalIF":2.6,"publicationDate":"2012-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1939-1676.2012.01015.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31015050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulmonary hemorrhage in horses seroreactive to leptospirosis in Rio de Janeiro, Brazil.","authors":"Camila Hamond,&nbsp;Gabriel Martins,&nbsp;Walter Lilenbaum","doi":"10.1111/j.1939-1676.2012.01020.x","DOIUrl":"https://doi.org/10.1111/j.1939-1676.2012.01020.x","url":null,"abstract":"","PeriodicalId":17462,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"26 6","pages":"1237; author reply 1238"},"PeriodicalIF":2.6,"publicationDate":"2012-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1939-1676.2012.01020.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31063335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic utility of abdominal ultrasonography in dogs with chronic diarrhea.","authors":"M S Leib,&nbsp;M M Larson,&nbsp;D C Grant,&nbsp;W E Monroe,&nbsp;G C Troy,&nbsp;D L Panciera,&nbsp;J H Rossmeisl,&nbsp;S R Werre","doi":"10.1111/j.1939-1676.2012.01009.x","DOIUrl":"https://doi.org/10.1111/j.1939-1676.2012.01009.x","url":null,"abstract":"BACKGROUND\u0000Chronic diarrhea is common in dogs and has many causes. Ultrasonographic descriptions of many gastrointestinal diseases have been published, but the diagnostic utility of ultrasonography in dogs with chronic diarrhea has not been investigated.\u0000\u0000\u0000HYPOTHESIS\u0000Diagnostic utility of abdominal ultrasound will be highest in dogs with GI neoplasia and lowest in those with inflammatory disorders.\u0000\u0000\u0000ANIMALS\u000087 pet dogs with chronic diarrhea.\u0000\u0000\u0000METHODS\u0000Prospective study in which medical records were reviewed and contribution of abdominal ultrasound toward making diagnosis was scored.\u0000\u0000\u0000RESULTS\u0000In 57/87 (66%) of dogs, the same diagnosis would have been reached without ultrasonography. In 13/87 (15%) of dogs, the ultrasound examination was vital or beneficial to making the diagnosis. Univariable analysis identified that increased diagnostic utility was associated with weight loss (P = .0086), palpation of an abdominal or rectal mass (P = .0031), diseases that commonly have mass lesions visible on ultrasound examination (P < .0001), and a final diagnosis of GI neoplasia. Multivariable regression indicated that utility of abdominal ultrasonography would be 30 times more likely to be high in dogs in which an abdominal or rectal mass was palpated (odds ratio 30.5, 95% CI 5.5-169.6) (P < .0001) versus dogs without a palpable mass. In 15/87 (17%) of dogs, additional benefits of ultrasonography to case management, independent of the contribution to the diagnosis of diarrhea, were identified.\u0000\u0000\u0000CONCLUSIONS AND CLINICAL IMPORTANCE\u0000Overall, the diagnostic utility of abdominal ultrasonography was low in dogs with chronic diarrhea. Identification of factors associated with high diagnostic utility is an indication to perform abdominal ultrasonography in dogs with chronic diarrhea.","PeriodicalId":17462,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"26 6","pages":"1288-94"},"PeriodicalIF":2.6,"publicationDate":"2012-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1939-1676.2012.01009.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30974812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}