Journal of Veterinary Internal Medicine最新文献

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Semiautomatic volumetry of the temporal lobes of the brain and correlation with electroencephalography results in dogs with assumed idiopathic epilepsy. 假定患有特发性癫痫的狗的大脑颞叶半自动体积测量及与脑电图结果的相关性。
IF 2.6 2区 农林科学
Journal of Veterinary Internal Medicine Pub Date : 2024-11-04 DOI: 10.1111/jvim.17237
Paulina Kinga Drobot, Aleksandra Banasik, Karolina Owsińska-Schmidt, Marcin Wrzosek, Przemysław Podgórski
{"title":"Semiautomatic volumetry of the temporal lobes of the brain and correlation with electroencephalography results in dogs with assumed idiopathic epilepsy.","authors":"Paulina Kinga Drobot, Aleksandra Banasik, Karolina Owsińska-Schmidt, Marcin Wrzosek, Przemysław Podgórski","doi":"10.1111/jvim.17237","DOIUrl":"https://doi.org/10.1111/jvim.17237","url":null,"abstract":"<p><strong>Background: </strong>Lesions causing refractory epilepsy, often associated with temporal lobe epilepsy (TLE), can be undetectable on standard magnetic resonance imaging (MRI) in dogs. Automated brain volumetry, widely used in human medicine, can now be applied in veterinary medicine because of the availability of brain atlases.</p><p><strong>Objectives: </strong>This study aimed to develop an automatic volumetry method, translate the outcomes into the assessment of temporal lobe volumes in dogs with idiopathic epilepsy, and correlate the results with the electroencephalography (EEG) data of epileptiform discharges (EDs).</p><p><strong>Animals: </strong>Thirty-one dogs of various breeds with dominant temporal lobe discharge.</p><p><strong>Methods: </strong>Retrospective, observational study. The MRI and EEG examination results of dogs referred for neurological diagnosis data between 2016 and 2021 were retrospectively analyzed. An automated volumetry method was developed, which allowed the evaluation of temporal lobe volumes of the dogs. The asymmetric ratio (AR) was then estimated, and the results were correlated with the EEG EDs.</p><p><strong>Results: </strong>12/31 (38%; 95% CI: 21.8%-57.8%) dogs had an asymmetric ratio >6%. Among them, reduction in temporal lobe volumes correlated with the side of the EEG EDs in 7 cases. There was no statistical correlation between temporal lobe volume changes and ED location.</p><p><strong>Conclusions and clinical importance: </strong>Preliminary volumetric analysis of the temporal lobes indicates the presence of volume differences between the lobes in some dogs with idiopathic epilepsy. Diagnosis of TLE in dogs based on MRI volumetry in correlation with EEG examination, especially for dogs with drug-resistant epilepsy, can influence the development of new therapeutic options, such as surgery.</p>","PeriodicalId":17462,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142575762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association among raised intraventricular pressure, clinical signs, and magnetic resonance imaging findings in dogs with congenital internal hydrocephalus. 先天性内脑积水患犬脑室内压升高、临床症状和磁共振成像结果之间的关联。
IF 2.6 2区 农林科学
Journal of Veterinary Internal Medicine Pub Date : 2024-10-31 DOI: 10.1111/jvim.17235
Daniela Farke, Agnieszka Olszewska, Kathrin Büttner, Martin J Schmidt
{"title":"Association among raised intraventricular pressure, clinical signs, and magnetic resonance imaging findings in dogs with congenital internal hydrocephalus.","authors":"Daniela Farke, Agnieszka Olszewska, Kathrin Büttner, Martin J Schmidt","doi":"10.1111/jvim.17235","DOIUrl":"https://doi.org/10.1111/jvim.17235","url":null,"abstract":"<p><strong>Background: </strong>Dogs with internal hydrocephalus do not necessarily have high intraventricular pressure (IVP).</p><p><strong>Hypothesis/objectives: </strong>Not all reported MRI findings indicate high IVP and some clinical signs might be associated with elevated IVP and syringomyelia.</p><p><strong>Animals: </strong>Fifty-three dogs.</p><p><strong>Materials and methods: </strong>Cross-sectional study. Clinical signs and MRI findings were evaluated for an association of IVP >12 mm Hg and syringomyelia.</p><p><strong>Results: </strong>High IVP was associated with obtundation OR 4.64 (95% CI 1.27-16.93) (P = .02), head tilt OR 6.42 (95% CI 1.08-37.97) (P = .04) and nystagmus OR 8.24 (95% CI 1.44-47.07) (P = .02). Pain was associated with syringomyelia OR 3.4 (95% CI 0.98-11.78) (P = .05). The number of affected ventricles was associated with high IVP OR 2.85 (95% CI 0.97-8.33) (P = .05) and syringomyelia OR 12.74 (95% CI 2.93-55.4) (P = .0007). Periventricular edema OR 24.46 (95% CI 4.54-131.77), OR 7.61 (95% CI 1.91-30.32) (P < .0002, P = .004) and signal void sign OR 17.34 (95% CI 4.01-74.95), OR 4.18 (95% CI 1.16-15.02) (P < .0001, P = .03) were associated with high IVP and syringomyelia. The probability for syringomyelia is lower with disruption of the internal capsule OR 0.19 (95% CI 0.05-0.72) (P = .01) and higher VBR OR 0.25 (95% CI 0.1-0.63) (P = .004).</p><p><strong>Conclusions and clinical importance: </strong>Previously reported MRI findings are not predictive of high IVP. Clinical signs and MRI findings should be used to make a diagnosis of internal hydrocephalus in dogs with or without high IVP.</p>","PeriodicalId":17462,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142558148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pharmacodynamics of 2 dosages of orally administered esomeprazole in client-owned, healthy dogs: A prospective, crossover study. 在客户饲养的健康犬中口服两种剂量埃索美拉唑的药效学:前瞻性交叉研究。
IF 2.6 2区 农林科学
Journal of Veterinary Internal Medicine Pub Date : 2024-10-31 DOI: 10.1111/jvim.17233
Abby Ostronic, Christine Gremillion, Song Zhang, Joerg M Steiner, M Katherine Tolbert, Emily N Gould
{"title":"Pharmacodynamics of 2 dosages of orally administered esomeprazole in client-owned, healthy dogs: A prospective, crossover study.","authors":"Abby Ostronic, Christine Gremillion, Song Zhang, Joerg M Steiner, M Katherine Tolbert, Emily N Gould","doi":"10.1111/jvim.17233","DOIUrl":"https://doi.org/10.1111/jvim.17233","url":null,"abstract":"<p><strong>Background: </strong>Esomeprazole use is increasing in dogs, but the gastrointestinal adverse events associated with q12h dosing necessitate pharmacodynamic evaluation of a reduced dose and frequency of administration.</p><p><strong>Objectives: </strong>To compare the efficacy of 2 doses of (q24h) esomeprazole in raising intragastric pH in dogs.</p><p><strong>Animals: </strong>Nine healthy, client-owned dogs, >20 kg.</p><p><strong>Methods: </strong>Prospective, randomized, double blinded, crossover study. Esomeprazole (0.5 or 1 mg/kg q24h) was orally administered for up to 5 days per treatment arm, and the mean percentage time intragastric pH was ≥3 (MPT3) and ≥4 (MPT4) for 24 hours periods were compared to pretreatment pH using a continuous pH monitoring system. Dogs failing to reach pH goals (MPT3 ≥75%, MPT4 ≥66%) with once daily dosing received esomeprazole 1 mg/kg PO q12h to determine if a higher dose would improve acid suppression.</p><p><strong>Results: </strong>No significant difference in the MPT3 or MPT4 was identified between treatments for any time point (P > .05). Both doses increased the MPT pH ≥3 and 4 median [range] (0.5 mg/kg, 1 mg/kg) on days 1 (MPT3: 76.8% [44-100], 69.2% [28.2-100]; MPT4: 65.6% [16.7-99.3], 54.9% [14.9-93.3]; P = .0009) and 2 (MPT3:77.2% [27.4-100], 75.4% [49.4-89.5]; MPT4: 66.3% [15.5-100], 59.7% [33.8-81.2]; P = .0005) of PPI treatment compared to pretreatment (MPT3: 58.3% [0.02-93.9], 52.6% [6.1-94.7]; MPT4: 25.2% [0-86.8], 32.4% [1.8-89.3]). Six dogs (66%, [0.36, 0.97]) reached pH goals established in humans with q24h dosing.</p><p><strong>Conclusions and clinical importance: </strong>Both q24h PO esomeprazole doses were effective in raising intragastric pH, despite high intersubject variability, but 33% of dogs required q12h dosing to reach pH goals.</p>","PeriodicalId":17462,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142558152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical findings, prognostic factors, and outcome of protein-losing nephropathy in cats: A retrospective study. 猫蛋白丢失性肾病的临床发现、预后因素和预后:一项回顾性研究。
IF 2.6 2区 农林科学
Journal of Veterinary Internal Medicine Pub Date : 2024-10-31 DOI: 10.1111/jvim.17240
Noam Sugar, Hilla Chen, Gilad Segev
{"title":"Clinical findings, prognostic factors, and outcome of protein-losing nephropathy in cats: A retrospective study.","authors":"Noam Sugar, Hilla Chen, Gilad Segev","doi":"10.1111/jvim.17240","DOIUrl":"https://doi.org/10.1111/jvim.17240","url":null,"abstract":"<p><strong>Background: </strong>Primary glomerular disease resulting in protein-losing nephropathy (PLN) is an uncommon cause of chronic kidney disease in cats, yet is important to recognize because it warrants specific treatment that impacts outcome.</p><p><strong>Hypothesis/objective: </strong>Characterize clinicopathologic findings, prognostic indicators, and short- (≤30 days) and long-term survival of cats with PLN.</p><p><strong>Animals: </strong>Thirty-seven cats with naturally occurring PLN.</p><p><strong>Methods: </strong>Medical records of cats with PLN admitted to a veterinary teaching hospital were retrospectively reviewed.</p><p><strong>Results: </strong>Median age was 3 years (range, 1.5-11.5 years) and 17/37 (46%) were males. Short-term survival was 57%. The estimated median survival time of all cats was 424 days (95% confidence interval [CI], 0-1098 days). Common clinical signs included lethargy (57%), edema (46%) and weight loss (35%). Edema was more common in short-term survivors compared with nonsurvivors (odds ratio [OR], 0.21; 95% CI, 0.05-0.86-20.4; P = .04). Serum creatinine concentration at presentation was negatively associated with long-term survival (OR, 1.3; 95% CI, 1.03-1.52; P = .01). Administration of immunosuppressive and antiproteinuric medications was more common among short-term survivors compared with nonsurvivors (18/20 [90%] vs 9/16 [56%]; OR, 7.0; 95% CI, 1.2-40.8; P = .05 and 17/20 [85%] vs 7/16 [44%]; OR, 7.3; 95% CI, 1.5-35.2; P = .01, respectively). Partial or complete remission was documented in 11/31 (36%) cats and was associated with both short (OR, 3.3; 95% CI, 1.7-6.5; P < .001) and long-term survival (P = .003).</p><p><strong>Conclusion and clinical importance: </strong>Cats with PLN have a guarded prognosis, but achieving remission improves outcome. Cats presented with edema rather than azotemia are more likely to respond to treatment.</p>","PeriodicalId":17462,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142558149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correlation of serum chloride concentrations with components of the renin-angiotensin-aldosterone system in a dog with congestive heart failure. 充血性心力衰竭犬血清氯化物浓度与肾素-血管紧张素-醛固酮系统成分的相关性。
IF 2.6 2区 农林科学
Journal of Veterinary Internal Medicine Pub Date : 2024-10-31 DOI: 10.1111/jvim.17238
Cailey Banken, Autumn N Harris, Rachel Conway, Eduardo J Benjamin, Robin Shoemaker, Darcy Adin
{"title":"Correlation of serum chloride concentrations with components of the renin-angiotensin-aldosterone system in a dog with congestive heart failure.","authors":"Cailey Banken, Autumn N Harris, Rachel Conway, Eduardo J Benjamin, Robin Shoemaker, Darcy Adin","doi":"10.1111/jvim.17238","DOIUrl":"https://doi.org/10.1111/jvim.17238","url":null,"abstract":"<p><p>A 7-year-old male castrated Cavalier King Charles Spaniel was hospitalized for 12 days for treatment of severe congestive heart failure secondary to myxomatous mitral valve disease. During that time, 6 serum samples from different days were analyzed for serum biochemical and renin-angiotensin-aldosterone system components. Serum chloride concentrations (ranging from 71.6 to 103.1 mmol/L) were inversely related to angiotensin I concentrations, aldosterone concentrations, a surrogate marker of renin activity, and a surrogate marker of adrenal responsiveness to angiotensin II. In light of recent studies showing that hypochloremia is associated with advanced heart failure in dogs and is associated with poor outcomes in people, the information from the dog in this report supports exploration of RAAS dysregulation as an underlying mechanism.</p>","PeriodicalId":17462,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142558150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Oxygen consumption, locomotory-respiratory coupling and exercise-induced pulmonary hemorrhage in horses during the Paso Fino gait. 马匹在帕索菲诺步态中的耗氧量、运动-呼吸耦合和运动诱发的肺出血。
IF 2.6 2区 农林科学
Journal of Veterinary Internal Medicine Pub Date : 2024-10-31 DOI: 10.1111/jvim.17226
Shannon Massie, Renaud Léguillette, Warwick Bayly, Ray Sides, Angélica María Zuluaga-Cabrera
{"title":"Oxygen consumption, locomotory-respiratory coupling and exercise-induced pulmonary hemorrhage in horses during the Paso Fino gait.","authors":"Shannon Massie, Renaud Léguillette, Warwick Bayly, Ray Sides, Angélica María Zuluaga-Cabrera","doi":"10.1111/jvim.17226","DOIUrl":"https://doi.org/10.1111/jvim.17226","url":null,"abstract":"<p><strong>Background: </strong>Workload associated with the high frequency Colombian Paso Fino gait has not been evaluated.</p><p><strong>Objectives: </strong>To determine the oxygen consumption (V̇O<sub>2</sub>), heart rate (HR), stride frequency: breathing ratio, and hematology associated with the Paso Fino gait, including whether exercise-induced pulmonary hemorrhage (EIPH) occurs.</p><p><strong>Animals: </strong>Eleven Paso Fino horses.</p><p><strong>Methods: </strong>Prospective cohort study. Horses performed a standardized Paso Fino gait test across a wooden sounding board, simulating competition. V̇O<sub>2</sub> and ventilatory parameters (tidal volume [V<sub>T</sub>]; peak inspiratory and expiratory airflows [PkV̇<sub>I</sub>, PkV̇<sub>E</sub>]; respiratory rate [RR], minute ventilation [V̇E]) were measured using a portable ergospirometry facemask. Heart rate was measured using electrocardiograms. Post-exercise lactate, hematocrit, bicarbonate, pH, electrolytes, and biochemistry concentrations were measured. EIPH was assessed via tracheobronchoscopy. Four horses completed a secondary high-intensity gallop to elicit peak V̇O<sub>2</sub> for comparative purposes.</p><p><strong>Results: </strong>Median [IQR] mean individual HR during the Paso Fino gait was 190 [178, 201] bpm. Relative V̇O<sub>2</sub> measured 49.8 [48.4, 59.5] mL/(kg min; V<sub>T</sub> = 8.6 [8.0, 10.7] L; RR = 87.1 [75.4, 99.5] bpm; V̇E = 869 [740, 902] L/min; PkV̇<sub>I</sub> = 33.4 [32.7, 37.2] L/s; PkV̇<sub>E</sub> = 44.2 [40.3, 46.0] L/s). Horses took 2.8 [2.7, 2.9] strides/second and had a stride frequency: breathing ratio of 2.0 [1.8, 2.3]. Post-exercise blood lactate concentration and hematocrit measured 2.7 mmol/L and 50% respectively. Three horses showed endoscopic evidence of Grade-1 EIPH. The Paso Fino gait V̇O<sub>2</sub> and HR equaled 79% V̇O<sub>2</sub>pk and 91% maximal HR, respectively, based on the high-intensity gallop.</p><p><strong>Conclusions and clinical importance: </strong>The Paso Fino gait represents submaximal exercise based on V̇O<sub>2</sub> < V̇O<sub>2</sub>pk and blood lactate.</p>","PeriodicalId":17462,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142558151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multicenter study of factors associated with nonsurvival in hospitalized periparturient goats. 住院围产期山羊非存活相关因素的多中心研究。
IF 2.6 2区 农林科学
Journal of Veterinary Internal Medicine Pub Date : 2024-10-30 DOI: 10.1111/jvim.17234
Daniela Luethy, Catalina Cabrera, Lisette M Coll-Roman, Ashley R VanderBroek, Anje G Bauck, Jenna W Stockler, Clare Scully, Audrey A Kelleman, Evelyn E Mackay, Sarah M Depenbrock, Marie-Eve Fecteau, Michelle Abraham, Laurence Leduc, Charlene V Noll, Jorge A Hernandez
{"title":"Multicenter study of factors associated with nonsurvival in hospitalized periparturient goats.","authors":"Daniela Luethy, Catalina Cabrera, Lisette M Coll-Roman, Ashley R VanderBroek, Anje G Bauck, Jenna W Stockler, Clare Scully, Audrey A Kelleman, Evelyn E Mackay, Sarah M Depenbrock, Marie-Eve Fecteau, Michelle Abraham, Laurence Leduc, Charlene V Noll, Jorge A Hernandez","doi":"10.1111/jvim.17234","DOIUrl":"https://doi.org/10.1111/jvim.17234","url":null,"abstract":"<p><strong>Background: </strong>Periparturient reproductive complications appear to be common in hospitalized goats. More information is needed about periparturient reproductive complications and survival in goats with these conditions.</p><p><strong>Objective: </strong>Identify exposure factors associated with nonsurvival in periparturient does hospitalized ≤1 day or ≥2 days.</p><p><strong>Animals: </strong>A total of 198 periparturient does presented to 9 university veterinary hospitals from October 2021 to June 2022.</p><p><strong>Methods: </strong>Multicenter, matched case-control study. Conditional logistic regression was used to identify exposure factors associated with nonsurvival in periparturient does hospitalized ≤1 day or ≥2 days.</p><p><strong>Results: </strong>Overall doe survival was 79% (156/198). Survival in the 1st day of hospitalization was 71% (52/73) and survival in does hospitalized ≥2 days was 83% (104/125). Among goats hospitalized ≤1 day, labor duration before admission (odds ratio [OR] = 4.8; P = .04), uterine tears (OR = 48.2; P < .001), and vaginal/perineal trauma diagnosed during hospitalization (OR = 6.2; P = .03) were associated with nonsurvival. Among goats hospitalized ≥2 days, factors associated with nonsurvival included labor duration before admission (OR = 6.2; P = .004), pregnancy toxemia (OR = 6.07; P = .04), and Cesarean section (OR = 11.35; P = .02).</p><p><strong>Conclusions and clinical importance: </strong>Longer labor duration before admission is an important predictor of nonsurvival in hospitalized does. Clients should be educated that early detection and veterinary care are critical for improving outcome in periparturient does.</p>","PeriodicalId":17462,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142546189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of oxidative stress in dogs and cats with chronic kidney disease. 评估患有慢性肾病的猫狗体内的氧化应激。
IF 2.6 2区 农林科学
Journal of Veterinary Internal Medicine Pub Date : 2024-10-30 DOI: 10.1111/jvim.17230
Hilla Chen, Gilad Segev
{"title":"Evaluation of oxidative stress in dogs and cats with chronic kidney disease.","authors":"Hilla Chen, Gilad Segev","doi":"10.1111/jvim.17230","DOIUrl":"https://doi.org/10.1111/jvim.17230","url":null,"abstract":"<p><strong>Background: </strong>Oxidative stress is a potential contributor to chronic kidney disease (CKD) progression but has not been evaluated in dogs and cats with CKD.</p><p><strong>Hypothesis: </strong>Oxidative stress is higher in animals with CKD compared with healthy controls and decreases with the advancing CKD stage. The aim of this study was to determine the presence and intensity of oxidative stress in dogs and cats at different CKD stages.</p><p><strong>Animals: </strong>Sixty dogs and 30 cats with naturally acquired CKD; 10 dogs and 14 cats, healthy controls.</p><p><strong>Methods: </strong>Analytical cross-sectional study. Oxidative stress was evaluated by measuring the urinary concentration of F2-isoprostane (uF2-IsoPs) normalized to urinary creatinine.</p><p><strong>Results: </strong>Urinary F2-isoprostanes normalized to urinary creatinine of healthy dogs and of dogs with CKD Stages 1 to 4 was 3.3 ng/mg, 4.7 ng/mg (range, 1.0-73.4), 2.4 ng/mg (range, 0.4-7.8), 0.52 ng/mg (range, 0.01-2.9), and 0.37 ng/mg (range, 0.01-0.6), respectively. Urinary F2-isoprostanes differed among CKD stages (P < .001), but not compared with controls. uF2-IsoPs of healthy cats and cats with CKD Stages 1 to 4 was 0.68 ng/mg (range, 0.2-1.4), 0.97 ng/mg (range, 0.4-1.8), 0.6 ng/mg (range, 0.002-2.0), 0.94 ng/mg (range, 0.3-2.3), and 0.2 ng/mg (range, 0.01-0.4). Urinary F2-isoprostanes differed among stages (P = .05) but not compared with healthy controls.</p><p><strong>Conclusion and clinical importance: </strong>Oxidative stress might be present in dogs and cats with CKD. Its magnitude declines as the disease progresses, therefore, it should be considered a potential therapeutic target mostly at the early stages of the disease.</p>","PeriodicalId":17462,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142546188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Proceedings 34th Symposium ESVN-ECVN 23rd-24th September 2022. 第 34 届 ESVN-ECVN 研讨会论文集 2022 年 9 月 23-24 日。
IF 2.6 2区 农林科学
Journal of Veterinary Internal Medicine Pub Date : 2024-10-29 DOI: 10.1111/jvim.17218
{"title":"Proceedings 34th Symposium ESVN-ECVN 23rd-24th September 2022.","authors":"","doi":"10.1111/jvim.17218","DOIUrl":"https://doi.org/10.1111/jvim.17218","url":null,"abstract":"","PeriodicalId":17462,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142546190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of a customized glycemic pellets challenge with the oral sugar test to measure glycemic and insulinemic responses in horses. 比较定制血糖颗粒挑战和口服糖试验,以测量马的血糖和胰岛素反应。
IF 2.6 2区 农林科学
Journal of Veterinary Internal Medicine Pub Date : 2024-10-28 DOI: 10.1111/jvim.17191
Kristen Thane, Johanna Sonntag, Tobias Warnken, Dania Reiche, Cassandra Uricchio, Nicholas Frank
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