Journal of Veterinary Internal Medicine最新文献

{"title":"Quantitative assessment of specific bacterial taxa of the intestinal microbiota of healthy and diarrheic horses.","authors":"Laurie Boucher, Rockson Karmacharya, Luis G Arroyo, Mathilde Leclère, Jan S Suchodolski, Rachel Pilla, Sherri Powledge, Victor Dellevedove Cruz, Makayla Richardson, Carolyn Arnold, Marcio Carvalho Costa","doi":"10.1093/jvimsj/aalag231","DOIUrl":"10.1093/jvimsj/aalag231","url":null,"abstract":"<p><strong>Background: </strong>Alterations in intestinal microbiota composition, as determined by DNA sequencing, are reported in horses with acute colitis compared with healthy horses.</p><p><strong>Hypothesis/objectives: </strong>Changes in specific bacterial populations can detect overall intestinal disruption of the normal intestinal microbiota. Identify bacterial taxa that indicate intestinal dysbiosis or health in horses using quantitative PCR (qPCR).</p><p><strong>Animals: </strong>Thirty horses with undifferentiated colitis, 13 with colitis associated with Salmonella spp., 14 with antibiotic-associated diarrhea (AAD), 52 healthy horses from Canada and 48 from the United States.</p><p><strong>Methods: </strong>This was a retrospective multicenter cross-sectional study. Horses were included in this study through a search of medical records of acute colitis cases, for which a fecal sample was collected. qPCR assays were developed for 14 bacterial taxa and compared using Welch t-test, one-way Analysis of Variance (ANOVA), Kruskal-Wallis or Welch's ANOVA.</p><p><strong>Results: </strong>qPCR analysis showed significant differences in absolute abundance in 7 out of the 14 bacterial taxa tested. Differences that were consistent across all colitis groups included higher abundance of Enterobacteriaceae (mean log10DNA ± SD; Control_Canada: 2.51 ± 0.53 vs undifferentiated: 3.43 ± 1.00; Control_USA: 2.06 ± 0.91 vs Salmonella spp.: 3.65 ± 1.05 and AAD: 4.22 ± 0.97, all P < .01) and Escherichia coli (2.28 ± 1.13 vs 3.54 ± 1.54; 1.80 ± 1.25 vs 3.74 ± 1.30 and 3.90 ± 1.52, all P < .01) and lower abundance of Turicibacter spp. (4.10 ± 0.24 vs 3.86 ± 0.37; 3.64 ± 0.27 vs 3.17 ± 0.30 and 2.96 ± 0.60, respectively; all P < .01).</p><p><strong>Conclusions and clinical importance: </strong>This study reports changes in bacterial taxa across various colitis phenotypes and indicates that this approach could serve as a faster, cost-effective proxy for detecting dysbiosis in the gastrointestinal tract of horses.</p>","PeriodicalId":17462,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"40 5","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13644807/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149128058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phenotypic characterization of presumptive propriospinal myoclonus in young dogs (2013-2025).","authors":"Dakir Polidoro, Sofie F M Bhatti, Patrick Santens, Paul Mandigers, Koen M Santifort, Shinichi Kanazono, Diane Lu, Daniel Sánchez-Masián, Alberta de Stefani, Intan Nur Fatiha Shafie, Patricia Álvarez, Nina Meyerhoff, Tadej Jeroncic, Serene R Lai, Guillaume F Dutil, Cecilia Rohdin, Adrien Marchand, Stephanie Thomovsky, Theofanis Liatis","doi":"10.1093/jvimsj/aalag211","DOIUrl":"10.1093/jvimsj/aalag211","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Propriospinal myoclonus (PSM) is characterized by repetitive, brief jerks of the trunk, hips, and knees in humans and has not been reported in dogs.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Hypothesis/objectives: &lt;/strong&gt;To describe phenotype, diagnostic findings, treatment, and outcomes in presumptive PSM in dogs.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Animals: &lt;/strong&gt;Twenty-seven dogs with presumptive PSM.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Multicenter, retrospective study of dogs with myoclonus affecting the limbs and trunk without head involvement, identified through online calls for suspected cases.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Median age at onset was 9 months (range, 2-44 months). Propriospinal myoclonus involved pelvic limbs in all dogs, thoracic limbs in 14/27 (52%), and trunk in 9/27 (33%). Pelvic limb myoclonus was extensor in all dogs, whereas thoracic limb involvement was extensor in 12/27 (44%) and flexor in 3/27 (11%) dogs. Episodes were observed in a non-weight-bearing posture in all dogs, mainly lateral (25/27; 93%) and sternal (12/27; 44%) recumbency. Neurological examination was normal in all dogs. Abnormalities were not detected on magnetic resonance imaging of the spinal cord (4/6) or brain (6/6) in 5/6 dogs; in the remaining dog, findings were unrelated to the presumptive PSM. Follow-up information was available for 26/27 (96%) dogs. Sixteen dogs (59%) received no treatment, of which 9/16 (56%) showed spontaneous reduction in PSM frequency. Treatment with various antiseizure medications was started in 11/27 (41%) dogs, of which 5/11 (45%) improved.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions and clinical importance: &lt;/strong&gt;Presumptive PSM affected young dogs and is likely idiopathic. The condition is characterized by extensor myoclonus predominantly affecting pelvic limbs during recumbency, with preserved mentation. Spontaneous improvement seems common.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Abstract translated to dutch/flemish: &lt;/strong&gt;Achtergrond: Propriospinale myoclonus (PSM) wordt bij mens gekenmerkt door repetitieve, schokbewegingen van de romp, heupen en knieën. Tot op heden is deze aandoening niet beschreven bij honden.Doelstelling; Het beschrijven van het fenotype, diagnostische bevindingen, behandeling en klinische uitkomst.Dieren: Zevenentwintig honden met vermoedelijke PSM. Methoden-Multicentrische retrospectieve studie bij honden met myoclonus waarbij de ledematen waren betrokken, geïdentificeerd via online meldingen van vermoedelijke gevallen.Resultaten: De mediane leeftijd bij aanvang van de symptomen bedroeg 9 maanden (spreiding: 2-44 maanden). Bij alle honden was PSM aanwezig in de achterpoten, bij 14/27 (52%) in de voorpoten en bij 9/27 (33%) in de romp. De myoclonus van de achterpoten was bij alle honden in extensie. Ter hoogte van de voorpoten was de myoclonus in extensie (12/27 (44%) en in flexie (3/27 (11%). De episoden traden voornamelijk op in zijligging (25/27; 93%) en sternale (12/27; 44%). Neurologisch onderzoek was bij alle honden normaal. Magnetische re","PeriodicalId":17462,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"40 5","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13630453/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149111413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of clinical findings to distinguish between intestinal lymphoma or inflammatory bowel disease in horses.","authors":"Jolie Demchur, Alicia E Long, Holly L Stewart, Darko Stefanovski, Daniela Luethy","doi":"10.1093/jvimsj/aalag225","DOIUrl":"10.1093/jvimsj/aalag225","url":null,"abstract":"<p><strong>Background: </strong>Identifying clinical findings that are distinct between inflammatory bowel disease (IBD) and intestinal lymphoma could be helpful for providing preliminary guidance for clients regarding their horse's prognosis while awaiting histopathologic results.</p><p><strong>Hypothesis/objectives: </strong>To describe and compare the clinical findings of horses with a final histopathologic diagnosis of IBD vs intestinal lymphoma.</p><p><strong>Animals: </strong>Forty-six adult (≥1-year-old) horses with a final histopathologic diagnosis of IBD or intestinal lymphoma on endoscopic duodenal biopsy, surgical biopsy, or necropsy.</p><p><strong>Methods: </strong>Retrospective single-center case series via electronic medical record review of histopathology.</p><p><strong>Results: </strong>Eighteen horses had a final diagnosis of lymphoma (11 intestinal only, 7 multicentric including the intestinal tract) and 28 had IBD (22 lymphoplasmacytic IBD, 5 eosinophilic IBD, 1 mixed lymphoplasmacytic and eosinophilic IBD). Acute colic (54%) and recurrent colic (39%) were more common in horses with IBD than in horses with lymphoma (11% and 5%; P = .004 and P = .01, respectively). Ultrasonographic evidence of abdominal mesenteric lymphadenopathy was more commonly identified in horses with lymphoma than horses with IBD (60% vs 0%; P < .001). Clinicopathologic values were largely indistinguishable between groups.</p><p><strong>Conclusions and clinical importance: </strong>Clinical findings of IBD and intestinal lymphoma were largely indistinguishable in this cohort, although recurrent or acute colic might be more commonly seen in horses with IBD than those with lymphoma.</p>","PeriodicalId":17462,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"40 5","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13591480/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149012667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Periparturient changes in osteoimmunological markers and their association with hypocalcemia in dairy cows.","authors":"Julia Gleissenberger, Matthias Gleissenberger, Sebastian Becker, Manuel Schraml, Daniel Eingang, Johannes L Khol, Thomas Wittek","doi":"10.1093/jvimsj/aalag244","DOIUrl":"https://doi.org/10.1093/jvimsj/aalag244","url":null,"abstract":"<p><strong>Background: </strong>The transition period in dairy cows is associated with major metabolic adaptations, including increased calcium demand and altered bone metabolism. Osteoimmunological markers may reflect these changes and contribute to the prediction of periparturient hypocalcemia.</p><p><strong>Hypothesis/objectives: </strong>Evaluate osteoimmunological markers during the periparturient period and their association with parity and hypocalcemia in dairy cows.</p><p><strong>Animals: </strong>Sixty-six Fleckvieh, Holstein-Friesian, and New Zealand Friesian dairy cows and heifers from a research herd.</p><p><strong>Methods: </strong>Blood samples were collected at -21, -14, -7, and -0 days before calving, at calving, and at +0, +1, +3, +7, and + 14 days postpartum. Serum concentrations of total calcium, alkaline phosphatase (AP), C-terminal cross-linked telopeptide of type I collagen (CTX-I), osteocalcin (OC), receptor activator of nuclear factor κB (RANK), receptor activator of nuclear factor κB ligand (RANKL), and osteoprotegerin (OPG) were measured. Cows were classified according to postpartum serum calcium concentrations as normocalcemic, subclinical hypocalcemic, or low-calcium. Receiver operating characteristic (ROC) analysis was used to evaluate predictive performance.</p><p><strong>Results: </strong>The CTX-I concentrations were higher in primiparous and normocalcemic cows compared with low-calcium cows. Activity of AP was increased in normocalcemic cows during early lactation. OC, RANKL, and OPG showed no consistent association with calcium status. Concentration of CTX-I demonstrated high predictive value for hypocalcemia before calving (AUC, 0.75-0.90), whereas AP showed moderate and RANK limited predictive value.</p><p><strong>Conclusions and clinical importance: </strong>Markers of bone resorption, particularly CTX-I, were associated with calcium homeostasis during the transition period and may help identify cows at risk for periparturient hypocalcemia before clinical manifestations.</p>","PeriodicalId":17462,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"40 5","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13636724/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149111400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ClotPro viscoelastic testing in coagulation disorders in dogs: a retrospective analysis.","authors":"Pavlos G Doulidis, Carolina Frizzo-Ramos, Larissa J Prankch, Barbara Rütgen, Iwan A Burgener, Nicole Luckschander-Zeller","doi":"10.1093/jvimsj/aalag254","DOIUrl":"10.1093/jvimsj/aalag254","url":null,"abstract":"<p><strong>Background: </strong>Viscoelastic testing provides whole-blood assessment of coagulation, but clinical data on the performance of the ClotPro in dogs with naturally occurring diseases are limited.</p><p><strong>Hypothesis/objectives: </strong>To evaluate pathway coherence of ClotPro variables with routine coagulation tests and to explore disease-associated viscoelastic phenotypes, fibrinolysis, and hypercoagulability.</p><p><strong>Animals: </strong>Eighty-four client-owned dogs admitted to a university hospital.</p><p><strong>Methods: </strong>Retrospective cohort study. ClotPro variables (clotting time, amplitude at 10 min, maximum clot firmness, maximum lysis across extrinsic pathway test [EX], intrinsic pathway test [IN], fibrinogen test channel, aprotinin test [AP] channels) were compared with prothrombin time (PT), activated partial thromboplastin time (aPTT), platelet count (PLT), and D-dimer using Spearman correlation with Benjamini-Hochberg adjustment. Group differences were assessed with Kruskal-Wallis and Dunn's post hoc. Hyperfibrinolysis (HF) was defined using paired EX-AP. A hypercoagulability index (HCI) and platelet/fibrin-adjusted residual firmness were derived.</p><p><strong>Results: </strong>PT correlated with clotting time in EX channel (ρ = 0.48, q = 0.002) and aPTT with clotting time in IN channel (ρ = 0.42, q = 0.007). PLT correlated with maximum clot firmness in EX channel (EX_MCF) (ρ = 0.50, q = 0.001). maximum clot firmness in FIB channel correlated with EX_MCF (ρ = 0.58, q < 0.001) and maximum clot firmness in IN channel (ρ = 0.47, q = 0.003). maximum lysis in EX channel (EX_ML) correlated inversely with EX_MCF (ρ = -0.35, q = 0.028). D-dimer correlated with EX_ML (ρ = 0.30, q = 0.049). Group-level distributions overlapped substantially. HF was infrequent among cases (33% in dogs with hepatopathy and 21% in dogs with hemorrhagic diarrhea). The HCI differed across diseases (P = .0002), whereas platelet/fibrin-adjusted residual firmness did not.</p><p><strong>Conclusions and clinical importance: </strong>ClotPro variables demonstrated pathway-specific coherence with routine coagulation testing and consistent fibrinolysis patterns. Disease states did not define discrete viscoelastic phenotypes, supporting case-level interpretation.</p>","PeriodicalId":17462,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"40 5","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13652645/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149147950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Presumptive paroxysmal dyskinesia in 41 dogs: is the diet change enough?","authors":"Henry Mendo Reyes, Greta Galli, Evelina Burbaitè, Aurora Cocchetto, Erica Fiorentino, Marika Menchetti","doi":"10.1093/jvimsj/aalag238","DOIUrl":"10.1093/jvimsj/aalag238","url":null,"abstract":"<p><strong>Background: </strong>Paroxysmal dyskinesia (PD) in dogs comprises episodic, involuntary, nonepileptic movement disorders. Recent evidence suggests that PD may be associated with gluten sensitivity, paralleling human gluten-related neurologic syndromes.</p><p><strong>Hypothesis/objectives: </strong>Characterize clinical features, gastrointestinal comorbidities, gluten-related serology, and response to a gluten-free diet (GFD) in dogs with presumptive gluten-sensitive PD. We hypothesized that dietary modification would decrease episode frequency, particularly in dogs with gastrointestinal signs, seropositivity for anti-gliadin and anti-transglutaminase-2 immunoglobulin A antibodies or both.</p><p><strong>Animals: </strong>Forty-one client-owned dogs with presumptive PD.</p><p><strong>Methods: </strong>Retrospective review of dogs diagnosed with presumptive PD at a single institution between 2019 and 2023. Inclusion criteria included > 1 episode, video-documented episodes, normal interictal neurologic examination, serum gluten-related antibody titers, and ≥ 6 months of follow-up after transition to GFD.</p><p><strong>Results: </strong>Gastrointestinal signs were reported in 33/41 (80.5%) dogs; 21/41 (51.2%) had at least 1 positive antibody titer. After dietary change, 24/41 (58.5%) dogs achieved complete resolution, 15/41 (36.6%) showed partial response, and 2/41 (4.9%) remained unchanged, regardless of antibody status. All owners reported gastrointestinal improvement. Nine dogs relapsed after initial response: 6 after gluten ingestion, 1 associated with stress, and 2 despite strict GFD. Response to GFD was not significantly associated with gastrointestinal signs or antibody status.</p><p><strong>Conclusions and clinical importance: </strong>Although dietary response was not significantly associated with antibody status or gastrointestinal signs, GFD led to substantial clinical improvement in most dogs with PD across multiple breeds, supporting a potential link between gluten sensitivity and PD, and a possible role of the gut-brain axis in disease pathogenesis.</p>","PeriodicalId":17462,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"40 5","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13652642/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149148350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to letter regarding \"ACVIM-endorsed statement: consensus statement and systematic review on guidelines for the diagnosis and treatment of chronic inflammatory enteropathy in dogs\".","authors":"Romy M Heilmann, Albert E Jergens, Aarti Kathrani, Karin Allenspach, Silke Salavati Schmitz, Simon L Priestnall, Julien R S Dandrieux, Annette M O'Connor","doi":"10.1093/jvimsj/aalag258","DOIUrl":"10.1093/jvimsj/aalag258","url":null,"abstract":"","PeriodicalId":17462,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"40 5","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13662214/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149182642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myoclonus as a neurologic manifestation of hypoglycemia in dogs.","authors":"Dakir Polidoro, Theofanis Liatis, Patricia Álvarez, Sofie F M Bhatti","doi":"10.1093/jvimsj/aalag252","DOIUrl":"https://doi.org/10.1093/jvimsj/aalag252","url":null,"abstract":"<p><strong>Background: </strong>Myoclonus consists of brief, shock-like jerks and is not reported in dogs as a neurological manifestation of hypoglycemia.</p><p><strong>Hypothesis/objectives: </strong>To describe hypoglycemia-associated myoclonus in dogs and report diagnostic findings, treatment, and outcome.</p><p><strong>Animals: </strong>Ten dogs presenting myoclonus and concurrent hypoglycemia.</p><p><strong>Methods: </strong>Multicenter, retrospective study of dogs presenting hypoglycemia-related myoclonus.</p><p><strong>Results: </strong>All dogs presented with myoclonus. Neurological examination was abnormal in 5/10 (50%). Myoclonus was generalized in 8/10 (80%) dogs and focal (head) in 2/10 (20%), with progression to generalized tonic-clonic epileptic seizures in 5/10 (50%). Hypoglycemia (<3.3 mmol/L) was observed in all dogs (median, 2.07 mmol/L) during the myoclonic episodes. Insulinoma was a suspected (n = 1), presumptive (n = 5), or definitive (n = 3) diagnosis in 9/10 (90%) dogs. One dog (10%) developed iatrogenic hypoglycemia after IV administration of fast-acting human insulin and myoclonic episodes resolved after dose reduction. Among dogs with suspected, presumptive or confirmed insulinoma, 5/9 (56%) received medical treatment alone, 3/9 (33%) combined medical and surgical treatment, and 1/9 (11%) was not treated. Medical treatment included, prednisolone (n = 6), diazoxide (n = 3) and therapeutic diet (n = 6). Surgical treatment consisted of pancreatic mass resection. Medical or surgical treatment resulted in short-term improvement in myoclonus frequency in all dogs, however, four were later euthanized due to recurrence of hypoglycemia and myoclonus.</p><p><strong>Conclusions and clinical importance: </strong>Myoclonus might represent an underrecognized neurological manifestation of hypoglycemia in dogs. Measurement of blood glucose concentrations is a fundamental diagnostic approach for identifying hypoglycemia-related myoclonus. Treatment can lead to clinical improvement, but prognosis is dependent on the underlying cause.</p>","PeriodicalId":17462,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"40 5","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13660468/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149182421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomarkers of brain injury in foals with neonatal maladjustment syndrome.","authors":"Javier Perez Quesada, Kinnidy Coley, David Wong, Nimet Browne, Myriah Albrecht, Katarzyna Dembek","doi":"10.1093/jvimsj/aalag228","DOIUrl":"10.1093/jvimsj/aalag228","url":null,"abstract":"<p><strong>Background: </strong>Plasma concentrations of brain-derived neurotrophic factor (BDNF), glial-fibrillary-acidic protein (GFAP), and astrocytic protein S100B, might be linked to the pathophysiology of Neonatal Maladjustment Syndrome (NMS).</p><p><strong>Hypothesis/objectives: </strong>To measure serum concentration of BDNF and S100B, plasma concentration of GFAP, and neurosteroids (progesterone and 17α-hydroxyprogesterone) in foals with NMS, foals presented for other diseases, including premature, and healthy foals, and determine their association with outcome.</p><p><strong>Animals: </strong>Fourteen healthy foals, 19 NMS foals, 39 foals hospitalized for other diseases < 7 days of age.</p><p><strong>Methods: </strong>In this prospective, longitudinal study, concentrations of biomarkers were determined in all foals on admission, at day 1 and 2 of hospitalization. Plasma or serum concentration of biomarkers was measured with ELISA and single-molecule-array technology.</p><p><strong>Results: </strong>Forty-eight foals survived, 10 did not survive. Serum BDNF concentration was lower after 24 h of hospitalization in NMS foals (baseline: 3.0, 1.9-4.1 g/mL; day 1: 2.0, 1.2-2.8 pg/mL) (P = .02). Serum S100B was higher in septic foals with NMS (marginal means, 95% CI, 435.3, 290-580 ng/mL) compared to septic foals without NMS (238.9, 164.6-313.2 ng/mL) on admission (P = .01). Pregnane concentrations were higher in NMS foals compared to healthy and sick foals over the first 48 h of hospitalization (P < .05).</p><p><strong>Conclusions and clinical importance: </strong>Higher BDNF, S100B, and pregnane concentrations were consistent with NMS, and might allow for neurological assessment.</p>","PeriodicalId":17462,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"40 5","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13594675/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149017130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of submaximal exercise test variables with diagnosis of asthma in a mixed-breed cohort of leisure horses.","authors":"Lia K Meiseberg, Julien Delarocque, Nicole de Buhr, Bernhard Ohnesorge","doi":"10.1093/jvimsj/aalag227","DOIUrl":"10.1093/jvimsj/aalag227","url":null,"abstract":"<p><strong>Background: </strong>Submaximal exercise tests (SET) are used to assess respiratory health in various contexts. The diagnostic value of SETs for the assessment of asthma in the field remains uncertain.</p><p><strong>Hypothesis/objectives: </strong>A SET helps distinguish healthy horses and asthma phenotypes.</p><p><strong>Animals: </strong>Twenty-six privately owned mixed-breed leisure horses of a clinical cohort. Horses were healthy (8) or diagnosed with mild (miEA) (4), moderate (modEA) (7), or severe asthma (sEA) (7) according to history, clinical examination, and bronchoalveolar lavage fluid (BALF) cytology.</p><p><strong>Methods: </strong>Cross-sectional study using clinical data and samples from a hospital cohort. The SET included ECG, arterial blood gas, lactate, respiratory rate (RR), and heart rate (HR) analysis. Samples were taken at rest (time point (T) 0), and after defined intervals (twice 2 minutes trot (T1, T2) and gallop (T3, T4), followed by 3 minutes trot (T5) and gallop (T6)). HR and RR recovery were evaluated. Predictive values of variables towards diagnosis of asthma were estimated with ordinal models.</p><p><strong>Results: </strong>Arterial partial pressure of oxygen (pO2) at T0 had the strongest association with diagnosis (τ = -.513, LRT = 18.1, adj. P < .001). Hypoxemia at T6 was evident in all healthy and miEA horses. In contrast, some horses with modEA and sEA presented with increased pO2 at T6 compared to T0. Recovery lengths had no significant association with diagnosis (RR τ = .112, LRT = .805, adj. P = .493; HR τ = .174, LRT = 1.528, adj. P = .287) and demonstrated wide intra-group variation.</p><p><strong>Conclusions and clinical importance: </strong>The SET did neither confirm diagnosis of asthma nor provide adequate results to assess respiratory health or disease in this cohort.</p>","PeriodicalId":17462,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"40 5","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13594658/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149017196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}