Journal of Veterinary Internal Medicine最新文献

{"title":"Correction to: Myopathy due to a creatine deficiency disorder in a family of mixed breed dogs with a glycine amidinotransferase gene mutation.","authors":"","doi":"10.1093/jvimsj/aalag102","DOIUrl":"10.1093/jvimsj/aalag102","url":null,"abstract":"","PeriodicalId":17462,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"40 3","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13147436/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147839628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delta (Δ) 12-lead electrocardiography and vectorcardiography to identify the origin of focally induced atrial and ventricular premature depolarizations in horses.","authors":"Ellen Paulussen, Gunther van Loon, Eva Buschmann, Ingrid Vernemmen, Tammo Delhaas, Annelies Decloedt, Glenn Van Steenkiste","doi":"10.1093/jvimsj/aalag080","DOIUrl":"https://doi.org/10.1093/jvimsj/aalag080","url":null,"abstract":"<p><strong>Background: </strong>Cardiac arrhythmias are common in horses, but their clinical and prognostic relevance remains poorly defined. Despite the importance of localization for diagnosis and treatment, noninvasive methods to identify arrhythmogenic foci are limited.</p><p><strong>Hypothesis/objectives: </strong>Evaluate the ability of delta (Δ) 3- and 12-lead ECGs and 2-dimensional (2D) and 3-dimensional (3D) vectorcardiography (VCG) to identify the site of origin of focally induced atrial and ventricular premature depolarizations in horses.</p><p><strong>Animals: </strong>Eight healthy horses underwent 2 electrophysiological studies, 1 standing, and 1 under general anesthesia.</p><p><strong>Methods: </strong>Premature atrial and ventricular complexes were induced by intracardiac pacing at 29 anatomical sites. Simultaneous Δ 12-lead ECG and VCG recordings were obtained. Mean vector directions were analyzed, and classification accuracy was assessed at the chamber, regional, and site-specific levels.</p><p><strong>Results: </strong>Distinct pacing sites produced reproducible and location-specific activation patterns. For differentiating left- from right-sided origins, 3D-VCG had 99% and 82% accuracies for ventricular and atrial origins, respectively. The simplified Δ-based 2D-VCG also showed strong performance on the chamber level, with accuracies of 94% and 78%, respectively. Accuracy was lower for fine-grained intra-chamber localization, especially in the atria.</p><p><strong>Conclusions and clinical importance: </strong>Although 3D-VCG offers superior spatial resolution, 2D-VCG provides a good balance between diagnostic accuracy and practical applicability, especially for left- vs right-sided localization. Combined Δ 12-lead ECG and VCG enables accurate, noninvasive chamber-level localization of arrhythmia origins in horses. Standardized application in larger cohorts with naturally occurring arrhythmias may support targeted ablation strategies and improve arrhythmia management and sudden cardiac death risk stratification.</p>","PeriodicalId":17462,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"40 3","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147864246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Treatment outcomes and prognostic indicators of primary immune thrombocytopenia in 31 cats: a multicenter retrospective study (2000-2023).","authors":"","doi":"10.1093/jvimsj/aalag106","DOIUrl":"10.1093/jvimsj/aalag106","url":null,"abstract":"","PeriodicalId":17462,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"40 3","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13147433/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147839584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Outcomes of mitral valve repair in dogs with myxomatous mitral valve disease and preoperative atrial fibrillation.","authors":"","doi":"10.1093/jvimsj/aalag103","DOIUrl":"10.1093/jvimsj/aalag103","url":null,"abstract":"","PeriodicalId":17462,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"40 3","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13147434/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147839556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progressive abnormal gait in an adult Jack Russell Terrier with a homozygous frameshift variant in SETX (senataxin).","authors":"G Diane Shelton, Sofie F M Bhatti, Luc Van Ham, Steven G Friedenberg, Jonah N Cullen, Ling T Guo, Katie M Minor","doi":"10.1093/jvimsj/aalag085","DOIUrl":"https://doi.org/10.1093/jvimsj/aalag085","url":null,"abstract":"<p><p>Here we describe an 8-year-old intact male Jack Russell Terrier with a 9-month history of slowly progressive gait disturbances that advanced over 2 years to generalized stiffness without ataxia and severe bilateral hyperflexion of all limbs. Gait evaluation showed high lifting of both pelvic limbs resulting in a hopping movement in the rear end; the right pelvic limb was kept lifted, making the dog trot on the 3 other limbs. Both thoracic limbs were lifted higher than normal. Complete blood count and serum biochemistry analysis including creatine kinase activity were normal. Electrophysiological examination showed no abnormalities. Muscle biopsy samples collected at a later stage of the disease showed no abnormalities. A homozygous frameshift variant in SETX (senataxin) was identified and is predicted to truncate about 85% of the protein. The SETX variant adds a new gene variant to the list affecting Jack Russell Terriers with gait abnormalities.</p>","PeriodicalId":17462,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"40 3","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147864340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lumbar spinal cord ganglioglioma in a 2-year-old Boxer dog.","authors":"Julia Hauer, Margherita Polidori, Anna Oevermann, Joy Einwaller, Michael Schmohl, Annette Wessmann","doi":"10.1093/jvimsj/aalag081","DOIUrl":"10.1093/jvimsj/aalag081","url":null,"abstract":"<p><p>A 2-year-old Boxer dog was examined for a 2-week history of progressive, painful right-lateralized paraparesis. Magnetic resonance imaging showed a focal ovoid mass with suspected intramedullary, or less likely, intradural location at the level of L3 vertebral body. Based on the imaging features, neoplasia, and specifically, a nephroblastoma, was suspected. Surgical excision found a difficult to excise mass with indistinct borders. The dog showed marked deterioration postoperatively and was euthanized 3 days later due to suspected myelomalacia. Histopathology and immunohistochemistry of the biopsy revealed that the spinal cord was replaced by a poorly organized proliferation of cells that consisted of both neuronal and glial components, embedded within an edematous neuropil. Immunohistochemistry of the lesion showed positivity for neuronal and astrocytic markers. These findings were consistent with a ganglioglioma, a rare neoplasm in dogs.</p>","PeriodicalId":17462,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"40 3","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13137321/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147817004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of the myocardial and renal renin-angiotensin system in normal cats and cats with hypertrophic cardiomyopathy.","authors":"James E Wood, Marisa K Ames, Joanna L Kaplan, Victor Rivas, Machelle D Wilson, Oliver Domenig, Joshua A Stern","doi":"10.1093/jvimsj/aalag078","DOIUrl":"https://doi.org/10.1093/jvimsj/aalag078","url":null,"abstract":"<p><strong>Background: </strong>The tissue renin-angiotensin system (RAS) has not been characterized in cats.</p><p><strong>Hypothesis/objectives: </strong>To quantify RAS enzyme activity and angiotensin peptide (AP) concentrations in myocardial and renal tissue obtained at necropsy from healthy cats and cats with hypertrophic cardiomyopathy (HCM).</p><p><strong>Animals: </strong>A convenience sample of 17 adult purpose-bred cats, euthanized under other study protocols, with echocardiographically normal hearts (n = 8) or American College of Veterinary Internal Medicine stage B1 (n = 6) or C (n = 3) HCM.</p><p><strong>Methods: </strong>Prospective study. Tissues were incubated with spiked angiotensin I (AngI) or II (AngII) under control and inhibitor conditions to assess relative enzyme contributions to AngII or angiotensin 1-7 (Ang1-7) formation. Freezing was delayed for 3 h in paired samples from 7 cats. Angiotensin peptides were also directly quantified in homogenized tissues.</p><p><strong>Results: </strong>Renin-angiotensin system enzyme activity was present in necropsy tissues, which formed AngII and Ang1-7 when incubated with AP precursors. The median contribution of angiotensin-converting enzyme to AngII formation exceeded 85% in all tissues. The 90% confidence limits of the geometric mean of the ratio of the angiotensin production of paired samples met the equivalence requirement in 1/13 experiments. The AP concentrations were quantifiable and did not differ between cats with echocardiographically normal hearts and cats with HCM (myocardial AngI P = .11 and AngII P = .37; kidney AngI P = .84, AngII P = .73, and Ang 1-7 P = .84).</p><p><strong>Conclusions and clinical importance: </strong>Necropsy tissue RAS enzyme activity and some AP concentrations were quantifiable in this cohort. Renin-angiotensin system enzyme activity changed during a short (3 h) postmortem period.</p>","PeriodicalId":17462,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"40 3","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147864254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation and systematic review of temporal associations between vaccination and onset of immune-mediated hemolytic anemia or thrombocytopenia in dogs.","authors":"Victoria Neale, Sophie Broughton, Harriet R Hall, Natalia Caldecott, Amanda Paul, Barbara J Skelly, Barbara Glanemann, James W Swann","doi":"10.1093/jvimsj/aalag057","DOIUrl":"10.1093/jvimsj/aalag057","url":null,"abstract":"<p><strong>Background: </strong>Vaccination is implicated in development of human immune-mediated diseases, but studies in dogs yielded conflicting results for immune-mediated hemolytic anemia (IMHA) and thrombocytopenia (ITP).</p><p><strong>Hypothesis/objectives: </strong>To investigate temporal relationships between onset of IMHA or ITP and vaccination in dogs.</p><p><strong>Animals: </strong>Client-owned dogs with nonassociative IMHA (n = 295) and ITP (n = 163) at 4 referral hospitals, alongside control dogs (n = 1180 for IMHA, 652 for ITP) presented contemporaneously.</p><p><strong>Methods: </strong>Multicenter retrospective case-control study, with meta-analysis of published studies. Proportions vaccinated ≤ 30 days before disease onset were compared to controls, along with times since last vaccine.</p><p><strong>Results: </strong>Proportion of dogs vaccinated ≤ 30 days of disease onset was significantly higher in the IMHA group (35/295, 11.9%) compared with controls (72/1180, 6.1%; P = .0015). Dogs with IMHA vaccinated ≤ 30 days of disease onset were more likely to have received a L2 vaccine (Leptospira serovars Canicola and Icterohemorrhagiae) in their last dose than those vaccinated > 30 days before onset (P = .04). Meta-analysis indicated dogs with IMHA were 2.48 times (95% CI, 1.69-3.63) more likely to have been vaccinated in the past month than controls, but with high heterogeneity across this and 2 other studies. There was no difference in proportion of ITP dogs and controls vaccinated ≤ 30 days of disease onset, and meta-analysis with 1 other study showed no temporal association, though both analyses were likely underpowered.</p><p><strong>Conclusions and clinical importance: </strong>These results support a possible temporal association between vaccination and onset of IMHA in dogs. Our results do not establish a causal relationship between vaccination and IMHA.</p>","PeriodicalId":17462,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"40 2","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13069898/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147662902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative analysis of prognostic scoring systems for cats with suspected pancreatitis (472 cats).","authors":"Harry Cridge, Julia Winser, Julia Wells, Timothy Bolton, Sue Yee Lim, Ashley Kibodeaux, Ileana Michel, Betty Chow, Jared A Jaffey, Cameron Prior, Fergus Allerton, Sarah Guess, Ruby Prince, Andrew Mackin, Sichao Wang","doi":"10.1093/jvimsj/aalag065","DOIUrl":"10.1093/jvimsj/aalag065","url":null,"abstract":"<p><strong>Background: </strong>Various prognostic factors and schemes are proposed for use in cats with pancreatitis, but these have yet to be independently evaluated in a broad group of cats.</p><p><strong>Hypothesis/objectives: </strong>(1) To compare predicted prognosis for death and prolonged (≥5 days) hospitalization across biochemical variables and composite schemes and (2) to calculate discriminatory ability for length of hospitalization.</p><p><strong>Animals: </strong>Four hundred seventy-two client-owned cats with suspected pancreatitis.</p><p><strong>Methods: </strong>Multi-institutional retrospective study (2019-2024). Prognostic factors included potassium, feline pancreas-specific lipase, total bilirubin, total calcium, and total magnesium. Prognostic schemes retrospectively calculated were the Acute Patient Physiologic and Laboratory Evaluation (APPLE)full and fast, and the modified feline activity index (MFAI).</p><p><strong>Results: </strong>Total calcium (median: 9.3 [IQR: 8.7-9.9] vs 9.6 [IQR: 9.0-10.1] mg/dL, P = .03), APPLEfull (median: 41 [IQR: 35-46] vs 36 [IQR: 30-40], P < .001), APPLEfast (median: 20.5 [IQR: 14.5-27.0] vs 14.0 [IQR: 12.0-19.0], P < .001), and MFAI (median: 5 [IQR: 4-8] vs 4 [IQR: 3-6], P = .011) were significantly different between fatal and nonfatal cases. Acute Patient Physiologic and Laboratory Evaluationfast had the greatest area under the curve for case fatality (0.695; 95% CI, 0.617-0.773) while MFAI had the greatest concordance index with length of hospitalization (0.673; 95% CI, 0.639-0.706). Overall negative predictive values were high and positive predictive values (PPVs) were low for both case fatality and prolonged hospitalization.</p><p><strong>Conclusions and clinical importance: </strong>Composite scoring schemes appear to be of greater prognostic value than individual variables in cats with pancreatitis. Because of the low PPVs for case fatality and prolonged hospitalization, prognostic factors should be interpreted cautiously on an individual cat basis and should not serve as the basis of clinically consequential decisions.</p>","PeriodicalId":17462,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"40 2","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13077297/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147674232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurologic improvement and tumor shrinkage after radiotherapy in dogs with imaging-based intracranial neoplasia.","authors":"Nina Ruessli, Robert Herzig, Chris Staudinger, Felicitas Czichon, Valeria Meier, Richard Evans, Katrin Beckmann, Carla Rohrer Bley","doi":"10.1093/jvimsj/aalag069","DOIUrl":"https://doi.org/10.1093/jvimsj/aalag069","url":null,"abstract":"<p><strong>Background: </strong>Traditional measures of treatment success for radiotherapy in dogs with intracranial neoplasia include progression-free and overall survival time. Although important, these measures do not reflect neurologic function.</p><p><strong>Hypothesis/objectives: </strong>Assess tumor shrinkage by follow-up imaging and outcome using 2 neurodisability scoring systems-1 validated and 1 simplified.</p><p><strong>Animals: </strong>One hundred six dogs with imaging-diagnosed intracranial tumors treated with 10-fraction definitive-intent radiotherapy.</p><p><strong>Methods: </strong>Data were collected from 2 randomized trials. Neurologic function was prospectively assessed using a validated score, and a retrospective simplified score was added. Imaging was recommended every 6 months or upon clinical decline.</p><p><strong>Results: </strong>Diagnoses included extraparenchymal tumors (45.3%), intraparenchymal tumors (35.8%), and pituitary tumors (18.9%). Median follow-up was 581 days. The neurodisability score improved significantly before radiotherapy (median 1.0, P = .04) because of medical management, and again during treatment (median 0.0, P < .01). At peak response, 76% of dogs had no or only mild neurologic deficits. Tumor volume significantly decreased at 6 and 12 months (P < .01): median shrinkage at 6 months was -39% (extraparenchymal tumors), -83% (intraparenchymal tumors), and -47% (pituitary tumors). A moderate correlation between tumor reduction and neurodisability score was seen only at 6 months (r = 0.395, P = .002). Results were consistent across protocols.</p><p><strong>Conclusions and clinical importance: </strong>Radiotherapy led to lasting neurologic improvement and substantial tumor reduction. Neurologic function did not always correlate with tumor volume shrinkage, emphasizing the importance of incorporating and prioritizing neurologists' functional assessments in posttreatment evaluation.</p>","PeriodicalId":17462,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"40 2","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13116335/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147775409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}