Journal of the Turkish German Gynecological Association最新文献

{"title":"Comparative analysis of hormonal and metabolic indices in phenotypic subgroups of polycystic ovary syndrome.","authors":"Belgin Savran Üçok, Türkan Dikici Aktaş, Emel Özalp, Can Ozan Ulusoy, Özgür Volkan Akbulut, Aziz Kından, Fahri Burçin Fıratlıgil","doi":"10.4274/jtgga.galenos.2026.2025-9-22","DOIUrl":"10.4274/jtgga.galenos.2026.2025-9-22","url":null,"abstract":"<p><strong>Objective: </strong>To compare hormonal and metabolic characteristics across Rotterdam polycystic ovary syndrome (PCOS) phenotypes (A-D) and identify key predictors of hyperandrogenism.</p><p><strong>Material and methods: </strong>In this retrospective cohort study, women with PCOS were classified into four Rotterdam phenotypes. Hormonal and metabolic parameters were assessed in the early follicular phase, and composite indices including HOMA-IR, QUICKI, TG/HDL, and free androgen index (FAI) were calculated. Logistic regression and receiver operating characteristic analysis were used to evaluate predictors of hirsutism.</p><p><strong>Results: </strong>The study included 226 women, with respective phenotype subgroups of: A n=85; B n=29; C n=43; and D n=69. Phenotype A showed the most pronounced hyperandrogenic and metabolic alterations, whereas phenotype D displayed the mildest profile with lower androgen levels and hirsutism scores. Significant differences in insulin resistance and lipid-related indices were observed across phenotypes. FAI was the strongest predictor of hirsutism (area under the curve =0.861), followed by total testosterone and dehydroepiandrosterone sulfate, while sex-hormone binding globulin was inversely associated.</p><p><strong>Conclusion: </strong>PCOS phenotypes demonstrate distinct hormonal and metabolic patterns. Phenotype A represents the most metabolically and androgenically severe subgroup, whereas phenotype D is comparatively mild. FAI emerges as the most informative marker for hirsutism, supporting a phenotype-oriented approach to clinical assessment and follow-up in PCOS.</p>","PeriodicalId":17440,"journal":{"name":"Journal of the Turkish German Gynecological Association","volume":" ","pages":"29-35"},"PeriodicalIF":1.4,"publicationDate":"2026-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12954625/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146119212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A rare case of pyomyoma following hysterotomy in a premenopausal woman with leiomyoma","authors":"Sunayna Lashkari, Avantika Gupta, Ayushi Sethi, Sahithi Kosgi","doi":"10.4274/jtgga.galenos.2026.2025-8-5","DOIUrl":"10.4274/jtgga.galenos.2026.2025-8-5","url":null,"abstract":"","PeriodicalId":17440,"journal":{"name":"Journal of the Turkish German Gynecological Association","volume":" ","pages":"65-67"},"PeriodicalIF":1.4,"publicationDate":"2026-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12954623/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146125412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A bioinformatics approach to identify potential biomarkers of high-grade ovarian cancer.","authors":"Özlem Timirci Kahraman, Güldal İnal Gültekin, Deryanaz Billur, Esin Bayralı Ülker, Murat İşbilen, Saliha Durmuş, Tunahan Çakır, İlhan Yaylım, Turgay İsbir","doi":"10.4274/jtgga.galenos.2025.2025-1-1","DOIUrl":"10.4274/jtgga.galenos.2025.2025-1-1","url":null,"abstract":"<p><strong>Objective: </strong>High-grade ovarian cancer (HGOC) remains a significant therapeutic challenge due to its aggressive nature and poor prognosis. The aim was to elucidate the molecular drivers of HGOC through an integrated bioinformatics analysis.</p><p><strong>Material and methods: </strong>The microarray datasets (GSE6008 and GSE14764) served as the training set, while an independent microarray dataset (GSE23603) was used as the validation set. These datasets included low- and high-grade ovarian tumor samples and were downloaded from the ArrayExpress database. Selection criteria included clearly classified low-grade ovarian cancer and HGOC samples, as well as platform and sample processing methods compatibility. After normalization, differentially expressed genes (DEGs) were obtained using R software. Functional enrichment analysis [including gene ontology (GO) and pathway analysis] was performed using the DAVID database. A protein-protein interaction (PPI) network was constructed by STRING to identify hub genes associated with HGOC.</p><p><strong>Results: </strong>A total of 106 common DEGs were identified across all three datasets, including 66 up-regulated and 40 down-regulated genes. Given the study's focus on potential oncogenic drivers, subsequent analyses prioritized the 66 up-regulated genes. The DEGs were classified into three groups by GO terms (21 biological process, 10 molecular function and 12 cellular component). Kyoto Encyclopedia of Genes and Genomes pathway analysis showed enrichment in metabolic pathways, oxidative phosphorylation, drug metabolism, and cell cycle regulation. The top nine up-regulated hub genes in the PPI network were <i>GMPS, RFC4, YWHAZ, CHEK1, CYC1, MRPL13, MRPL15, SDHA,</i> and <i>CLPB</i>.</p><p><strong>Conclusion: </strong>The identification of these hub genes and pathways may represent an important step forward in our understanding of HGOC. While down-regulated genes may also hold biological significance, their analysis was beyond the scope of this study and warrants future investigation. Further experimental validation is needed to confirm the roles of the identified genes in disease pathogenesis and their potential as biomarkers and therapeutic targets.</p>","PeriodicalId":17440,"journal":{"name":"Journal of the Turkish German Gynecological Association","volume":"27 1","pages":"19-28"},"PeriodicalIF":1.4,"publicationDate":"2026-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12954626/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147344450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuropelviology in minimally invasive surgery: a surgical anatomy-based demonstration.","authors":"İlker Selçuk, Tufan Arslanca, Eda Kayalı, Derya Leblebici, Koray Görkem Saçıntı, Hakan Raşit Yalçın","doi":"10.4274/jtgga.galenos.2025.2025-7-10","DOIUrl":"10.4274/jtgga.galenos.2025.2025-7-10","url":null,"abstract":"<p><p>Autonomic nerves regulate the innervation and function of the bladder, uterus, and rectum via their terminal branches. This section emphasizes the superior hypogastric plexus, hypogastric nerve, pelvic splanchnic nerves, inferior hypogastric plexus, and its terminal branches, namely the vesical, rectal, and uterine nerves. Somatic nerves traverse the pelvis, providing motor and/or sensory innervation to the pelvic floor and lower limbs. It is important to recognize the obturator nerve, genitofemoral nerve, lateral femoral cutaneous nerve, lumbosacral trunk, and femoral nerve.</p>","PeriodicalId":17440,"journal":{"name":"Journal of the Turkish German Gynecological Association","volume":" ","pages":"319-320"},"PeriodicalIF":1.4,"publicationDate":"2025-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12676985/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145286237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-site HPV infection in women with cervical intraepithelial neoplasia: an exploratory analysis.","authors":"Tuğba Akçaoğlu, Yağmur Soykan, Neslihan Bayramoğlu Tepe, Ozan Doğan","doi":"10.4274/jtgga.galenos.2025.2025-3-10","DOIUrl":"10.4274/jtgga.galenos.2025.2025-3-10","url":null,"abstract":"<p><strong>Objective: </strong>Human papillomavirus (HPV) positivity is associated with cervical, oropharyngeal, and anal cancers. There is insufficient published evidence regarding the effectiveness of obtaining oropharyngeal and anal swabs from patients with cervical HPV positivity to detect potential pathologies. Our aim was to analyze the feasibility of this potential screening protocol in a pilot group.</p><p><strong>Material and methods: </strong>In this cross-sectional exploratory analysis, women diagnosed with cervical intraepithelial neoplasia (CIN) grades 1, 2, or 3 were recruited. In order to evaluate HPV infection beyond the cervix, oropharyngeal and anal swab samples from HPV-positive women presenting to the obstetrics and gynecology clinic with histopathologically confirmed CIN were collected.</p><p><strong>Results: </strong>A total of 30 women who provided informed consent were included in this pilot study. HPV 16 was the predominant cervical HPV type across all CIN grades (46.7% of cases), but HPV genotype did not significantly correlate with the severity of CIN lesions (p=0.786). No statistically significant association was found between cervical and anal HPV infections (p=0.427). Oral HPV positivity was rare (6.7%) and similarly showed no significant correlation with cervical HPV infection (p=0.499).</p><p><strong>Conclusion: </strong>These findings provide preliminary data on the effectiveness of multi-site HPV screening in this population. Future larger-scale studies are needed to determine whether detecting extra-cervical HPV in women with cervical HPV positivity will influence clinical management decisions.</p>","PeriodicalId":17440,"journal":{"name":"Journal of the Turkish German Gynecological Association","volume":" ","pages":"289-296"},"PeriodicalIF":1.4,"publicationDate":"2025-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12676993/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145081158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preferred working time models and equal opportunities in gynecology and obstetrics: a sub-analysis of the trinational FARBEN survey focusing on German participants from Western and Eastern federal states.","authors":"Nikolas Tauber, Maggie Banys-Paluchowski, Claudia Becker, Philipp Foessleitner, Martin Göpfert, Steffi Hartmann, Rama Kiblawi, Nora Kiessling, Amanda Klee, Natalia Krawczyk, Laura Dussan Molinos, Gert Naumann, Achim Rody, Henning Schäffler, Lina Schiestl, Barbara Schmalfeldt, Solveig Simowitsch, Markus Wallwiener, Martin Weiss, Niklas Amann","doi":"10.4274/jtgga.galenos.2025.2025-5-13","DOIUrl":"10.4274/jtgga.galenos.2025.2025-5-13","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was a sub-analysis of the FARBEN survey to compare the preferences and responses of participants from the Eastern and Western German federal states and to identify potential differences.</p><p><strong>Material and methods: </strong>The preferences of the German participants from the respondents in the tri-national FARBEN study were analyzed. Participation was voluntary and anonymous. The questionnaire consisted of 62 questions covering topics such as the workplace in general, work-time models, and professional goals. In the present study, only the data of the participants working in Germany were analyzed.</p><p><strong>Results: </strong>The sub-group consisted of 1,021 out of the total of 1,364 (74.85%) respondents for the FARBEN survey. Of these, 855 (83.7%) responses were from participants from the Western federal states, and 166 (16.3%) from the Eastern federal states. Gynecologists in the East generally became parents at a younger age (29.3 vs. 30.8 years) and the rate of childlessness was higher among gynecologists in the West (54.8% vs. 37.0%). In the West, full-time work was both more frequently preferred (13.0% vs. 5.4%) and practiced (52.1% vs. 41.5%).</p><p><strong>Conclusion: </strong>Many family policy aspects of the former German Democratic Republic facilitated and continues to facilitate the compatibility of work and family life for mothers in the East. Historical perspectives can be helpful in implementing improvements for women in terms of work-family balance in a female-dominated medical field such as gynecology.</p>","PeriodicalId":17440,"journal":{"name":"Journal of the Turkish German Gynecological Association","volume":" ","pages":"256-267"},"PeriodicalIF":1.4,"publicationDate":"2025-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12676992/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145213053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcome of trial of labour after one previous cesarean section at Federal Medical Centre, Bida, north central, Nigeria.","authors":"Folorunsho Benard Adewale, Adebowale Samuel Adefemi, Adewale Olufemi Ashimi, Abdulkarim Omoyine Musa","doi":"10.4274/jtgga.galenos.2025.2025-4-12","DOIUrl":"10.4274/jtgga.galenos.2025.2025-4-12","url":null,"abstract":"<p><strong>Objective: </strong>To determine the success rate and feto-maternal outcomes following trial of labor among women with one previous cesarean section (C/S) seen at the Federal Medical Centre, Bida, Nigeria.</p><p><strong>Material and methods: </strong>This was a prospective cohort study among selected women with a previous C/S admitted for trial of labor after C/S over a 15 month period. Demographic and medical history data was collected by questionnaire. Women achieving vaginal birth after cesarean (VBAC) and those undergoing emergency repeat C/S (ERCS) were compared statistically for differences and associations based on a range of variables.</p><p><strong>Results: </strong>A total of 150 women with one previous C/S were included. Out of 150 study participants, 105 (70.0%) achieved VBAC while 45 (30.0%) had ERCS. Women with previous vaginal delivery had higher odds of achieving VBAC. Poor progress of labor was the most common indication for ERCS (17/45; 37.8%). The most frequent maternal complication following abdominal delivery was post-partum hemorrhage (n=15; 33.3%) while perineal laceration (n=26;24.8%) was the commonest among women who achieved VBAC. The ERCS cohort suffered significantly more complications in comparison to those who had VBAC. Comparison of fetal outcomes by mode of delivery were comparable, except that neonates admitted into special care baby unit were more likely to have been born via ERCS (odds ratio 5.231; 95% confidence interval 1.247-21.950) compared to those born via VBAC. There was no perinatal or maternal mortality. However, one case of ruptured uterus was recorded.</p><p><strong>Conclusion: </strong>These results demonstrated that good outcome following trial of labour is achievable among well selected women, even in low resource settings.</p>","PeriodicalId":17440,"journal":{"name":"Journal of the Turkish German Gynecological Association","volume":" ","pages":"268-275"},"PeriodicalIF":1.4,"publicationDate":"2025-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12676977/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145286310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Awareness and use of emergency contraception among women attending antenatal clinic in a tertiary hospital in Nigeria.","authors":"Folorumsho Benard Adewale, Adedeji Olugbenga Adekanye, Sunday Adesubomi Erinle, Ikemefuna Christopher Nwosu, Anthonia Eseroghene Nwosu","doi":"10.4274/jtgga.galenos.2025.2025-5-3","DOIUrl":"10.4274/jtgga.galenos.2025.2025-5-3","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the knowledge and use of emergency contraception (EC) amongst antenatal care attendees at the Federal Medical Center, Bida (FMCB), Nigeria.</p><p><strong>Material and methods: </strong>This was a cross-sectional, hospital-based, descriptive study involving women attending routine check-up at antenatal clinic of FMCB. Self-administered questionnaires were completed by the women after having obtained written informed consents. Data was analyzed using the Statistical Package for the Social Sciences (SPSS), version 23.0 (IBM Inc., Armonk, New York, USA). Descriptive statistical analysis was employed. Statistical significance was set at a p value of <0.05.</p><p><strong>Results: </strong>This research involved 129 women and demonstrated that only 43 (33.3%) had any knowledge of EC. Eighteen of these (41.9%) had their source of information from health workers followed by friends and peers (n=12, 27.9%) and one (2.3%) from public health campaign. Only 17.5% had used EC, with the majority (65.2%) using levonorgestrel pills, 13.1% used an intrauterine contraceptive device and 3.3% used the combined oral contraceptive pills. About two-thirds (67.4%) had no idea when EC would be effective. Age, tertiary level of education, religion, ethnicity, and upper socioeconomic status were all significantly associated with awareness of EC.</p><p><strong>Conclusion: </strong>The majority of the women in our cohort were not aware of EC and the proportion who had used EC was even lower. Therefore, there is a need to increase the awareness and effective use of EC through health education and advocacy.</p>","PeriodicalId":17440,"journal":{"name":"Journal of the Turkish German Gynecological Association","volume":"26 4","pages":"246-255"},"PeriodicalIF":1.4,"publicationDate":"2025-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12676980/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145660963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autoamputation of the ovary after missed diagnosis of ovarian dermoid cyst torsion: a case report and review of literature.","authors":"Ayşe Seyhan, İrem Usta Korkut, Bülent Urman","doi":"10.4274/jtgga.galenos.2025.2025-1-10","DOIUrl":"10.4274/jtgga.galenos.2025.2025-1-10","url":null,"abstract":"<p><p>Torsion is the most frequent complication of ovarian dermoid cysts. Adnexal torsion typically presents as a severe abdominal pain and is treated as an acute surgical emergency. However, if surgery is delayed or the diagnosis is not made in a timely manner, autoamputation of the ovary is a very rare, but possible, complication. Herein, we report a case of an autoamputated ovary with a dermoid cyst and review the literature. A 33-year-old patient presented with pelvic pain lasting three weeks and was scheduled for a laparoscopy due to the presence of bilateral ovarian cysts, with a dermoid cyst identified on the left ovary. During the procedure, it was discovered that both the left fallopian tube and ovary were absent. The infundibulo-pelvic ligament appeared to terminate abruptly at the pelvic brim. Moreover, an 8 cm pelvic mass was found lodged in the cul-de-sac, which was extensively adherent to the bowel and the uterus, and was covered by vascular omental tissue. Histopathological analysis revealed that this pelvic mass was a dermoid cyst. The cyst contained adipose tissue, hair, and microscopic ovarian stroma, confirming the diagnosis. This case highlights the complexity of diagnosing and managing pelvic masses. Clinicians should maintain a high index of suspicion for ovarian torsion and consider the possibility of autoamputation when an ovary is not found in its anatomical location, especially if imaging suggests the presence of a dermoid cyst. This case also underscores the importance of meticulous surgical dissection for the complete removal of such masses.</p>","PeriodicalId":17440,"journal":{"name":"Journal of the Turkish German Gynecological Association","volume":" ","pages":"304-308"},"PeriodicalIF":1.4,"publicationDate":"2025-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12676991/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145286297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scleredema adultorum of Buschke over the abdomen during pregnancy: an uncommon presentation.","authors":"Thota Sai Sumanth, Deepthi Konda, Kailas Anteshwar Mulsange, Banka Sai Swetha","doi":"10.4274/jtgga.galenos.2025.2025-6-11","DOIUrl":"10.4274/jtgga.galenos.2025.2025-6-11","url":null,"abstract":"","PeriodicalId":17440,"journal":{"name":"Journal of the Turkish German Gynecological Association","volume":" ","pages":"314-315"},"PeriodicalIF":1.4,"publicationDate":"2025-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12676986/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145422077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}