Journal of thermal biology最新文献

{"title":"Boosting chemotherapeutic response: Citric acid-coated Mn0.9Zn0.1Fe2O4 nanoparticles mediated magnetic fluid hyperthermia potentiates docetaxel efficacy in LNCaP cells","authors":"Uma N. Iyer,&nbsp;Kinnari H. Parekh,&nbsp;Neeraj D. Jain","doi":"10.1016/j.jtherbio.2026.104576","DOIUrl":"10.1016/j.jtherbio.2026.104576","url":null,"abstract":"<div><div>Current therapeutic strategies for prostate cancer (PC) are associated with significant adverse effects, drug resistance, and many other limitations. Docetaxel (DTX), a widely used chemotherapeutic agent for PC, requires high doses, often resulting in severe side effects. Combining DTX with hyperthermia has the potential to enhance therapeutic efficacy while reducing the required drug concentration. In this context, magnetic fluid hyperthermia (MFH) is emerging as a promising treatment modality for solid tumors, including PC. In this study, the combinatorial effect of citric acid-coated Mn_0.9Zn_0.1Fe₂O₄ magnetic nanoparticle-mediated MFH and DTX on PC cells LNCaP is analyzed. Cell viability, therapeutic synergy, and mode of cell death are evaluated following the two treatment sequences: (i) DTX at IC₂₀ for 24 and 48 h followed by MFH (42<strong>-</strong>45 °C for 1 h), and (ii) MFH followed by DTX for the same durations. The results show that therapeutic efficacy strongly depends on treatment sequence. MFH followed by DTX induces the highest cytotoxicity, achieving approximately 80–85% cell death, predominantly through apoptosis, indicating strong synergism. In contrast, the reverse sequence results in approximately 60% cell death while maintaining a synergistic interaction. These findings highlight the importance of treatment sequencing and the potential of MFH-assisted combination therapy to enhance therapeutic outcomes in PC.</div></div>","PeriodicalId":17428,"journal":{"name":"Journal of thermal biology","volume":"141 ","pages":"Article 104576"},"PeriodicalIF":3.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149111500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Species identity and local adaptation affect heat stress tolerance more consistently than plasticity in a guild of thrips pests","authors":"Fei-Man Yuan,&nbsp;Jin-Cui Chen,&nbsp;Min Chen,&nbsp;Ary Anthony Hoffmann,&nbsp;Shu-Jun Wei","doi":"10.1016/j.jtherbio.2026.104586","DOIUrl":"10.1016/j.jtherbio.2026.104586","url":null,"abstract":"<div><div>Understanding the main factors influencing heat tolerance is critical for predicting pest responses to this stress. Previous insect studies have suggested that heat tolerance may be influenced by species identity, local adaptation, and phenotypic plasticity, with potential constraints among these factors. However, studies that allow the simultaneous partitioning of these effects are rare except in a few model organisms. We address this issue in a guild of four thrips pest. All species followed an injury accumulation model, with <em>Megalurothrips usitatus</em>, <em>Frankliniella intonsa</em>, and <em>Frankliniella occidentalis</em> exhibiting similar coefficients of thermal sensitivity (z = 5.2 to 5.4), while <em>Thrips palmi</em> showed higher sensitivity (z = 6.85), demonstrating a more rapid decline in tolerance with increasing temperature. Common-garden experiments showed significant among-population variation of heat tolerance within each species, with patterns appearing to match local climates. Nevertheless, species identity remained the dominant determinant of heat tolerance when compared to geographical variation. Short non-lethal exposures to heat (hardening) and longer-term exposures (acclimation) produced variable responses depending on species and conditions. Variance partitioning revealed species identity as the dominant determinant of heat tolerance, explaining 22.3% of the total variance, compared with among-population geographic variation (19.4%), Plasticity collectively accounted for 12.05% of the total variance, comprising 4.69% from baseline plasticity and 7.36% from species-specific plastic responses. This multidimensional framework clarifies how genetic differentiation and limited plasticity interact to shape thrips thermal niches and provides a mechanistic basis for predicting seasonal dominance and range shifts of these key pest species under intensifying heat extremes.</div></div>","PeriodicalId":17428,"journal":{"name":"Journal of thermal biology","volume":"141 ","pages":"Article 104586"},"PeriodicalIF":3.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149167339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determinants of critical thermal maximum (CTMax) in the Nile tilapia (Oreochromis niloticus): Effects of body mass, dissolved oxygen concentration, and thermal ramping rate","authors":"Kwasi Adu Obirikorang,&nbsp;Angela Otokuwah Monnie,&nbsp;Doris Yeboah Baah,&nbsp;Michael Sedohia,&nbsp;Jesslyn Akrokoh,&nbsp;Stephen Gyamfi,&nbsp;Jedida Osei Bediako","doi":"10.1016/j.jtherbio.2026.104581","DOIUrl":"10.1016/j.jtherbio.2026.104581","url":null,"abstract":"<div><div>The critical thermal maximum (CTMax) is widely used to quantify upper thermal limits, yet estimates can vary depending on intrinsic biological traits and experimental conditions. This study examined how life stage, dissolved oxygen availability, and thermal ramping rate influence CTMax in the Nile tilapia (<em>Oreochromis niloticus</em>). The relationship between life stage and CTMax was assessed in 123 individuals (1–66 g) categorized into fingerlings (1-10 g), juveniles (10-25 g) and adults (&gt;25 g). Dissolved oxygen effects were tested in fish of uniform mass (20 ± 1 g) under extreme hypoxia (1 mg L⁻¹), moderate hypoxia (4 mg L⁻¹), normoxia (8 mg L⁻¹), and hyperoxia (16 mg L⁻¹). Thermal ramping rate effects were evaluated at 0.05, 0.1, 0.2, and 0.3 °C min⁻¹. Life stage had a significant negative relationship with CTMax (R² = 0.68, p &lt; 0.0001). Fingerlings (&lt;10 g) exhibited the highest thermal tolerance (&gt;43.5 °C), whereas adults (&gt;25 g), particularly those exceeding 40 g, frequently displayed CTMax values below 41.5 °C, with juveniles (10–25 g) showing intermediate thermal limits. Dissolved oxygen significantly influenced thermal tolerance (p &lt; 0.0001), with mean CTMax values of 41.6 ± 0.7 °C and 42.1 ± 0.4 °C under extreme and moderate hypoxia, respectively, compared with 43.7 ± 0.5 °C under normoxia. Hyperoxia produced only a marginal increase (44.0 ± 0.5 °C) relative to normoxia. Thermal ramping rate also strongly affected CTMax (p &lt; 0.0001), declining from 43.4 ± 0.2 °C at 0.05 °C min⁻¹ to 40.9 ± 0.7 °C at 0.3 °C min⁻¹. These findings emphasize the importance of standardizing protocols when assessing thermal tolerance and predicting vulnerability to warming in tropical fishes.</div></div>","PeriodicalId":17428,"journal":{"name":"Journal of thermal biology","volume":"141 ","pages":"Article 104581"},"PeriodicalIF":3.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149168178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thermal and salinity tolerance of feral and pet-traded cherry shrimp Neocaridina davidi (Bouvier, 1904)","authors":"Sebastian Prati,&nbsp;Pierre Valade,&nbsp;Laetitia Faivre,&nbsp;Aleksandra Jabłońska,&nbsp;Rafał Maciaszek,&nbsp;Caio Akira Miyai,&nbsp;Alice Mendonça Oliveira Moura Lima,&nbsp;Sébastien Jaquemet","doi":"10.1016/j.jtherbio.2026.104582","DOIUrl":"10.1016/j.jtherbio.2026.104582","url":null,"abstract":"<div><div>Temperature and salinity are key abiotic factors influencing the physiology, distribution, and survival of aquatic organisms, yet their combined effects remain poorly understood, especially in landlocked freshwater decapods. We provide experimental data on the single and, for the first time, combined effects of temperature and salinity in atyid shrimps, focusing on <em>Neocaridina davidi</em>, an exotic and potentially invasive species widely traded in the aquarium industry. We used dynamic assays (CTmin, CTmax, and LTmax) and reaction norms to compare pet-traded and feral <em>N. davidi</em> populations with different life histories acclimated to 15-27°C and 0-10‰. These included the oldest known European population in a thermally and saline-polluted channel in Poland and recently established populations on Réunion Island.</div><div>Overall, increased salinity reduced thermal tolerance. Despite being a landlocked freshwater shrimp, <em>N. davidi</em> exhibited moderate salinity tolerance, suggesting possible dispersal into low-to moderately saline brackish waters. However, ecological performance declined with rising salinity before physiological limits were reached. All populations showed thermal plasticity, though the magnitude of these responses varied among populations, consistent with differences in environmental history, phenotypic plasticity, and potentially genetic differentiation. These findings highlight the importance of both physiological plasticity and environmental context in shaping tolerance to interacting abiotic stressors when predicting invasion dynamics and the future distribution of this emerging invader.</div></div>","PeriodicalId":17428,"journal":{"name":"Journal of thermal biology","volume":"141 ","pages":"Article 104582"},"PeriodicalIF":3.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149169542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Swimming performance and thermal limits of early-life Brachymystax tsinlingensis under environmental stressors: implications for conservation stocking of an endangered salmonid","authors":"Xing-chen Guo,&nbsp;Hong-can Yang,&nbsp;Yi-zhou Wang,&nbsp;Peng Liu,&nbsp;Qiong Zhou,&nbsp;Kai-yong Lan,&nbsp;Yu-zhuo Zhang,&nbsp;Jun-yi Li,&nbsp;Xiang-hong Dong,&nbsp;Rui-jiao Li,&nbsp;Zhen-lu Wang,&nbsp;Jian Shao","doi":"10.1016/j.jtherbio.2026.104587","DOIUrl":"10.1016/j.jtherbio.2026.104587","url":null,"abstract":"<div><div>The endangered cold-water salmonid <em>Brachymystax tsinlingensis</em>, endemic to China, faces ongoing threats from habitat degradation, yet conservation stocking efforts lack a robust physiological basis. To address this gap, we quantified swimming performance and kinematics in larvae and juveniles of this species, and assessed the effects of starvation, light intensity, and acute temperature change on aerobic (critical swimming speed, <em>U</em>_crit) and anaerobic (burst swimming speed, <em>U</em>_burst) capacities. A pronounced ontogenetic shift was observed: juveniles exhibited higher absolute and relative swimming speeds than larvae, supporting the selection of juveniles for stocking. Starvation exceeding three days significantly reduced both <em>U</em>_crit and <em>U</em>_burst in juveniles, whereas larvae experienced high mortality (&gt;40%) before measurable declines in swimming performance, revealing stage-specific vulnerability. Juvenile <em>U</em>_burst was optimal under intermediate illumination (320–340 lx), suggesting a behavioral preference that may inform release site selection. Temperature emerged as the dominant abiotic filter: swimming performance (<em>U</em>_crit) followed a unimodal response, peaking at 20–23°C and declining markedly at 26°C, while <em>U</em>_burst showed a progressive decline with increasing temperature, defining a critical thermal limit for this species. These findings demonstrate that swimming behaviour and performance in early-life <em>B. tsinlingensis</em> are shaped by ontogeny, energy status, light environment and water temperature, with interactive effects that define critical tolerance thresholds. By linking behavioural and physiological responses to environmental stressors, this study provides a quantitative basis for informing conservation and management strategies for this endangered species.</div></div>","PeriodicalId":17428,"journal":{"name":"Journal of thermal biology","volume":"141 ","pages":"Article 104587"},"PeriodicalIF":3.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149166771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A semi-analytical dual-phase-lag model for the thermal and mechanical responses of skin tissue under continuous laser irradiation","authors":"Hao-Jie Jiang,&nbsp;Xin-Xin Meng,&nbsp;Lin-Han Xu","doi":"10.1016/j.jtherbio.2026.104575","DOIUrl":"10.1016/j.jtherbio.2026.104575","url":null,"abstract":"<div><div>The aim of this study is to establish a one-dimensional semi-analytical framework that sequentially couples the dual-phase-lag non-Fourier heat transfer theory with generalized linear thermoelasticity to predict the transient temperature, displacement, and stress responses of skin tissue under continuous-wave laser irradiation, and to quantify how the phase-lag parameters, intrinsic tissue properties and laser characteristics govern the thermomechanical safety boundaries of laser thermotherapy. The governing equations are decoupled by the separation of variables method and Duhamel's integral, and the resulting series solutions agree with COMSOL finite-element benchmarks to within 0.12% for the peak temperature and 5% for the peak stress. The results reveal three primary modulation mechanisms. First, an increase in the heat flux phase lag reduces both the surface peak temperature and the maximum compressive stress, whereas an increase in the temperature gradient phase lag promotes deeper energy diffusion and elevates the temperature and thermal expansion strain in sub-surface tissues. Second, the intrinsic tissue properties exert a dual damping effect: a higher tissue density attenuates both the thermal and mechanical responses, whereas increased microcirculatory blood perfusion provides only limited cooling against extreme temperature peaks. Third, the laser characteristics govern the safety boundaries: longer wavelengths substantially reduce the surface temperature and compressive stress, whereas a higher power density nonlinearly escalates the induced mechanical stress and the associated risk of tissue damage. The proposed model provides theoretical support for the preliminary determination of laser thermotherapy safety thresholds and the optimization of personalized treatment protocols, while the reported stress-based thresholds remain theoretical predictions that require experimental and clinical validation.</div></div>","PeriodicalId":17428,"journal":{"name":"Journal of thermal biology","volume":"141 ","pages":"Article 104575"},"PeriodicalIF":3.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149075118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ontogenetic variation in thermal biology: assessing life stage-specific adaptations and sensitivity in animals.","authors":"Flemming T Dahlke, Zara-Louise Cowan, Patrice Pottier, Katharina Ruthsatz, Elisa Thoral","doi":"10.1016/j.jtherbio.2026.104574","DOIUrl":"https://doi.org/10.1016/j.jtherbio.2026.104574","url":null,"abstract":"","PeriodicalId":17428,"journal":{"name":"Journal of thermal biology","volume":" ","pages":"104574"},"PeriodicalIF":3.2,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149111469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Technological evolution of hyperthermia: From traditional moxibustion to nanomaterial-mediated platforms for inflammatory diseases\" [J. Therm. Biol. 140, (2026) 104557].","authors":"Chenxi Duan, Miaomiao Wang, Jiahui Fan, Hongming Zhang, Lu Gan, Lihua Wang, Ying Zhu, Xiaoqing Cai, Jing Zhang, Yanhong Sun","doi":"10.1016/j.jtherbio.2026.104572","DOIUrl":"https://doi.org/10.1016/j.jtherbio.2026.104572","url":null,"abstract":"","PeriodicalId":17428,"journal":{"name":"Journal of thermal biology","volume":" ","pages":"104572"},"PeriodicalIF":3.2,"publicationDate":"2026-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148956262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kentish plovers Anarhynchus alexandrinus increase parental cooperation in variable environments","authors":"Gustavo Liñán-Cembrano,&nbsp;Cristina Ramo,&nbsp;Alejandro Pérez-Hurtado,&nbsp;Macarena Castro,&nbsp;Miguel A. Rendón,&nbsp;Juan A. Amat","doi":"10.1016/j.jtherbio.2026.104543","DOIUrl":"10.1016/j.jtherbio.2026.104543","url":null,"abstract":"<div><div>Environmental variability significantly influences parental care, likely because parental care can buffer nest survival against environmental variations, enabling those receiving greater parental care to tolerate a wider range of conditions. Under harsh conditions (e.g., high temperatures), this buffering effect may be reinforced through increased parental cooperation. Here, using data from a coastal and an inland site, we examined the effects of high ambient temperature (T_a) and wind, and their variability, on nest attendance and behavioural thermoregulation in Kentish plovers <em>(Anarynchus alexandrinus</em>). To quantify plover activity at their nests in relation to T_a, low-cost dataloggers were fully customised. A system was designed around a single board computer, connected to a webcam, a temperature sensor, and a clock module to synchronise timestamps when comparing results from dataloggers. In the Kentish plover, males typically incubate at night, whereas females incubate during the day; however, at elevated T_a, males also contribute to diurnal incubation. We found that at higher T_a, the plovers increased the frequency of heat-dissipating behaviours and switched incubation bouts between pair members more frequently. Wind speed additionally influenced the thermoregulatory behaviour of plovers, likely through convective cooling, thereby allowing longer periods of uniparental incubation. Furthermore, we show that at the same temperature, males exhibited higher nest attendance at the more variable inland site. Because this involvement exceeded that observed at the coastal site under equivalent temperatures, it may provide a safety margin against environmental variability. These findings support the hypothesis that environmental variability contributes to variations in parental cooperation during incubation.</div></div>","PeriodicalId":17428,"journal":{"name":"Journal of thermal biology","volume":"140 ","pages":"Article 104543"},"PeriodicalIF":3.2,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148579061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute heat exposure induces lifetime shifts in non-fertilising sperm allocation in a sperm-heteromorphic insect","authors":"Junyan Liu,&nbsp;Yidie Xu,&nbsp;Mengbo Guo,&nbsp;Xinyi Gu,&nbsp;Sijia Yu,&nbsp;Anis Syahirah Mokhtar,&nbsp;Gina Aliya Sopha,&nbsp;Binhui Hu,&nbsp;Jianyu Deng","doi":"10.1016/j.jtherbio.2026.104562","DOIUrl":"10.1016/j.jtherbio.2026.104562","url":null,"abstract":"<div><div>Ectotherm reproduction is vulnerable to acute heat stress, yet the longitudinal impacts of transient thermal events on male reproduction remain poorly understood. Using the stored-product pest <em>Plodia interpunctella</em>, a sperm-heteromorphic moth, we investigated how acute thermal stress (4 h at 40°C) impacts males’ lifetime reproductive resource allocation and offspring fitness. Heat-exposed adult males and controls (26°C) were paired daily with non-stressed females. We found that transient heat stress did not significantly impact pre-courtship duration, courtship duration, copulation latency, longevity, or lifetime mating frequency, nor did it alter offspring developmental duration. Total offspring production and lifetime eupyrene (fertile) sperm transfer also remained unaffected. However, heat-exposed males exhibited a massive hyper-allocation of non-fertilising sperm, ejaculating 53.4% more apyrene sperm at a 56.8% faster rate, increasing lifetime apyrene production by 41.0%. This hyper-allocation suggests that non-fertilising apyrene sperm act as a critical compensatory mechanism, buffering eupyrene sperm to maintain intact reproductive output following severe thermal stress. Although male reproductive performance proved resilient, we observed a subtle inter-generational cost: a 3.5% reduction in male offspring body weight. Our findings highlight a novel, potential adaptive role for sperm heteromorphism, demonstrating that sperm-heteromorphic insects can leverage plastic, morph-specific ejaculate tailoring to safeguard fertility against acute thermal extremes.</div></div>","PeriodicalId":17428,"journal":{"name":"Journal of thermal biology","volume":"140 ","pages":"Article 104562"},"PeriodicalIF":3.2,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148844240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}