Journal of thermal biology最新文献

{"title":"Biothermomechanical interactions in two-dimensional living tissue under Atangana–Baleanu fractional derivatives","authors":"Areej Almuneef ,&nbsp;Ibrahim Abbas ,&nbsp;Alaa A. El-Bary ,&nbsp;Zuhur Alqahtani","doi":"10.1016/j.jtherbio.2025.104140","DOIUrl":"10.1016/j.jtherbio.2025.104140","url":null,"abstract":"<div><div>This study investigates the impact of the Atangana-Baleanu (AB) fractional derivative in two-dimensional living tissue under pulse heat flux. Atangana-Baleanu (AB) derivatives with local and non-singular kernels are accounted for in the fractional-order formulation. Unlike classical models such as Pennes' equation, which assumes infinite thermal propagation speed, the proposed framework captures finite thermal and mechanical wavefronts. The half-space surface's border experiences a pulse-shaped heat flux, yet the edge is fixed in displacement and free of shear stress. The analytical solutions for the variables are derived using Laplace and Fourier transforms combined with the eigenvalue approach methodology. The numerical calculations have been done, and the finding are graphically displayed to estimate the impacts of fractional order parameter and heat flux pulse time in temperature distribution and mechanical responses. Numerical results indicate that thermal and mechanical waves propagate through living tissues over a finite distance, effectively addressing the unrealistic predictions of Pennes' model.</div></div>","PeriodicalId":17428,"journal":{"name":"Journal of thermal biology","volume":"130 ","pages":"Article 104140"},"PeriodicalIF":2.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144106013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive transcriptomic and proteomic analysis reveals biological changes and potential regulatory mechanisms of endothelial cells under heat stress conditions","authors":"Keran Jia ,&nbsp;Jie Zheng ,&nbsp;Saicong Hu ,&nbsp;Daxin Lei ,&nbsp;Mengyu Jiang ,&nbsp;Jiajia Zhang ,&nbsp;Mengge Cui ,&nbsp;Jia Wang ,&nbsp;Yan Cui ,&nbsp;Fukun Wang","doi":"10.1016/j.jtherbio.2025.104138","DOIUrl":"10.1016/j.jtherbio.2025.104138","url":null,"abstract":"<div><div>Endothelial cells are crucial for vascular function, and they respond to heat stress by altering gene and protein expression. This study investigated the impact of heat stress on endothelial cells using transcriptomic and proteomic analyses. Human umbilical vein endothelial cells (HUVECs) were exposed to heat stress at 43 °C for 6 h, resulting in significant changes in gene and protein expression patterns. In particular, ORAI1, a key regulator of intracellular Ca²⁺ levels, was significantly upregulated. The integration of transcriptomic and proteomic data revealed genes and proteins associated with endothelial cell damage and repair processes. Validation experiments confirmed the upregulation of ORAI1 and increased intracellular Ca²⁺ levels under heat stress. These findings enhance our understanding of endothelial cell responses to heat stress and suggest potential therapeutic targets for heat-related diseases.</div></div>","PeriodicalId":17428,"journal":{"name":"Journal of thermal biology","volume":"130 ","pages":"Article 104138"},"PeriodicalIF":2.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144116859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hybrid AI models for thermal imaging and analysis of neurological disorders using thermoplasmonics","authors":"Y. Ravi Kumar ,&nbsp;M. Vanitha ,&nbsp;KDV Prasad ,&nbsp;Kanchan Bala ,&nbsp;Deepak Gupta ,&nbsp;P. Venkateswara rao","doi":"10.1016/j.jtherbio.2025.104133","DOIUrl":"10.1016/j.jtherbio.2025.104133","url":null,"abstract":"<div><div>This paper describes a novel Artificial Intelligence-based approach to predict and analyse heat distribution in multi-tiered tissue structures by using plasmonic nanoparticle enhanced Multi-Spectral Thermal Imaging (MSTI). The optimization problem combines biophysical simulation with innovative machine learning techniques to improve the thermal mapping and analysis of biological tissues.</div><div>The described technique uses gold (Au) and silver (Ag) nanoparticles of sizes 25–35 nm, being characteristic of their thermoplasmonic properties and capable of obtaining high-resolution thermal images through multi-spectral imaging. A new Rank Entropy Machine Learning (RE-ML), incorporating probabilistic hidden chain features and entropy analysis of the thermal patterns resulting from plasmonic nanoparticle interaction, is presented.</div><div>The RE-ML framework then regenerates thermal distributions which undergo global and local entropy characterizations assessment before a probabilistic Hidden chain model's feature ranking determines the features to be preferentially used. The system obtains 97.8 % accuracy in specific tissue-level pattern recognition, excelling in neurological tissues; high precision of 98.6 %; sensitivity of 98.5 %; and specificity of 99.0 % in visualizing and analyzing thermal distributions over different tissue regions.</div><div>Despite its 0.14 error rate, the system is highly accurate in forecasting heat distribution. Thus, the proposed approach exhibits unmatched precision in thermal pattern recognition and presents possibilities for enhancing the heat maps of biological tissues.</div></div>","PeriodicalId":17428,"journal":{"name":"Journal of thermal biology","volume":"130 ","pages":"Article 104133"},"PeriodicalIF":2.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143935211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of acute high-temperature on gill tissue structure, serum biochemical indices, antioxidant capacity and liver transcriptomics of Thamnaconus septentrionalis","authors":"Ying Chen ,&nbsp;Si-Qing Chen ,&nbsp;Bo Zhang ,&nbsp;Zhi-Jie Zheng ,&nbsp;Yu-Ao Zhang ,&nbsp;Qing Chang ,&nbsp;Juan-Wen Yu ,&nbsp;Tian-Shi Zhang ,&nbsp;Jin-Chao Zhu ,&nbsp;Li Bian","doi":"10.1016/j.jtherbio.2025.104098","DOIUrl":"10.1016/j.jtherbio.2025.104098","url":null,"abstract":"<div><div>As global extreme heat events become more frequent, aquaculture faces significant challenges due to prolonged high summer temperatures, which lead to elevated water temperatures. Investigating the physiological and biochemical responses of fish to thermal stress, as well as breeding heat-resistant varieties, are essential strategies for addressing these challenges. <em>Thamnaconus septentrionalis</em> is an important aquaculture species in southern China. When water temperatures exceed 30 °C during the summer, this species experiences reduced feeding, growth stagnation, and increased mortality rates. To elucidate the physiological and biochemical response mechanisms of <em>T. septentrionalis</em> under thermal stress, this study established a high-temperature group (30 °C) and a control group (20 °C) for a 48-h thermal stress experiment. Tissue samples were collected from the experimental fish at 0, 12, 24, and 48 h post-stress. The effects of acute thermal stress on gill tissue structure, serum biochemical indicators, liver antioxidant capacity, and liver transcriptomics were explored. The results revealed that the gill tissues of the high-temperature group exhibited slight bending of the gill filaments, terminal swelling, and cellular vacuolization, along with a tendency for adjacent gill filaments to fuse. The liver antioxidant capacity and serum biochemical indicators in the high-temperature group were significantly elevated compared to the control group (<em>P</em> &lt; 0.05). Transcriptomic sequencing identified 5536 differentially expressed genes (<em>P</em> &lt; 0.05), with 2639 genes upregulated and 2897 downregulated. Gene Ontology (GO) enrichment analysis indicated that differentially expressed genes were primarily associated with metabolic processes and redox reactions. KEGG pathway analysis showed significant enrichment of genes in pathways related to amino acid metabolism, carbon metabolism, and glycolysis/gluconeogenesis, with notable downregulation observed in the high-temperature group. This study provides valuable theoretical insights into the mechanisms underlying the response of <em>T. septentrionalis</em> to high-temperature stress, contributing to the understanding of aquaculture resilience in the face of climate change.</div></div>","PeriodicalId":17428,"journal":{"name":"Journal of thermal biology","volume":"129 ","pages":"Article 104098"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143747041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hydrothermal physiology and vulnerability to climatic change: insight from European vipers","authors":"Nahla Lucchini ,&nbsp;Fernando Martínez-Freiría ,&nbsp;Inês Freitas ,&nbsp;Óscar Zuazo ,&nbsp;Mathias Dezetter ,&nbsp;Olivier Lourdais","doi":"10.1016/j.jtherbio.2025.104115","DOIUrl":"10.1016/j.jtherbio.2025.104115","url":null,"abstract":"<div><div>Clarifying physiological adaptations is crucial to understand species distribution and predict vulnerability to changing climatic conditions. Considering energy and water constraints jointly is necessary because these facets are intertwined in ectotherms. The genus <em>Vipera</em> is a diversified group of Palearctic snakes with parapatric distributions and contrasted climatic affinities. These species are active thermoregulators relying on basking to maintain their body temperature. While some species such as <em>V. berus</em> and <em>V. seoanei</em> are adapted to cold and wet environments, other species have intermediate (temperate-oceanic) affinities (<em>V. aspis)</em>, and some such as <em>V. latastei</em> and <em>V. ammodytes</em> inhabit warm and semi-arid climates. We studied physiological traits related to energy and water balance in these five species to better understand species' vulnerability to climate change. First, using open-flow respirometry we quantified standard metabolic rate (SMR) and evaporative water loss (TEWL) at three temperatures (15 °C, 25 °C and 33 °C). Cold- and wet-adapted species exhibited higher metabolic rates and evaporative water loss, reflecting adaptations to colder, wetter environments, while warm- and dry-adapted species showed lower rates. Second, we used these data to investigate their physiological responses to extreme climatic events (ECE). Simulated responses to summer heat spells revealed a major increase in energy expenditure and water loss rates across species. However, the effect was more prominent in cold- and wet-adapted species. This study underscores the physiological constraints that cold and wet-adapted species face during extreme climate events, providing insights into the vulnerabilities of ectotherms to ongoing environmental changes.</div></div>","PeriodicalId":17428,"journal":{"name":"Journal of thermal biology","volume":"129 ","pages":"Article 104115"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143904198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A reinforcement learning approach for real-time adjustment of thermal imaging parameters in thermoplasmonic applications","authors":"G. Dinesh ,&nbsp;Srigitha. S. Nath ,&nbsp;Md Zair Hussain ,&nbsp;Mohd Ashraf ,&nbsp;M. Kameswara Rao ,&nbsp;Laxmana siridhara Arigela","doi":"10.1016/j.jtherbio.2025.104123","DOIUrl":"10.1016/j.jtherbio.2025.104123","url":null,"abstract":"<div><div>The application of thermoplasmonics faces challenges related to precise temperature control distribution for managing heat in heterogeneous materials. A hybrid Silicon Carbide (SiC) and Aluminium (Al) paste was developed for effective temperature control in thermoplasmonic heating-based applications. The thermal images of this hybrid paste of SiC-Al is examined for multimodal parameters to estimate the plasmonic heat.</div><div>Reinforcement learning (RL) is implemented over the SiC-Al composite's thermal images using the estimated parameters for effective heat distribution, employing optimized laser power density, irradiation time, and heating period for thermoplasmonic applications. Optimizing the RL technique reduced the temperature in the central region from 75 to 70 °C, and increased it in the peripheral area from 45 to 55 °C.</div><div>Laser intensity was changed from 100 mW to 75 mW at the center to avoid overheating the tissue, the exposure time was altered from 30s to 45s, and the positioning was 5 cm away (rather than 2 cm) from the center to allow better heat conductivity.</div><div>The structural changes thereof were verified through Raman spectroscopy by altering the vibrational modes of the samples. The heating methodology employed enabled a decreased thermal gradient of up to about 10 °C. Thus, the hybrid paste SiC-Al exhibits significant thermoplasmonic material applications.</div></div>","PeriodicalId":17428,"journal":{"name":"Journal of thermal biology","volume":"129 ","pages":"Article 104123"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143906740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fever exerts opposing effects on the binding affinities of two neutralizing monoclonal antibodies against Staphylococcal Enterotoxin B","authors":"Puneet K. Singh ,&nbsp;Su-Mi Choi ,&nbsp;Ik Joo Chung ,&nbsp;Sook In Jung ,&nbsp;Razvan C. Stan","doi":"10.1016/j.jtherbio.2025.104112","DOIUrl":"10.1016/j.jtherbio.2025.104112","url":null,"abstract":"<div><h3>Rationale</h3><div>Infections with methicillin-resistant <em>Staphylococcus aureus</em> are a major source of morbidity and mortality worldwide. While no vaccines against this pathogen are yet available, passive therapy with neutralizing monoclonal antibodies against a key <em>S. aureus</em> toxin, the Staphylococcal Enterotoxin B (SEB), can be clinically effective. Further, fever response is a key symptom of this infection, and typically precedes or is concomitant to antibody therapy against SEB.</div></div><div><h3>Objective</h3><div>To investigate the role of febrile temperatures on the formation of immune complexes between SEB and two therapeutic monoclonal antibodies, 6D3 and 14G8.</div></div><div><h3>Results</h3><div>Using molecular dynamics simulations, free binding energy calculations and Surface Plasmon Resonance experiments, we reveal that at high fever (i.e. 312K (39 °C), compared to the physiologic body temperature of 310K (37 °C), the activity of 6D3 mAb is markedly reduced. In contrast, the binding affinity of antibody 14G8 benefits from the higher temperature.</div></div><div><h3>Conclusions</h3><div>Febrile temperatures differentially affect the binding affinities of monoclonal antibodies used in the therapy against <em>S. aureus</em>, and judicious control of the body temperature of the patients before their administration may potentiate their activity.</div></div>","PeriodicalId":17428,"journal":{"name":"Journal of thermal biology","volume":"129 ","pages":"Article 104112"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143851337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Probiotics/prebiotics effect on chicken gut microbiota and immunity in relation to heat-stress and climate-change mitigation","authors":"Yara Sayed ,&nbsp;Mariam Hassan ,&nbsp;Heba M. Salem ,&nbsp;Khaled Al-Amry ,&nbsp;Gamal Eid","doi":"10.1016/j.jtherbio.2025.104097","DOIUrl":"10.1016/j.jtherbio.2025.104097","url":null,"abstract":"<div><div>Heat stress is a serious hazard that threatens world poultry production. The avian gut microbiome plays a critical role in improving nutrient utilization, competing with pathogens, stimulating an immune response, and reducing inflammatory reactions. Hence, the gut microbiome has a positive impact on the host's health which appears in the shape of improved body weight, feed conversion rate, and increased birds' productivity (meat or eggs). Accordingly, this review shed light on the chicken gut microbiome, its correlation with the immunity of chicken, and how this affects the general health condition of the bird as well as, the role of prebiotics and probiotics in improving the gut health and increasing birds' productivity, especially under climate change and heat stress condition. The review aims to focus on the significance of maintaining healthy chickens in order to increase the production of poultry meat to satisfy human needs. A robust microbiota and a well-functioning immune system synergistically contribute to the optimal health and productivity of chickens.</div></div>","PeriodicalId":17428,"journal":{"name":"Journal of thermal biology","volume":"129 ","pages":"Article 104097"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143776727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of a lightweight water circulation cooling blanket for the prevention of exertional heat stroke","authors":"Xin Li ,&nbsp;Xin Wang ,&nbsp;Rui Yan ,&nbsp;Qing Song ,&nbsp;Bo Ning ,&nbsp;Shuyuan Liu ,&nbsp;Qian Wang","doi":"10.1016/j.jtherbio.2025.104130","DOIUrl":"10.1016/j.jtherbio.2025.104130","url":null,"abstract":"<div><h3>Background</h3><div>Exertional heat stroke (EHS) is acknowledged as a leading cause of sudden death among athletes and manual laborers. Rapid cooling treatment serves as a primary strategy for preventing and managing exercise-induced hyperthermia, underscoring the growing demand for swift and effective cooling devices.</div></div><div><h3>Objectives</h3><div>This study aimed to evaluate the cooling performance and effectiveness of a lightweight water circulation cooling blanket.</div></div><div><h3>Methods</h3><div>This randomized crossover design study recruited 12 male volunteers engaged in professional endurance exercise training outdoors. Participants completed a 3-km exercise session in a hot chamber (ambient temperature ≈ 40 °C; relative humidity [RH] ≈ 40 %), which was immediately followed by a 15-min cooling test (ambient temperature ≈ 31 °C; RH ≈ 65 %). During this cooling phase, participants were assigned to either lay on a lightweight water circulation cooling blanket (LWC condition) or to receive natural cooling (CON condition). Subsequently, all participants were required to complete another 3-km endurance exercise and a subsequent cooling phase under the same environmental conditions as those in the first round. The analysis included measurements of core temperature (T_core), heart rate (HR), skin temperature (T_skin), thermal sensation, and rating of perceived exertion (RPE).</div></div><div><h3>Results</h3><div>After two cooling sessions, T_core measurements were significantly reduced in the LWC condition during the cooling phase. The peak T_core recorded after the second exercise session was lower in the LWC condition compared to the CON condition. Additionally, HR, T_skin, thermal sensation, and RPE were lower in the LWC condition than those observed in the CON condition post-cooling.</div></div><div><h3>Conclusions</h3><div>The lightweight water circulation cooling blanket demonstrated effective cooling capabilities and enhanced recovery of both HR and RPE. This device may serve as a practical solution for emergency cooling following intense exercise or during recovery intervals between training sessions in extreme heat, benefiting both athletes and manual laborers.</div></div>","PeriodicalId":17428,"journal":{"name":"Journal of thermal biology","volume":"129 ","pages":"Article 104130"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143928291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Automating thermal limits: continuous, objective, and high-throughput thermal data for small mobile ectotherms","authors":"Sophie L. Mallett ,&nbsp;Lily Leahy ,&nbsp;Ian P. Vaughan ,&nbsp;Tristan Klaftenberger ,&nbsp;Xim Cerdá ,&nbsp;Lucy J. Wheatley ,&nbsp;Kester Leyshon ,&nbsp;Shane King ,&nbsp;Will Dawson ,&nbsp;Kelsey Harrendence ,&nbsp;Icaro Wilker ,&nbsp;Tom R. Bishop","doi":"10.1016/j.jtherbio.2025.104127","DOIUrl":"10.1016/j.jtherbio.2025.104127","url":null,"abstract":"","PeriodicalId":17428,"journal":{"name":"Journal of thermal biology","volume":"129 ","pages":"Article 104127"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143924101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}