Effects of curcumin on jejunal morphology and intestinal integrity of broiler under heat stress

IF 2.9 2区生物学 Q2 BIOLOGY

Journal of thermal biology Pub Date : 2025-10-01 DOI:10.1016/j.jtherbio.2025.104296

Ding-Ding Zhang, Meng-Ru Xue, Yu-Ting Liu, Hong-Jie Cui, Ding-Ping Bai

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Abstract

Heat stress adversely affects poultry production, intestinal health, and antioxidant levels. This study investigated the effects of curcumin supplementation on the jejunal morphology of broilers under heat stress. A total of 108 one-day-old male Arbor Acres broilers were divided into three groups: the control group (C), the heat stress group (HS), and the curcumin group (CUR). The C and HS groups were fed a basal diet, while the CUR group received 50 mg/kg of curcumin, supplemented from days 8–42. From days 21–42, the HS and CUR groups were exposed to 34 ± 1 °C for 8 h daily (9:00–17:00), with the remaining time spent at 22 ± 1 °C. The C group was maintained at 22 ± 1 °C throughout the experiment. The results revealed that curcumin supplementation alleviated jejunal mucosal damage. under heat stress. It increased the villus height to crypt depth ratio (V/C ratio) and significantly upregulated the expression of TJP1, ZO-1, MLCK, and BCL-2. Additionally, curcumin downregulated the expression of CASP3 and CASP9 in the jejunum. Furthermore, curcumin activated autophagy by enhancing the expression of SIRT1, PGC-1α, and Beclin1. In summary, curcumin supplementation can help maintain gut health in broilers under heat stress and exert protective effects at the cellular level.

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姜黄素对热应激下肉鸡空肠形态和肠道完整性的影响

热应激对家禽生产、肠道健康和抗氧化水平有不利影响。本试验研究了添加姜黄素对热应激条件下肉鸡空肠形态的影响。选取108只1日龄爱拔益加肉鸡雄性，分为3组：对照组(C)、热应激组（HS）和姜黄素组（CUR）。C组和HS组饲喂基础饲粮，CUR组在第8 ~ 42天添加50 mg/kg姜黄素。从第21-42天开始，HS组和CUR组每天暴露在34±1°C环境中8 h(9:00-17:00)，其余时间在22±1°C环境中。C组维持在22±1°C。结果表明，添加姜黄素可减轻空肠黏膜损伤。在热应力下。增加绒毛高度与隐窝深度比（V/C），显著上调TJP1、ZO-1、MLCK、BCL-2的表达。此外，姜黄素下调空肠CASP3和CASP9的表达。此外，姜黄素通过增强SIRT1、PGC-1α和Beclin1的表达来激活自噬。综上所述，补充姜黄素有助于维持热应激肉鸡肠道健康，并在细胞水平上发挥保护作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of thermal biology 生物-动物学

CiteScore

5.30

自引率

7.40%

发文量

196

审稿时长

14.5 weeks

期刊介绍： The Journal of Thermal Biology publishes articles that advance our knowledge on the ways and mechanisms through which temperature affects man and animals. This includes studies of their responses to these effects and on the ecological consequences. Directly relevant to this theme are: • The mechanisms of thermal limitation, heat and cold injury, and the resistance of organisms to extremes of temperature • The mechanisms involved in acclimation, acclimatization and evolutionary adaptation to temperature • Mechanisms underlying the patterns of hibernation, torpor, dormancy, aestivation and diapause • Effects of temperature on reproduction and development, growth, ageing and life-span • Studies on modelling heat transfer between organisms and their environment • The contributions of temperature to effects of climate change on animal species and man • Studies of conservation biology and physiology related to temperature • Behavioural and physiological regulation of body temperature including its pathophysiology and fever • Medical applications of hypo- and hyperthermia Article types: • Original articles • Review articles