Journal of travel medicine最新文献

{"title":"An unexpected outbreak at sea: revisiting Hantavirus transmission dynamics.","authors":"Anna Bogacka, Jakrapun Pupaibool, Perry J J van Genderen, Aisha Khatib, Maciej Grzybek, Ralph Huits","doi":"10.1093/jtm/taag041","DOIUrl":"10.1093/jtm/taag041","url":null,"abstract":"","PeriodicalId":17407,"journal":{"name":"Journal of travel medicine","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148031901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severe congenital Chagas disease in twins of a Bolivian migrant mother.","authors":"Rodrigo Muñoz, César Águila, Javier Muñoz-Lora, María José Iriarte, Valesca Gajardo, Mónica Pinto, María Isabel Jercic, Thomas Weitzel","doi":"10.1093/jtm/taag042","DOIUrl":"10.1093/jtm/taag042","url":null,"abstract":"","PeriodicalId":17407,"journal":{"name":"Journal of travel medicine","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147987843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Closed cohorts vs open borders: travel medicine lessons from the Ebola and Andes hantavirus outbreaks.","authors":"Perry J J van Genderen, Aisha Khatib, Jakrapun Pupaibool, Ralph Huits, Anna Bogacka, Maciej Grzybek","doi":"10.1093/jtm/taag045","DOIUrl":"10.1093/jtm/taag045","url":null,"abstract":"","PeriodicalId":17407,"journal":{"name":"Journal of travel medicine","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148150271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of the healthcare burden of dengue disease in Germany: a retrospective analysis of statutory health insurance data (2014-23).","authors":"Christoph Lübbert, Markus Frühwein, Carolin Stephanie Dinjer, Caroline Mächler, Eduardo Bittencourt de Gomensoro, Tobias Vogelmann, Bojana Milovanović","doi":"10.1093/jtm/taag047","DOIUrl":"10.1093/jtm/taag047","url":null,"abstract":"<p><strong>Background: </strong>The burden of dengue disease in Germany is a growing public health concern. While travellers to dengue-endemic countries are at increased risk of contracting a dengue infection, data describing dengue-related healthcare utilization and outcomes in Germany are limited. This study investigated the healthcare burden of dengue disease in travellers returning to Germany.</p><p><strong>Methods: </strong>A retrospective analysis (InGef research database) was used to estimate dengue incidence using anonymized representative data from the German Statutory Health Insurance from approximately 7 million insured persons/year during 2015-23. Outpatient and inpatient healthcare use and dengue associated costs were investigated.</p><p><strong>Results: </strong>From 2015 to 2023, among 10 151 240 insured persons, 887 dengue episodes were recorded. Patients had a median age of 33 years (interquartile range 26-46) and 52% were male. Each year, 103-182 episodes were reported (COVID-19 pandemic period [2020-22]: 10-62). Excluding the pandemic years, incidence was 1.4-2.5/100 000 persons, with an estimated total of 1453-2639 cases/year in Germany. Of the 37% hospitalized persons, 4% required intensive care. Mean hospital stay was 3.3 days; most patients were discharged after 1 overnight stay and no dengue related deaths were reported. Overall, 41% of patients took sick leave during their episode (mean sick leave for hospitalized patients: 8.8 working days); 38% of those not hospitalized took sick leave lasting 6.9 working days on average. Patients with dengue had 2-fold increased healthcare visits, resulting in a 162% increase in costs (mean costs/episode/quarter: 930€) compared with the pre-index period, with these costs mainly driven by outpatient care (23%) and hospitalization (64%). Hospitalized patients had a 4-fold rise in costs (quarterly costs/episode: 1700€; inpatient care accounting for 80%) compared with the pre-index period.</p><p><strong>Conclusions: </strong>Dengue virus infection in travellers returning to Germany impacted the healthcare system in Germany, leading to high costs, hospitalizations and physician visits and considerable sick leave.</p>","PeriodicalId":17407,"journal":{"name":"Journal of travel medicine","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13318845/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148218275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is it time to systematically address HIV pre-exposure prophylaxis in travellers?","authors":"Izar Blazquez, Berta Torres, Alex Almuedo-Riera, Juan Ambrosioni, Daniel Camprubí-Ferrer","doi":"10.1093/jtm/taag032","DOIUrl":"10.1093/jtm/taag032","url":null,"abstract":"","PeriodicalId":17407,"journal":{"name":"Journal of travel medicine","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147839179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cruise ships as amplifiers of emerging zoonotic threats: implications of the suspected Andes hantavirus cluster aboard MV Hondius.","authors":"Shweta Thaledi, Shekhar Pal, Deepak Juyal","doi":"10.1093/jtm/taag034","DOIUrl":"10.1093/jtm/taag034","url":null,"abstract":"","PeriodicalId":17407,"journal":{"name":"Journal of travel medicine","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147973455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hantavirus at the hajj: decoupling perceived risk from epidemiological reality.","authors":"Jaffar A Al-Tawfiq, Shahul H Ebrahim, Ziad A Memish","doi":"10.1093/jtm/taag038","DOIUrl":"10.1093/jtm/taag038","url":null,"abstract":"","PeriodicalId":17407,"journal":{"name":"Journal of travel medicine","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147982244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frequency and persistence of post-acute symptoms after chikungunya, dengue, Zika and malaria in travellers: a prospective multi-centre study.","authors":"Davidson H Hamer, Jean Marie Loreau, Ralph Huits, Marta Díaz-Menéndez, Martin P Grobusch, Sapha Barkati, Cédric P Yansouni, Federico Gobbi, Emmanuel Bottieau, Lin H Chen, Alexandre Duvignaud, Denis Malvy, Francesco Castelli, Silvia Odolini, Cornelis A De Pijper, Hilmir Asgeirsson, Lucia Moro, Kei Yamamoto, Adrián Sánchez-Montalvá, Cosmina Zeana, Paul Kelly, Watcharapong Piyaphanee, Daniel L Bourque, Anne McCarthy, Fabrice Simon, Philippe Gautret, Jean Baptiste Mardon, Gaëtan Texier, Emilie Javelle","doi":"10.1093/jtm/taag037","DOIUrl":"10.1093/jtm/taag037","url":null,"abstract":"<p><strong>Background: </strong>Long-term follow-up data on the travel-associated burden of vector-borne diseases (VBDs) are scarce. A prospective multi-site observational study was conducted to delineate the longitudinal course, symptom patterns, physical and mental burden and factors associated with prolonged illness in travellers after four VBDs.</p><p><strong>Methods: </strong>Patients with confirmed travel-associated acute chikungunya, dengue, Zika or falciparum malaria were recruited at 15 GeoSentinel sites from 2016 to 2021. Persistent signs and symptoms were evaluated at 1, 3, 6, 12 and 18 months (M) post-diagnosis, using a multi-modular study questionnaire with quality of life (QOL) evaluated by 12-item short-form health survey (SF-12). Demographic, premorbid and acute disease characteristics were tested in multivariate analyses to determine factors associated with persistence of symptoms at M3. Missing data were imputed by rules and statistical methods.</p><p><strong>Results: </strong>Among 273 patients enrolled, 35 (13%) had chikungunya, 110 (40%) dengue, 19 (7%) Zika and 109 (40%) falciparum malaria. Median age was 38 years (interquartile range 30-49), 148/273 (54%) were men. At M3, 24/35 (69%) of chikungunya, 27/110 (25%) of dengue, 8/19 (42%) of Zika and 12/109 (11%) of malaria patients had persistent symptoms. The proportion of symptomatic chikungunya patients was 18/35 (51%) at M6, mainly due to musculoskeletal symptoms including arthritis and stiffness. In dengue patients, fatigue and musculoskeletal symptoms without arthritis persisted until 1 year. Zika patients reported persisting headaches, musculoskeletal symptoms including arthritis and fatigue. One month after malaria, fatigue was the main persisting symptom, which resolved almost completely at M3. At M12, 6/35 (17%) of chikungunya, 5/110 (5%) dengue, 3/19 (16%) Zika and only 1/109 (1%) of malaria patients were still symptomatic.Impaired QOL was noted at M3 by 23/35 (66%) of patients with chikungunya, 20/110 (18%) with dengue and 6/19 (32%) with Zika but only 4/109 (4%) with malaria. Female sex, Zika, chikungunya and musculoskeletal symptoms during acute infection were associated with persistent M3 symptoms.</p><p><strong>Conclusions: </strong>Post-arboviral symptoms and impaired QOL persisted beyond 6 months after chikungunya, dengue and Zika. In contrast, post-malaria fatigue syndrome resolved within 3 months.</p>","PeriodicalId":17407,"journal":{"name":"Journal of travel medicine","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147973469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapid whole-genome sequencing of Plasmodium DNA from cryptic malaria cases in UK travellers provides insights into infection origins, transmission and antimalarial resistance.","authors":"Mark K I Tan, Nina Billows, Debbie Nolder, Sophie Moss, Jody E Phelan, Joseph Thorpe, Jonathan L Edgeworth, Colin J Sutherland, Peter L Chiodini, Susana Campino, Taane G Clark","doi":"10.1093/jtm/taag028","DOIUrl":"10.1093/jtm/taag028","url":null,"abstract":"<p><strong>Background: </strong>The UK reports approximately 2000 imported malaria cases annually, necessitating effective surveillance to determine infection sources and transmission routes, inform strategies for prevention and detect molecular markers of drug resistance that may compromise treatment outcomes. Defined by their unclear route of infection, cryptic malaria cases pose a particular challenge for malaria surveillance because they may signify undetected localized transmission or malaria re-introduction and therefore necessitate additional public health resources and epidemiological investigations. Here, we demonstrate the utility of near-real-time whole-genome sequencing (WGS) in providing high genomic resolution and detailed molecular characterization to help resolve cryptic malaria cases in the UK.</p><p><strong>Methods: </strong>Plasmodium DNA (9 isolates) sourced from clinical blood samples underwent WGS using either Illumina or Oxford Nanopore Technologies (ONT) platforms. Sequence data were rapidly analysed with Malaria-Profiler, which performs read mapping, variant calling, quality control, drug resistance prediction and artificial intelligence (AI)-based geographic origin inference using a reference database of more than 15 000 isolate genomes. Plasmodium ovale spp. and P. falciparum infections identified among family members were further analysed to assess parasite relatedness using identity-by-descent and multiplicity of infection approaches to investigate transmission clusters.</p><p><strong>Results: </strong>Using a combination of Illumina and ONT WGS platforms alongside Malaria-Profiler, we rapidly profiled parasites from four cryptic P. falciparum malaria cases in the UK, identifying drug resistance markers and predicting geographic origins through AI-based methods. We also applied WGS to family-related clusters of P. ovale spp. and P. falciparum cases, confirming (sub)species identities and enabling fine-scale transmission cluster analysis.</p><p><strong>Conclusions: </strong>This study highlights the power of real-time WGS and AI-enhanced tools for high-resolution malaria genomic surveillance. By enabling rapid characterization of cryptic and imported cases, this approach supports timely public health responses, including targeted epidemiological investigations and, where appropriate, the de-escalation of entomological surveillance. In doing so, this approach helps sustain malaria elimination in non-endemic settings.</p>","PeriodicalId":17407,"journal":{"name":"Journal of travel medicine","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13318844/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147690807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cryptococcus neoformans meningoencephalitis, chorioretinitis and recurrent obstructive pneumonia in an immunocompetent migrant from Paraguay.","authors":"Francesca F Norman, Elia Gomez-Garcia de la Pedrosa, Mercedes Serrador, Julio J González-López, Marta Gonzalez-Sanz, Pilar Martín-Dávila, Alejandra Lora-Plaza, Oscar Zaragoza, Carmen Quereda","doi":"10.1093/jtm/taag043","DOIUrl":"10.1093/jtm/taag043","url":null,"abstract":"","PeriodicalId":17407,"journal":{"name":"Journal of travel medicine","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148138012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}