Journal of travel medicine最新文献

{"title":"Zika virus infection in a traveller returning to France from Seychelles, 2024.","authors":"Laura Pezzi, Nazli Ayhan, Justine Brulé, Guillaume André Durand, Gilda Grard, Xavier Lamballerie, Raphaelle Klitting","doi":"10.1093/jtm/taaf048","DOIUrl":"https://doi.org/10.1093/jtm/taaf048","url":null,"abstract":"<p><p>In August 2024, a case of Zika virus infection was identified in metropolitan France in a traveller returning from Seychelles. Genomic analysis confirmed the strain belongs to the Asian lineage. Recent epidemiological findings provide the first evidence of ZIKV circulation in the western Indian Ocean region.</p>","PeriodicalId":17407,"journal":{"name":"Journal of travel medicine","volume":" ","pages":""},"PeriodicalIF":9.1,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144174385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Bismuth Subsalicylate on the Prevention of Travellers' Diarrhoea, 2018-2023.","authors":"Kristina M Angelo, Zainab Salah, Marina Rogova, Ian D Plumb, Allison T Walker, Graeme Prentice-Mott, Charandeep Waraich, Sunkyung Kim, Edward Ryan, Regina C LaRocque, Elizabeth Oliver, Kristen Heitzinger, K Allison Perry-Dow, Bradley A Connor","doi":"10.1093/jtm/taaf047","DOIUrl":"https://doi.org/10.1093/jtm/taaf047","url":null,"abstract":"<p><strong>Background: </strong>Travellers' diarrhoea (TD) is the most common travel-related illness. Bismuth subsalicylate (BSS) is indicated for the treatment of TD. BSS is also used off-label for the prevention of TD, based on studies from the 1980s indicating TD protection, however, these studies have limitations. The objective of this study was to determine the efficacy of BSS in the prevention of TD.</p><p><strong>Methods: </strong>This study was a prospective, double-blinded, placebo-controlled, randomized clinical trial (NCT03535272) with two arms: BSS 4 tablets twice daily (2.1 grams of BSS total) vs placebo. Travellers were included if they were ≥ 18 and < 70 years of age at the time of enrollment, were leaving for an international trip ≥7 days after their pretravel consultation, travelling in country for ≥7 days but ≤ 21 days, and travelling to either Southeast Asia, South Central Asia, North Africa, or Sub-Saharan Africa. Self-completed web-based questionnaires were administered before, during, and after travel.</p><p><strong>Results: </strong>270 participants were included. The median age was 32 years (Interquartile range [IQR]: 27-44); 63% were female. Travellers were most frequently White (144; 61%) and non-Hispanic (239; 94%). The most frequent country of travel was Kenya (n = 87; 32%). The median total trip duration was 10 days ([IQR]: 8-13). The most frequent reason for travel was leisure/tourism (230; 85%). There was no significant difference among the groups for symptoms of loose stool and/or diarrhoea, although target sample size was not reached.</p><p><strong>Conclusions: </strong>This study provides the first new data since the 1980s about the potential use of BSS in the prevention of TD. These data should not be viewed as evidence in isolation because of sample size constraints; further studies are needed to determine if there is a benefit in certain traveller groups or under certain circumstances.</p>","PeriodicalId":17407,"journal":{"name":"Journal of travel medicine","volume":" ","pages":""},"PeriodicalIF":9.1,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144174377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognosis of isolated hyperparasitemia in adults with imported severe malaria.","authors":"Sébastien Gaultier, Sandrine Houzé, Marc Thellier, Michael Thy, Nathan Peiffer-Smadja, Hermann Do Rego, Stéphane Jauréguiberry, Jean-François Timsit, Etienne Montmollin","doi":"10.1093/jtm/taaf042","DOIUrl":"https://doi.org/10.1093/jtm/taaf042","url":null,"abstract":"<p><strong>Background: </strong>Parasitemia > 4% (HP) is the most frequent severity criterion considered in adults with imported malaria, isolated hyperparasitemia (iHP) accounting for 10-40% cases. Its prognostic significance is controversial.</p><p><strong>Methods: </strong>Multicenter retrospective study including all adult patients with imported Plasmodium falciparummalaria and HP admitted to 16 hospitals in the Greater Paris area between 2018 and 2022 and reported to the National Reference Center. Among HP patients, iHP at hospital admission was identified by retrospective analysis of medical records to minimize classification bias. The primary endpoint was a composite outcome using the Desirability of Outcome Ranking (DOOR) method with three levels of decreasing desirability: hospital survival, absence of organ support requirement, shortest length of stay. Association between HP, iHP and outcomes was evaluated by negative binomial regression models.</p><p><strong>Results: </strong>Of 355 patients enrolled with HP, 135 (38%) had iHP. iHP patients were predominantly male (55.6%), aged 41 [32-52.3] years, and born in an endemic country (86.4%). Compared with patients with HP and additional severity criteria, iHP was independently associated with a lower risk of worse DOOR (RR 0.56, 95%CI[0.48-0.65]). No deaths were recorded in the iHP population, and 2/135 (1.5%) patients required organ support. In the iHP population, immunosuppression (RR 1.65, 95%CI[1.16-2,37]) and parasitemia>10% (RR 1.57, 95%CI[1.01-2.24]) were independently associated with worse DOOR. Only 47 (34.8%) iHP patients were admitted to an ICU at diagnosis, and 40 (29.6%) were treated with oral therapy alone.</p><p><strong>Conclusion: </strong>In imported malaria in France, iHP was associated with a low risk of serious adverse outcomes overall. In patients with iHP, immunosuppression and parasitemia > 10% were associated with an increased risk of adverse outcome, highlighting the importance of a close hospital monitoring.</p>","PeriodicalId":17407,"journal":{"name":"Journal of travel medicine","volume":" ","pages":""},"PeriodicalIF":9.1,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recognizing post malaria neurological syndrome in travellers: insights from three cases.","authors":"Elisa Riera, Alex Almuedo, Miriam J Álvarez-Martínez, Daniel Camprubí-Ferrer","doi":"10.1093/jtm/taaf041","DOIUrl":"https://doi.org/10.1093/jtm/taaf041","url":null,"abstract":"<p><p>Post malaria neurological syndrome (PMNS) is infrequent, but might be underdiagnosed in travellers. Following a previous publication on the Journal, we present three additional cases of PMNS to broaden the discussion and offer possible insights on when to suspect it and how to proceed.</p>","PeriodicalId":17407,"journal":{"name":"Journal of travel medicine","volume":" ","pages":""},"PeriodicalIF":9.1,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144111347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strengthening sexual violence prevention in travel medicine: lessons from a UNESCO World Heritage Site.","authors":"Veysel Mert Kara","doi":"10.1093/jtm/taaf027","DOIUrl":"10.1093/jtm/taaf027","url":null,"abstract":"","PeriodicalId":17407,"journal":{"name":"Journal of travel medicine","volume":" ","pages":""},"PeriodicalIF":9.1,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"'What about my teeth?'-Tales of missing dental travel health advice.","authors":"Irmgard L Bauer","doi":"10.1093/jtm/taaf026","DOIUrl":"10.1093/jtm/taaf026","url":null,"abstract":"","PeriodicalId":17407,"journal":{"name":"Journal of travel medicine","volume":" ","pages":""},"PeriodicalIF":9.1,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143743255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Considerations for prevention and standby emergency treatment for travellers at high risk of COVID-19 hospitalization.","authors":"Pragna Patel, David O Freedman","doi":"10.1093/jtm/taaf029","DOIUrl":"10.1093/jtm/taaf029","url":null,"abstract":"","PeriodicalId":17407,"journal":{"name":"Journal of travel medicine","volume":" ","pages":""},"PeriodicalIF":9.1,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Volar petechial rash in neurorickettsioses: an important clinical clue.","authors":"Nitin Gupta, Anjely Sebastian, Pothumarthy Venkata Swathi Kiran, Rachana Bhat, Prithvishree Ravindra, Muralidhar Varma, Tirlangi Praveen Kumar","doi":"10.1093/jtm/taaf020","DOIUrl":"10.1093/jtm/taaf020","url":null,"abstract":"","PeriodicalId":17407,"journal":{"name":"Journal of travel medicine","volume":" ","pages":""},"PeriodicalIF":9.1,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143557115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dengue virus infection in travellers after dengue vaccination, Germany 2023-24.","authors":"Raskit Lachmann, Christina Frank, Hendrik Wilking, Kerstin Kling","doi":"10.1093/jtm/taaf037","DOIUrl":"10.1093/jtm/taaf037","url":null,"abstract":"","PeriodicalId":17407,"journal":{"name":"Journal of travel medicine","volume":" ","pages":""},"PeriodicalIF":9.1,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12118062/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143978979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Performance of ChatGPT-4o in the diagnostic workup of fever among returning travellers requiring hospitalization: a validation study.","authors":"Dana Yelin, Neta Shirin, Itai Harris, Yovel Peretz, Dafna Yahav, Eli Schwartz, Eyal Leshem, Ili Margalit","doi":"10.1093/jtm/taaf005","DOIUrl":"10.1093/jtm/taaf005","url":null,"abstract":"<p><strong>Background: </strong>Febrile illness in returned travellers presents a diagnostic challenge in non-endemic settings. Chat generative pretrained transformer (ChatGPT) has the potential to assist in medical tasks, yet its diagnostic performance in clinical settings has rarely been evaluated. We conducted a validation assessment of ChatGPT-4o's performance in the workup of fever in returning travellers.</p><p><strong>Methods: </strong>We retrieved the medical records of returning travellers hospitalized with fever during 2009-2024. Their clinical scenarios at time of presentation to the emergency department were prompted to ChatGPT-4o, using a detailed uniform format. The model was further prompted with four consistent questions concerning the differential diagnosis and recommended workup. To avoid training, we kept the model blinded to the final diagnosis. Our primary outcome was ChatGPT-4o's success rates in predicting the final diagnosis when requested to specify the top three differential diagnoses. Secondary outcomes were success rates when prompted to specify the single most likely diagnosis, and all necessary diagnostics. We also assessed ChatGPT-4o as a predicting tool for malaria and qualitatively evaluated its failures.</p><p><strong>Results: </strong>ChatGPT-4o predicted the final diagnosis in 68% [95% confidence interval (CI) 59-77%], 78% (95% CI 69-85%) and 83% (95% CI 74-89%) of the 114 cases, when prompted to specify the most likely diagnosis, top three diagnoses and all possible diagnoses, respectively. ChatGPT-4o showed a sensitivity of 100% (95% CI 93-100%) and a specificity of 94% (95% CI 85-98%) for predicting malaria. The model failed to provide the final diagnosis in 18% (20/114) of cases, primarily by failing to predict globally endemic infections (16/21, 76%).</p><p><strong>Conclusions: </strong>ChatGPT-4o demonstrated high diagnostic accuracy when prompted with real-life scenarios of febrile returning travellers presenting to the emergency department, especially for malaria. Model training is expected to yield an improved performance and facilitate diagnostic decision-making in the field.</p>","PeriodicalId":17407,"journal":{"name":"Journal of travel medicine","volume":" ","pages":""},"PeriodicalIF":9.1,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143007589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}