Aisha N Khatib, Eduardo Alfonso Hernández Muñoz, Jill E Weatherhead
{"title":"Three nations, one tournament: a North American travel medicine perspective on the 2026 FIFA World Cup™.","authors":"Aisha N Khatib, Eduardo Alfonso Hernández Muñoz, Jill E Weatherhead","doi":"10.1093/jtm/taag072","DOIUrl":"10.1093/jtm/taag072","url":null,"abstract":"","PeriodicalId":17407,"journal":{"name":"Journal of travel medicine","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148592394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
George Kassianos, Larry Goodyer, Eduardo Eugênio Bittencourt de Gomensoro, Umesh Doobaree, Tracy Leong, Jennifer A Davidson, Bojana Milovanović
{"title":"Assessment of the healthcare burden of dengue disease in England: a retrospective analysis (2010-2023).","authors":"George Kassianos, Larry Goodyer, Eduardo Eugênio Bittencourt de Gomensoro, Umesh Doobaree, Tracy Leong, Jennifer A Davidson, Bojana Milovanović","doi":"10.1093/jtm/taag059","DOIUrl":"10.1093/jtm/taag059","url":null,"abstract":"<p><strong>Background: </strong>Dengue virus is transmitted by Aedes mosquitos, which are now prevalent in destinations commonly visited by UK travellers. Increased international travel and factors including climate change contribute to the global increase in dengue cases. Here, we evaluate the healthcare burden of dengue in England.</p><p><strong>Methods: </strong>This retrospective, descriptive, cohort study (2010-2023) utilized data collected from National Health Service healthcare records in the Clinical Practice Research Datalink Aurum, linked with Hospital Episode Statistics, and Office for National Statistics mortality data. The primary objective was to determine the occurrence of hospitalized dengue. Other objectives were evaluation of healthcare resource utilization and costs, characteristics of hospitalized dengue cases, and complications due to dengue. Exploratory cohorts for suspected dengue in primary care were also reported.</p><p><strong>Results: </strong>Data from Clinical Practice Research Datalink-linked records for 596 patients comprising the hospitalized dengue cohort were evaluated; the incidence rate of hospitalized dengue progressively increased from 2010 until the highest in 2019 (5.8 per million person-years); rates increased in 2022 after COVID-19 lockdowns. Approximately one-third of hospitalized dengue cases were aged 18-29 years, most were White or Asian, and the most common complication was gastrointestinal conditions (gastroenteritis/colitis; 34.7 cases per 1000 person-years). Healthcare costs in the year following hospitalized dengue cases were mostly driven by inpatient admission costs; ~20% of cases had a subsequent hospital admission (~50% were dengue-related). A total of 2286 suspected cases of dengue were reported in primary care, with 1066 unconfirmed and 1220 confirmed cases.</p><p><strong>Conclusions: </strong>Increasing incidence of dengue cases in England has followed global trends. The associated healthcare burden of imported dengue suggests a need for targeted public health strategies, particularly among younger travellers. Improvements in general practitioners' reporting of suspected dengue cases and associated details of symptoms and travel history are warranted.</p>","PeriodicalId":17407,"journal":{"name":"Journal of travel medicine","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13621469/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148376206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Boxuan Wang, Enrico Lorenzetti, Francesco Parino, Vittoria Colizza, Eugenio Valdano
{"title":"International risk of secondary hantavirus clusters following MV Hondius outbreak.","authors":"Boxuan Wang, Enrico Lorenzetti, Francesco Parino, Vittoria Colizza, Eugenio Valdano","doi":"10.1093/jtm/taag052","DOIUrl":"10.1093/jtm/taag052","url":null,"abstract":"","PeriodicalId":17407,"journal":{"name":"Journal of travel medicine","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148277886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fred L Thomas, Diana A Mabayoje, Bahijja T Raimi-Abraham, Anna M Checkley, Anjana Sahu, Maŋnyɛ Naa Tsotsoo Soyoo I, Antoinette Tangono, Siân O Mafiamba, Peter L Chiodini
{"title":"'Africans Against Malaria'-introducing a new diaspora-led initiative to strengthen malaria prevention amongst UK-based travellers visiting friends and relatives in malaria-endemic African countries.","authors":"Fred L Thomas, Diana A Mabayoje, Bahijja T Raimi-Abraham, Anna M Checkley, Anjana Sahu, Maŋnyɛ Naa Tsotsoo Soyoo I, Antoinette Tangono, Siân O Mafiamba, Peter L Chiodini","doi":"10.1093/jtm/taag077","DOIUrl":"https://doi.org/10.1093/jtm/taag077","url":null,"abstract":"","PeriodicalId":17407,"journal":{"name":"Journal of travel medicine","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149002195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Natalia Rodriguez-Valero, Mary Gawthrop, Sanch Kanagarajah, Hilary Kirkbride, Koye Balogun, Lisa Ford, Dipti Patel
{"title":"Developing Country Vaccination Recommendations for Travellers: The UK National Travel Health Network and Centre (NaTHNaC) Methodology for Typhoid and Hepatitis A.","authors":"Natalia Rodriguez-Valero, Mary Gawthrop, Sanch Kanagarajah, Hilary Kirkbride, Koye Balogun, Lisa Ford, Dipti Patel","doi":"10.1093/jtm/taag086","DOIUrl":"https://doi.org/10.1093/jtm/taag086","url":null,"abstract":"<p><strong>Background: </strong>The National Travel Health Network and Centre (NaTHNaC) regularly reviews country-specific vaccination recommendations to align with current epidemiological evidence. This update aimed to refine hepatitis A and typhoid vaccination guidance by integrating recent data and clarifying decision-making criteria.</p><p><strong>Methods: </strong>A structured review of hepatitis A and typhoid epidemiology (2022-2025) used Global Burden of Disease data, World Bank income classifications, and Age at Midpoint of Population Immunity values to assess hepatitis A endemicity. Typhoid risk was categorised using incidence thresholds defining high, intermediate, and low risk. National income level served as a proxy for sanitation, while antimicrobial resistance informed recommendations. Extensively drug-resistant typhoid prompted vaccination recommendations for most travellers regardless of incidence. Where data were limited, previous NaTHNaC guidance, UK Health Security Agency information, outbreak reports, and expert consensus were used. Epidemiologically borderline countries underwent individual review, and recommendations were validated before publication.</p><p><strong>Results: </strong>Hepatitis A recommendations were based on endemicity, incidence, and income status. High endemicity or incidence generally warranted vaccination for most travellers, whereas low endemicity in high-income countries usually did not. Thirty recommendation updates were introduced, affecting 15.4% of countries worldwide (30/195), mainly in Central Asia and the Caribbean. Several high-income countries, including Israel and Panama, were reclassified to lower risk, although vaccination remains recommended for certain travellers to countries such as South Korea and Chile because of recurrent outbreaks.Typhoid guidance incorporated incidence, income level, and antimicrobial resistance patterns. Forty recommendation updates were made, affecting 20.5% of countries worldwide (40/195). Changes included lower-risk classifications across much of the Americas and increased-risk classifications in parts of the Middle East, Eastern Europe, and Oceania.</p><p><strong>Conclusions: </strong>These revisions strengthen evidence-based travel health advice and highlight the need for continued adaptation of vaccination policies. However, limitations in surveillance and modelling data, including incomplete reporting and potential bias propagation, emphasise the need for improved global infectious disease monitoring.</p>","PeriodicalId":17407,"journal":{"name":"Journal of travel medicine","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149002186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zihao Guo, Yongdi Yu, Zhaojun Ding, Lirong Cao, Sheikh Taslim Ali, Zhuang Cui, Kai Wang, Marc K C Chong, Daihai He, Shi Zhao, Abdulrazaq G Habib, Yuantao Hao
{"title":"Early transmission risks of Ebola disease outbreak caused by Bundibugyo virus in the Democratic Republic of the Congo.","authors":"Zihao Guo, Yongdi Yu, Zhaojun Ding, Lirong Cao, Sheikh Taslim Ali, Zhuang Cui, Kai Wang, Marc K C Chong, Daihai He, Shi Zhao, Abdulrazaq G Habib, Yuantao Hao","doi":"10.1093/jtm/taag085","DOIUrl":"https://doi.org/10.1093/jtm/taag085","url":null,"abstract":"","PeriodicalId":17407,"journal":{"name":"Journal of travel medicine","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148977231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sakarn Charoensakulchai, Tammatat Veeramanomai, Patcharapol Wittayatechakul, Suda Punrin, Watcharapong Piyaphanee
{"title":"Management of travelers to high altitude with self-reported sulfonamide allergy: experience from a travel clinic in Thailand.","authors":"Sakarn Charoensakulchai, Tammatat Veeramanomai, Patcharapol Wittayatechakul, Suda Punrin, Watcharapong Piyaphanee","doi":"10.1093/jtm/taag084","DOIUrl":"https://doi.org/10.1093/jtm/taag084","url":null,"abstract":"","PeriodicalId":17407,"journal":{"name":"Journal of travel medicine","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148982986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Seungjae Byun, Yeongtaek Hwang, Yejun Son, Taelim Choi, Hyeon Jin Kim, Lee Smith, Ho Geol Woo, Christa J Nehs, Dong Keon Yon, Jiseung Kang
{"title":"Meningitis Burden and Vaccine Impact in the WHO Western Pacific Region, 1990-2023.","authors":"Seungjae Byun, Yeongtaek Hwang, Yejun Son, Taelim Choi, Hyeon Jin Kim, Lee Smith, Ho Geol Woo, Christa J Nehs, Dong Keon Yon, Jiseung Kang","doi":"10.1093/jtm/taag083","DOIUrl":"https://doi.org/10.1093/jtm/taag083","url":null,"abstract":"<p><strong>Background: </strong>Meningitis remained a major cause of death and disability worldwide, but evidence on long-term trends, pathogen distribution, and the impacts of the vaccine program across the WHO Western Pacific Region (WPR) remained limited.</p><p><strong>Methods: </strong>We used the World Health Organization Immunization Data and the Global Burden of Diseases Study (GBD) 2023 for the period 1990-2023. We assessed the incidence and mortality of meningitis across 32 WPR countries. Incidence and mortality were analyzed by age, sex, and 17 pathogens, with age-standardized rates calculated using the GBD global standard population. To evaluate the impact of the vaccine program, we applied negative binomial generalized linear models with a log link function and population offset to annual pathogen-specific death counts, characterizing vaccine exposure by program introduction and annual coverage.</p><p><strong>Results: </strong>From 1990 to 2023, incident cases of meningitis in the WPR declined from 638.02 thousand (95% uncertainty interval [UI], 497.54-789.94) to 162.67 thousand (136.19-192.51), and deaths declined from 78.16 thousand (55.76-103.50) to 15.17 thousand (11.45-21.03), although marked between-country disparities persisted. Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae accounted for the greatest number of meningitis-related deaths, although their burden declined over time. Haemophilus influenzae type b (Hib3) introduction was associated with a 31.85% reduction in Haemophilus influenzae meningitis deaths across the WPR (95% CI, -39.40% to -23.35%), and pneumococcal conjugate (PCV3) introduction with an 11.53% reduction in Streptococcus pneumoniae meningitis deaths (95% CI, -21.20% to -0.68%). Under a counterfactual scenario of 95% vaccine coverage, Haemophilus influenzae meningitis deaths were projected to further decline by 14.82% (95% CI, 7.33%-21.41%), and Streptococcus pneumoniae meningitis deaths by 12.27% (2.43%-20.92%).</p><p><strong>Conclusions: </strong>The burden of meningitis in the WPR declined substantially from 1990 to 2023, but persistent cross-country inequalities and shifts in age-specific and pathogen-specific patterns remained. Hib3 and PCV3 vaccine introductions were associated with meaningful reductions in vaccine-targeted meningitis mortality, though the effect varied across countries.</p>","PeriodicalId":17407,"journal":{"name":"Journal of travel medicine","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2026-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148956220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Artificial Intelligence and Complementary Digital Health Technologies Across the Travel Medicine Continuum: A Narrative Review.","authors":"Perry J J van Genderen, Eric N M van Sprang","doi":"10.1093/jtm/taag082","DOIUrl":"https://doi.org/10.1093/jtm/taag082","url":null,"abstract":"<p><strong>Background: </strong>Artificial intelligence (AI) and complementary digital health technologies are increasingly being applied to improve prevention, diagnosis and surveillance in travel medicine. This narrative review evaluates current applications of these technologies across the pre-travel, peri-travel and post-travel phases of the travel continuum.</p><p><strong>Methods: </strong>A narrative literature review was conducted using a clinically oriented three-phase framework encompassing pre-travel preparation, peri-travel monitoring and post-travel diagnosis and surveillance. Machine learning, clinical decision-support systems, large language models, wearable technologies, telemedicine, outbreak surveillance, precision diagnostics and interoperable digital health infrastructure were reviewed.</p><p><strong>Results: </strong>Machine learning improved individualized risk prediction before travel and supported diagnostic decision-making after travel, while clinical decision-support systems enabled more personalized preventive and therapeutic recommendations. During travel, AI-assisted border screening detected SARS-CoV-2 outbreaks up to nine days earlier than conventional surveillance, and wearable Internet of Things (IoT) technologies enabled continuous physiological monitoring in travelers and mass gatherings. The MALrisk model predicted imported malaria with an area under the receiver operating characteristic curve of 0.98, achieving 100% sensitivity and 72% specificity. In hospitalized returned travelers, ChatGPT-4o identified the correct diagnosis in 68% of patients and included the correct diagnosis among its three leading differential diagnoses in 78%, while metagenomic next-generation sequencing increased the diagnostic yield by 24.2% beyond routine investigations.</p><p><strong>Conclusions: </strong>AI and complementary digital health technologies have the potential to improve travel healthcare throughout the travel continuum. The principal challenge is no longer the development of individual AI applications, but determining how complementary technologies can be effectively integrated into routine travel medicine. Current evidence remains largely retrospective, highlighting the need for prospective multicenter implementation studies evaluating clinically meaningful outcomes.</p>","PeriodicalId":17407,"journal":{"name":"Journal of travel medicine","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148912796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Typhoid Fever in Africa: Trends, Demographic Determinants, and Relevance to Travel Medicine.","authors":"Kui Wang, Shanshan Zhang","doi":"10.1093/jtm/taag073","DOIUrl":"https://doi.org/10.1093/jtm/taag073","url":null,"abstract":"<p><strong>Background: </strong>Although global typhoid fever burden has declined, African destination-level risk remains incompletely characterised for travel medicine. We assessed trends, demographic drivers and traveller-relevant typhoid risk across African destinations.</p><p><strong>Methods: </strong>We analysed GBD 2023 modelled estimates for typhoid fever in 54 African Union destinations, 2010-2023. Outcomes were incidence, prevalence, deaths and DALYs. We estimated age-standardised rates, all-age numbers and trends, developed a burden-trend typology, attributed DALY-count changes to population growth, age-structure change and age-specific DALY-rate change, and estimated destination-specific expected cases per 100 000 travellers. This model-derived metric was used for relative destination ranking, not as an observed individual-level traveller risk estimate. We also performed exploratory interrupted time-series, ecological deaths-to-incidence ratio and 2030 scenario extrapolation analyses.</p><p><strong>Results: </strong>From 2010 to 2023, estimated incident cases declined from approximately 1.36 million to 902 000, and age-standardised incidence from 103.8 to 52.3 per 100 000. Age-standardised prevalence, death and DALY rates declined from 6.6 to 3.3, 1.3 to 0.7, and 96.9 to 53.9 per 100 000, respectively. The highest 2023 incidence rates occurred in the Central African Republic, the Republic of the Congo, the Democratic Republic of the Congo, Gabon and Angola; the Democratic Republic of the Congo had the largest absolute burden. Malawi was the only high-burden, non-declining destination across incidence, deaths and DALYs. DALY counts decreased by approximately 403 000, mainly due to lower age-specific DALY rates. Traveller risk ranged from 0.03 to 9.0 expected cases per 100 000 travellers, with the five highest-risk destinations in Central Sub-Saharan Africa. Scenario extrapolation suggested incidence may decline to 36.1 per 100 000 by 2030.</p><p><strong>Conclusions: </strong>Typhoid fever incidence is declining overall, but substantial heterogeneity persists across African destinations. These findings support destination-specific risk assessment, typhoid vaccination where appropriate, food and water precautions, and clinical vigilance for febrile returning travellers from higher-risk destinations.</p>","PeriodicalId":17407,"journal":{"name":"Journal of travel medicine","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2026-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148900828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}