Journal of the European Academy of Dermatology and Venereology最新文献

{"title":"Melanoma concealed by tattoos: Analysis of ink pigmentation and advanced diagnostic methodologies","authors":"Wiktor Kruczek, Zuzanna Pawlus, Paulina Rutecka, Aleksandra Kozik, Aleksandra Frątczak, Kornelia Pietrauszka, Mirosław Śnietura, Beata Bergler-Czop","doi":"10.1111/jdv.20730","DOIUrl":"10.1111/jdv.20730","url":null,"abstract":"","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":"39 9","pages":"e820-e823"},"PeriodicalIF":8.0,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144022964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel NFKBIA variant causing autosomal ectodermal dysplasia with immunodeficiency.","authors":"Pablo López Sanz, Carla Gianelli, Carlos Zozaya Nieto, Esperanza Escribano Palomino, Lucía Del Pino Molina, Rebeca Rodríguez Pena, Laura Miguel Berenguel, Brenda Sánchez Garrido, Tristán Gabriel Sobral Costas, Raúl de Lucas Laguna, Elena Ruiz, Carmen Cámara Hijón, Eduardo López-Granados, María Bravo García-Morato, Marta Feito Rodríguez","doi":"10.1111/jdv.20712","DOIUrl":"https://doi.org/10.1111/jdv.20712","url":null,"abstract":"","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144027148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Switching PD-1 to BRAF + MEK inhibition improves recurrence-free survival in patients receiving a second course of adjuvant melanoma therapy.","authors":"Katharina Schumann, Kai Christian Klespe, Cornelia Mauch, Carmen Loquai, Ulrike Schultheis, Sevil Börger, Alexander Thiem, Steffen Emmert, Magdalena Hoellwerth, Peter Koelbinger, Van Anh Nguyen, Marina Wanner, Erika Richtig, Wiebke K Peitsch, Wolfgang Harth, Veronika Zenderowski, Andreas Dominik Braun, Miriam Mengoni, Reinhard Dummer, Johanna Mangana, Lara Valeska Maul, Frank Meis, Klemens Rappersberger, Oana Diana Persa, Tilo Biedermann, Christian Posch","doi":"10.1111/jdv.20708","DOIUrl":"https://doi.org/10.1111/jdv.20708","url":null,"abstract":"<p><strong>Background: </strong>PD-1 or BRAF + MEK inhibition is considered the current gold standard in adjuvant melanoma therapy. Little is known if, after the recurrence of the disease and surgery, a second course of adjuvant therapy might be beneficial.</p><p><strong>Methods: </strong>A multicenter, retrospective study investigating a second course of adjuvant therapy after recurrence and surgery in stage III-IV melanoma patients. Patients received nivolumab (NIV), pembrolizumab (PEM) or dabrafenib plus trametinib (D + T) between 01/2017 and 10/2021. The primary endpoint was 12-month recurrence-free survival (RFS2). Further analyses included descriptive and correlative statistics.</p><p><strong>Results: </strong>Sixty-six patients from 22 centers in Germany, Austria and Switzerland were included. Thirty-two patients received D + T as second-course adjuvant therapy, 9 patients received PEM and 25 patients received NIV. Recurrence-free survival for the second-course adjuvant treatment (RFS2) was assessed after 12 and 24 months and showed a superiority of adjuvant BRAF + MEK over PD-1 therapy (12-months RFS2: 90.6% vs. 70.6%, HR 4.226 [95% CI 1.154-15.48]; p = 0.030; 24-months RFS2 71.9% vs. 52.9%, HR 3.154 [95% CI 1.374-7.242]; p = 0.007). There was no significant decrease in OS with either BRAF + MEK or PD-1 treatment (12-months OS: 100% both, 24-months OS: 100% vs. 93.8%). Furthermore, therapy sequences were investigated. For better comparability, only BRAF V600 mutated patients were assessed: RFS2 was significantly better for patients with a class switch from PD-1 to BRAF + MEK compared to BRAF + MEK to PD-1 (HR 4.401 (1.04-18.63), p = 0.044). No new safety signals were detected.</p><p><strong>Conclusion: </strong>In the investigated cohort, a second course of adjuvant melanoma treatment is feasible and provides similar RFS compared to an initial course of adjuvant therapy using BRAF + MEK inhibitors; however, RFS2 is reduced for PD-1 antibodies. In addition, both treatments were convincing with a 24-month OS of almost 100%. Switching from adjuvant PD-1 to BRAF + MEK treatment provided better overall RFS compared to switching from adjuvant BRAF + MEK to PD-1 treatment.</p>","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144031846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dermatologists' perception of teledermatology and risk factors for burnout: A cross-sectional study.","authors":"Tomás Toledo Pastrana, Catalina Paredes Coronel, Francisco José Martín Gutiérrez, Clara Fernández-Martín Valdés, Araceli Corrales Rodríguez, Libe Aspe Unanue, Albert Casulleras González, Carmen Alcántara Reifs, Anna Bota Llorca, Luis Ortega Berbel, Victor Dios Guillan, Jorge Short Apellaniz, Marta Del Olmo Rodriguez, Bernadette Pfang","doi":"10.1111/jdv.20715","DOIUrl":"https://doi.org/10.1111/jdv.20715","url":null,"abstract":"","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144027144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-world experience of multiple switches between adalimumab biosimilars in patients with psoriasis.","authors":"Ole Krogh-Jensen, Christopher Willy Schwarz, Diljit Kaur-Knudsen, Claus Zachariae, Nikolai Loft, Lone Skov","doi":"10.1111/jdv.20727","DOIUrl":"https://doi.org/10.1111/jdv.20727","url":null,"abstract":"","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144027447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined intercellular and basement membrane zone deposits in pemphigus: Frequency and implications.","authors":"Jeanne Emile, Sabine Grootenboer-Mignot, Nicolas Ortonne, Barbara Papouin, Thibaut Belmondo, Saskia Ingen-Housz-Oro","doi":"10.1111/jdv.20725","DOIUrl":"https://doi.org/10.1111/jdv.20725","url":null,"abstract":"","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144008735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on “Understanding patient priorities in teledermatology for psoriasis: A discrete choice experiment”","authors":"Renu Sah,&nbsp;Ankita Mathur,&nbsp;Venkata Dileep Kumar Veldi","doi":"10.1111/jdv.20731","DOIUrl":"10.1111/jdv.20731","url":null,"abstract":"","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":"39 10","pages":"e932-e933"},"PeriodicalIF":8.0,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144033079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to ‘International consensus on methotrexate dosing for patients with atopic dermatitis: An eDelphi study’","authors":"","doi":"10.1111/jdv.20720","DOIUrl":"10.1111/jdv.20720","url":null,"abstract":"<p>Caron AGM, van Huizen AM, Musters AAH, Gerbens LAA, Middelkamp Hup MA, Flohr C, et al. International Consensus on Methotrexate Dosing for Patients With Atopic Dermatitis: An eDelphi Study. <i>Journal of the European Academy of Dermatology and Venereology</i>. 2025; 39: 331–339. https://doi.org/10.1111/jdv.20271.</p><p>In the Acknowledgement section, the middle name was omitted from the author name Michael Boffa. The correct name is Michael J Boffa.</p><p>We apologize for this error.</p>","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":"39 8","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jdv.20720","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144023005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In response: Rifampicin and clindamycin for epidermal growth factor receptor inhibitor-related acneiform rash","authors":"Azael Freites-Martinez,&nbsp;Zoe Apalla,&nbsp;Vincent Sibaud","doi":"10.1111/jdv.20719","DOIUrl":"10.1111/jdv.20719","url":null,"abstract":"","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":"39 8","pages":"e734-e735"},"PeriodicalIF":8.4,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144027443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychodermatological scalp syndromes: Splitting the hair for diagnostic precision.","authors":"Hitaishi Mehta, Anuradha Bishnoi, Tarun Narang","doi":"10.1111/jdv.20729","DOIUrl":"https://doi.org/10.1111/jdv.20729","url":null,"abstract":"","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144022971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}