Journal of the European Academy of Dermatology and Venereology最新文献

{"title":"Sentinel lymph node biopsy may no longer be a critical component of melanoma management.","authors":"Athanassios Kyrgidis, Anthony J Dixon, Michael Sladden, Howard K Steinman, Christos C Zouboulis, Aimilios Lallas, Samantha Schneider, Harvey Smith, Alexander Nirenberg, Caterina Longo, Giuseppe Argenziano, Catalin Popescu, Thrasyvoulos Tzellos, Stuart Anderson, J Meirion Thomas","doi":"10.1111/jdv.20349","DOIUrl":"https://doi.org/10.1111/jdv.20349","url":null,"abstract":"","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142289992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mental health in hidradenitis suppurativa: A complex matter.","authors":"Klasiena Bouwman, Deveny A Y van der Weijden, V Carel R Jiawan, Behrooz Z Alizadeh, Barbara Horváth","doi":"10.1111/jdv.20358","DOIUrl":"https://doi.org/10.1111/jdv.20358","url":null,"abstract":"","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2024-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142289990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tangential biopsy of the nail bed and matrix, with plate evaluation, for diagnosis of lichen planus.","authors":"L Bertanha, A O Michalany, I I Damas, N Di Chiacchio, M L Cintra","doi":"10.1111/jdv.20352","DOIUrl":"https://doi.org/10.1111/jdv.20352","url":null,"abstract":"","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142289993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to 'Enhancing multimodal deep learning for improved precision and efficiency in medical diagnostics'.","authors":"Kaili Chen, Zhi Yang, Qianwen Li, Hai Long, Rong Xiao, Kai Hu, Haijing Wu, Qianjin Lu","doi":"10.1111/jdv.20347","DOIUrl":"https://doi.org/10.1111/jdv.20347","url":null,"abstract":"","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142289991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"B-type natriuretic peptide levels are associated with chronic itch: A case-control study.","authors":"Luis F Andrade, Zaim Haq, Parsa Abdi, Kayla D Mashoudy, Moses Alfaro, Michael J Diaz, Gil Yosipovitch","doi":"10.1111/jdv.20338","DOIUrl":"https://doi.org/10.1111/jdv.20338","url":null,"abstract":"","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142289985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improvements in patient-reported outcomes with oral roflumilast for psoriasis: Results from a randomized controlled trial (PSORRO).","authors":"Mette Gyldenløve,Jennifer Astrup Sørensen,Simon Francis Thomsen,Simon Fage,Lars Iversen,Lone Skov,Claus Zachariae,Alexander Egeberg,Mia-Louise Nielsen","doi":"10.1111/jdv.20343","DOIUrl":"https://doi.org/10.1111/jdv.20343","url":null,"abstract":"","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":"18 1","pages":""},"PeriodicalIF":9.2,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142262236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness and safety of methotrexate in the treatment of mycosis fungoides: Real-world data from a multicentre study.","authors":"Vasiliki Nikolaou,Evdoxia Panou,Antonios Tsimpidakis,Ioannis-Alexios Koumprentziotis,Aikaterini Patsatsi,Marina Siakantaris,Sabine-Elke Kruger-Krasagakis,Leonidas Marinos,Elisavet Georgiou,Kyriaki Lampadaki,Aliki Velissari,Athina-Ioanna Daponte,Aikaterini Doxastaki,Stella Kaliampou,Aristeidis Vaiopoulos,Iliana Konstandinou,Marios Koumourtzis,Eleftheria Lakiotaki,Vassiliki Pappa,Athanasios Tsamaldoupis,Alexander Stratigos,Evangelia Papadavid","doi":"10.1111/jdv.20350","DOIUrl":"https://doi.org/10.1111/jdv.20350","url":null,"abstract":"BACKGROUNDMethotrexate (MTX) has been a longstanding therapeutic option for mycosis fungoides (MF); however, data on its real-world effectiveness remain limited.OBJECTIVESTo evaluate treatment-related outcomes of oral MTX in patients with early- and late-stage MF.METHODSThis is a retrospective multicentre analysis involving MF subjects from five referral centres for cutaneous lymphomas in Greece. Data regarding the effectiveness and safety were analysed.RESULTSIn total, 211 MF patients were enrolled (males, 68.3%) with a median (IQR) age of diagnosis at 68.3 (56-75) years. Late-stage (IIB-IVB) disease was present in 124 patients (59.3%). MTX monotherapy was administered to 112 (53.1%) patients, with 99 receiving combination regimens with phototherapy, interferon and retinoids. MTX was used as first-line regimen in 103 (48.9%) cases. An overall response rate (ORR) of 55.5% was observed with 29.9% of patients achieving complete responses. MTX demonstrated greater effectiveness as a first-line treatment compared to subsequent use with no significant differences between monotherapy and combination therapy. The median time to best response was 3.8 months (IQR 2.3-9.9 months). Patients with erythrodermic disease (Stage III) had better ORRs compared to patients with tumour stage disease (Stage II) (61.1% vs. 44.8% respectively). The progression-free survival (PFS) varied according to stage, with a median PFS of 17.1 months for early-stage disease, 5.7 months for Stage IIB disease, 46 months for Stage III and 9.6 months for Stage IV disease (0.7-.). Serious adverse (Grade 3) events leading to treatment discontinuation occurred in 14 (6.7%) cases. All patients received oral MTX once weekly with a median weekly dose of 15 mg/week (7.5-25).CONCLUSIONOur findings support MTX as a viable treatment option for MF, particularly when used in the first-line setting, offering a favourable benefit/risk profile. Response rates are stage-dependent, with erythrodermic patients achieving superior and durable responses.","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":"27 1","pages":""},"PeriodicalIF":9.2,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142262237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bullous pemphigoid burden of disease, management and unmet therapeutic needs.","authors":"V P Werth,D F Murrell,P Joly,M Ardeleanu,V Hultsch","doi":"10.1111/jdv.20313","DOIUrl":"https://doi.org/10.1111/jdv.20313","url":null,"abstract":"Bullous pemphigoid (BP) is an autoimmune blistering disease that can have a profound negative impact on quality of life. BP most often affects the elderly, a population with a high medical burden and special safety concerns. In this review, we outline the BP disease course, diagnosis, epidemiology and comorbidities, and describe tools commonly used to assess BP disease activity and severity and the impact of BP on health-related quality of life. We also outline biologic treatments currently under investigation for the treatment of BP and highlight the importance of considering safety when treating elderly patients.","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":"50 1","pages":""},"PeriodicalIF":9.2,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142262238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Educational, labour market and relationship outcomes in people with acne","authors":"John S. Barbieri, Dóra K. Farkas, Niels Skipper, Ketaki Bhate, Sinéad M. Langan, Line Kibsgaard, Henrik T. Sørensen, Sigrun A. J. Schmidt","doi":"10.1111/jdv.20323","DOIUrl":"https://doi.org/10.1111/jdv.20323","url":null,"abstract":"BackgroundAlthough acne is associated with scarring, mental health comorbidities and bullying, little is known about its impact on socio‐economic outcomes.ObjectivesTo examine the association between acne and educational, labour market and relationship outcomes.MethodsWe conducted a nationwide registry‐based cohort study in Denmark. We included birth cohorts from 1982 to 1988 and compared those with and without acne identified using hospital diagnosis codes and redeemed prescriptions. Our main educational outcome was educational attainment. The main labour market outcomes were earned income at age 30 and long‐term unemployment at any time before age 30. The main relationship outcomes were single partnership and childlessness by age 30. Outcomes were assessed using Poisson regression for binary outcomes and linear regression for continuous outcomes, adjusted for sex, calendar year, mother's socio‐economic position and hormonal contraception use.ResultsThose with acne had a lower risk of not completing upper secondary education (relative risk (RR): 0.79; 95% confidence interval [CI]: 0.76–0.83) and higher education (RR: 0.90; 95% CI: 0.88–0.91), with absolute differences up to 4 percentage points. Persons with acne had slightly higher income (mean percentile difference: 2.6%, 95% CI: 2.2–2.9) and lower risk of long‐term unemployment than those without acne (9.8% vs. 11.4%; RR: 0.90; 95% CI: 0.87–0.93). The prevalence of being single until age 30 was similar (19.7% vs. 20.1%; adjusted RR: 0.96; 95% CI: 0.94–0.98) but childlessness was slightly more prevalent (60.5% vs. 57.5%; adjusted RR: 1.03; 95% CI: 1.02–1.04). However, all associations were attenuated or lost in secondary analysis restricted to exposure‐discordant siblings to address confounding from family‐related factors.ConclusionsAcne during adolescence does not seem to affect long‐term educational, labour market or relationship outcomes. However, there is a need for additional studies to validate the findings in untreated patients and different health and social systems.","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":"33 1","pages":""},"PeriodicalIF":9.2,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142262247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single‐centre experience with tralokinumab in dupilumab‐experienced and naïve patients with atopic dermatitis","authors":"Claire Fossati, Emmanuella Guenova, Curdin Conrad, Michel Gilliet, Teofila Seremet","doi":"10.1111/jdv.20348","DOIUrl":"https://doi.org/10.1111/jdv.20348","url":null,"abstract":"","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":"54 1","pages":""},"PeriodicalIF":9.2,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142262239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}