Journal of the European Academy of Dermatology and Venereology最新文献

{"title":"Low satisfaction with medical care among patients with hidradenitis suppurativa: A multicenter study.","authors":"Kerstin Wolk, Giorgia Cugno, Georgios Kokolakis, Sylke Schneider-Burrus, Dagmar Wilsmann-Theis, Katharina Assaf, Rotraut Moessner, Christian Kromer, Falk G Bechara, Nessr Abu Rached, Wiebke K Peitsch, Lisa C Schneider, Andreas Happ, Valentina Siddi, Diana Kubitzki, Durdana Groß, Markus Friedrich, Staffan Vandersee, Khusru Asadullah, Robert Sabat","doi":"10.1111/jdv.20718","DOIUrl":"https://doi.org/10.1111/jdv.20718","url":null,"abstract":"","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144030843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inherited CARD9 deficiency in a patient with both subcutaneous mucormycosis and hepatic candidiasis.","authors":"Lu Zhang, Yi Zhang, Zhuoqing Gong, Yiheng Liu, Zhe Wan, Yinggai Song, Xiaowen Wang, Ruoyu Li","doi":"10.1111/jdv.20709","DOIUrl":"https://doi.org/10.1111/jdv.20709","url":null,"abstract":"","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144016704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High anal Chlamydia trachomatis load is associated with LGV and symptoms in MSM: Results of a cross-sectional study.","authors":"Arabella Touati, Cécile Laurier-Nadalié, Charles Cazanave, Cécile Bébéar, Olivia Peuchant","doi":"10.1111/jdv.20714","DOIUrl":"https://doi.org/10.1111/jdv.20714","url":null,"abstract":"","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143978884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"European Guideline (EuroGuiDerm) on atopic eczema: Living update","authors":"A. Wollenberg,&nbsp;M. Kinberger,&nbsp;B. Arents,&nbsp;N. Aszodi,&nbsp;S. Barbarot,&nbsp;T. Bieber,&nbsp;H. A. Brough,&nbsp;P. Calzavara-Pinton,&nbsp;S. Christen-Zaech,&nbsp;M. Deleuran,&nbsp;M. Dittmann,&nbsp;N. Fosse,&nbsp;K. Gáspár,&nbsp;L. A. A. Gerbens,&nbsp;U. Gieler,&nbsp;G. Girolomoni,&nbsp;S. Gregoriou,&nbsp;S. Holland,&nbsp;C. G. Mortz,&nbsp;A. Nast,&nbsp;U. Nygaard,&nbsp;E. M. Rehbinder,&nbsp;J. Ring,&nbsp;M. Rossi,&nbsp;E. Serra-Baldrich,&nbsp;D. Simon,&nbsp;Z. Z. Szalai,&nbsp;J. C. Szepietowski,&nbsp;A. Torrelo,&nbsp;T. Werfel,&nbsp;R. N. Werner,&nbsp;C. Flohr","doi":"10.1111/jdv.20639","DOIUrl":"10.1111/jdv.20639","url":null,"abstract":"<p>The evidence- and consensus-based living guideline on atopic eczema was developed in accordance with the EuroGuiDerm Guideline and Consensus Statement Development Manual. The original EuroGuiDerm Guideline on atopic eczema was published in June 2022. Since then, the part of the guideline dealing with systemic therapy has been updated twice. This paper summarizes the results of the second update. Twenty-eight experts (including clinicians and patient representatives) from 12 European countries participated. The updated guideline provides guidance on which patients should be treated with systemic therapies, as well as recommendations and detailed information on each systemic drug. The systemic treatment options discussed in the guideline comprise conventional immunosuppressive drugs (azathioprine, ciclosporin, glucocorticosteroids, methotrexate and mycophenolate mofetil), biologics (dupilumab, lebrikizumab, nemolizumab and tralokinumab) and Janus kinase (JAK) inhibitors (abrocitinib, baricitinib and upadacitinib). Additionally, the updated guidelines address considerations for paediatric, adolescent, pregnant and breastfeeding patients. For all other aspects, please refer to the 2022 version.</p>","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":"39 9","pages":"1537-1566"},"PeriodicalIF":8.0,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jdv.20639","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143989132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular safety of systemic psoriasis treatments: A prospective cohort study in the BIOBADADERM registry","authors":"Juan José Lluch-Galcerá,&nbsp;José Manuel Carrascosa,&nbsp;Alicia González-Quesada,&nbsp;Antonio Sahuquillo-Torralba,&nbsp;Raquel Rivera-Díaz,&nbsp;Esteban Daudén,&nbsp;Isabel Belinchón,&nbsp;Francisco José Gómez-García,&nbsp;Enrique Herrera-Acosta,&nbsp;Diana P. Ruiz-Genao,&nbsp;José Luís Lopez-Estebaranz,&nbsp;Ofelia Baniandrés-Rodríguez,&nbsp;Marta Ferrán,&nbsp;Pablo de la Cueva,&nbsp;Lourdes Rodríguez,&nbsp;Almudena Mateu,&nbsp;Josep Riera-Monroig,&nbsp;José Carlos Ruiz-Carrascosa,&nbsp;Mariano Ara-Martín,&nbsp;María Teresa Abalde-Pintos,&nbsp;Mónica Roncero-Riesco,&nbsp;Conrad Pujol-Marco,&nbsp;Carmen García-Donoso,&nbsp;Mar Llamas-Velasco,&nbsp;Elena Del Alcázar,&nbsp;Jorge Alonso Suárez-Pérez,&nbsp;Belén Rodríguez-Sánchez,&nbsp;Kevin Díez-Madueño,&nbsp;Ricardo Ruiz-Villaverde,&nbsp;Victoria Lezcano-Biosca,&nbsp;Beatriz González-Sixto,&nbsp;Miguel Ángel Descalzo,&nbsp;Ignacio García-Doval","doi":"10.1111/jdv.20705","DOIUrl":"10.1111/jdv.20705","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Psoriasis is a chronic inflammatory disease with multiple comorbidities, including an increased risk of major adverse cardiovascular events (MACE). There is limited and contradictory evidence comparing the impact of systemic treatments for psoriasis on MACE.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To evaluate the incidence of MACE associated with each systemic treatment used for patients with psoriasis and compare these rates to those observed with methotrexate (MTX).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We conducted a prospective cohort study using data from the BIOBADADERM registry. Propensity score matching was used to adjust for baseline differences between treatment groups. We calculated the incidence rate (IR) of MACE for each systemic treatment class, including biologics (anti-TNF, IL-12/23, IL-17 and IL-23 inhibitors), conventional systemic therapies (MTX, cyclosporine, dimethyl fumarate and acitretin) and apremilast (APR). The IR for each group was compared to those observed in patients treated with MTX using Poisson regression models adjusted for potential confounders, with 95% confidence intervals (95% CI). The primary outcome was the adjusted incidence rate ratios (IRR) for MACE between patients receiving MTX and those receiving another systemic treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>We analysed data from 5622 patients, 11,368 treatment cycles and 21,762 person-years (PYs). APR (IRR = 0.17; 95% CI, 0.04–0.70) and IL-17 (IRR = 0.43; 95% CI, 0.20–0.91) were associated with a significant reduction in the risk of MACE compared to MTX. Cyclosporine was associated with an increased risk of MACE (IRR = 3.59; 95% CI, 1.17–10.99) compared to MTX. The remaining systemic psoriasis treatments were not significantly associated with an increased or decreased risk of MACE.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This real-world evidence study indicates a potential association between APR and IL-17 with a lower incidence of MACE, while CYC showed a higher incidence compared to MTX. These findings underscore the importance of considering cardiovascular outcomes when selecting systemic therapies for patients with psoriasis.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":"39 9","pages":"1631-1642"},"PeriodicalIF":8.0,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144017328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-frequency ultrasonography combined with Mohs micrographic surgery for treating recurrent DFSP.","authors":"Yuancheng Liu, Shuang Zhao, Tianhong Wei","doi":"10.1111/jdv.20722","DOIUrl":"https://doi.org/10.1111/jdv.20722","url":null,"abstract":"","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144020067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unaddressed confounders in the evaluation of isotretinoin pregnancy prevention compliance: A call for refined analyses","authors":"Jianjun Hao,&nbsp;Dongmei Li,&nbsp;Jing Yang","doi":"10.1111/jdv.20710","DOIUrl":"10.1111/jdv.20710","url":null,"abstract":"","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":"39 10","pages":"e936-e937"},"PeriodicalIF":8.0,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144032809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of GLP-1RA on inflammatory skin diseases: A comprehensive review.","authors":"Ioanna A Paschou, Evangelia Sali, Stavroula A Paschou, Theodora Psaltopoulou, Electra Nicolaidou, Alexander J Stratigos","doi":"10.1111/jdv.20694","DOIUrl":"https://doi.org/10.1111/jdv.20694","url":null,"abstract":"<p><p>Glucagon-like peptide 1 receptor agonists (GLP-1RA) are commonly used as treatment for type 2 diabetes mellitus and obesity. GLP-1RA have been found to be valuable therapeutic approaches not only for glucose control, but also for weight loss and cardiovascular risk reduction. It has also been established that GLP-1RA have immunological and anti-inflammatory effects. The aim of this article was to comprehensively review the literature and to collect, analyse and quantitatively resynthesize evidence on the possible effects of GLP-1RA on inflammatory skin diseases. Through body weight reduction and subsequent systemic inflammation reduction, but mainly through their direct interaction with signalling pathways of inflammation and immune cells, GLP-1RA can improve psoriasis and hidradenitis suppurativa (HS). Clinical data of the positive effects of GLP-1RA in patients with psoriasis and HS are presented. Moreover, the immune cells and inflammatory pathways affected by GLP-1RA are discussed.</p>","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144022923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Standardizing the 'MOAHLFA (P) index' for contact allergy research.","authors":"Wolfgang Uter, Klaus Ejner Andersen, Richard Brans, Magnus Bruze, Steffen Schubert, Margarida Gonçalo","doi":"10.1111/jdv.20713","DOIUrl":"https://doi.org/10.1111/jdv.20713","url":null,"abstract":"","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144028601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Er:YAG laser ablation: Possibly a valuable tool in the management of refractory Hailey–Hailey disease","authors":"Danielle Rogner","doi":"10.1111/jdv.20651","DOIUrl":"https://doi.org/10.1111/jdv.20651","url":null,"abstract":"&lt;p&gt;Management of Hailey–Hailey disease (HHD) remains challenging, traditionally involving symptomatic treatments aimed at controlling flare-ups and reducing discomfort. However, these treatments can sometimes offer only temporary relief, and they carry risks of side effects.&lt;span&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/span&gt;\u0000 &lt;/p&gt;&lt;p&gt;In order to improve patients' quality of life (QoL), there is a continuing interest in other treatment modalities for HHD. In 1987, Don et al. published the first case report of successful Carbon dioxide laser abrasion in a patient, and since then, there have been various case reports and studies on HHD treated with ablative lasers such as Er:YAG and CO&lt;sub&gt;2&lt;/sub&gt; lasers, indicating that this seems to be a safe and effective therapy.&lt;span&gt;&lt;sup&gt;2, 3&lt;/sup&gt;&lt;/span&gt;\u0000 &lt;/p&gt;&lt;p&gt;However, there was a lack of in-depth analysis of this treatment in a large cohort, making the argumentation for the cost-coverage of this off-label therapy towards the health insurance difficult, as well as lacking clarification for the exact laser treatment protocol.&lt;/p&gt;&lt;p&gt;The study by Debeuf et al. offers compelling evidence for the efficacy of Er:YAG ablative laser therapy in achieving long-term remission of HHD and improving QoL. This single-centre observational study included eight patients with genetically/histopathologically confirmed HHD, and the results showed that a single Er:YAG laser ablation led to complete remission in most of the HHD plaques, even after a median follow-up of 38 months. It also demonstrated significant improvements in the patients' QoL, measured by Skindex-29 and DLQI questionnaires.&lt;/p&gt;&lt;p&gt;One of the key strengths is its focus on ultrastructural changes following laser therapy. Electron microscopy revealed that Er:YAG laser treatment restored the number of desmosomes, decreased intercellular distance and diminished perinuclear retraction of keratin filaments in HHD plaques. These findings suggest that laser therapy not only provides clinical improvement but also corrects some of the underlying cellular abnormalities associated with HHD, possibly enhancing the skin's barrier function, therefore also reducing bacterial colonization in these areas and overall decreasing the risk of secondary infections and also viral superinfections.&lt;span&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/span&gt;\u0000 &lt;/p&gt;&lt;p&gt;The findings are consistent with previous studies that have reported successful use of ablative laser therapies in the treatment of HHD. Er:YAG laser ablation is less prone to scarring, and its precision allows for effective targeting of the affected skin areas while minimizing damage to surrounding tissues.&lt;span&gt;&lt;sup&gt;4&lt;/sup&gt;&lt;/span&gt;\u0000 &lt;/p&gt;&lt;p&gt;However, the authors also acknowledge the limitations of ablative laser therapy, including the need for accurate and consequent wound care, the potential for scarring and hypopigmentation, and the limitation of treating large body surface areas due to lidocaine dosage limits. Furthermore, they suggest that l","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":"39 5","pages":"895-896"},"PeriodicalIF":8.4,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jdv.20651","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143871723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}