Journal of the European Academy of Dermatology and Venereology最新文献

{"title":"Bullous pemphigoid burden of disease, management and unmet therapeutic needs.","authors":"V P Werth,D F Murrell,P Joly,M Ardeleanu,V Hultsch","doi":"10.1111/jdv.20313","DOIUrl":"https://doi.org/10.1111/jdv.20313","url":null,"abstract":"Bullous pemphigoid (BP) is an autoimmune blistering disease that can have a profound negative impact on quality of life. BP most often affects the elderly, a population with a high medical burden and special safety concerns. In this review, we outline the BP disease course, diagnosis, epidemiology and comorbidities, and describe tools commonly used to assess BP disease activity and severity and the impact of BP on health-related quality of life. We also outline biologic treatments currently under investigation for the treatment of BP and highlight the importance of considering safety when treating elderly patients.","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":"50 1","pages":""},"PeriodicalIF":9.2,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142262238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Educational, labour market and relationship outcomes in people with acne","authors":"John S. Barbieri, Dóra K. Farkas, Niels Skipper, Ketaki Bhate, Sinéad M. Langan, Line Kibsgaard, Henrik T. Sørensen, Sigrun A. J. Schmidt","doi":"10.1111/jdv.20323","DOIUrl":"https://doi.org/10.1111/jdv.20323","url":null,"abstract":"BackgroundAlthough acne is associated with scarring, mental health comorbidities and bullying, little is known about its impact on socio‐economic outcomes.ObjectivesTo examine the association between acne and educational, labour market and relationship outcomes.MethodsWe conducted a nationwide registry‐based cohort study in Denmark. We included birth cohorts from 1982 to 1988 and compared those with and without acne identified using hospital diagnosis codes and redeemed prescriptions. Our main educational outcome was educational attainment. The main labour market outcomes were earned income at age 30 and long‐term unemployment at any time before age 30. The main relationship outcomes were single partnership and childlessness by age 30. Outcomes were assessed using Poisson regression for binary outcomes and linear regression for continuous outcomes, adjusted for sex, calendar year, mother's socio‐economic position and hormonal contraception use.ResultsThose with acne had a lower risk of not completing upper secondary education (relative risk (RR): 0.79; 95% confidence interval [CI]: 0.76–0.83) and higher education (RR: 0.90; 95% CI: 0.88–0.91), with absolute differences up to 4 percentage points. Persons with acne had slightly higher income (mean percentile difference: 2.6%, 95% CI: 2.2–2.9) and lower risk of long‐term unemployment than those without acne (9.8% vs. 11.4%; RR: 0.90; 95% CI: 0.87–0.93). The prevalence of being single until age 30 was similar (19.7% vs. 20.1%; adjusted RR: 0.96; 95% CI: 0.94–0.98) but childlessness was slightly more prevalent (60.5% vs. 57.5%; adjusted RR: 1.03; 95% CI: 1.02–1.04). However, all associations were attenuated or lost in secondary analysis restricted to exposure‐discordant siblings to address confounding from family‐related factors.ConclusionsAcne during adolescence does not seem to affect long‐term educational, labour market or relationship outcomes. However, there is a need for additional studies to validate the findings in untreated patients and different health and social systems.","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":"33 1","pages":""},"PeriodicalIF":9.2,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142262247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single‐centre experience with tralokinumab in dupilumab‐experienced and naïve patients with atopic dermatitis","authors":"Claire Fossati, Emmanuella Guenova, Curdin Conrad, Michel Gilliet, Teofila Seremet","doi":"10.1111/jdv.20348","DOIUrl":"https://doi.org/10.1111/jdv.20348","url":null,"abstract":"","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":"54 1","pages":""},"PeriodicalIF":9.2,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142262239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low‐dose oral minoxidil for the treatment of monilethrix: A retrospective review","authors":"Emadodin Darchini‐Maragheh, Anthony Moussa, Dmitri Wall, Nekma Meah, Rodney Sinclair","doi":"10.1111/jdv.20329","DOIUrl":"https://doi.org/10.1111/jdv.20329","url":null,"abstract":"","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":"118 1","pages":""},"PeriodicalIF":9.2,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142262243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A cluster of early syphilis cases with ocular manifestations on the island of Crete","authors":"Dimitra Koumaki, Georgios Evangelou, Faidra Marazaki, Danae Petrou, Maria Gorgomiti, Stamatios Gregoriou, Petros Ioannou, Vasiliki Koumaki, Efstathios T. Detorakis, Aikaterini Chalkia, Maria Vavouranaki, Konstantinos Krasagakis","doi":"10.1111/jdv.20345","DOIUrl":"https://doi.org/10.1111/jdv.20345","url":null,"abstract":"","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":"23 1","pages":""},"PeriodicalIF":9.2,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142262252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ChatGPT and acne: Accuracy and reliability of the information provided-The AI-check study.","authors":"Vincenzo Bettoli, Luigi Naldi, Eugenio Santoro, Maria Rosa Valetto, Anna Bolzon, Fortunato Cassalia, Simone Cazzaniga, Sergio Cima, Andrea Danese, Silvia Emendi, Monica Ponzano, Nicoletta Scarpa, Pietro Dri","doi":"10.1111/jdv.20324","DOIUrl":"https://doi.org/10.1111/jdv.20324","url":null,"abstract":"","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142289986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of age on the severity of psoriasis.","authors":"Shir Azrielant, Su M Lwin, Christopher E M Griffiths","doi":"10.1111/jdv.20340","DOIUrl":"https://doi.org/10.1111/jdv.20340","url":null,"abstract":"","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142289994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evidence of early coronary atherosclerotic plaque in hidradenitis suppurativa compared to the background population is indicative of myocardial infarction risk.","authors":"N Kearney, B O'Riordan, R Hughes, C McCourt, M Ledwidge, K McDonald, D O'Kane, J D Dodd, B Kirby","doi":"10.1111/jdv.20339","DOIUrl":"https://doi.org/10.1111/jdv.20339","url":null,"abstract":"","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142289988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of two molecularly and prognostically distinct subtypes in acral melanoma using network prediction method.","authors":"Mingzhu Yin, Yiding Zhang, Wenhua Wang, Shuang Zhao, Juan Su, Shao Li, Xiang Chen","doi":"10.1111/jdv.20335","DOIUrl":"https://doi.org/10.1111/jdv.20335","url":null,"abstract":"<p><strong>Background: </strong>Acral melanoma, characterized by its aggressiveness and poor prognosis compared to other melanoma subtypes, poses significant challenges in clinical management. However, the molecular underpinnings driving the biological and clinical features of this disease remain poorly understood.</p><p><strong>Objectives: </strong>In this study, our aim was to elucidate the molecular landscape and the correlation between subtypes and clinical features of acral melanoma.</p><p><strong>Methods: </strong>We conducted comprehensive analyses to dissect the molecular characteristics of acral melanoma, employing a combination of multi-omics data analysis and network-based disease gene prediction algorithms. Single-cell RNA-Seq data were utilized to investigate the contribution of immunocytes to the molecular classification of acral melanoma. Additionally, we used clinical samples to validate the correlation between new subtypes and the prognosis of acral melanoma and the expression of subtype markers and verified the interaction between macrophages and acral melanoma cells at cellular level.</p><p><strong>Results: </strong>Our study reveals the existence of two distinct subtypes of acral melanoma exhibiting marked differences in clinical behaviour, cellular and molecular mechanisms. We identified a robust biomarker panel (EREG, VSIG4, FCGR3A and RAB20) that accurately distinguishes these two subtypes with an impressive AUC of 0.946, validated using clinical samples. Subtype I, characterized by thinner Breslow thickness, demonstrates a favourable prognosis, whereas Subtype II represents a high-risk subtype with a propensity for dermal invasion. Notably, the signature gene EREG of Subtype I is enriched in FCN1⁺ macrophages, known for promoting inflammatory and immune responses. Conversely, signature genes VSIG4 and FCGR3A of Subtype II are enriched in SPP1⁺ macrophages, which exhibit significant crosstalk with tumour cells.</p><p><strong>Conclusions: </strong>Our findings significantly enhance the understanding of the molecular landscape of acral melanoma and offer novel insights into its clinical management by identifying distinct subtypes and potential therapeutic targets. The findings have to be confirmed in different cohorts in the future for full validation.</p>","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142289989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti‐IL‐23 therapy for the treatment of moderate‐to‐severe inverse psoriasis: A 52‐week multicentre study","authors":"Joan Ceravalls, Ricardo Ruiz‐Villaverde, Susana Armesto, Josep Manel Fernández‐Armenteros, Josep Riera‐Monroig, Tamara Gracia‐Cazaña, Mònica Quintana‐Codina, Maribel Iglesias‐Sancho, Montserrat Salleras, Adrián Imbernón Moya, Francisco Javier Melgosa Ramos, Marta Ferran","doi":"10.1111/jdv.20346","DOIUrl":"https://doi.org/10.1111/jdv.20346","url":null,"abstract":"","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":"23 1","pages":""},"PeriodicalIF":9.2,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142262240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}