Journal of the European Academy of Dermatology and Venereology最新文献

{"title":"Tattoos in patients with atopic dermatitis: What the dermatologist should know?","authors":"Nicolas Kluger","doi":"10.1111/jdv.20624","DOIUrl":"https://doi.org/10.1111/jdv.20624","url":null,"abstract":"","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlating histopathology and line-field confocal optical coherence tomography in Paget's disease.","authors":"Safa Idoudi, Antoine Delpuech, Clara Tavernier, Maxime Battistella, Celeste Lebbe, Baryour Baroudjian","doi":"10.1111/jdv.20610","DOIUrl":"https://doi.org/10.1111/jdv.20610","url":null,"abstract":"","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143531591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk of oesophageal strictures in mucous membrane pemphigoid: Insights from a real-world cohort study.","authors":"Henning Olbrich, Sabrina Patzelt, Evelyn Gaffal, Khalaf Kridin, Philip Curman, Enno Schmidt, Ralf J Ludwig, Michael Kasperkiewicz","doi":"10.1111/jdv.20603","DOIUrl":"https://doi.org/10.1111/jdv.20603","url":null,"abstract":"","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143501681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shifting the focus: Exploring happiness as a health outcome in dermatology","authors":"Flora Balieva","doi":"10.1111/jdv.20536","DOIUrl":"https://doi.org/10.1111/jdv.20536","url":null,"abstract":"<p>Happiness is under-researched in medicine. The World Happiness Report highlights the role of societal factors: income equality, social freedom and healthcare access in influencing population-level happiness.<span><sup>1</sup></span> The majority of dermatological research focuses on disability indices such as impairment in mental health, reduced health-related quality of life (HRQoL), economic burden and other negative measurements that impair well-being. In this issue of the JEADV, Ziehfreund, Wecker et al. present their study<span><sup>2</sup></span> in which they chose to adopt a positive perspective, exploring happiness as the key health outcome. The authors investigated happiness in 1039 patients with psoriasis and atopic dermatitis (AD).</p><p>The study employs a combination of subjective self-assessments using standardized instruments (Dermatology Life Quality Index (DLQI), Satisfaction with Life Scale (SWLS), subjective well-being with the Scale of Positive and Negative Experience (SPANE), a heuristic happiness single item scale and self-assessed disease severity) as well as objective clinical measures of disease severity (Psoriasis Area and Severity Index [PASI] and SCORing Atopic Dermatitis [SCORAD]) to integrate diverse data, which were then used to perform quantile regression. This approach offers valuable insights into the factors influencing happiness across a spectrum of experiences.</p><p>The authors selected their measurements based on prior existing publications and their own experience in the field, ensuring that results could be compared across studies and patient groups. Furthermore, the participants were recruited from eight European countries, providing insights into geographical differences in happiness levels and their relationship with dermatological health. This broad scope is a valuable contribution to cross-cultural research in dermatology.</p><p>Patients with AD reported greater impairment in HRQoL compared to patients with psoriasis. The authors attribute this difference to symptoms such as itch and fatigue. However, fatigue is more explored in psoriasis, while tiredness in AD is more likely to result from sleep loss due to severe itching.<span><sup>3</sup></span> Another reason for lower experienced happiness in patients with AD may be due to psoriasis patients having had access to effective biological treatments, available since the early 2000s, whereas similar treatments for AD have only recently become available.<span><sup>4</sup></span> The last two decades have offered psoriasis patients considerably better improvement in symptoms than for patients with AD, thus a different patient journey. In the study by Ziehfreund, Wecker et al.,<span><sup>2</sup></span> patients with AD exhibited more severe disease symptoms than patients with psoriasis, and current or previous use of systemic treatments was linked to higher happiness scores in some quantiles. These findings underscore the importance of adequate medical","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":"39 3","pages":"455-456"},"PeriodicalIF":8.4,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jdv.20536","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143481585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editor's Picks March 2025","authors":"","doi":"10.1111/jdv.20543","DOIUrl":"https://doi.org/10.1111/jdv.20543","url":null,"abstract":"<p>Reflectance confocal microscopy is a skin imaging technique that improves the detection of subclinical malignant pigmentary lesions. In a prospective study, Elshot et al. show the clinical utility of handheld reflectance confocal microscopy (HHRCM) to precisely define surgical margins for lentigo maligna prior to surgical intervention (Figure 1). Lesion mapping is relatively rapid, improving the ability of surgery to achieve complete removal of the tumour. Using HHRCM is associated with dramatically reduced recurrence. This study shows the high utility of skin imaging techniques when mastered by expert centres resulting in improved patient outcomes.</p><p>Elshot YS, Lasso Peña DJP, Zupan-Kajcovski B, et al. Successful implementation of handheld reflectance confocal microscopy as the standard of care in the (surgical) management of lentigo maligna (melanoma). J Eur Acad Dermatol Venereol 2025; <b>39</b>:604–611. doi:10.1111/jdv.20210</p><p>According to psychologist Martin Seligman, happiness has three major dimensions: pleasantness, engagement and connection. In a large European study, Ziehfreund et al. evaluated happiness and quality of life in 1039 patients with psoriasis or atopic dermatitis. The authors show the negative effect of inflammatory skin diseases on happiness and the positive effect of systemic treatment.</p><p>They also identify significant differences between European countries, with Italian and Austrian patients exhibiting the highest level of happiness. These data highlight that skin diseases can hinder the quest for happiness, but dermatological care has a positive impact (Figure 2).</p><p>Ziehfreund S, Wecker H, Mittag S, et al. Happiness across the borders-A cross-sectional study among patients with psoriasis and atopic dermatitis in Europe. J Eur Acad Dermatol Venereol 2025; <b>39</b>:529–542. doi:10.1111/jdv.20288</p><p>A major component of the psychological burden of skin diseases is stigmatization. People with visible skin diseases suffer from frequent microaggressions that have a detrimental effect on self-confidence and well-being.</p><p>In a systematic review, Stuhlmann et al. aimed to identify mechanisms and parameters that contribute to self-stigmatization in patients with inflammatory skin diseases (Figure 3). They identified social stigma, lack of acceptance and lack of social support as main predictors of self-stigma. Interventions to promote acceptance, social support and information dissemination about skin diseases should help patients to better cope with the psychological burden of skin diseases.</p><p>Stuhlmann CFZ, Traxler J, Paucke V, da Silva Burger N, Sommer R. Predictors and mechanisms of self-stigma in five chronic skin diseases: A systematic review. J Eur Acad Dermatol Venereol 2025; <b>39</b>:622–630. doi:10.1111/jdv.20314</p><p>Global warming and wasted natural resources are current major challenges. I am always impressed by the long queues of colleagues waiting for samples from cosmeceutical comp","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":"39 3","pages":"445-446"},"PeriodicalIF":8.4,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jdv.20543","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143481336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond the surface: Integrating sex and gender in dermatologic therapy","authors":"Ion Birkenmaier, Julia-Tatjana Maul","doi":"10.1111/jdv.20542","DOIUrl":"https://doi.org/10.1111/jdv.20542","url":null,"abstract":"<p>In recent decades, dermatology has seen significant progress in the development of targeted and biologic therapies for inflammatory skin diseases. Yet, as underscored by the systematic review by Preis et al.,<span><sup>1</sup></span> medical research and clinical practice have too often marginalized sex- and gender-based variations, creating a one-size-fits-all approach. This newly published work dives into how both biological (sex) and sociocultural (gender) factors alter disease trajectories, therapeutic outcomes and risk profiles in dermatological conditions such as psoriasis and atopic dermatitis.</p><p>A noteworthy finding of this systematic review is the discrepancy in treatment success and adverse events between men and women. In psoriasis, for instance, female sex was frequently linked to increased side effects,<span><sup>2</sup></span> as also shown in our more recent work from Switzerland.<span><sup>3</sup></span> Paradoxically, lower treatment response was seen in other studies.<span><sup>4</sup></span> These observations imply that weight-based dosing, hormonal milieu, psychosocial variables or adherence may skew women's clinical outcomes. While it remains difficult to separate strictly biological processes from sociocultural influences, the review highlights how chronic disease burden may be amplified in women, often leading to earlier discontinuation of systemic therapies.</p><p>In addition, the review documents that men tend to more readily receive systemic treatments and at a younger age, suggesting possible biases in the initiation and timing of intervention.<span><sup>5</sup></span> For women of childbearing age, concerns over teratogenic risks and physician hesitancy may delay the start of systemic therapies. Moreover, insufficient patient-level knowledge about psoriasis, as well as lack of clinical studies with safety data in pregnancy, is frequently cited as barriers. This delay can perpetuate the underutilization of potentially beneficial treatments in women, while men—though less likely to have childbearing concerns—may face other healthcare hurdles such as reluctance to seek early dermatologic consultation.</p><p>As the authors rightly note, existing data predominantly conflate ‘sex’ and ‘gender’ into a single category, making it difficult to measure how purely biological differences (e.g., hormonal fluctuations and body mass index) interact with social and psychological factors (e.g., stigma and cultural norms). Standardizing study designs to define ‘sex’ and ‘gender’ more precisely would greatly improve clarity around treatment outcomes. Indeed, the call for more granular trials resonates with the shift towards personalized medicine, wherein each patient's biological background and social context could inform optimized therapeutic pathways.</p><p>Finally, is it truly time for novel, sex-specific dermatologic guidelines? The authors present compelling evidence that a blanket ‘one-guideline-fits-all’ approach misses cri","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":"39 3","pages":"453-454"},"PeriodicalIF":8.4,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jdv.20542","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143481584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Towards greener conferences: Addressing the sustainability of cosmeceutical samples","authors":"M. Keperti, M. Trakatelli","doi":"10.1111/jdv.20545","DOIUrl":"https://doi.org/10.1111/jdv.20545","url":null,"abstract":"<p>It is widely known that during large-scale events, such as the annual EADV Congress, a great number of cosmeceutical samples are distributed to the delegates. The environmental impact of such products raises significant concerns due to the wasteful nature of samples. The publication by Salimi and Tso<span><sup>1</sup></span> in this issue places in the forefront sustainability implications such practices entail and proposes practical solutions for reducing environmental harm giving us food for thought on how to run greener meetings in the future.</p><p>Indeed, the most common practices linked to cosmeceutical samples are the single-use packaging plastics, the indiscriminately distribution and the negligent disposition of the products.<span><sup>1</sup></span> The magnitude of the problem should not be underestimated. Conferences of such size attract thousands of attendees, each receiving promotional specimens in quantities far exceeding individual needs. A significant portion of these items ends up discarded, contributing to plastic waste. The reliance on non-recyclable packaging exacerbates the problem, as these materials often end up in landfills, releasing harmful chemicals into the environment and microplastics.<span><sup>2</sup></span></p><p>The authors clearly state feasible solutions to tackle this undesirable reality. Conference organizers are responsible for developing and implementing a green policy, part of which should be the inclusion of sustainable healthcare as a key conference agenda item. It is crucial that all the recyclable materials do not end up in landfills and so the conference could implement green policy, placing both recycling stations and boxes for reusable packaging. Delegates can also play an important part and make more sustainable choices by returning excess and unwanted items or even consider requesting samples from each company's local representative instead of collecting them at the conference.</p><p>On the other hand, industries must welcome the returned, unused samples from the delegates, as a part of the ‘reduce reuse recycle’ movement<span><sup>3</sup></span> or donate them to the local community or charity. If there isn't a local representative of the company in an individual's country, the industry should be ready to assist the delegate to gain access to the samples through digital marketing. A carrier bag should be optional or the delegates should be invited to bring their own, packaging materials must be recycled and recyclable, and biodegradable/organic materials ought to be chosen over single use materials.</p><p>In order to minimize distribution of excess samples the adoption of digital sampling methods is required. By using QR codes, delegates can request product samples delivered to their homes, reducing the need for bulk distribution and minimizing waste. This approach has the added advantage for the industry as it provides companies with valuable insights into consumer preferences and enables a ","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":"39 3","pages":"463-464"},"PeriodicalIF":8.4,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jdv.20545","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143481396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reflectance confocal microscopy: Presurgical margin assessment improves lentigo maligna and lentigo maligna melanoma management","authors":"Christoph Sinz, Pascale Guitera","doi":"10.1111/jdv.20549","DOIUrl":"https://doi.org/10.1111/jdv.20549","url":null,"abstract":"<p>Elshot et al.<span><sup>1</sup></span> emphasized in their article a cardinal subject in the management of Lentigo maligna (LM) and Lentigo maligna melanoma (LMM), a subtype of melanoma which commonly occurs on sun-exposed skin of the face, scalp and neck region, especially in elderly men. It is known to be associated with a noticeable incomplete excision rate and a significant recurrence rate after wide local excision (WLE).<span><sup>2</sup></span> The main explanation for these issues is LM/LMM subclinical extension, invisible to clinical examination using dermoscopy and Wood's lamp, leading to an underestimation of its actual size. This study's main objective is to investigate the influence of presurgical mapping of biopsy-proven LM/LMM with handheld reflectance confocal microscopy (HH-RCM) with a focus on surgical treatment, follow-up outcomes and management decisions.</p><p>The promising results of this research draw attention on how HH-RCM could become a standard of care in the surgical and also non-surgical management of LM and LMM. One of the most striking, and promising, findings is that the resection margins after WLE in the presurgical HH-RCM group were cleared in 96.5% of cases. Moreover, this exceptional clearance rate was also associated with a median histologic margin of 3.0 mm which, if achieved, is expected to significantly reduce risk of local recurrence.<span><sup>2</sup></span></p><p>It has to be acknowledged that the local recurrence rate of 1.4% in this study is potentially due to a shorter follow-up as observed in previous studies stating longer post-interventional observation periods with local recurrence rates ranging from 8% to 20%.<span><sup>2</sup></span></p><p>According to another finding, RCM detected in 60% of the cases subclinical atypical cells beyond the initial surgical margins which underlines the superiority of RCM compared to clinical examination with dermoscopy alone.<span><sup>3</sup></span> Identifying subclinical extent goes hand in hand with an increased lesion size. It is arguable that this clinical underestimation of the actual lesion size is introducing lower histologic clearance rates after wide local excision (WLE) and higher recurrence rates due to a smaller extent of the histologic margins.</p><p>Additionally, the authors reported that 75% of initially misdiagnosed LM were actually invasive melanomas highlighting another interesting aspect of RCM mapping: Despite the limited visualization of deeper skin structures down to a depth of around 200 μm, RCM has still the potential to identify invasive LMM components.<span><sup>4</sup></span></p><p>Identifying invasive or subclinical components and a refusal of (further) surgery are the most common reasons for a modified management such as an adaption of the surgical method, treatment with topical imiquimod or radiation therapy. In all these scenarios, presurgical HH-RCM margin assessment with a described median mapping duration in this study of only","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":"39 3","pages":"459-460"},"PeriodicalIF":8.4,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jdv.20549","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143481588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Closing the gap between possibilities and reality in psoriasis management","authors":"Rolland Gyulai","doi":"10.1111/jdv.20546","DOIUrl":"https://doi.org/10.1111/jdv.20546","url":null,"abstract":"<p>Psoriasis treatment has evolved tremendously during the last few decades. I remember, as a resident dermatologist during the mid-1990s, we treated most of our severe psoriasis patients by rotating low-to-medium efficacy therapies: topical treatments (salicylic acid, corticosteroids, dithranol) phototherapy, acitretin and less frequently cyclosporine or methotrexate. Many patients regularly spent weeks in the hospital, and treatment success was usually partial and temporary, lasting for only a few months. The introduction of first-generation biologics marked a significant shift in the management of psoriasis. Methotrexate, which was used as the comparator in clinical trials, became the standard non-biological treatment, and patients began to experience longer more complete remissions. During the last decade, several novel biologics entered the psoriasis field, which showed clear superiority over both conventional and previous-generation biologics. Some biologics have been registered even as first-line treatments, theoretically enabling the early introduction of highly effective therapy. These advancements have led to more ambitious treatment goals by both doctors and patients. Today, even a cure—that is long-term remission off-treatment—seems scientifically realistic.<span><sup>1</sup></span></p><p>Notwithstanding these groundbreaking achievements, dermatologists still face considerable challenges in providing optimal care for psoriasis patients. With expanding indications, exponentially growing patient populations and sky-rocketing medication prices, health funders around the world are struggling to fit therapeutic options into sustainable financing schemes.</p><p>The article by Speeckaert et al.<span><sup>2</sup></span> in this issue of the Journal attempts to elucidate whether and how the integration of novel developments in psoriasis management (such as redefined disease severity or treatment goals, newer biologics or biosimilars, personalized dosing or telemedicine) could lead to (more) sustainable psoriasis care. The authors employ a quasi-Delphi methodology and relate their research to the Belgian psoriasis management environment as an example. They conclude that several factors may contribute to better and still sustainable psoriasis management, such as the implementation of a treat-to-target approach, the use of minimal disease activity (defined as PASI90 or PGA ≤ 1; itch VAS ≤ 10 mm; absence of disturbing lesions; no moderate-to-severe adverse events; DLQI ≤ 1; full tolerability; incapacity in daily functioning VAS score ≤ 1) as optimal therapeutic objective, or the use of teleconsultations for patient follow-up.</p><p>The authors also offer a critique of the current Belgian reimbursement criteria, which mandate the utilization of three conventional antipsoriatic therapies (phototherapy, methotrexate and cyclosporine) prior to the administration of biologics. They propose that only phototherapy and one conventional therapy should be n","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":"39 3","pages":"449-450"},"PeriodicalIF":8.4,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jdv.20546","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143481338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of JAK inhibitors in treating lichen planopilaris or frontal fibrosing alopecia.","authors":"Chaofan Wang, Yiqun Jiang","doi":"10.1111/jdv.20614","DOIUrl":"https://doi.org/10.1111/jdv.20614","url":null,"abstract":"","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143492582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}