Journal of the European Academy of Dermatology and Venereology最新文献

{"title":"Impact of prior biologic exposure on drug survival in atopic dermatitis.","authors":"Xu Li, Shuang Wu, Yanfei Li, Jingxue Guo, Peng Jin, Lili Zhi","doi":"10.1111/jdv.20678","DOIUrl":"https://doi.org/10.1111/jdv.20678","url":null,"abstract":"","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143743252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of mucous membrane pemphigoid in childhood: A multicentre study of 12 cases.","authors":"Laure Chêne, Christelle Le Roux-Villet, Ludovic Martin, Audrey Lasek-Duriez, Juliette Miquel, Hélène Aubert, Nicolas Macagno, Lucie Vitek, Florian Lombart, Jean-Jacques Morand, Emmanuelle Bourrat, Christine Chiaverini, Marie-Aleth Richard, Stéphanie Mallet","doi":"10.1111/jdv.20675","DOIUrl":"https://doi.org/10.1111/jdv.20675","url":null,"abstract":"","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143743250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to Reply to: EuroGuiderm guideline on lichen sclerosus-Treatment of lichen sclerosus.","authors":"Gudula Kirtschig, Maria Kinberger, Alexander Kreuter, Rosalind Simpson","doi":"10.1111/jdv.20669","DOIUrl":"https://doi.org/10.1111/jdv.20669","url":null,"abstract":"","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143729935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of etrasimod in alopecia areata: A multicentre, randomized, double-blind, placebo-controlled, Phase 2 study.","authors":"B King, N Mesinkovska, M Senna, X Luo, J Minkiewicz, A Selfridge","doi":"10.1111/jdv.20605","DOIUrl":"https://doi.org/10.1111/jdv.20605","url":null,"abstract":"<p><strong>Background: </strong>Etrasimod, an oral, selective sphingosine 1-phosphate 1, 4 and 5 receptor modulator approved for the treatment of ulcerative colitis, has been studied in immune-mediated inflammatory diseases, including alopecia areata (AA).</p><p><strong>Objectives: </strong>To evaluate the efficacy and safety of etrasimod in adults with moderate to severe AA.</p><p><strong>Methods: </strong>This Phase 2, randomized, double-blind, placebo-controlled trial included patients (aged ≥18 years) with moderate to severe AA, defined as a Severity of Alopecia Tool (SALT) score of ≥25. Patients were sequentially enrolled into two cohorts. Cohort 1 included patients (SALT score of ≥50) randomized 2:1 to etrasimod 2 mg or placebo. Cohort 2 included patients (SALT score ≥25 to <95) randomized 4:1:2 to etrasimod 3 mg, 2 mg or placebo. Patients completed a 24-week double-blind and 28-week open-label extension period. The primary endpoint was percent change from baseline (%CFB) in SALT score at Week 24. Safety was monitored throughout the trial.</p><p><strong>Results: </strong>Eighty patients were randomized to etrasimod 2 mg (n = 31), 3 mg (n = 25) or placebo (n = 24). At Week 24, least squares mean (SE) percent changes from baseline in SALT score for the etrasimod 2 mg, 3 mg and placebo groups were -13.8 (8.6), -21.4 (6.9) and 0.35 (8.9), respectively. The least squares mean difference (95% CI; P value) in SALT score %CFB of etrasimod 2 mg and 3 mg versus placebo was -14.1 (-38.9 to 10.6; p = 0.2579) and - 21.8 (-44.4 to 0.9; p = 0.0592), respectively; statistical superiority was not achieved. The proportions of patients achieving ≥30%, ≥50% or ≥75% improvement in baseline SALT score at Week 24 were generally numerically higher in etrasimod groups versus placebo. Treatment-emergent adverse events occurred in 67.7%, 80.0% and 78.3% of patients receiving etrasimod 2 mg, 3 mg and placebo, respectively, by Week 24.</p><p><strong>Conclusions: </strong>Etrasimod did not meet the primary and secondary efficacy endpoints, but efficacy was numerically higher with etrasimod than with placebo. The etrasimod clinical programme for AA has been discontinued. Etrasimod was well tolerated, and its safety profile was consistent with other etrasimod studies to date.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov: NCT04556734.</p>","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143719914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A decade of gliptin-induced bullous pemphigoid.","authors":"Eirini Kavvalou, Maria Polina Konstantinou, Sabine Kruger-Krasagakis, Konstantinos Krasagakis","doi":"10.1111/jdv.20663","DOIUrl":"https://doi.org/10.1111/jdv.20663","url":null,"abstract":"","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Segmental corymbiform congenital melanocytic naevi: Implications for melanocytic embryology.","authors":"Nicole Knöpfel, Paul Kuentz, Angana Mitra, Olumide Ogunbiyi, Antoine Communie, Pierre Vabres, Andrew Muinonen-Martin, Neil J Sebire, Ludovic Martin, Satyamaanasa Polubothu, Veronica A Kinsler","doi":"10.1111/jdv.20661","DOIUrl":"https://doi.org/10.1111/jdv.20661","url":null,"abstract":"","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ambassadors in Dermatology and Venereology: An interview with Professor Fabio Ayala","authors":"Fabio Ayala","doi":"10.1111/jdv.20589","DOIUrl":"https://doi.org/10.1111/jdv.20589","url":null,"abstract":"&lt;p&gt;Year of birth: 1947&lt;/p&gt;&lt;p&gt;I was essentially born into the world of Dermatology, as both my grandfather and father were dermatologists. Growing up in Naples, I lived and breathed Dermatology from an early age. Our house was large and included the office where they ran their private practice, alongside their public work. My father, after serving as a university assistant, was the Head of the Dermatology Unit at Salerno Hospital for over 25 years. Perhaps for these reasons, my own son decided to follow in their footsteps and became a dermatologist 25 years ago.&lt;/p&gt;&lt;p&gt;I had two main teachers: Pietro Santoianni and my father, Libero.&lt;/p&gt;&lt;p&gt;In 1973, when the Second Medical School was founded in Naples, Prof. Pietro Santoianni was appointed Head of the Dermatology Clinic, and I was named his first Assistant. He was an excellent researcher, and he served as Director until 2004, when I succeeded him as Head of the Department. Pietro Santoianni was fascinated by the new dermatological equipment that began appearing on the market since the 1970s. Our Department acquired the first Italian liquid nitrogen cryotherapy apparatus and the first Helio-neon laser. Although excellent results on skin ulcers had been reported in the literature, we demonstrated the ineffectiveness of this kind of laser light. I presented these findings at a Gordon Research Conference in Chicago. I also recall that the first phototherapy equipment was purchased and used in our Department for both research and clinical applications starting in the 1970s.&lt;/p&gt;&lt;p&gt;As for my father, Libero, he was not only an exceptional teacher of dermatological practice but also an extraordinary life mentor. I began working in the Dermatology Unit in Salerno shortly before graduating, learning clinical and dermatological semiology at the patient's bedside. At that time in Italy, as in France, the importance of dermatological disease classification according to primary morphology prevailed, underlining the fundamental importance of basic lesions in achieving a correct diagnosis.&lt;/p&gt;&lt;p&gt;The society I hold most dear is the Italian Society of Allergological, Occupational and Environmental Dermatology (SIDAPA). I served as a board member from 1999 to 2004 and later as President from 2005 to 2008. In this area of Dermatology, I also represented Italy on the Council of the European Society of Contact Dermatitis (ESCD) from 1994 to 1998.&lt;/p&gt;&lt;p&gt;Another society close to my heart is the Italian Society of Dermatology Medical, Surgical, Aesthetic and Sexually Transmitted Diseases (SIDeMaST). I was a board member and secretary from 1993 to 1999, and later served as treasurer from 2007 to 2009 and again from 2012 to 2015. This society represents the historical evolution of the Società Italiana di Dermatologia e Sifilografia (SIDES), one of the oldest European dermatological societies, founded in 1885.&lt;/p&gt;&lt;p&gt;In addition, I have been a member of other societies, including the European Academy of Dermatology and Venereolo","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":"39 4","pages":"725-729"},"PeriodicalIF":8.4,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jdv.20589","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-world efficacy and safety of ritlecitinib in alopecia areata: A single-centre experience.","authors":"Youyu Sheng, Qin Wang, Ke Tao, Kai Yang, Yifei Zhu, Zheng Li, Chunya Ni, Jinran Lin, Wenyu Wu","doi":"10.1111/jdv.20664","DOIUrl":"https://doi.org/10.1111/jdv.20664","url":null,"abstract":"","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Illuminating nail disorders: A comprehensive overview of advanced imaging techniques","authors":"Pauline Lecerf,&nbsp;Bertrand Richert","doi":"10.1111/jdv.20535","DOIUrl":"https://doi.org/10.1111/jdv.20535","url":null,"abstract":"&lt;p&gt;The nail apparatus is a heterogenous structure where soft and hard keratinized tissues meet over a bony phalanx. The distance between each of these structures is very small often less than a millimetre. For the non-expert, choosing the right and most informative medical imaging is difficult. This often leads to inadequate and expensive imaging. The article by Sechi et al., ‘Advances in Image-Based Diagnosis of Nail Disorders’, provides a comprehensive review of all available imaging technologies to explore the nail apparatus, X-rays excluded.&lt;span&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/span&gt; Practical tips and tables are included to help select the appropriate imaging techniques for various nail disorders, fostering an evidence-based approach to diagnosis and treatment.&lt;/p&gt;&lt;p&gt;&lt;i&gt;Nail unit dermoscopy&lt;/i&gt; magnifies nail disorders not visible with the naked eye and explores superficial structures. Its limitations are depth penetration and interpretation variability. The authors remind us of a useful trick, the smartphone flashlight fingertip transillumination, especially helpful in identifying myxoid cysts and glomus tumours&lt;span&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/span&gt; (Figure 1).&lt;/p&gt;&lt;p&gt;&lt;i&gt;High-frequency ultrasound (HFUS)&lt;/i&gt; is a widely available, non-radiating, real-time imaging technique that allows deep tissue penetration, effective for examining structures from the nail plate to the bony cortex of the distal phalanx, diagnosing and assessing and monitoring inflammatory nail diseases. It details tumour's location, size, shape, echogenicity and vascularization. It does not need the removal acrylic or prosthetic nails. HFUS is limited in detecting lesions smaller than 0.1 mm but is largely operator-dependant.&lt;/p&gt;&lt;p&gt;Physicians should be aware that exploring the nail unit with &lt;i&gt;magnetic resonance imaging (MRI)&lt;/i&gt; has specific requirements: a dedicated coil for optimal spatial resolution is required. This device is not available in all centres. The use of other coils like wrist or knee coils are unable to provide correct images. MRI is particularly useful for detecting small or occult lesions, mostly liquid or vascular, and presurgical mapping. One of its best indications is recurrent glomus tumour, revealing a satellite lesion unnoticed during the surgery. A pilot study suggested that MRI could be proposed as preoperative imaging of squamous cell carcinoma for locoregional assessment and guide biopsy.&lt;span&gt;&lt;sup&gt;3&lt;/sup&gt;&lt;/span&gt; Recently, MRI images could be converted into 3D models for printing, which are valuable for creating customized nail prosthetics, educating healthcare professionals and assisting in surgical planning.&lt;span&gt;&lt;sup&gt;4&lt;/sup&gt;&lt;/span&gt;&lt;/p&gt;&lt;p&gt;&lt;i&gt;Optical coherence tomography (OCT)&lt;/i&gt; is a non-invasive imaging technique that provides high resolution of biological tissues in real-time. It is not widely available. OCT allows a penetration depth of 1–2 mm of both the nail plate and bed with a resolution of 3–15 μm. OCT helps in monitoring nail psoriasis and distinguishing between ","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":"39 4","pages":"709-710"},"PeriodicalIF":8.4,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jdv.20535","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-world experience of switching from tralokinumab to lebrikizumab in atopic dermatitis.","authors":"Teppei Hagino, Akihiko Uchiyama, Keiji Kosaka, Takeshi Araki, Hidehisa Saeki, Eita Fujimoto, Sei-Ichiro Motegi, Naoko Kanda","doi":"10.1111/jdv.20660","DOIUrl":"https://doi.org/10.1111/jdv.20660","url":null,"abstract":"","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}