Journal of the European Academy of Dermatology and Venereology最新文献

{"title":"On the importance of assessing stigma in dermatological research","authors":"Fanny C. Kpenou, Khaled Ezzedine","doi":"10.1111/jdv.20606","DOIUrl":"https://doi.org/10.1111/jdv.20606","url":null,"abstract":"<p>In this issue of the JEADV, an article by Butt et al.<span><sup>1</sup></span> studied the psychometric properties of the revised internalized skin bias questionnaire. As the scientific literature accumulates evidence on the mental burden of skin diseases and the influence of psychological stress on their development, it has prompted a need for dermatological research to increasingly—and inevitably—consider complex psychosocial factors in order to further understand the hidden impact of these visible diseases. Indeed, in addition to being the largest organ, the skin is also the most exposed, and as such, any change in its appearance is likely to be visible. Thus, unlike many other conditions, skin diseases are often immediately noticeable, thereby impacting interactions with others and the environment. This inherent key effect makes the concept of stigma particularly relevant to skin diseases. In a recently published study,<span><sup>2</sup></span> we and others have invested efforts in developing a specific instrument aimed at assessing stigmatization across a relatively wide range of skin diseases in France. Within this context, it is important to recognize the intricacy of stigma. As a result, no single instrument can fully capture all relevant aspects of stigma, making it more challenging to assess this complex psychological construct.<span><sup>3</sup></span> Furthermore, one should acknowledge that social circumstances and cultural differences pose an additional challenge to the dissemination of these types of instruments on a larger scale, among other barriers that researchers may face.</p><p>While integrating these critical processes in health studies is a difficult task, it naturally follows from the obligation to improve therapeutic strategies for (and with) patients according to a more holistic perspective. People with skin diseases were historically excluded from these efforts because common dermatoses were often neglected, but it is now well established that such disorders can lead to significant psychological and social impairments. The current conundrum highlights the necessity of adopting a more person-centred approach in therapeutic planning for skin diseases,<span><sup>4</sup></span> thus widening healthcare providers' perspectives to more than strictly medical interventions. The work of Butt et al. on internalized stigma, or self-stigma, is a needed step towards highlighting the importance of incorporating this critical yet underexplored dimension of stigmatization into everyday clinical practice. Although the authors have explored one of the many facets of stigmatization, there remains a need to explore other dimensions of this important concept, such as enacted stigma. These initiatives should be supported to continue delving into the complex relationships between psychosocial factors and skin diseases. This growing interest in integrating these layered psychological concepts into dermatological assessment will set a new g","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":"39 4","pages":"721-722"},"PeriodicalIF":8.4,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jdv.20606","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing biomarker-based prognostication in melanoma","authors":"Clio Dessinioti, Alexander J. Stratigos","doi":"10.1111/jdv.20591","DOIUrl":"https://doi.org/10.1111/jdv.20591","url":null,"abstract":"<p>Biomarker-driven risk stratification in cutaneous melanoma remains an area of intensive research, with the ultimate goal of refining prognostic accuracy and optimizing patient management. By identifying patients at higher risk for recurrence or melanoma-specific mortality, biomarkers have the potential to enhance patient counselling, tailor follow-up intensity and guide shared decision-making regarding adjuvant therapy.</p><p>In this issue, Dixon et al.<span><sup>1</sup></span> propose the BAUSSS algorithm (Breslow thickness, Age, Ulceration, Subtype, Sex and Site) as a novel tool to estimate 15-year melanoma-specific mortality percentage (MSMP) in patients with primary melanoma. Their approach integrates a nomogram-derived table including Breslow thickness, age and ulceration (from the Lifemath online tool) and a second table incorporating the independent relative risks of melanoma subtype, sex and anatomical site (extracted from the El Sharouni study). The final MSMP estimate is derived by multiplying the respective values from both tables. However, several methodological considerations warrant attention. The El Sharouni study, which serves as a key data source for BAUSSS, was conducted in 5644 patients from the Melanoma Institute Australia (MIA), all of whom underwent sentinel lymph node biopsy (SLNB). That study's prognostic model included multiple variables—Breslow thickness, age, ulceration, subtype, sex, site, mitotic rate and regression—and was derived from a relatively short median follow-up period (3.9 years). The El Sharouni study analyzed melanoma-specific survival (MSS) only in the MIA cohort, and thus external validation was not possible, limiting the model's generalizability.<span><sup>2</sup></span> Likewise, the development and validation of the new combined BAUSSS method to predict melanoma-specific mortality at 15 years was not described .<span><sup>1</sup></span></p><p>While prognostic models offer valuable insights, their clinical applicability should be interpreted with caution. External validation is crucial to ensure reproducibility across diverse patient populations, and model performance should be assessed using calibration plots and discrimination metrics (such as the concordance index or c-index). Current melanoma survival calculators vary in their predictions due to differences in included prognostic factors (e.g. categorical vs. continuous variables), statistical modelling approaches, patient cohorts used for model development. The AJCC online prediction tool, which was developed and validated for MSS for localized melanoma in US, Australian and European populations, focuses on thickness, ulceration, lesion site and age as key prognostic factors.<span><sup>3</sup></span> The EORTC nomogram, designed for recurrence and melanoma-specific mortality in SLNB-negative patients, incorporates Breslow thickness, ulceration and primary site. Notably, external validation showed that adding sex, age, melanoma subtype and mito","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":"39 4","pages":"719-720"},"PeriodicalIF":8.4,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jdv.20591","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severe adverse drug reactions induced by lamotrigine: Are prescription guidelines being followed?","authors":"Alice Thorn, Bénédicte Lebrun Vignes, Anne Welfringer-Morin, Juliette Lebret, Brigitte Milpied, Paola Sanchez-Pena, Claire Bernier, Florence Tetart, Marie Tauber, Emilie Sbidian, Saskia Ingen-Housz-Oro","doi":"10.1111/jdv.20662","DOIUrl":"https://doi.org/10.1111/jdv.20662","url":null,"abstract":"","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microsatellitosis of cutaneous melanomas in wide local excision specimens after excisional biopsy.","authors":"Pablo Vargas-Mora, Rubén González-Cuevas, Celia Requena, Esperanza Manrique-Silva, Víctor Traves, Eduardo Nagore","doi":"10.1111/jdv.20653","DOIUrl":"https://doi.org/10.1111/jdv.20653","url":null,"abstract":"","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early termination does not negatively impact the outcome of adjuvant immunotherapy in melanoma.","authors":"Dirk Tomsitz, Elisabeth Livingstone, Carmen Loquai, Martin Kaatz, Ulrike Leiter, Bastian Schilling, Patrick Terheyden, Jessica Hassel, Michael Sachse, Jens Ulrich, Edgar Dippel, Frank Meiss, Claudia Pföhler, Alexander Kreuter, Rudolf Herbst, Michael Weichenthal, Lisa Zimmer, Friedegund Meier, Ricarda Rauschenberg, Peter Mohr, Fiona Brunnert, Imke von Wasielewski, Ralf Gutzmer, Dirk Schadendorf, Carola Berking, Selma Ugurel, Lucie Heinzerling","doi":"10.1111/jdv.20650","DOIUrl":"https://doi.org/10.1111/jdv.20650","url":null,"abstract":"<p><strong>Background: </strong>Adjuvant treatment with anti-PD1 antibodies has been shown to effectively reduce the risk of recurrence in patients with resected metastatic melanoma. Whether a full 12-month duration of treatment is needed to achieve full clinical benefit is not known. This study investigated the survival outcome depending on the duration of adjuvant anti-PD1 therapy.</p><p><strong>Methods: </strong>From the prospective multicentre real-world skin cancer registry ADOREG data of 620 patients who finished adjuvant treatment with nivolumab or pembrolizumab for AJCCv8 stage III/IV resected melanoma was analyzed. Recurrence-free survival (RFS) and overall survival (OS) were compared between patients with regular treatment duration (52 ± 4 weeks; n = 229) and no disease recurrence during therapy (A₁) and patients with a premature end of treatment (<48 weeks; n = 214, B). Patients with disease recurrence during adjuvant treatment were included in cohort A₂.</p><p><strong>Results: </strong>The median duration of follow-up was 26.0 months [interquartile range (IQR) 18.0-34.0] in group A₁ [median treatment duration 51.3 weeks (IQR 50.0-52.1) and 19.0 months (IQR 13.0-29.0)] in group B [median treatment duration 22.2 weeks (IQR 10.0-34.8)]. Reasons for early discontinuation were treatment-related side effects in 45.3% (n = 97) and other reasons than toxicity in 54.7% (n = 117). The 2-year rate of RFS was 72.4% (95% CI, 68.5-76.3) for patients in group B and 51.5% (95% CI, 48.8-54.2) in patients with regular and intended regular treatment duration (A₁ plus A₂). When analysing the patients who did not relapse during adjuvant treatment (A₁), there was a significantly higher RFS rate of 84.1% (95% CI, 81.5-86.7). When only assessing patients with a recurrence after more than 12 months after initiation of therapy, there was a trend towards better RFS in patients with regular treatment duration.</p><p><strong>Conclusion: </strong>In patients with resected metastatic melanoma, shorter treatment duration with anti-PD1 antibodies is not associated with a worse outcome.</p>","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143676888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-life effectiveness and safety of baricitinib in adults with alopecia areata: A multicentre study.","authors":"A Mourtada, C Douarec, M Wargny, V Hebert, Z Reguiai, P Joly, J Seneschal, C Toussaint, H Aubert, M Le Moigne, C Bernier, T Passeron, C Jacobzone Leveque, P Reygagne, S Le Naour, C Berthin, C Bara, M Fouchard, R Janela-Lapert, M Masson Regnault, M B Duval, M Jachiet, M Fenot, H Adamski, M E Marniquet, S Barbarot","doi":"10.1111/jdv.20657","DOIUrl":"https://doi.org/10.1111/jdv.20657","url":null,"abstract":"","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143676856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pyemotes spp. dermatitis and comet sign.","authors":"Cesar Guijarro-Sanchez, Irene Rivera-Ruiz","doi":"10.1111/jdv.20648","DOIUrl":"https://doi.org/10.1111/jdv.20648","url":null,"abstract":"","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143670210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of liver fibrosis by transient elastography in Brazilian patients with psoriasis using methotrexate.","authors":"Mariana Dos Santos Pereira, Daniela Kampel Stolnicki, Luna Azulay-Abulafia, Renata de Mello Perez, Carlos Antônio Rodrigues Terra Filho, João Carlos Regazzi Avelleira","doi":"10.1111/jdv.20654","DOIUrl":"https://doi.org/10.1111/jdv.20654","url":null,"abstract":"","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Passive versus active educational interventions for nevus and melanoma classification: A randomized controlled study.","authors":"M Spadafora, R Pampena, K Peris, L Del Regno, L Cornacchia, M C Fargnoli, C Pellegrini, P Quaglino, S Ribero, P G Calzavara-Pinton, M C Arisi, M Mirra, M Raucci, A Fusco, S Kaleci, J Chester, G Pellacani, C Longo","doi":"10.1111/jdv.20649","DOIUrl":"https://doi.org/10.1111/jdv.20649","url":null,"abstract":"<p><strong>Backgrounds: </strong>Patients or family members first notice around 50% of primary melanoma lesions. Targeted educational campaigns for non-medical individuals improve melanoma detection rates, but the most effective initiatives are unclear.</p><p><strong>Objectives: </strong>To compare the efficacy of passive versus active intervention for non-medical individuals in classifying nevi and melanomas.</p><p><strong>Methods: </strong>A multicentric randomized controlled study randomly assigned subjects to receive active intervention (a dermatologist explaining basic rules for melanoma detection) or passive intervention (subject independently reading the basic rules). Subjects were asked to classify 60 clinical photos of nevi and melanomas as 'at risk' of malignancy and nominated the rule(s) they applied at 3 time points-before (T0), immediately following (T1), and 30 ± 2 days after (T2) the educational intervention.</p><p><strong>Results: </strong>We randomized 364 patients. We included in the analysis 336 subjects (female 61.3%, 156 in the passive and 180 in the active intervention group) with a mean age of 44.5 years. Overall, detection rates of lesions 'at risk' improved from 71.2% (T0) to 86.4% (T1). At T2, detection rates were significantly higher after active intervention (83.7% vs. 86.8%, p = 0.017). Although an overall improvement was described after both interventions, rates of correct responses according to lesion-specific features were significantly higher in the active intervention group for lesions that met ugly duckling (UD) rule criteria at T1 and both rules (ABCDE and UD rules) criteria at T2. Correct (full or partial) rule applications were observed in 80% at T1 (40.2% and 38.4%, respectively) and at T2 (40.4% and 37.8%, respectively), with significantly higher correct rule application in the active group at T1 (p = 0.001) and T2 (p = 0.03).</p><p><strong>Conclusions: </strong>Active educational intervention is more effective than passive education in improving nevi and melanomas classification and correct rule application in non-medical individuals, with stable performance observed over time.</p>","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the environmental sustainability of dermatology conferences.","authors":"P N Lim, T Griffiths, R Sheppeard, A Gan, A Wernham, S Tso","doi":"10.1111/jdv.20652","DOIUrl":"https://doi.org/10.1111/jdv.20652","url":null,"abstract":"","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143670194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}