Journal of the European Academy of Dermatology and Venereology最新文献

{"title":"Mycophenolate mofetil as a steroid-sparing agent in oral mucous membrane pemphigoid: A retrospective review.","authors":"Katie K Lovell, Matthew L Hrin, Joseph L Jorizzo, Lindsay C Strowd","doi":"10.1111/jdv.20362","DOIUrl":"https://doi.org/10.1111/jdv.20362","url":null,"abstract":"","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142349124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Time is the answer: Dupilumab effectiveness in prurigo nodularis patients","authors":"Sara Pruneddu","doi":"10.1111/jdv.20295","DOIUrl":"https://doi.org/10.1111/jdv.20295","url":null,"abstract":"<p>Prurigo nodularis (PN) is a highly impactful skin condition, frequently occurring in the context of older patients with comorbidities. In this setting, identifying effective, safe and long-lasting treatments has been a topic of active discussion amongst clinicians.<span><sup>1</sup></span> Very few licenced medications are currently available to alleviate patients' clinical manifestations and to improve symptoms of high impact such as itch and sleep disturbance.</p><p>This issue of the Journal contains a further valuable contribution to this discussion by Chiricozzi and colleagues, who present their real-world experience in Italy of the long-term response to dupilumab for this indication. The authors present a series of 64 patients, half of whom have been followed up for almost 2 years, whose life has been transformed by a beneficial long-term use of dupilumab for PN.<span><sup>2</sup></span></p><p>Prior to receiving this medication, most patients received a plethora of other systemic treatments, including phototherapy, systemic steroids (50 patients), ciclosporin (31 patients) and methotrexate (four patients), which had all been discontinued either because of inefficacy or side effects. While the authors do not mention on the length of treatment on the aforementioned immunosuppressants, it is reasonable to postulate that it would have been relatively short, since only methotrexate is commonly used beyond 52 weeks because of well-known side effects of oral steroids and ciclosporin.</p><p>Data on effectiveness and safety of dupilumab in PN is well-established and extensively described.<span><sup>3</sup></span> However, several reported aspects of real-world experience addressed in this letter provide new insights into the appropriate management of these patients.</p><p>In this cohort, patients without an atopic diathesis and normal IgE respond less quickly to the given medication, but went on to achieve a IGA CPNs 0–1 (Investigator global assessment [IGA]—CPN) at 52 weeks. Thus, when commencing dupilumab in the setting of PN patients with no atopic background, and a normal IgE at baseline, pre-treatment counselling should include informing the patient of the possibility of a slower response to treatment. This observation will also provide clinicians with the confidence to continue treatment to 52 weeks, even when initial response is less impressive than one typically sees in the context of eczema.</p><p>The other important finding is the demonstrated progressive and sustained downtrend of patient-reported outcomes, such as itch severity (NRS itch), sleep deprivation (NRS sleep) and quality of life (DLQI) scores, far beyond the 16 weeks required by NICE for continuation of the given medication. Again, this will allow clinicians to be optimistic with their patients about the likelihood of continuing improvement beyond 16 weeks.</p><p>Dupilumab has been demonstrated to have an excellent safety profile, with no known organ specific toxicity to live","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":"38 10","pages":"1848-1849"},"PeriodicalIF":8.4,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jdv.20295","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142320693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editor's Picks October 2024","authors":"","doi":"10.1111/jdv.20303","DOIUrl":"https://doi.org/10.1111/jdv.20303","url":null,"abstract":"<p></p><p>Carle Paul</p><p>In this review from the EADV and Body Art Task Force, Giulbudagian and colleagues provide a comprehensive and well-organized overview of the possible complications of tattooing including infections, granulomatous reactions and allergic inflammatory reactions (Figure 1).</p><p>Evidence behind tattoos remains complex yet under-researched. Moreover, product standardization and regulation are challenging as tattoo inks are industrial products with many impurities and contaminants, including insoluble particles. Toxicological studies, particularly regarding risks of carcinogenicity, organ exposure, allergy and photosensitivity, and standardization of tattoo ink production with health regulatory assessment are warranted at both the European and global levels to ensure consumer safety.</p><p>Giulbudagian M, Battisini B, Bäumler W, Blass Rico AM, Bocca B, Brungs C, et al. Lessons learned in a decade: medical-toxicological view of tattooing. <i>J Eur Acad Dermatol Venereol</i>. 2024;38:1926-1938. https://doi.org/10.1111/jdv.20072</p><p>Clinical diagnosis of nail unit lesions remains a challenge for most of us. In this systematic review, Slawinska et al. present 19 studies including over 200 patients, summarizing the clinical utility of intraoperative dermoscopy of the nail unit after nail plate avulsion. They suggest that this technique may help to better define the most appropriate surgical diagnostic procedure and may improve our diagnostic capabilities. Further prospective studies are needed to confirm these preliminary findings and to demonstrate the truth lying behind the nail plate (Figure 2).</p><p>Sławińska M, Żółkiewicz J, Ribereau-Gayon E, Maińska U, Sobjanek M, Thomas L. Intra-operative dermoscopy (onychoscopy) of the nail unit- a systematic review. <i>J Eur Acad Dermatol Venereol</i>. 2024;38:1988-1996. https://doi.org/10.1111/jdv.20078</p><p>In this population-based cohort study, Buja et al. provide insight into the epidemiology of melanoma in adolescent and young adults, describing the steady increase in melanoma incidence from 1990 to 2019 (Figure 3). They also show gender differences, with males having less advanced lesions and the trunk as the primary site, while women are affected on the lower limbs as the most common primary site.</p><p>Such important elements could influence specific prevention campaigns for this population and may influence the fashion industry to cover sites most at risk with UV-protective clothes.</p><p>Buja A, Rugge M, Trevisiol C, Zanovello A, Brazzale AR, Zorzi M, et al. Cutaneous melanoma in adolescents and young adults. <i>J Eur Acad Dermatol Venereol</i>. 2024;38:1997-2004. https://doi.org/10.1111/jdv.20077</p><p>Diagnosing cutaneous T-cell lymphoma in adults may be challenging for dermatologists. Kook et al. reviewed records of 46 patients who were non-responders to dupilumab. Among those re-evaluated, slightly over half (54%) were diagnosed with cutaneous T-cell lymphoma (CTCL) (Fi","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":"38 10","pages":"1837-1839"},"PeriodicalIF":8.4,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jdv.20303","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142320755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combining an anti-IL-4Rα biologic with a JAK1 inhibitor leads to a higher treatment response in resistant atopic dermatitis versus monotherapy alone: A case series.","authors":"A Ferreirinha, P Simões Farinha, T Pessoa E Costa, B Duarte","doi":"10.1111/jdv.20359","DOIUrl":"https://doi.org/10.1111/jdv.20359","url":null,"abstract":"","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142349121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The complex relationship between maternal smoking and atopic dermatitis in children","authors":"Christian Vestergaard","doi":"10.1111/jdv.20260","DOIUrl":"https://doi.org/10.1111/jdv.20260","url":null,"abstract":"<p>In this issue of the JEADV, L. Chao et al. perform a meta-analysis of studies examining the effect of smoking during pregnancy on the risk of atopic dermatitis in offspring.<span>¹</span> While it is well-established that smoking during pregnancy adversely affects foetal development, particularly in terms of birth weight and overall growth, the impact on atopic dermatitis remains less understood. A recent study from Japan found that maternal smoking during pregnancy increases the risk of asthma in offspring, even after adjusting for pre- and postnatal covariates.<span>²</span></p><p>Using PRISMA criteria, the authors identified 15 studies and found that active smoking does not increase the risk of atopic dermatitis, whereas passive smoking does.<span>¹</span> This finding is consistent with a 2016 study that also found no increased risk associated with active smoking during pregnancy.<span>³</span> The distinction between the effects of active and passive smoking is intriguing, as one might expect a dose-dependent response to tobacco smoke, with stronger associations for active smoking.</p><p>It is well-known that active tobacco smoking affects the immune system<span>⁴</span> and has direct effects on the skin barrier and epidermal keratinocytes.<span>⁵</span> However, the exact impact of these changes, particularly in the context of passive smoking, is still unclear and warrants further research.</p><p>Interestingly, L. Chao et al. note a trend suggesting that maternal smoking may have a protective effect against atopic dermatitis. This could be due to confounding factors, such as a lower genetic predisposition to atopic diseases in children of mothers who smoke. Additionally, there may be biases, such as non-smoking mothers being more sensitive to passive smoke exposure and over-reporting atopic dermatitis symptoms in their children.<span>¹</span></p><p>The study by L. Chao et al. consolidates the current epidemiological evidence and discusses it in light of our understanding of the pathogenesis of atopic dermatitis and the biological effects of tobacco smoke. While there is substantial evidence of the harmful effects of smoking on foetal development, the results of this study raise important questions about how maternal immune responses and skin barrier functions influence the risks to the foetus. Further research is needed to clarify these complex interactions.</p><p>No conflicts of interest for this study.</p>","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":"38 10","pages":"1840-1841"},"PeriodicalIF":8.4,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jdv.20260","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142320756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contributions of dermoscopy in daily practice nailfold capillaroscopy","authors":"Y. Mostmans,&nbsp;B. Richert","doi":"10.1111/jdv.20297","DOIUrl":"https://doi.org/10.1111/jdv.20297","url":null,"abstract":"<p>We read with great interest the article by Monfort et al.<span>¹</span> demonstrating the value of nailfold dermoscopy to predict the absence of a scleroderma pattern on nailfold videocapillaroscopy (NVC) in the work-up for Raynaud's phenomenon (RP).</p><p>This study is valuable for the multidisciplinary microcirculatory community on different levels. Firstly, it suggests an easy-to-use screening tool for different specialists to exclude secondary RP, based on four <i>‘simple’</i> dermoscopy criteria. Dermoscopy has been shown in previous studies to be a suitable device for performing nailfold capillaroscopy. It has a reasonable cost and is easier to use than other devices such as a photomacrography system, stereomicroscope, digital USB microscope, ophthalmoscope or NVC. Secondly, commercially available image analysis software is currently limited to video capillaroscopes, allowing a standardized approach to analyse capillaroscopic characteristics and use in a research setting. This study emphasizes the advantages of dermoscopy and the difference we, as dermatologists accustomed to using and interpreting dermoscopy images, can make economically. These results underline the need for a more practical point of view in differentiating primary from secondary RP. The evolving landscape of artificial intelligence (AI) applications in dermatological diagnostics will certainly expand the future use of dermoscopy in the daily clinical work-up of RP.</p><p>Thirdly, this study also exposes several gaps in knowledge and controversies regarding the position of dermatoscopy in diagnosing connective tissue diseases. Because of its good validity and inter- and intra-observer reliability, it is suggested to be a useful tool for identifying capillary abnormalities suggestive of a scleroderma-spectrum disorder, comparable to NVC.<span>²</span> It is even proposed as part of the rheumatology fellow curriculum.<span>³</span> Nevertheless, Monfort et al. clearly show in their study that dermoscopy has still poor specificity to detect capillary abnormalities.</p><p>In conclusion, this study shows that normal nailfold dermoscopy can predict normal NVC if four easy-to-observe criteria are absent, but also displays poor specificity for dermoscopy to detect capillary abnormalities, in contrast to previous literature. Differences in definitions between studies can explain different outcomes. AI could be a solution for a more accurate dermoscopy analysis in RP work-up in the future.</p><p>Yora Mostmans and Bertrand Richert declares no conflict of interest in relation to this work.</p>","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":"38 10","pages":"1842-1843"},"PeriodicalIF":8.4,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jdv.20297","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142320697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Why and how to choose patient-reported outcome measures in dermatology?","authors":"Emilie Brenaut","doi":"10.1111/jdv.20261","DOIUrl":"https://doi.org/10.1111/jdv.20261","url":null,"abstract":"&lt;p&gt;I read with great interest the article by Pereira et al.&lt;span&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/span&gt; on the acceptability from the patients' perspective and perceived benefits from physicians' perspective of the patient-reported outcome measures (PROMs) to assess pruritus. As the number of PROMs has increased in recent years, this question is of great interest. The authors showed that PROMs are welcomed by patients, with high levels of acceptability and relevance, which is important for the relational and ethical aspects. For physicians, the usefulness and feasibility depended on the questionnaire. Measuring pruritus with the numerical rating scale (NRS) and the impairment of quality of life with the Dermatology Life Quality Index (DLQI) were considered the most beneficial in clinical routine.&lt;/p&gt;&lt;p&gt;PROMs are tools used to capture patients' reports of their experiences. It is still debated whether they should be used in everyday life and become an indispensable tool in the future, or whether their use should be reserved for clinical research, where their interest seems obvious and their use essential.&lt;/p&gt;&lt;p&gt;A systematic review identified many benefits for PROMs: promoting active patient involvement, improving the focus of consultations, improving the quality of care, enabling standardized monitoring of patient outcomes and improving the patient-clinician relationship.&lt;span&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/span&gt; Perceived limitations included the ability of PROMs to shift the focus of consultations, create unrealistic expectations of care, inhibit patient-clinician interaction, lack clinically meaningful information and not be suitable for all patients. The main disadvantage in daily practice is the time required to complete various questionnaires, but different tools can help clinicians, such as the use of mobile phones, tablets or computers, with possible completion before the consultation.&lt;/p&gt;&lt;p&gt;Pereira's study&lt;span&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/span&gt; evaluated five PROMs, related to pruritus intensity (NRS), symptom control (Itch-Controlled Days, ItchCD), quality of life (DLQI; 5-Pruritus Life Quality, 5PLQ) and general health status (EuroQol, EQ-VAS). There are a large number of PROMs available today, which can be divided into different categories: (1) generic, that is an instrument that can be used across therapeutic areas, such as the EQ-VAS, (2) dermatology-specific, that is an instrument that is specific to dermatology and can be used across skin conditions, such as the DLQI and (3) disease-specific, that is an instrument that can only be used for a particular skin condition such as the Prurigo Control Test (PCT).&lt;span&gt;&lt;sup&gt;3&lt;/sup&gt;&lt;/span&gt; First, clinicians need to select the most appropriate PROM, for their clinical practice or a clinical trial, and for the disease. Second, they have to consider the measurement properties (such as reliability, validity and responsiveness) and keep in mind that there is no ideal dermatology-specific PROM.&lt;span&gt;&lt;sup&gt;3, 4&lt;/sup&gt;&lt;/span&gt; The PROM should be vali","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":"38 10","pages":"1846-1847"},"PeriodicalIF":8.4,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jdv.20261","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142320699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The odyssey of diagnosis of mycosis fungoides: Sailing beyond clonality and histology","authors":"Oleg E. Akilov","doi":"10.1111/jdv.20263","DOIUrl":"https://doi.org/10.1111/jdv.20263","url":null,"abstract":"&lt;p&gt;The study by Kook et al.&lt;span&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/span&gt; addresses the complexities of revisiting the diagnosis of severe atopic dermatitis (AD) in patients who exhibit an insufficient response to dupilumab. This reconsideration is prompted by the necessity to rule out mycosis fungoides (MF). Kook et al. employed comprehensive MF diagnostic criteria, confirming the diagnosis in 19 out of 35 patients. They reported epidermotropic lymphocytes in all patients and atypical lymphocytes in 17 patients. TCR clonality was confirmed in all patients, with 8 showing clonality in multiple biopsies. Immunohistochemical analysis revealed an increased CD4/CD8 ratio and loss of CD7 in all patients.&lt;/p&gt;&lt;p&gt;While approach to diagnosis of MF by Kook et al. is per current standards, it should be noted that clonal T-cell populations and loss of CD7 can also be present in AD, highlighting the diagnostic challenges in these cases. Indeed, studies have shown that TCR clonality is not uncommon in AD, as both lesional and nonlesional AD skin can share identical T-cell clones, complicating the differentiation from MF.&lt;span&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/span&gt; Additionally, the loss of CD7 expression has been observed in atopic dermatitis, further blurring the lines between benign and malignant conditions.&lt;span&gt;&lt;sup&gt;3&lt;/sup&gt;&lt;/span&gt; This traditional approach highlights the limitations of current diagnostic modalities in differentiating between severe AD and MF.&lt;/p&gt;&lt;p&gt;We encountered a similar diagnostic challenge in our study of CD8&lt;sup&gt;+&lt;/sup&gt; hypopigmented MF.&lt;span&gt;&lt;sup&gt;4&lt;/sup&gt;&lt;/span&gt; Traditional methods, such as histology and TCR clonality assessments, were insufficient to conclusively identify malignant cells. To overcome this, we developed an alternative approach utilizing single-cell RNA sequencing (scRNA-seq) to create a malignant transcriptome panel. This advanced technique allowed us to precisely distinguish malignant cells from reactive clonal populations, providing a clearer understanding of the disease pathology and guiding more accurate therapeutic interventions.&lt;span&gt;&lt;sup&gt;4&lt;/sup&gt;&lt;/span&gt;&lt;/p&gt;&lt;p&gt;Incorporating a transcriptomic panel, particularly one tailored to distinguishing between reactive and malignant T-cell populations, could address the diagnostic challenges rise in difficult diagnostic cases similar to what was presented by Kook et al.&lt;span&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/span&gt; Our findings with HMF indicate that a small population of malignant cells was obscured by a larger population of clonal reactive cells. Similarly, in AD, a clonal population of CD4&lt;sup&gt;+&lt;/sup&gt; T cells may not be obligatorily malignant. By employing scRNA-seq, distinct transcriptomic signatures can accurately differentiate malignant from reactive clonal T cells, suggesting a path forward for refining the diagnostic approach in MF.&lt;/p&gt;&lt;p&gt;Furthermore, it is notable that treatments utilized for MF, such as methotrexate, retinoids and narrow-band ultraviolet B (NBUVB), have also shown effectiveness in patients with AD, indicatin","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":"38 10","pages":"1844-1845"},"PeriodicalIF":8.4,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jdv.20263","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142320698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health-related quality of life in cutaneous T-cell lymphoma: A post hoc analysis of a phase 3 trial in mycosis fungoides and Sézary syndrome.","authors":"P L Ortiz Romero, Y H Kim, K Molloy, P Quaglino, J Scarisbrick, S Thornton, K Sandilands, J E Dent, A Nixon, A Williams, M M Shinohara","doi":"10.1111/jdv.20357","DOIUrl":"10.1111/jdv.20357","url":null,"abstract":"<p><strong>Background: </strong>Mycosis fungoides (MF) and Sézary syndrome (SS) are common subtypes of cutaneous T-cell lymphoma that primarily affect the skin but may spread to the lymph nodes, viscera and blood. The symptom burden may compromise health-related quality of life (HRQL). The phase 3 MAVORIC study (ClinicalTrials.gov identifier NCT01728805) in patients with relapsed/refractory MF/SS reported improved HRQL with mogamulizumab compared with vorinostat.</p><p><strong>Objectives: </strong>Use baseline (pre-treatment) data from the MAVORIC study to describe the symptom burden of MF/SS and identify characteristics associated with worse HRQL.</p><p><strong>Methods: </strong>Data were from 372 adults with stage IB-IVB histologically confirmed relapsed/ refractory MF or SS. Associations between demographic and medical history variables and worse HRQL (Skindex-29, ItchyQol and Functional Assessment of Cancer Therapy - General [FACT-G]) were determined by regression models.</p><p><strong>Results: </strong>In the cohort of 372 adults, 70% were white; 42% were female; mean age was 63 (SD 13.0) years. Fifty-five per cent had MF and 45% had SS; 77% had advanced (stage IIB-IV) disease, involving the skin in all patients and the blood and/or nodes in 66%. HRQL scores showed impairment versus normative means (where available), with the greatest impact on Symptoms and Emotions in the Skindex-29, Functioning in the ItchyQol, and Functional Wellbeing in the FACT-G. In regression analysis, worse HRQL across all domains and total score was associated with being female and younger, worse mSWAT score and worse itch for the Skindex-29 (n = 352), and being female, younger, Black/African American, worse performance status and worse itch for the ItchyQol (n = 369). Associations across domains and total score were not found for the FACT-G. Associations between domains and demographic/medical history were seen for all instruments.</p><p><strong>Conclusions: </strong>The symptoms of advanced MF/SS compromise all HRQL domains. Treatment goals and therapeutic choice should be informed by individual patients' disease burden.</p>","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142308025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on 'Efficacy of interventions for cutaneous squamous cell carcinoma in situ (Bowen's disease): A systematic review and meta-analysis of proportions'.","authors":"G Gaitanis, I D Bassukas","doi":"10.1111/jdv.20360","DOIUrl":"https://doi.org/10.1111/jdv.20360","url":null,"abstract":"","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142289987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}