Journal of the European Academy of Dermatology and Venereology最新文献

{"title":"2024 European guidelines for the management of genital herpes.","authors":"Rajul Patel, Benjamin Moran, Emily Clarke, Anna Maria Geretti, Stephan Lautenschlager, John Green, Gilbert Donders, Mikhail Gomberg, Shyam Samraj, George Sorin Tiplica, Elizabeth Foley","doi":"10.1111/jdv.20450","DOIUrl":"https://doi.org/10.1111/jdv.20450","url":null,"abstract":"<p><p>Genital herpes is one of the most common sexually transmitted infections worldwide. Using the best available evidence, this guideline recommends strategies for diagnosis, management and follow-up of the condition as well as for minimizing transmission. Early recognition and initiation of therapy is key and may reduce the duration of illness or avoid hospitalization with complications, including urinary retention, meningism or severe systemic illness. The guideline covers a range of common clinical scenarios, such as recurrent genital herpes, infection during pregnancy and coinfection with human immunodeficiency virus.</p>","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142770242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of inflammatory skin biomarkers with clinical response in RGRN-305-treated patients with hidradenitis suppurativa.","authors":"Hakim Ben Abdallah, Anne Bregnhøj, Thomas Emmanuel, Trine Bertelsen, Koen Dudink, Kelsey R van Straalen, Matylda Kubacz, Gautam Ghatnekar, Errol P Prens, Lars Iversen, Claus Johansen","doi":"10.1111/jdv.20468","DOIUrl":"https://doi.org/10.1111/jdv.20468","url":null,"abstract":"","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142770243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The integration of dermatology experts into primary care to assess and treat patients with skin lesions is cost-effective: A quasi-experimental study.","authors":"Maria Lovén, Laura Huilaja, Markus Paananen, Paulus Torkki","doi":"10.1111/jdv.20451","DOIUrl":"https://doi.org/10.1111/jdv.20451","url":null,"abstract":"<p><strong>Background: </strong>The management of patients with skin changes can be challenging in primary healthcare; general practitioners (GPs) often lack the expertise to make accurate assessments and treatment decisions. The standard care pathway for skin changes can result in extended treatment times and costs.</p><p><strong>Objectives: </strong>This study was designed to evaluate the cost-effectiveness of integrating a dermatologist into the primary care setting to assess and treat patients with skin disorders. The primary outcome was the incremental cost-effectiveness ratio (ICER) for each malignant or pre-malignant skin disease found and treated. The secondary outcomes included ICER for any treated skin finding, number needed to excise to find malignant or pre-malignant skin disease, number of hospital referrals required and changes in quality of life (QoL) in the presence and absence of the integration.</p><p><strong>Methods: </strong>This was a quasi-experimental cohort study conducted at three primary healthcare centres in Finland. In the two intervention centres, patients with skin findings visited a dermatologist; in the control centre they visited a GP. Cost-effectiveness was assessed using the incremental cost-effectiveness ratio (ICER). QoL was assessed with the PROMIS v1.2, calculative EQ-5D-3L and PROMIS Anxiety 4a instruments.</p><p><strong>Results: </strong>In total, 186 integration and 176 control patients were included. For an additional patient treated for a (pre-)malignant skin disease, the ICER was €852 lower and with any skin disease €381 lower in the integration group than with standard care. Fewer biopsies were required for each malignant or pre-malignant skin disease in the integration group compared to the control group (2.1 and 6.5 per patient; p < 0.001) and lower proportion of patients were referred to hospital (8.1 vs. 17.1%, p < 0.001). Patient QoL did not differ between groups.</p><p><strong>Conclusions: </strong>The integration of dermatological expertise into primary care settings is cost-effective and can streamline the management of patients with skin conditions without worsening their QoL.</p>","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142769896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Line-field confocal optical coherence tomography of basal cell carcinoma: A retrospective study on diagnostic performance.","authors":"Lyna Mtimet, Lucas Boussingault, Dina Aktas, Margot Fontaine, Carmen Orte Cano, Gwendoline Diet, Clement Lenoir, Makiko Miyamoto, Elisa Cinotti, Linda Tognetti, Alessandra Cartocci, Pietro Rubegni, Susana Puig, Josep Malvehy, Javiera Perez-Anker, Jean-Luc Perrot, Véronique Del Marmol, Mariano Suppa","doi":"10.1111/jdv.20459","DOIUrl":"https://doi.org/10.1111/jdv.20459","url":null,"abstract":"<p><strong>Introduction: </strong>Line-field confocal optical coherence tomography (LC-OCT) represents one of the newest non-invasive in vivo skin imaging techniques. Previous studies described morphologic criteria of basal cell carcinoma (BCC) under LC-OCT examination. Preliminary data on LC-OCT diagnostic performance for BCC have recently been published but showed only a modest improvement compared to dermoscopy, possibly due to study limitations.</p><p><strong>Objectives: </strong>The main objective of this study was to find diagnostic performance parameters of LC-OCT for differentiating BCC from its clinical/dermoscopic mimickers and for discriminating among BCC subtypes. An additional objective was to suggest a simple, user-friendly diagnostic algorithm based on the most powerful LC-OCT features in the field of BCC and its imitators.</p><p><strong>Materials and methods: </strong>Equivocal BCC lesions imaged with an LC-OCT device prior to biopsy/excision were included. Three observers blinded for histopathological diagnosis retrospectively formulated clinical, dermoscopic and LC-OCT diagnoses and evaluated LC-OCT features for each study lesion.</p><p><strong>Results: </strong>A total of 303 lesions (173 BCCs and 130 non-BCCs) from 225 patients were included. For the differentiation of BCC from BCC imitators, the use of LC-OCT increased the diagnostic accuracy compared to clinical examination by 24% and compared to dermoscopy by 12%. For the discrimination of sBCC from other BCC subtypes, LC-OCT increased the diagnostic accuracy compared to clinical examination by 18% and compared to dermoscopy by 12%. The presence of lobule with millefeuille pattern was a significant feature for BCC diagnosis. Lobule shape and location allowed BCC subtype discrimination.</p><p><strong>Conclusions: </strong>The accuracy of BCC diagnosis can be increased by at least 12% with the use of LC-OCT compared to clinical and dermoscopic examinations alone, both in terms of BCC differentiation from clinical/dermoscopic imitators and in terms of BCC-subtype discrimination. A diagnostic algorithm based on significant features for BCC diagnosis is proposed, for which further validation is required.</p>","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142770246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to 'A literature review and expert consensus statement on diagnostics in suspected metal implant allergy'.","authors":"","doi":"10.1111/jdv.20466","DOIUrl":"https://doi.org/10.1111/jdv.20466","url":null,"abstract":"","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142751290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AI versus dermatologist performance in psoriasis body surface area assessment: A ground truth-validated, anatomical segment-based comparative study (AI PASS).","authors":"Maksym Breslavets, Tetyana Svyatenko, Denys Breslavets, Nataliia Hrechkina, Tatiana Lapa, Ganna Borodina, Alina Breslavets","doi":"10.1111/jdv.20456","DOIUrl":"https://doi.org/10.1111/jdv.20456","url":null,"abstract":"","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142739811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative analysis of temperature-controlled cryotherapy versus intralesional triamcinolone acetonide injection for alopecia areata: An intrasubject split-lesion pilot study.","authors":"Hanjae Lee, Ji Won Lee, Sooyun Park, Hyunsun Park, Gun-Ho Kim, Ohsang Kwon","doi":"10.1111/jdv.20464","DOIUrl":"https://doi.org/10.1111/jdv.20464","url":null,"abstract":"","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142739829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Darier disease: Current insights and challenges in pathogenesis and management.","authors":"Monika Ettinger, Susanne Kimeswenger, Isabella Deli, Judith Traxler, Sabine Altrichter, Petar Noack, Jakob D Wikstrom, Emmanuella Guenova, Wolfram Hoetzenecker","doi":"10.1111/jdv.20448","DOIUrl":"https://doi.org/10.1111/jdv.20448","url":null,"abstract":"<p><p>Darier disease is a rare autosomal dominant genodermatosis caused by mutations in the ATP2A2 gene encoding for sarcoendoplasmic reticulum Ca²⁺ ATPase isoform 2. The skin disease is characterized by a chronic relapsing course with recurrent reddish-brown keratotic papules and plaques located mainly in seborrhoeic areas. Due to chronic inflammation and epidermal barrier defects of the skin, patients often develop severe bacterial and viral superinfections. Therapeutic options are limited, mainly symptomatic and in most cases unsatisfactory in the long term. Patients are advised to avoid aggravating factors such as high temperature, high humidity, UV radiation and mechanical irritation. To prevent superinfection, antiseptics and periodic use of topical corticosteroids are fundamental in treatment. In case of bacterial and viral superinfection, systemic anti-infective therapy is often necessary. Currently, the most effective treatment option for extensive and persistent skin lesions is systemic retinoids, which are thought to mainly target the epidermal compartment (e.g. by reducing hyperkeratosis). One hallmark of Darier disease patients is chronic skin inflammation. We and others have previously reported Th17 cells in the dermal infiltrate of inflamed Darier disease skin. Counteracting inflammation by blocking the IL-23/IL-17 axis improved skin manifestations in a small cohort of previously therapy-resistant patients over 1 year. Furthermore, several other topical treatment options for mild disease as well as various ablative therapies and surgical excision have been proposed to be effective in some patients with hypertrophic skin lesions. This article aims to outline the pathogenesis, clinical features, diagnosis/differential diagnosis and available treatment modalities of Darier disease.</p>","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142739831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Topographical variations in the skin barrier and their role in disease pathogenesis.","authors":"Z Dajnoki, A Kapitány, K Eyerich, S Eyerich, D Törőcsik, A Szegedi","doi":"10.1111/jdv.20463","DOIUrl":"https://doi.org/10.1111/jdv.20463","url":null,"abstract":"<p><p>The skin barrier can be divided into at least four functional units: chemical, microbial, physical and immunological barriers. The chemical and microbial barriers have previously been shown to exhibit different characteristics in topographically distinct skin regions. There is increasing evidence that the physical and immunological barriers also show marked variability in different areas of the skin. Here, we review recent data on the topographical variations of skin barrier components, the contribution of these variations to the homeostatic function of the skin and their impact on the pathogenesis of specific immune-mediated skin diseases (such as atopic dermatitis and papulopustular rosacea). Recognition of these topographical barrier differences will improve our understanding of skin homeostasis and disease pathogenesis and provide a basis for body site-specific targeted therapies.</p>","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142739834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Objective actinic keratosis assessment by standardized clinical photography tool.","authors":"Sebastian Sitaru, Christine Gasteiger, Christian Posch","doi":"10.1111/jdv.20455","DOIUrl":"https://doi.org/10.1111/jdv.20455","url":null,"abstract":"","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142729419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}