Journal of the European Academy of Dermatology and Venereology最新文献

{"title":"Ethnic disparities in the treatment of port-wine stains in patients with Sturge-Weber syndrome.","authors":"Sabrina Duran, Iraj Hasan, Lauren Parsons, Wei Fang, Zachary Zinn","doi":"10.1111/jdv.20645","DOIUrl":"https://doi.org/10.1111/jdv.20645","url":null,"abstract":"","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143649415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Completed suicide in patients with skin disease: A systematic review and meta-analysis.","authors":"B Hrvatin Stancic, M A S Henning, N Eriksen, J Emilie Dornonville de la Cour, D M L Saunte, G B E Jemec","doi":"10.1111/jdv.20609","DOIUrl":"https://doi.org/10.1111/jdv.20609","url":null,"abstract":"<p><strong>Background: </strong>Several skin diseases have been associated with suicidality. However, the term 'suicidality' encompasses ideation, which weakens the conclusions. In contrast, the much stronger endpoint of completed suicide and skin disease remains ambiguous.</p><p><strong>Objective: </strong>To determine the risk of completed suicide in adult patients with skin diseases.</p><p><strong>Methods: </strong>The Pubmed, Embase and PsycINFO databases were performed from inception up to June 2023. All original studies in English with a minimum of 10 adult patients that assessed the relationship between a skin disease and death by suicide, were eligible for inclusion.</p><p><strong>Results: </strong>Thirty-seven met the inclusion criteria. Owing to expected interstudy variations, a random effects model was used. A total of 13 skin diseases were identified: 17 population-based high-quality studies, 3,800,748 patients with skin disease, and 33,722,675+ controls were included in the meta-analysis (MA). Each skin disease was analysed separately. Psoriasis: six studies were included in the MA (odds ratio (OR): 1.42, 95% confidence interval (CI) (0.76; 2.68) and found no association. Dermatitis: five studies were included in the MA OR: 1.54, 95% CI (0.57; 4.17) and found no association. Melanoma: four studies were included in the MA, which found an association between melanoma and suicide Standardized mortality rate (SMR): 2.89, 95% CI (1.97; 3.81). Non-melanoma skin cancer: two studies were included in the MA; female patients showed an increased risk of completed suicide compared to the control group SMR: 1.30, 95% CI (1.12; 1.49). In patients with hidradenitis suppurativa, two studies were included in the MA OR: 2.86, 95% CI (1.56; 5.24) and showed a positive association between HS and completed suicide.</p><p><strong>Conclusions: </strong>Suicidality should be considered by physicians when treating dermatological disease, especially when treating patients with hidradenitis suppurativa and melanoma. The association between other skin diseases and completed suicide remains unclear, and further research is indicated.</p>","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143649412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carbon footprint analyses: A valuable tool for dermatology journals to pioneer sustainable practices.","authors":"Eugene Tan, Dennis Niebel, Misha Rosenbach","doi":"10.1111/jdv.20644","DOIUrl":"https://doi.org/10.1111/jdv.20644","url":null,"abstract":"","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic review of checkpoint inhibitor-induced epidermal necrolysis.","authors":"Rebecca Creamer, Freya Hamar-Davies, Mark Harries, Daniel Creamer","doi":"10.1111/jdv.20621","DOIUrl":"https://doi.org/10.1111/jdv.20621","url":null,"abstract":"","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Haematopoietic stem cell transplant in cutaneous T-cell lymphomas: A multicentre propensity-score matched study.","authors":"Lía Bejarano, Mercè Grau-Pérez, Marina Paíno-Román, María Pilar García Muret, Mercedes Morillo, Cristina Muniesa, Juan Torre-Castro, M Teresa Estrach, Elena Amutio Díez, Rosa Mª Lzu Belloso, Yeray Peñate, Constanza Martínez-Mera, Rafael Botella-Estrada, Miren Josune Michelena Eceiza, Pablo L Ortiz Romero, Mar Blanes, Ricardo Fernández-de-Misa, Lucía Prieto-Torres, María Elisabet Parera Amer, Helena Iznardo, Carlos Moreno-Vílchez, Octavio Servitje, Ignacio García-Doval, Javier Cañueto","doi":"10.1111/jdv.20638","DOIUrl":"https://doi.org/10.1111/jdv.20638","url":null,"abstract":"<p><strong>Background: </strong>Advanced cutaneous T-cell lymphomas (CTCL) are rare, generally refractory to therapeutic options, and have a poor prognosis. Haematopoietic stem cell transplantation (HSCT), mainly allogeneic HSCT (allo-HSCT), is considered a potentially curative option in CTCL refractory to other therapies. However, around half of patients relapse, and allo-HSCT is associated with significant adverse events. The available evidence on the usefulness of HSCT in CTCL generally comes from isolated cases and case series with a limited number of patients.</p><p><strong>Objective: </strong>Our aim was to evaluate the outcome of patients undergoing HSCT for advanced primary CTCL in Spain in a real-world environment and to compare their survival with that of similar patients who did not receive HSCT.</p><p><strong>Methods: </strong>We performed a retrospective observational study nested within the Primary Cutaneous Lymphoma Registry (RELCP) of the Spanish Academy of Dermatology and Venereology, collecting data on all patients receiving HSCT. Then, we performed propensity score matching (PSM) to pair HSCT patients with non-HSCT patients, adjusting for diagnosis, highest disease stage and age at diagnosis. We then performed survival analysis by means of Cox regression.</p><p><strong>Results: </strong>Of 2848 patients included in the RELCP, 51 patients underwent HSCT. Thirty-six patients (70.6%) achieved a complete response and seven patients (13.7%) partial response. Relapse was developed by 56.9% of patients, and 39.2% died (19.6% due to disease progression and 15.7% due to HSCT complications, mainly graft-versus-host disease (GVHD) and sepsis). Overall survival (OS) after HSCT at 5 years was 58.9%. No differences in OS were found between HSCT and non-HSCT groups.</p><p><strong>Conclusions: </strong>We did not observe a survival benefit among HSCT patients compared to non-HSCT patients within the RELCP cohort. This could be due to patients having received a mean of 6.3 lines of treatment before HSCT. Larger studies might help identify subgroups of patients who might benefit from HSCT.</p>","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143597103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cumulative life course impairment: Evidence for hidradenitis suppurativa.","authors":"Maneli Doroudian Tehrani, Ruby S Gibson, Corey L Snyder, Martina L Porter, Alexa B Kimball","doi":"10.1111/jdv.20607","DOIUrl":"https://doi.org/10.1111/jdv.20607","url":null,"abstract":"<p><p>Hidradenitis suppurativa (HS) adversely affects quality of life, education, work, relationships and mental health. The debilitating effects of HS can compound over a patient's lifetime and have lasting repercussions. The cumulative life course impairment (CLCI) model analyses the disease factors that could affect the life course trajectory of a patient, including effects on major life decisions and opportunities, such as relationships, career path, education and starting a family. As with other diseases, direct longitudinal data for CLCI would require large long cohort studies. Nonetheless, the evidence supports that common domains delineated in the CLCI document impact that are consistent with the negative impact of HS on life course.</p>","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143597058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic variation of the gene COL17A1 and bullous pemphigoid in patients with neurodegenerative disorders.","authors":"Meltzanidou Parthena, Fantakis Antonios, Vassileva Snejina, Drenovska Kossara, Deretzi Georgia, Chatzopoulou Aikaterini, Kyriakou Aikaterini, Lazaridou Elisavet, Lambropoulos Alexandros, Syrrou Maria, Patsatsi Aikaterini","doi":"10.1111/jdv.20630","DOIUrl":"https://doi.org/10.1111/jdv.20630","url":null,"abstract":"","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of biologics for hidradenitis suppurativa: A network meta-analysis of phase III trials.","authors":"Laura Calabrese, Alessandra Cartocci, Pietro Rubegni, Lars E French, Benjamin Kendziora","doi":"10.1111/jdv.20617","DOIUrl":"https://doi.org/10.1111/jdv.20617","url":null,"abstract":"<p><strong>Background: </strong>Phase III clinical trials are designed to evaluate the therapeutic effect of drugs and their superiority over other treatment methods, but biologics for hidradenitis suppurativa (HS) have not been compared head-to-head in phase III studies.</p><p><strong>Objective: </strong>To evaluate the relative efficacy and safety of biologics for HS in a network meta-analysis including available data from phase III trials.</p><p><strong>Methods: </strong>MEDLINE and Embase were searched for phase III trials investigating the efficacy and/or safety of at least one biologic for moderate-to-severe HS. The odds ratios for reaching an HS Clinical Response 50 (HiSCR50) and for the occurrence of adverse events after 12-16 weeks were compared between treatments.</p><p><strong>Results: </strong>PIONEER I and II (adalimumab 40 mg weekly vs. placebo), SUNSHINE and SUNRISE (secukinumab 300 mg every 2 vs. 4 weeks vs. placebo) as well as BE HEARD I and II (bimekizumab 320 mg every 2 vs. 4 weeks vs. placebo) with 2731 patients were included. Adalimumab weekly was ranked most effective in reaching a HiSCR50 with significant superiority over secukinumab every 2 weeks (OR = 1.74; 95% confidence interval [CI]: 1.11-2.73) and 4 weeks (OR = 1.72; 95% CI: 1.09-2.7) and insignificant superiority over bimekizumab every 2 weeks (OR = 1.23; 95% CI: 0.74-2.06) and 4 weeks (OR = 1.25; 95% CI: 0.73-2.14). Adalimumab showed the fewest adverse events with significant superiority over bimekizumab every 2 weeks (OR = 0.52; 95% CI: 0.32-0.86) and insignificant superiority over bimekizumab every 4 weeks (OR = 0.79; 95% CI: 0.47-1.33) and secukinumab every 2 weeks (OR = 0.69; 95% CI: 0.45-1.07) and 4 weeks (OR = 0.71; 95% CI: 0.46-1.1).</p><p><strong>Conclusions: </strong>Among currently approved biologic agents for moderate-to-severe HS, adalimumab demonstrated the highest efficacy and safety in the first 12-16 weeks of treatment.</p>","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Secondary resistance to sonidegib is rare in locally advanced basal cell carcinoma.","authors":"Eva Muñoz Couselo, Carola Berking, Jean François Baurain, Serena Martelli, Ramon Arntz, Paola Savoia","doi":"10.1111/jdv.20629","DOIUrl":"https://doi.org/10.1111/jdv.20629","url":null,"abstract":"","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erectile dysfunction in dermatology and venereology: From aetiopathogenic mechanisms to practical considerations for dermato-venereologists.","authors":"Andrei Tanasov, George-Sorin Tiplica","doi":"10.1111/jdv.20618","DOIUrl":"https://doi.org/10.1111/jdv.20618","url":null,"abstract":"<p><p>Erectile dysfunction (ED) is an often undiagnosed but significantly prevalent condition among male dermato-venereological patients, characterized by a complex pathophysiology and a substantial impact on quality of life. This review aimed to synthesize recent literature on the increased risk of ED in skin diseases, the underlying pathogenic mechanisms-including vasculogenic, endocrine, neurogenic, psychogenic and immunologic pathways-as well as the dermatologist's role in managing patients' sexual health. Inflammatory conditions (e.g. psoriasis, atopic dermatitis, lichen simplex chronicus and chronic hand eczema), infections (viral, bacterial and fungal, including sexually transmitted infections), autoimmune conditions (e.g. scleroderma and pemphigus) and disorders of the apocrine and eccrine glands (such as hidradenitis suppurativa) have all been linked to ED. The multi-systemic nature of many dermatologic diseases has become increasingly evident due to their associations with cardiovascular and metabolic comorbidities (atherosclerosis, hypertension, metabolic syndrome and vitamin D deficiency), central and peripheral neuropathies, endocrine disorders (hypogonadism and diabetes mellitus) or genito-urinary sequelae of sexually transmitted infections, while psychogenic ED further highlights the major mental health burden of skin conditions. Dermatologists are in the unique position to evaluate patients' sexual function and risk factors, investigate potential causes through accessible routine tests, prescribe impotence medication, consider erectile and overall sexual function in the dermatologic treatment choice and provide integrative lifestyle recommendations. Addressing sexual health in dermatologic practice offers significant benefits for both patients and healthcare systems, improving compliance, reducing logistical challenges and optimizing financial outcomes.</p>","PeriodicalId":17351,"journal":{"name":"Journal of the European Academy of Dermatology and Venereology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}