Journal of the Endocrine Society最新文献

{"title":"Oral Sodium Loading Test Is More Sensitive Than Seated Saline Infusion Test to Confirm Overt Primary Aldosteronism.","authors":"Laurence Duquet, Laura Lefebvre, Samuel Lemaire-Paquette, Mandy Malick, Pierre-Luc Mallet, Matthieu St-Jean","doi":"10.1210/jendso/bvae209","DOIUrl":"10.1210/jendso/bvae209","url":null,"abstract":"<p><strong>Context: </strong>Primary aldosteronism (PA), a frequent but underdiagnosed cause of hypertension, is associated with a significant burden of cardiovascular and renal complications. Studies have reported divergent results regarding the diagnostic performance of seated saline infusion test (SSIT) and oral sodium loading test (OSLT), 2 confirmatory tests recommended by the Endocrine Society Clinical Practice Guidelines. To our knowledge, no study directly compared the results of SSIT and OSLT to diagnose overt PA.</p><p><strong>Objective: </strong>We assessed the diagnostic performance of SSIT and OSLT in a group of patients with hypertension and elevated screening aldosterone-renin ratio (ARR). The diagnostic standard was defined as hypertension with or without hypokalemia with an elevated screening ARR and at least 1 abnormal confirmation test including OSLT and SSIT.</p><p><strong>Methods: </strong>A monocentric retrospective study was conducted, including 87 patients with hypertension with a positive screening who underwent both SSIT and OSLT. A diagnostic performance analysis was conducted using urinary aldosterone at a threshold of 27 nmol/day as the criterion for OSLT, in comparison to a plasma aldosterone concentration (PAC) exceeding 140 pmol/L following the saline infusion.</p><p><strong>Results: </strong>A statistically significant difference in sensitivity was observed between OSLT and SSIT, with OSLT demonstrating superior performance (<i>P</i> = .025). The aforementioned test exhibited concordance in 59 cases (65.5%), indicating that these methods are not equivalent (McNemar test <i>P</i> = .036).</p><p><strong>Conclusion: </strong>OSLT demonstrated a significantly higher sensitivity for diagnosing overt PA in comparison with the SSIT in our cohort of patients with hypertension with an abnormal screening ARR.</p>","PeriodicalId":17334,"journal":{"name":"Journal of the Endocrine Society","volume":"9 3","pages":"bvae209"},"PeriodicalIF":3.0,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11795192/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Low Maternal Weight on Pregnancy and Neonatal Outcomes.","authors":"Nikhita Chahal, Tanya Qureshi, Soukaina Eljamri, Janet M Catov, Pouneh K Fazeli","doi":"10.1210/jendso/bvae206","DOIUrl":"10.1210/jendso/bvae206","url":null,"abstract":"<p><strong>Objective: </strong>To examine the effect of underweight maternal body mass index (BMI) on pregnancy complications and neonatal outcomes.</p><p><strong>Design: </strong>Cohort study.</p><p><strong>Setting: </strong>Tertiary academic center.</p><p><strong>Patients: </strong>A total of 16 361 mothers who delivered a singleton between 2015-2021 with either a BMI <18.5 kg/m² (n = 732) or normal BMI (18.5 ≥ BMI <23 or 25 kg/m², n = 15 629) at the initial prenatal visit or within 6 months of the initial visit.</p><p><strong>Main outcome measures: </strong>Birthweight, gestational age, neonatal intensive care unit admission, preterm birth, and fetal death; obstetrical complications including preeclampsia/eclampsia, premature rupture of membranes, preterm premature rupture of membranes, and postpartum hemorrhage.</p><p><strong>Results: </strong>Underweight women were younger and less likely to have private insurance (<i>P</i> < .01 for both) than normal-weight women. Approximately 23% of infants born to underweight mothers were small for gestational age and 15% were low birth weight vs 13.5% and 9% of infants of normal-weight mothers, respectively (<i>P</i> < .01 for both). These differences remained significant after adjusting for potential confounders. In adjusted logistic regression models, underweight women had a decreased risk of premature rupture of membranes and postpartum hemorrhage compared to normal-weight women.</p><p><strong>Conclusion: </strong>Underweight BMI during pregnancy is associated with an increased risk of small for gestational age and low birth weight infants and a decreased risk of premature rupture of membranes and postpartum hemorrhage. These findings suggest underweight BMI during pregnancy increases the risk of adverse neonatal outcomes, while maternal-related pregnancy outcomes are less affected.</p>","PeriodicalId":17334,"journal":{"name":"Journal of the Endocrine Society","volume":"9 1","pages":"bvae206"},"PeriodicalIF":3.0,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11635456/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142818503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social Determinants of Health for Cardiovascular-Kidney-Metabolic Syndrome Among Patients With Diabetes.","authors":"Kibret Enyew Belay, Yeweyenhareg Feleke, Theodros Aberra Alemneh, Asteway Mulat Haile, Dawit Girma Abebe","doi":"10.1210/jendso/bvae208","DOIUrl":"10.1210/jendso/bvae208","url":null,"abstract":"<p><strong>Context: </strong><i>Cardiovascular-kidney-metabolic (CKM)</i> syndrome is a recently introduced term that is a complex disease consisting of cardiovascular disease, renal disease, obesity, and diabetes. The association of social determinants of health (SDOH) with CKM syndrome is not fully known.</p><p><strong>Objective: </strong>We aimed to assess SDOH affecting CKM syndrome among adult patients with diabetes at follow-up at a tertiary hospital in Ethiopia.</p><p><strong>Methods: </strong>A cross-sectional hospital-based study was used. Data were collected using a Kobo toolbox and entered into SPSS version 29 for further analysis.</p><p><strong>Results: </strong>A total of 422 adult patients with diabetes were included in this study. The mean ± SD age of the patients was 54.14 ± 13.74 years. Fifty-two percent of the patients were male. In this study, 52.4% had cardiovascular kidney metabolic syndrome. Male patients (AOR: 1.73; 95% CI, 1.01-2.94), lost to follow-up for more than a year due to lack of money (AOR: 2.69; 95% CI, 1.01-7.22), missed an appointment due to lack of transportation in the past 1 year (AOR: 2.98; 95% CI, 1.21-7.33), were patients with disability (AOR: 1.97; 95% CI, 1.12-3.48), had hypertension (AOR: 3.12; 95% CI, 1.85-5.28), had obesity (AOR: 2.27, 95% CI, 1.17, 4.40), and were in retirement (AOR: 2.12; 95% CI, 1.04-4.30) these being more significantly associated with CKM syndrome.</p><p><strong>Conclusion: </strong>More than half of patients had CKM syndrome. More attention should be given to SDOH, including male sex, financial constraints, transportation issues, disability, and retirement.</p>","PeriodicalId":17334,"journal":{"name":"Journal of the Endocrine Society","volume":"9 1","pages":"bvae208"},"PeriodicalIF":3.0,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11635457/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142818513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship Between 1,5 Anhydroglucitol, Glycemia, and Breastfeeding During Pregnancy and Postpartum: A Pilot Study.","authors":"Marti D Soffer, Kaitlyn E James, Michael Callahan, Emily A Rosenberg, William H Barth, Camille E Powe","doi":"10.1210/jendso/bvae207","DOIUrl":"10.1210/jendso/bvae207","url":null,"abstract":"<p><strong>Background: </strong>Assessments for hyperglycemia are vital to pregnancy and postpartum (PP) care, but gold-standard oral glucose tolerance tests (OGTTs) are burdensome. We examined changes in 1,5 anhydroglucitol (1,5AG) levels during gestation and PP and assessed for associations with other measures of glycemia.</p><p><strong>Study design: </strong>Pregnant participants (n = 50) in the Study of Pregnancy Regulation of Insulin and Glucose cohort underwent OGTTs at a mean of 13 weeks ([visit 1 (V1)] and 26 weeks [visit 2 (V2)] of gestation and PP. Nonpregnant controls had a single OGTT. 1,5AG was measured using frozen plasma samples. Changes in 1,5AG across pregnancy were assessed with longitudinal mixed effects linear models. We assessed relationships between 1,5AG and glycemia at each timepoint using Spearman correlations and linear regression models. To determine the relationship of 1,5AG with breastfeeding (BF) status, stratified analyses were performed.</p><p><strong>Results: </strong>1,5AG decreased from V1 to V2 (β = -3.6 μg/mL, <i>P</i> < .001) and remained low PP compared to V1 (β = -1.4 μg/mL, <i>P</i> = .018). Comparisons between pregnant/PP and nonpregnant participants revealed lower 1,5AG values at all timepoints (V1 β = -9.9μg/mL, <i>P</i> < .001; V2 β = -14.0 μg/mL, <i>P</i> < .001, PP β = -11.4μg/mL, <i>P</i> < .001). There was no association between 1,5AG and glycemia. Compared to those exclusively feeding formula, 1,5AG levels were significantly lower in exclusively BF women (β = -8.8 μg/mL, <i>P</i> < .001) and intermediate in women feeding both breastmilk and formula (β = -6.1μg/mL, <i>P</i> < .001), independent of glycemia.</p><p><strong>Conclusion: </strong>1,5AG decreases during gestation and remains low PP. Breastfeeding is associated with lower 1,5AG levels, indicating plausible excretion into breastmilk. 1,5AG is unlikely to be useful in assessing glycemia in pregnant or PP women.</p>","PeriodicalId":17334,"journal":{"name":"Journal of the Endocrine Society","volume":"9 1","pages":"bvae207"},"PeriodicalIF":3.0,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11635448/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142818507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of Whole-Exome Sequencing and Pedigree Analysis to Identify X-linked Hypophosphatemia in Saudi Arabian Families.","authors":"Mohamed H Al-Hamed, Sarah Bakhamis, Sara I Abdelfattah, Afaf Alsagheir","doi":"10.1210/jendso/bvae203","DOIUrl":"10.1210/jendso/bvae203","url":null,"abstract":"<p><strong>Context: </strong>X-linked hypophosphatemia (XLH) is the most common form of inherited hypophosphatemic rickets (HR), caused by pathogenic variants in the <i>PHEX</i> gene. Genetic diagnosis of XLH facilitates early treatment optimization, especially for patients suitable for burosumab, a recombinant anti-fibroblast growth factor-23 monoclonal antibody.</p><p><strong>Objective: </strong>This study aimed to use whole-exome sequencing (WES) and pedigree analysis to identify patients with XLH.</p><p><strong>Methods: </strong>Medical records at a single center in Saudi Arabia were screened between 2014 and 2024 to identify patients with suggested HR. Of the 800 patients identified, 27 had had suspected XLH. The genetic study comprised 100 patients drawn from these 27 families.</p><p><strong>Results: </strong>Clinical manifestations were widespread and variable within families. Severe disease was reported in 55% of children and 25% of adults. At presentation, all children were receiving either conventional therapy (60%) or burosumab (40%); however, 53% of adults were not treated. WES provided a genetic diagnosis in 23 families: alterations in the <i>PHEX</i> gene (20 families), with homozygous <i>ENPP1</i> and <i>DMP1</i> variants detected in 2 and 1 families, respectively. Pathogenic/likely pathogenic variants were detected in 23 families (diagnostic yield 85%). Ten novel likely pathogenic variants were detected. Pedigree analysis provided information to support disease-specific patient management.</p><p><strong>Conclusion: </strong>WES detected a diagnostic molecular abnormality in 85% of families with HR phenotypes; <i>PHEX</i> variants were the most common. Combined use of WES and pedigree analysis highlighted the underdiagnosis of adult XLH in this population, with most family members being diagnosed after the pedigree analysis.</p>","PeriodicalId":17334,"journal":{"name":"Journal of the Endocrine Society","volume":"9 1","pages":"bvae203"},"PeriodicalIF":3.0,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11631126/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Hypothyroidism on Cardiovascular-Related Healthcare Utilization in the US Population With Diabetes.","authors":"Marcelo Ramirez, Antonio C Bianco, Matthew D Ettleson","doi":"10.1210/jendso/bvae204","DOIUrl":"10.1210/jendso/bvae204","url":null,"abstract":"<p><strong>Context: </strong>Suboptimal treatment of hypothyroidism (HT) is associated with adverse cardiovascular disease (CVD) outcomes, for which patients with diabetes mellitus (DM) are at increased risk.</p><p><strong>Objective: </strong>This study aimed to compare CVD-related healthcare utilization in DM patients with and without HT in the US population.</p><p><strong>Methods: </strong>Participant data were collected from the Medical Expenditure Panel Survey (MEPS) over 10 years (2011-2020). Medical conditions were identified by ICD-9/ICD-10 codes associated with expenditures. Healthcare utilization outcomes included number of emergency, hospital, and outpatient visits associated with coronary artery disease (CAD), stroke/transient ischemic attack (TIA), or heart failure; prescriptions related to CVD; and number of visits to specialty providers. A propensity score-based fine stratification matching approach was used to balance sociodemographic covariates to determine the relative risk (RR) contributed by HT on CVD-related care utilization.</p><p><strong>Results: </strong>A total of 15 580 adult participants with DM were identified, of whom 11.9% had treated HT. In the weighted analysis, a significantly greater proportion of participants with HT had CAD and stroke/TIA-associated visits compared to those without HT (respectively, 22.4% vs 17.8%, <i>P = </i>.002; and 7.3% vs 5.4%, <i>P = </i>.020). In the matched analysis, participants with HT were more likely to see a specialist (cardiology, endocrinology, and nephrology). Participants with HT were more likely to be treated with cholesterol-lowering medications, beta-blockers, and diuretics.</p><p><strong>Conclusion: </strong>HT as a comorbidity with DM was associated with increased healthcare utilization related to CVD, specifically visits associated with stroke/TIA, increased use of specialty care, and greater utilization of CVD-related medications.</p>","PeriodicalId":17334,"journal":{"name":"Journal of the Endocrine Society","volume":"9 1","pages":"bvae204"},"PeriodicalIF":3.0,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11635454/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142818514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Stronger IMPACT on Career Development for Early- and Mid-career Faculty.","authors":"Daniel A Gorelick, Jason Gertz, Kaitlin J Basham, Lindsey S Treviño","doi":"10.1210/jendso/bvae191","DOIUrl":"10.1210/jendso/bvae191","url":null,"abstract":"<p><p>Nuclear receptors are important in normal physiology and disease. Physicians and scientists who study nuclear receptors organize and attend conferences and symposia devoted to foundational and translational nuclear receptor research, but the field lacks a platform for early-stage investigators and aspiring leaders. In 2019, Zeynep Madak-Erdogan, Rebecca Riggins, and Matthew Sikora founded Nuclear Receptor (NR) Interdisciplinary Meeting for Progress And Collaboration Together (IMPACT, https://nrimpact.com), a collaborative group designed for early- and mid-career faculty who study nuclear receptors in any context or organism [1]. NR IMPACT addresses challenges for early- and mid-career faculty. Here, we review the progress of NR IMPACT and discuss how our peer-mentoring cohort is removing hurdles for new faculty and advancing nuclear receptor biology.</p>","PeriodicalId":17334,"journal":{"name":"Journal of the Endocrine Society","volume":"8 12","pages":"bvae191"},"PeriodicalIF":3.0,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11574551/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142676118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of Hypothalamic Obesity With GLP-1 Analogs.","authors":"Paul Dimitri, Christian L Roth","doi":"10.1210/jendso/bvae200","DOIUrl":"10.1210/jendso/bvae200","url":null,"abstract":"<p><strong>Introduction: </strong>Congenital and acquired damage to hypothalamic nuclei or neuronal circuits controlling satiety and energy expenditure results in hypothalamic obesity (HO). To date, successful weight loss and satiety has only been achieved in a limited number of affected patients across multiple drug trials. Glucagon-like peptide-1 (GLP-1) acts via central pathways that are independent from the hypothalamus to induce satiety. GLP-1 receptor agonists (GLP-1RAs) may provide an alternative approach to treating HO.</p><p><strong>Methods: </strong>We performed a comprehensive search in Medline, Google Scholar, and clinical trials registries (ClinicalTrials.gov; clinicaltrialsregister.eur). This nonsystematic literature review was conducted to identify scientific papers published from January 2005 to February 2024 using the Pubmed and Embase databases. Key words used were GLP-1, GLP-1RA, hypothalamic obesity, suprasellar tumor, and craniopharyngioma.</p><p><strong>Results: </strong>Our search identified 7 case studies, 5 case series, and 2 published clinical trials relating to the use of GLP-1RAs in HO. All case studies demonstrated weight loss and improved metabolic function. In contrast, results from case series were variable, with some showing no weight loss and others demonstrating moderate to significant weight loss and improved metabolic parameters. In the ECHO clinical trial, nearly half the subjects randomized to weekly exenatide showed reduced body mass index (BMI). Paradoxically, BMI reduction was greater in patients with more extensive hypothalamic injuries.</p><p><strong>Conclusion: </strong>GLP-1RAs potentially offer a new approach to treating HO. There is a need to stratify patients who are more likely to respond. Further randomized controlled trials are required to determine their efficacy either in isolation or combined with other therapies.</p>","PeriodicalId":17334,"journal":{"name":"Journal of the Endocrine Society","volume":"9 1","pages":"bvae200"},"PeriodicalIF":3.0,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11655849/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142864747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fidelity of BMI, Waist, and Waist-to-Height Ratio as Adiposity Measures in Normoglycemic Black vs White American Adults.","authors":"Zhao Liu, Peace Asuzu, Avnisha Patel, Jim Wan, Samuel Dagogo-Jack","doi":"10.1210/jendso/bvae202","DOIUrl":"10.1210/jendso/bvae202","url":null,"abstract":"<p><strong>Objective: </strong>To assess ethnic disparities in the association between indirect and direct measures of adiposity in African American (AA) and European American (EA) adults.</p><p><strong>Methods: </strong>We analyzed the indirect [weight, body mass index (BMI), waist circumference (WC), waist-to-height ratio (WHtR)] and direct [total fat, trunk fat, fat-free mass (FFM)] adiposity measures in healthy AA and EA adults. Assessments included anthropometry, oral glucose tolerance test, body composition by dual-energy X-ray absorptiometry (DXA), and calculation of direct-to-indirect adiposity ratios (total fat/BMI, trunk fat/WC, trunk fat/WHtR, and FFM/weight).</p><p><strong>Results: </strong>A total of 314 subjects (167 AA, 147 EA) underwent DXA. All participants (mean age 44.2 ± 10.6 years) had normal fasting and 2-hour glucose values. The BMI (AA vs EA) was 31.2 ± 7.42 kg/m² vs28.8 ± 6.78 kg/m² (<i>P</i> = .0014); WC 95.3 ± 16.0 cm vs 92.9 ± 15.0 cm (<i>P</i> = .15). Significant correlations (<i>P</i> < .0001) were observed between BMI and total fat (r = 0.68), WC, and trunk fat (r = 0.61) and WHtR vs trunk fat (r = 0.77) for the combined cohort, with heterogeneity in the strength of association by sex and ethnicity. Fat-free mass was higher in AA vs EA participants (<i>P</i> = .03). Total fat/BMI was lower in AA vs EA participants (<i>P</i> = .0047); trunk fat/WC (<i>P</i> = .004) and trunk fat/WHtR (<i>P</i> = .0026) were lower in AA men vs EA men.</p><p><strong>Conclusion: </strong>The BMI overestimated body fat in AA participants vs EA participants, and WC overestimated trunk fat in AA men vs EA men. These data indicate ethnic disparities in the fidelity of indirect measures of adiposity and argue for ethnic-specific BMI thresholds for determination of overweight/obesity.</p>","PeriodicalId":17334,"journal":{"name":"Journal of the Endocrine Society","volume":"9 1","pages":"bvae202"},"PeriodicalIF":3.0,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11604086/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142751226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blood Pressure Decreases in Overweight Elderly Individuals on Vitamin D: A Randomized Trial.","authors":"Maya Rahme, Laila Al-Shaar, Hani Tamim, Ghada El-Hajj Fuleihan","doi":"10.1210/jendso/bvae168","DOIUrl":"10.1210/jendso/bvae168","url":null,"abstract":"<p><strong>Context: </strong>Evidence for a beneficial role of vitamin D on blood pressure (BP) outcomes is inconclusive.</p><p><strong>Objective: </strong>This work aimed to investigate the effect of 2 doses of cholecalciferol (vitamin D₃) supplementation coadministered with calcium on systolic blood pressure (SBP) and diastolic blood pressure (DBP).</p><p><strong>Methods: </strong>Exploratory analyses were conducted from a 1-year, multicenter, double-blind, randomized controlled trial (RCT). Total of 221 ambulatory older overweight individuals received calcium dose and oral vitamin D₃, at the equivalent of 600 IU/day or 3750 IU/day.</p><p><strong>Results: </strong>SBP and DBP decreased significantly in the overall group, and in the high-dose group at 6 and 12 months. Similar trends were observed in the low-dose group, but did not achieve statistical significance. In participants with a body mass index (BMI) greater than 30, SBP decreased significantly in both treatment groups whereas DBP significantly decreased in the high-dose group only. In the subgroups of hypertensive participants (N = 143), there was a decrease in SBP and DBP at 6 and 12 months, with both vitamin D doses and independently of BMI levels. Using multivariate linear mixed models with random effects in the overall group of participants, SBP at 6 and 12 months was significantly predicted by BMI (β = .29; <i>P</i> = .05) and by baseline SBP (β = .16; <i>P</i> < .001), but not by vitamin D treatment dose.</p><p><strong>Conclusion: </strong>Vitamin D and calcium decrease SBP and DBP in overweight older individuals, but more is not necessarily better. This effect is seen in individuals with BMI greater than 30, in hypertensive patients, and seems to be largely independent of dose.</p>","PeriodicalId":17334,"journal":{"name":"Journal of the Endocrine Society","volume":"8 12","pages":"bvae168"},"PeriodicalIF":3.0,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11555685/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142622804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}