Journal of the Endocrine Society最新文献

{"title":"Response to Letter to the Editor From Spence: [Prevalence and Characteristics of Low-renin Hypertension in a Primary Care Population].","authors":"Sonali S Shah, Renata Libianto, Stella May Gwini, Grant Russell, Morag J Young, Peter J Fuller, Jun Yang","doi":"10.1210/jendso/bvae148","DOIUrl":"10.1210/jendso/bvae148","url":null,"abstract":"","PeriodicalId":17334,"journal":{"name":"Journal of the Endocrine Society","volume":"8 10","pages":"bvae148"},"PeriodicalIF":3.0,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11398892/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142289979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gene Misexpression in a <i>Smoc2</i>+ve/<i>Sox2</i>-Low Population in Juvenile <i>Prop1</i>-Mutant Pituitary Gland.","authors":"Bailey E Masser, Michelle L Brinkmeier, Yuxuan Lin, Qin Liu, Aya Miyazaki, Jannatun Nayeem, Leonard Y M Cheung","doi":"10.1210/jendso/bvae146","DOIUrl":"10.1210/jendso/bvae146","url":null,"abstract":"<p><p>Mutations in the pituitary-specific transcription factor Prophet of Pit-1 (<i>PROP1</i>) are the most common genetic etiology of combined pituitary hormone deficiency (CPHD). CPHD is associated with short stature, attributable to growth hormone deficiency and/or thyroid-stimulating hormone deficiency, as well as hypothyroidism and infertility. Pathogenic lesions impair pituitary development and differentiation of endocrine cells. We performed single-cell RNA sequencing of pituitary cells from a wild-type and a <i>Prop1</i>-mutant P4 female mouse to elucidate population-specific differential gene expression. We observed a <i>Smoc2</i>+ve population that expressed low <i>Sox2</i>, which trajectory analyses suggest are a transitional cell state as stem cells differentiate into endocrine cells. We also detected ectopic expression of <i>Sox21</i> in these cells in the <i>Prop1^df/df</i> mutant. <i>Prop1</i>-mutant mice are known to overexpress <i>Pou3f4</i>, which we now show to be also enriched in this <i>Smoc2</i>+ve population. We sought to elucidate the role of <i>Pou3f4</i> during pituitary development and to determine the contributions of <i>Pou3f4</i> upregulation to pituitary disease by utilizing double-mutant mice lacking both <i>Prop1</i> and <i>Pou3f4.</i> However, our data showed that <i>Pou3f4</i> is not required for normal pituitary development and function. Double mutants further demonstrated that the upregulation of <i>Pou3f4</i> was not causative for the overexpression of <i>Sox21</i>. These data indicate loss of <i>Pou3f4</i> is not a potential cause of CPHD, and further studies may investigate the functional consequence of upregulation of <i>Pou3f4</i> and <i>Sox21</i>, if any, in the novel <i>Smoc2</i>+ve cell population.</p>","PeriodicalId":17334,"journal":{"name":"Journal of the Endocrine Society","volume":"8 10","pages":"bvae146"},"PeriodicalIF":3.0,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11382140/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142289975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporal Trends in Acute Adrenal Insufficiency Events in Children With Congenital Adrenal Hyperplasia During 2019-2022.","authors":"Xanthippi Tseretopoulou, Salma R Ali, Jillian Bryce, Nadia Amin, Navoda Atapattu, Tania A S S Bachega, Federico Baronio, Rita Ortolano, Niels H Birkebaek, Walter Bonfig, Martine Cools, Justin H Davies, Tessy Thomas, Liat de Vries, Heba Elsedfy, Nermine H Amr, Christa E Flueck, Evgenia Globa, Tulay Guran, Zehra Yavas-Abali, Ayla Guven, Sabine E Hannema, Violeta Iotova, Daniel Konrad, Nina Lenherr-Taube, Nils P Krone, Sofia Leka-Emiri, Elpis Vlachopapadopoulou, Corina Lichiardopol, Otilia Marginean, Renata Markosyan, Uta Neumann, Marek Niedziela, Magdalena Banaszak-Ziemska, Franziska Phan-Hug, Sukran Poyrazoglu, Ursina Probst-Scheidegger, Tabitha Randell, Gianni Russo, Mariacarolina Salerno, Sumudu Seneviratne, Margarett Shnorhavorian, Ajay Thankamony, Rieko Tadokoro-Curraro, Erica van den Akker, Judith van Eck, Ana Vieites, Malgorzata Wasniewska, S Faisal Ahmed","doi":"10.1210/jendso/bvae145","DOIUrl":"10.1210/jendso/bvae145","url":null,"abstract":"<p><strong>Background: </strong>It is unclear whether targeted monitoring of acute adrenal insufficiency (AI) related adverse events (AE) such as sick day episodes (SDEs) and hospitalization rate in congenital adrenal hyperplasia (CAH) is associated with a change in the occurrence of these events.</p><p><strong>Aim: </strong>Study temporal trends of AI related AE in the I-CAH Registry.</p><p><strong>Methods: </strong>In 2022, data on the occurrence of AI-related AE in children aged <18 years with 21-hydroxylase deficiency CAH were compared to data collected in 2019.</p><p><strong>Results: </strong>In 2022, a total of 513 children from 38 centers in 21 countries with a median of 8 children (range 1-58) per center had 2470 visits evaluated over a 3-year period (2019-2022). The median SDE per patient year in 2022 was 0 (0-2.5) compared to 0.3 (0-6) in 2019 (<i>P</i> = .01). Despite adjustment for age, CAH phenotype and duration of study period, a difference in SDE rate was still apparent between the 2 cohorts. Of the 38 centers in the 2022 cohort, 21 had also participated in 2019 and a reduction in SDE rate was noted in 13 (62%), an increase was noted in 3 (14%), and in 5 (24%) the rate remained the same. Of the 474 SDEs reported in the 2022 cohort, 103 (22%) led to hospitalization compared to 299 of 1099 SDEs (27%) in the 2019 cohort (<i>P</i> = .02).</p><p><strong>Conclusion: </strong>The I-CAH Registry can be used for targeted monitoring of important clinical benchmarks in CAH. However, changes in reported benchmarks need careful interpretation and longer-term monitoring.</p>","PeriodicalId":17334,"journal":{"name":"Journal of the Endocrine Society","volume":"8 10","pages":"bvae145"},"PeriodicalIF":3.0,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11387114/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142289982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Metabolic Syndrome on Pregnancy Outcomes in Women Without Polycystic Ovary Syndrome.","authors":"Siyuan Li, Shuxin Ma, Xiangyi Yao, Peihao Liu","doi":"10.1210/jendso/bvae143","DOIUrl":"10.1210/jendso/bvae143","url":null,"abstract":"<p><strong>Context: </strong>Metabolic syndrome (MetS) is a cluster of metabolic risk factors that predict cardiovascular disease. Previous studies suggested that MetS impaired clinical outcomes in women with polycystic ovary syndrome (PCOS) undergoing in vitro fertilization (IVF).</p><p><strong>Objective: </strong>To evaluate the effects of MetS on IVF/intracytoplasmic sperm injection (ICSI) outcomes in women without PCOS.</p><p><strong>Methods: </strong>This retrospective study collected 8539 eligible women without PCOS who came for their first cycle of IVF/ICSI to the Institute of Women, Children and Reproductive Health, Shandong University, from 2017 to 2020, including 1147 subjects in the MetS group and 7392 in the control group. The primary outcome was live birth. Secondary outcomes included other pregnancy outcomes and the risk of maternal and neonatal complications.</p><p><strong>Results: </strong>Women in the MetS group had a lower live birth rate (50.6% vs 54.9%, adjusted odds ratio [aOR] 0.87, 95% CI 0.75-1.00, <i>P</i> = .045) and higher risks of late miscarriage (5.8% vs 3.3%, aOR 1.52, 95% CI 1.02-2.27, <i>P</i> = .041), gestational diabetes mellitus (13.7% vs 7.0%, aOR 1.84, 95% CI 1.30-2.60, <i>P</i> = .001), hypertensive disorder of pregnancy (7.8% vs 3.5%, aOR 1.79, 95% CI 1.14-2.83, <i>P</i> = .012), and preterm birth (9.0% vs 4.4%, aOR 2.03, 95% CI 1.33-3.08, <i>P</i> = .001). Singleton newborns in the MetS group were at higher risk of large for gestational age (33.3% vs 20.5%, aOR 1.66, 95% CI (1.31-2.13), <i>P</i> < .001) but at lower risk of small for gestational age (2.7% vs 6.2%, aOR 0.48, 95% CI 0.25-0.90, <i>P</i> = .023).</p><p><strong>Conclusion: </strong>MetS was associated with adverse IVF/ICSI outcomes in women without PCOS.</p>","PeriodicalId":17334,"journal":{"name":"Journal of the Endocrine Society","volume":"8 10","pages":"bvae143"},"PeriodicalIF":3.0,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11368129/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142120052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fragility Fractures and Cortisol Secretion in Patients With Nonfunctioning Adrenal Incidentalomas.","authors":"Vittoria Favero, Elisa Cairoli, Cristina Eller-Vainicher, Valentina Morelli, Antonio Stefano Salcuni, Silvia Della Casa, Giovanna Muscogiuri, Carla Columbu, Flavia Pugliese, Sabrina Corbetta, Luca Persani, Alfredo Scillitani, Iacopo Chiodini","doi":"10.1210/jendso/bvae144","DOIUrl":"10.1210/jendso/bvae144","url":null,"abstract":"<p><strong>Context: </strong>The risk of vertebral fractures (VFx) in patients with nonfunctioning adrenal incidentalomas (NFAI) is unknown.</p><p><strong>Objective: </strong>This work aimed to assess in NFAI patients the prevalence and incidence of VFx and a hormonal marker to identify patients at risk.</p><p><strong>Methods: </strong>A retrospective, cross-sectional, and longitudinal study of outpatients was conducted. A total of 306 NFAI patients (cross-sectional arm) and 213 controls were evaluated for VFx prevalence; 85 NFAI patients (longitudinal arm, follow-up 30.3 ± 17.5 months) were evaluated for VFx incidence. Main outcome measures included serum cortisol after 1 mg-dexamethasone test (F-1mgDST), lumbar spinal (LS), and femoral neck (FN) bone mineral density (BMD) and VFx presence, by radiograph of the spine.</p><p><strong>Results: </strong>Cross-sectional arm: prevalent VFx associated with F-1mgDST with a cutoff of 1.2 µg/dL (33 nmol/L, area under the curve 0.620 ± 0.39; <i>P</i> = .002). Compared with controls and NFAI patients with F-1mgDST less than 1.2 µg/dL (group A), NFAI patients with F-1mgDST greater than or equal to 1.2 µg/dL (group B) showed a higher VFx prevalence (10.8%, 12.6%, and 29.5%, respectively; <i>P</i> < .001 all comparisons), which was associated with F-1mgDST greater than or equal to 1.2 µg/dL (odds ratio 3.02; 95% CI, 1.63-5.58; <i>P</i> < .001) accounting to confounders. Longitudinal arm: the VFx incidence was higher in group B than in group A (19.3% vs 3.6%; <i>P</i> = .05). In group B, all incident VFx occurred in patients without low BMD. The F-1mgDST cutoff for predicting an incident VFx was 1.2 µg/dL, although statistical significance was not reached after adjustment for confounders (<i>P</i> = .061).</p><p><strong>Conclusion: </strong>In NFAI patients, F-1mgDST levels greater than or equal to 1.2 µg/L (33 nmol/L) are associated with prevalent VFx and may identify patients at risk of incident VFx.</p>","PeriodicalId":17334,"journal":{"name":"Journal of the Endocrine Society","volume":"8 10","pages":"bvae144"},"PeriodicalIF":3.0,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11348107/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142108695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diabetes Stigma and Clinical Outcomes: An International Review.","authors":"Kelsey B Eitel, Catherine Pihoker, Catherine E Barrett, Alissa J Roberts","doi":"10.1210/jendso/bvae136","DOIUrl":"10.1210/jendso/bvae136","url":null,"abstract":"<p><p>Diabetes stigma is the social burden of living with diabetes. People with diabetes may experience or perceive an adverse social judgment, prejudice, or stereotype about living with diabetes at work, school, in healthcare settings, popular culture, or relationships. This review describes the methods that have been used to assess diabetes stigma, and explores the prevalence of diabetes stigma, associated sociodemographic and socioeconomic factors, cultural factors, and how diabetes stigma is associated with clinical outcomes, including HbA1c levels, diabetic ketoacidosis, severe hypoglycemia, and chronic complications, in addition to psychosocial complications in youth, adolescents, and adults with type 1 diabetes (T1D) and type 2 diabetes (T2D). The prevalence of diabetes stigma has been reported as high as 78% in adults with T1D, 70% in adults with T2D, 98% in youth and adolescents with T1D, and is unknown in youth and adolescents with T2D. Diabetes stigma has been associated with lower psychosocial functioning, decreased self-care behaviors, higher HbA1c levels, and higher frequency of diabetes complications in adults with T1D and T2D. In adolescents and young adults with T1D, diabetes stigma is associated with lower psychosocial functioning, higher HbA1c levels, and higher frequency of diabetic ketoacidosis and severe hypoglycemia episodes in addition to chronic complications. In youth and adolescents with T2D, one study demonstrated an association of diabetes stigma with lower psychosocial functioning, higher HbA1c levels, and presence of retinopathy. Gaps exist in our understanding of the mechanisms of diabetes stigma, particularly in youth and adolescents with T2D.</p>","PeriodicalId":17334,"journal":{"name":"Journal of the Endocrine Society","volume":"8 9","pages":"bvae136"},"PeriodicalIF":3.0,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11299019/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141893652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of Succinate Dehydrogenase Gene Variant Carriers by Blood Biomarkers.","authors":"Marcel Gebhardt, Carola Kunath, Dennis Fröbel, Alexander M Funk, Mirko Peitzsch, Svenja Nölting, Timo Deutschbein, Andrzej Januszewicz, Henri J L M Timmers, Mercedes Robledo, Arne Jahn, Georgiana Constantinescu, Graeme Eisenhofer, Christina Pamporaki, Susan Richter","doi":"10.1210/jendso/bvae142","DOIUrl":"10.1210/jendso/bvae142","url":null,"abstract":"<p><strong>Background: </strong>Carriers of germline pathogenic variants (PVs) in succinate dehydrogenase genes (<i>SDHx</i>) are at risk of developing tumors, including paragangliomas, gastrointestinal stromal tumors, and renal cell carcinomas. Early tumor detection is paramount for improved clinical outcome. Blood-based biomarkers could aid in identifying individuals with PVs early and provide functional evidence in patients with variants of unknown significance.</p><p><strong>Methods: </strong>Blood plasma, urine, peripheral blood mononuclear cells, and erythrocytes from patients with and without <i>SDHx</i> PVs were investigated for central carbon metabolites. These were measured by liquid chromatography-tandem mass spectrometry and nuclear magnetic resonance spectroscopy and included among others, succinate, fumarate, α-ketoglutarate, and lactate.</p><p><strong>Results: </strong>Plasma succinate to fumarate ratios effectively distinguished tumor-bearing and asymptomatic patients with and without <i>SDHx</i> PV with promising diagnostic performance (areas under the receiver operating characteristic curve 0.86-0.95), although higher levels were noted in individuals with <i>SDHB</i> PV. Metabolites in urine and in peripheral blood mononuclear cell extracts were largely similar between groups. Erythrocytes showed strong metabolic alterations in patients with <i>SDHx</i> PV compared to controls, with 8 of 13 low-molecular organic acids being significantly different (<i>P</i> < .05). The lactate-α-ketoglutarate-ratio of erythrocytes identified individuals with <i>SDHx</i> PV equally well as plasma, with a sensitivity and specificity of 92% (AUC 0.97).</p><p><strong>Conclusion: </strong>Blood biomarkers have been underutilized for identifying carriers of <i>SDHx</i> PV or to validate variants of unknown significance. Our findings advocate for further investigation into a combined approach involving plasma and erythrocytes for future diagnostic strategies.</p>","PeriodicalId":17334,"journal":{"name":"Journal of the Endocrine Society","volume":"8 9","pages":"bvae142"},"PeriodicalIF":3.0,"publicationDate":"2024-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11323779/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141982594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma Steroid Profiling Between Patients With and Without Diabetes Mellitus in Nonfunctioning Adrenal Incidentalomas.","authors":"Yui Nakano, Maki Yokomoto-Umakoshi, Kohta Nakatani, Hironobu Umakoshi, Hiroshi Nakao, Masamichi Fujita, Hiroki Kaneko, Norifusa Iwahashi, Tatsuki Ogasawara, Tazuru Fukumoto, Yayoi Matsuda, Ryuichi Sakamoto, Yoshihiro Izumi, Takeshi Bamba, Yoshihiro Ogawa","doi":"10.1210/jendso/bvae140","DOIUrl":"10.1210/jendso/bvae140","url":null,"abstract":"<p><strong>Context: </strong>Adrenal incidentalomas, including nonfunctioning adrenal incidentalomas (NFAI), are associated with a high prevalence of diabetes mellitus (DM). While NFAI is diagnosed by exclusion when no hormone excess exists, subtle cortisol secretion may exist and contribute to DM development. However, it alone cannot explain the increased risk, and whether other steroid metabolites are involved remains unclear.</p><p><strong>Purpose: </strong>To investigate steroid metabolites associated with DM in patients with NFAI using plasma steroid profiles.</p><p><strong>Methods: </strong>Using liquid chromatography-tandem mass spectrometry, 22 plasma steroid metabolites were measured in 68 patients with NFAI (31 men and 37 women). Data were adjusted for age before normalization.</p><p><strong>Results: </strong>Discriminant analysis showed that plasma steroid profiles discriminated between patients with and without DM in men (n = 10 and = 21, respectively) but not women: 11β-hydroxytestosterone, an adrenal-derived 11-oxygenated androgen, contributed most to this discrimination and was higher in patients with DM than in those without DM (false discovery rate = .002). 11β-hydroxytestosterone was correlated positively with fasting plasma glucose (r = .507) and hemoglobin A1c (HbA1c) (r = .553) but negatively with homeostatic model assessment of β-cell function (HOMA2-B) (r = -.410). These correlations remained significant after adjusting for confounders, including serum cortisol after the 1-mg dexamethasone suppression test. Bayesian kernel machine regression analysis verified the association of 11β-hydroxytestosterone with HbA1c and HOMA2-B in men.</p><p><strong>Main conclusion: </strong>Plasma steroid profiles differed between those with and without DM in men with NFAI. 11β-hydroxytestosterone was associated with hyperglycemia and indicators related to pancreatic β-cell dysfunction, independently of cortisol.</p>","PeriodicalId":17334,"journal":{"name":"Journal of the Endocrine Society","volume":"8 9","pages":"bvae140"},"PeriodicalIF":3.0,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11322837/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141982595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SHBG, Free Testosterone, and Type 2 Diabetes Risk in Middle-aged African Men: A Longitudinal Study.","authors":"Ikanyeng D Seipone, Amy E Mendham, Karl-Heinz Storbeck, Imken Oestlund, Clement N Kufe, Tinashe Chikowore, Maphoko Masemola, Nigel J Crowther, Andre Pascal Kengne, Shane Norris, Tommy Olsson, Todd Brown, Lisa K Micklesfield, Julia H Goedecke","doi":"10.1210/jendso/bvae129","DOIUrl":"10.1210/jendso/bvae129","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate longitudinal changes in SHBG and free testosterone (free T) levels among Black middle-aged African men, with and without coexistent HIV, and explore associations with incident dysglycaemia and measures of glucose metabolism.</p><p><strong>Design: </strong>This longitudinal study enrolled 407 Black South African middle-aged men, comprising primarily 322 men living without HIV (MLWOH) and 85 men living with HIV (MLWH), with normal fasting glucose at enrollment. Follow-up assessments were conducted after 3.1 ± 1.5 years.</p><p><strong>Methods: </strong>At baseline and follow-up, SHBG, albumin, and total testosterone were measured and free T was calculated. An oral glucose tolerance test at follow-up determined dysglycaemia (impaired fasting glucose, impaired glucose tolerance, type 2 diabetes) and glucose metabolism parameters including insulin sensitivity (Matsuda index), insulin resistance (homeostasis model assessment of insulin resistance), and beta(β)-cell function (disposition index). The primary analysis focussed on MLWOH, with a subanalysis on MLWH to explore whether associations in MLWOH differed from MLWH.</p><p><strong>Results: </strong>The prevalence of dysglycaemia at follow-up was 17% (n = 55) in MLWOH. Higher baseline SHBG was associated with a lower risk of incident dysglycaemia (odds ratio 0.966; 95% confidence interval 0.945-0.987) and positively associated with insulin sensitivity (β = 0.124, <i>P</i> < .001) and β-cell function (β = 0.194, <i>P</i> = .001) at follow-up. Free T did not predict dysglycaemia. In MLWH, dysglycaemia prevalence at follow-up was 12% (n = 10). Neither baseline SHBG nor free T were associated with incident dysglycaemia and glucose metabolism parameters in MLWH.</p><p><strong>Conclusion: </strong>SHBG levels predict the development of dysglycaemia in middle-aged African men but do not exhibit the same predictive value in MLWH.</p>","PeriodicalId":17334,"journal":{"name":"Journal of the Endocrine Society","volume":"8 8","pages":"bvae129"},"PeriodicalIF":3.0,"publicationDate":"2024-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11272087/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141759495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: \"Potential Mediating Role of Iron Biomarkers in the Association of Sex With Glucose, Insulin, and Type 2 Diabetes\".","authors":"","doi":"10.1210/jendso/bvae133","DOIUrl":"https://doi.org/10.1210/jendso/bvae133","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1210/jendso/bvae098.].</p>","PeriodicalId":17334,"journal":{"name":"Journal of the Endocrine Society","volume":"8 8","pages":"bvae133"},"PeriodicalIF":3.0,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11255475/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141723815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}